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원자층 증착법으로 성장한 HfO<sub>2</sub> 박막의 제조
김희철,김민완,김형수,김혁종,손우근,정봉교,김석환,이상우,최병호,Kim Hie-Chul,Kim Min-Wan,Kim Hyung-Su,Kim Hyug-Jong,Sohn Woo-Keun,Jeong Bong-Kyo,Kim Suk-Whan,Lee Sang-Woo,Choi Byung-Ho 한국재료학회 2005 한국재료학회지 Vol.15 No.4
The growth of hafnium oxide thin films by atomic layer deposition was investigated in the temperature range of $175-350^{\circ}C$ using $Hf[N(CH_3)_2]_4\;and\;O_2$ as precursors. A self-limiting growth of $0.6\AA/cycle$ was achieved at the substrate temperature of $240-280^{\circ}C$. The films were amorphous and very smooth (0.76-0.80 nm) as examined by X-ray diffractometer and atomic force microscopy, respectively. X-ray photoelectron spectroscopy analysis showed that the films grown at $300^{\circ}C$ was almost stoichiometric. Electrical measurements performed on $MoW/HfO_2$(20 nm)/Si MOS structures exhibited high dielectric constant$(\~17)$ and a remarkably low leakage current density of at an applied field of $1.5-6.2\times10^{-7}A/cm^2$ MV/cm, probably due to the stoichiometry of the films.
Bell's Palsy와 Ramsay Hunt Syndrome 환자군의 치료 기간에 따른 호전도의 비교 연구
김희철,김정호,김영일,Kim, Hee-Chul,Kim, Jeong-Ho,Kim, Young-Il 대한침구의학회 2008 대한침구의학회지 Vol.25 No.4
Objectives : The aim of this study is comparing the improvement of Bell's palsy and Ramsay hunt syndrome according to treatment duration. Methods : The 11cases diagnosed as Ramsay hunt syndrome and 30cases of Bell's palsy who visited Cheong-ju Oriental Medical hospital from February 2006 to June 2008 were evaluated. We used Yanagihara's unweighted Grading System to confirm the improvement. Results : In the analysis of cause, except the "none", the most common cause was "Overwork" in both two group. After 5-day treatment the score was getting worse but after 10-day treatment score was improved in both group. The improvement of Bell's palsy group was better than that of Ramsay hunt syndrome group after 5-day and 10-day treatment, but there was no significance. Conclusions : In comparison of Yanagihara's unweighted grading score checked before treatment, after 5-day, 10-day and 15-day treatment between Bell's palsy and Ramsay hunt sundrome, there was no statistical significant difference.
산발성 위암에서 Microsatellite Instability 빈도와 hMLH1 촉진자부위 메칠화
김희철,노선애,육정환,오성태,김병식,유창식,김진천,Kim Hee Cheol,Roh Sun Ae,Yook Jeong Hwan,Oh Sung Tae,Kim Byung Sik,Yu Chang Sik,Kim Jin Cheon 대한위암학회 2003 대한위암학회지 Vol.3 No.1
Background: An aberrant function of the mismatch repair system has been reported to underlie carcinogenesis in several tumors, including colorectal and gastric carcinomas, and to induce the typical genotype of microsatellite instability (MSI). Purpose: We aimed to determine the frequency of MSI in early-onset sporadic gastric carcinoma and elucidate the role of promoter methylation in hMLH1 as the mechanism of MSI. Materials and Methods: Thirty-six early-onset sporadic gastric carcinomas were analyzed to determine the status of MSI and the frequency of methylation of the promoter region in hMLH1. MSI was determined using five markers recommended by NCI: MSI-H (high), MSI-L (low), and MSS (Microsatellite stable). Methylation specific PCR (MSP) and direct automated genomic sequencing analysis with DNA modified by sodium bisulfite have been performed to confirm promoter region methylation. All the data were analyzed regarding characteristics of molecular changes, and clinicopathologic variables. Results: The microsatellite status was determined as MSI-H in five cases ($13.8\%$), MSI-L in 13 cases ($36.1\%$), and MSS in 18 cases ($50.0\%$). hMLH1 was methylated in seven cases ($19.4\%$). In all cases of MSI-H, promoter of hMLH1 was methylated, and in two of the 13 cases of MSI-L, hMLH1 promoter methylation was identified. Methylation was not found in any cases of MSS. Promoter methylation in hMLH1 was significantly correlated with MSI status (P<0.001). We could not find any relationship between MSI and clinicopathologic parameters. Conclusion: These results suggest that an abnormal function of the mismatch repair system may be associated with gastric carcinogenesis in more than $10\%$ of early-onset gastric carcinomas and MSI appeared to be closely related to the promoter methylation in hMLH1.
음이항분포 정보를 가진 베이지안 소프트웨어 신뢰도 성장모형에 관한 연구
김희철,박종구,이병수,Kim, Hui-Cheol,Park, Jong-Gu,Lee, Byeong-Su 한국정보처리학회 2000 정보처리논문지 Vol.7 No.3
Software reliability growth models are used in testing stages of software development to model the error content and time intervals betwewn software failures. In this paper, using priors for the number of fault with the negative binomial distribution nd the error rate with gamma distribution, Bayesian inference and model selection method for Jelinski-Moranda and Goel-Okumoto and Schick-Wolverton models in software reliability. For model selection, we explored the sum of the relative error, Braun statistic and median variation. In Bayesian computation process, we could avoid the multiple integration by the use of Gibbs sampling, which is a kind of Markov Chain Monte Carolo method to compute the posterior distribution. Using simulated data, Bayesian inference and model selection is studied.
한국인 정신분열병 환자에서 항정신병 약물의 치료 반응과 도파민 D2, D3 및 D4 수용체 유전자 다형성
김희철,정성원,김대광,정철호,Kim, Hee-Cheol,Jung, Sung-Won,Kim, Dae-Kwang,Jung, Chul-Ho 대한생물정신의학회 2007 생물정신의학 Vol.14 No.3
항정신병 약물의 치료 반응을 예측해 줄 수 있는 유전자 지표를 찾기 위한 최근의 많은 약물유전학 연구들은 일관된 결과를 보고하지 못하고 있다. 본 연구는 항정신병 약물의 치료 반응과 도파민 D2, D3 및 D4 수용체 유전자 다형성과 관련성을 조사하였다. 연구 대상은 18~60세에 해당되면서 정신분열병의 DSM-IV 진단기준을 만족하고 본 연구에 대해 서면 동의한 국립부곡병원의 입원 환자 200명이었다. 연구는 대상자들의 입원 당시 병록지를 검토하여 후향적으로 이루어졌다. 대상자들은 퇴원할 당시를 기준으로 약물치료 반응 정도에 따라'반응군'과'비반응군'으로 구분되었으며 양군 사이의 도파민 수용체 유전자 다형성 차이를 비교하였다. 대상자 200명 중에서 188명(94%)이 비전형 항정신병 약물을 사용하였고 반응군은 141명(70.5%)이었다. 도파민 D2 수용체 유전자 Ser311Cys 다형성, 도파민 D3 수용체 유전자 Ser9Gly 다형성, 도파민 D4 수용체 유전자 exon III의 48개 염기반복 다형성에서 반응군과 비반응군 사이의 대립유전자 및 유전자형 빈도의 차이를 보이지 않았다. 결론적으로 본 연구에서는 항정신병 약물의 치료 반응과 도파민 D2 수용체 유전자 Ser311Cys 다형성, 도파민 D3 수용체 유전자 Ser9Gly 다형성, 그리고 도파민 D4 수용체 유전자 exon III의 48개 염기반복 다형 성과는 연관성이 없었다. 향후에는 단일의 항정신병 약물에 대한 전향적인 방법의 통제된 연구가 필요하다. Objectives:A considerable number of pharmacogenetic studies have been performed in recent years to define the association of antipsychotic drug response with dopamine receptor polymorphisms. The purpose of this study was to investigate the relationship between the therapeutic response to antipsychotic drugs and the polymorphisms of the dopamine D2, D3, and D4 receptor genes(DRD2, DRD3 and DRD4, respectively). Methods:We conducted retrospective chart review of 200 consecutively hospitalized patients with the diagnosis of schizophrenia(DSM-IV) who were treated with various antipsychotics(94% atypical antipsychotics) at Bugok National Hospital, Korea. The patients were divided into two groups, responders and non-responders, by responsiveness to antipsychotic drugs according to a four-point scale used in previous studies; responders included moderate to marked responded patients and non-responders included none to minimal responded patients. We analyzed the Ser311Cys polymorphism in the DRD2, the Ser9Gly polymorphism in the DRD3, and the exon III 48 bp repeat polymorphism in the DRD4. Results:Among the total patients of 200, 141(70.5%) were categorized as responders. There were no significant differences in the frequencies of the DRD2, DRD3, and DRD4 alleles and genotypes between responders and non-responders. Conclusion:These results suggest that the Ser311Cys polymorphism in the DRD2, the Ser9Gly polym- orphism in the DRD3, and the exon III 48bp repeat polymorphism in the DRD4 are not associated with the therapeutic response to antipsychotic drugs in Korean schizophrenic patients. A larger prospective study is needed to elucidate the association between antipsychotic response and dopamine receptor gene polymorphism.
수명분포가 감마족인 기록값 통계량에 기초한 무한고장 NHPP 소프트웨어 신뢰성장 모형에 관한 비교 연구
김희철,신현철,Kim, Hee-Cheul,Sin, Hyun-Cheul 한국융합보안학회 2006 융합보안 논문지 Vol.6 No.3
본 논문에서는 기록값 통계량을 이용한 무한 고장 NHPP 모형들이 제안되었다. 이 모형들은 결함당 고장 발생률이 단조 증가하거나 단조 감소하는 패턴을 가진다. 그리고 수명 분포에서는 어랑 분포, 랄리 분포와 굼벨를 이용한 소프트웨어 신뢰성 모형을 적용하여 비교연구에 초점을 두었다. 고장 간격 시간 자료를 이용한 무한 고장 NHPP 모형들에 대한 모수 추정법은 최우 추정법을 사용하였고 적용 분포들의 적용을 용이하게 하기 위하여 특수한 형태를 제시하였다. 고장 자료의 분석을 위하여 산술 및 라플라스 추세 검정과 적합도 및 치우침 검정을 실시하여 그 결과를 나열하였다. Infinite failure NHPP models for a record value satisfies mode proposed in the literature exhibit either monotonic increasing or monotonic decreasing failure occurrence rates per fault. In this paper, propose comparative study of software reliability model using Erlang distribution, Rayleigh and Gumbel distribution. Equations to estimate the parameters using maximum likelihood estimation of infinite failure NHPP model based on failure data collected in the form of interfailure times are developed. For the sake of proposing distribution, we used to the special pattern. Analysis of failure data set using arithmetic and Laplace trend tests, goodness-of-fit test, bias tests is presented.