오존노출 후 백서 기도점막의 형태학적 변화

김병국,나기상,신시옥,Kim, Byung-Kook,Rha, Ki-Sang,Shin, See-Ok 대한기관식도과학회 2000 大韓氣管食道科學會誌 Vol.6 No.1

Objectives : This study was designed to compare the morphological changes in the nasal, tracheal and main bronchial mucosa in rats exposed to 0, 0.3, 0.6, 0.9 and 1.2 ppm ozone for 7 days, 6 hours per day. Materials and Methods : We observed the nasal, tracheal and main bronchial mucosa in rats exposed to 0, 0.3, 0.6, 0.9 and 1.2 ppm ozone for 7days, 6hours per day with LM, SEM and TEM. Results : In light microscopy, influx of inflammatory cells, epithelial hyperplasia, loss of cilia and increased goblet cells were observed in all rats except those exposed to 0.3 ppm. these findings increased with the increase of ozone concentration, but there were no significant differences among the nasal, tracheal and main bronchial mucosa in rats exposed to the same ozone concentration. In scanning electron microscopy, a loss of cilia was observed in rats exposed to 0.3 ppm in some sections and 0.6 ppm and 1.2 ppm in all sections. In transmission electron microscopy, vacuolization of epithelial cells was observed in rats exposed to 0.3 ppm in some sections and 0.6 ppm in all sections. These results suggest that electron microscopic observation is necessary to study morphology of airway mucosa in rats exposed to ozone below 0.3 ppm. And also the morphological changes in nasal septal epithelium may reflect those of tracheal and bronchial epithelium after high concentration ozone-exposure.

외상성 시신경 손상에서 고단위 부신피질 홀몬제와 시신경 감압술의 치료효과

이수나(Su Na Lee),나기상(Ki Sang Rha),박근성(Keun Sung Park) 대한안과학회 2001 대한안과학회지 Vol.42 No.9

주침샘의 병변 없이 경부림프절에 발생한 Warthin씨 종양 1예

이용수(Young-Su Lee),박지수(Ji-Su Park),나기상(Ki Sang Rha),구본석(Bon Seok Koo),장재원(Jae Won Chang) 대한두경부종양학회 2015 대한두경부 종양학회지 Vol.31 No.2

Warthin’s tumor is the second most common salivary gland benign tumor, typically occurring in the fifth to seventh decades of life which shows an indolent feature. It is usually found in the parotid gland but occasionally in extra-parotid locations such as peri-parotid lymph node. However, Report of solitary Warthin’s tumor in cervical lymph node is unusual. We here report a case of 72-year-old male with simultaneous malignant melanoma on eyelid and cervical lymph node enlargement in cervical level II area thus mimicking malignancy metastasis. After excisional biopsy under the local anesthesia, pathology was reported as papillary cystadenoma lymphomatosum, which is a histologically pathognomic finding of Warthin’s tumor. However, there was no suspicious tumorous lesion in major or minor salivary glands. This case suggests that Warthin’s tumor should be considered as a possible pathology in solitary lymph node lesion of neck.

난알부민 감작 백서에서 오존이 비점막의 알레르기 반응에 미치는 영향

주인하(In Ha Ju),김용민(Yong Min Kim),정봉진(Bong Jin Jung),김현이(Hyun Yi Kim),박찬일(Chan Il Park),나기상(Ki Sang Rha) 대한천식알레르기학회 2002 천식 및 알레르기 Vol.22 No.2

N/A N/A

아데노이드 및 구개편도 절제술이 비저항과 비강 내 Geometry에 미치는 영향

나기상,박찬희,구본석,김영덕,김관호,박용호 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

수술 전 최소단면적이나 비강 부피는 아데노이드나 구개편도의 비대 정도와 상관관계를 보이지 않았으나 비저항은 아데노이드 비대 정도와 유의한 상관관계를 보였다. 구개편도 및 아데노이드 절제술 후 코막힘과 구호흡 증상의 유의한 호전을 보였다. 수술 후 비강의 최소단면적과 부피 등 nasal geometry는 통계적으로 유의한 변화가 없었으나 비저항은 수술 후 유의한 감소를 보였으며 수술 후 비저항의 감소 정도는 아데노이드 비대 정도와 유의한 상관 관계를 보였다 . 이상의 결과로 아데노이드와 구개편도의 비대를 보이는 소아에서 코막힘 증상을 일으키는 데는 아데노이드 비대가 주요 원인이 되며 주로 비강의 후방에 위치한 아데노이드의 mass effect에 의할 것으로 생각한다. The aim of this study was to determine whether adenoid or tonsillar hypertrophy and subsequent adenoidectomy and tonsillectomy affect pediatric nasal airway resistance and nasal geometry and to evaluate the relationships between the degree of hypertrophy and nasal airway resistance or nasal geometry. Thirty-two children, aged 3 to 15 years, selected for adenoidectomy and tonsillectomy due to chronic nasal obstruction and mouth breathing were enrolled. The size of adenoid was evaluated by cephalometric radiograph. The degree of tonsillar hypertrophy was graded clinically. Nasal airway resistance and nasal geometry was evaluated by active anterior rhinomanometry and acoustic rhinometry respectively. These measurements were repeated one month and three months post-operatively. The size of adenoid was found well correlated to preoperative nasal airway resistance. However, there were no correlations between the degree of tonsillar hypertrophy and preoperative nasal airway resistance or nasal geometry. Nasal geometry was not changed after operation. However, nasal airway resistance was reduced significantly at 3 months after operation and the size of adenoid was found well correlated to postoperative changes of nasal airway resistance.

백서에서 실험적으로 유발된 알레르기성 비염

나기상,전우진,김용민 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2

The present study was made with the aims of establishing an acceptable nasal allergy model in rats and presenting the basic data for further studies. Eleven Wistar rats were divided into an unsensitized control group (4 rats) and sensitized allergic group (seven rats). The sensitized group were immunized intraperitoneally with ovalbumin-aluminum hydroxide gel solution, followed by intranasal nebulization of ovalbumin. One day later, nasal provocation was performed by nasal instillation of 1% ovalbumin solution. We counted the number of snorting or scratching for 5 minutes after provocation. And we observed general morphology and also examined the number of eosinophil or mast cell in the stained tissue under a light microscope at 400 times magnification. The nasal symptoms and the infiltration of eosinophil or mast cell were significantly increased in allergy group than in control group. In allergy group, loss of cilia or epithelial hyperplasia were noted in some sections. In conclusion, an animal model of nasal allergy was successfully developed in Wistar rats.

급성 편도염 치료에 있어서 Loracarbef의 효과

나기상,성열웅,박찬일 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.1

The treatment of upper respiratory tract infection requires an agent with marked increased activity against broad sprectrum of pathogens, including β-lactamase producing bacteria. Loracarbef, a member of the carbacephem class of antibiotics resistant to β-lactamase producing pathogens, was evaluated for its efficacy and safety in the treatment of acute tonsillitis in adults. 30 patients with acute tonsillitis were given 200mg of loracarbef twice daily for 7 days. All patients were evaluated for the presence and severity of two subjective symptoms (sore throat and swallowing difficulty) and two objective signs (fever and throat injection) before and after the treatment. Overall clinical responses were assessed as : cure ; improvement ; relapse ; or failure. Of the 30 patients, 29 (97%) patients had a successful clinical responses (cure or improvement), 1 patient experienced a relapse, and there were no clinical failures. Loracarbef was well tolerated in all patients, although 1 patient complained of mild nausea. Our results indicate that loracarbef is a safe and effective alternative agent for the treatment of patients with acute tonsillitis.

만성 부비동염 환자에서 비기류에 대한 민감도의 변화

나기상,이석호,임동우,김병국,박찬일 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2

Nasal patency may be considered to have two aspects: the resistance to airflow and the sensation of airflow. Although the sensation of nasal airflow has received little attention from clinicians, it is likely that it is of great importance in clinical practice. However, there are no study that assess the sensation of nasal airflow in patients complaining of nasal obstruction. The aim of this study is to assess the airflow sensitivity of the nose in patients with chronic paranasal sinusitis. To assess the airflow sensitivity, we designed an apparatus delivering a pulsing jet of air at varying velocities. We measured threshold velocities at six different sites of each nasal cavity in fifteen patients and compared with the values in normal subjects. All patients had bilateral chronic sinusitis with polyp. The threshold velocities at all but site 5 were higher in sinusitis patients than in normal subjects. The difference at site 1, 3, 4 and 6 was statistically significant. Since a high threshold velocity indicates low sensitivity, our results suggest that airflow sensitivity is lowered in patients with chronic sinusitis. Disturbance of airflow sensation may contribute to the sensation of nasal obstruction in patients with chronic paranasal sinusitis.

만성 부비동염 환자에서 부비동 내시경수술 후 후각기능의 호전

나기상,신광철,김용민 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2

Few studies on the outcome of endoscopic sinus surgery have assessed the effect of this treatment on the sense of smell. We have collected data prospectively on 30 patients with bilateral chronic sinusitis, before and 8 weeks after surgery. Patients were asked after surgery whether their sense of smell was normal, better, a little better, the same, or worse. Olfactory detection thresholds were obtained using butanol sniff bottles. Subjective sensation of olfaction was improved in 70%, the same in 30% of patients. However, olfactory threshold score was improved in 50%, the same in 32%, and worse in 18% postoperatively. Normosmic nose was found in 10% before surgery. 26.7% showed hyposmic, and 63.3% were anosmic before surgery. The postoperative butanol test showed that 11.7% was normosmic, 50% hyposmic and 38.3% anosmic. Preoperative butanol threshold scores were lower as the severity of sinusitis increased while the degree of postoperative improvement showed no correlation with the severity of sinusitis. Cases of primary surgery showed higher preoperative butanol threshold scores and more pronounced postoperative improvement than cases of revision surgery. The results of this study suggest that impairment of olfaction in chronic sinusitis may be significantly improved following endoscopic sinus surgery.

정상가토의 ABR역치 및 잠복시

나기상 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2

Auditory brain stem responses were recorded in normal rabbits anesthetized with 10% chloral hydrate. Five distinct peaks were regularly observed, two( wave lI and Wave V)of them were more pronounced. The mean ABR threshold was 17.8 dB at 2KHz, 7.2 dB at 4KHz, and 3.9 dB at 6KHz. The wave latencies were gradually prolonged with decrease of stimulus intensity.