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DNA probe를 이용한 비결핵항산균의 분리 및 폐질환자들의 임상적 특징
김희규 ( Hee Kyoo Kim ),김유리 ( Yu Ri Kim ),박정필 ( Jung Pil Park ),김낭희 ( Nang Hee Kim ),옥철호 ( Chul Ho Ok ),정만홍 ( Maan Hong Jung ),장태원 ( Tae Won Jang ),정석훈 ( Seok Hoon Jeong ),김철민 ( Cheol Min Kim ),박희경 ( Hee 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.3
목적 : NTM질환이 과거에는 공중 건강에 치명적인 것으로 생각하지 않았다. 최근에 NTM이 높은 빈도로 발견되고 있고, 분리균의 임상적인 중요성도 커지고 있다. 본 연구는 부산의 한 삼차 의료기관에서 의뢰한 임상 검체에서 분리된 NTM의 균종 분포와 폐질환을 일으킨 균주의 임상적 특징에 대해 알아보고자 하였다. 대상 및 방법 : 2003년 3월부터 2003년 12월까지 10개월간 진단검사의학과 임상미생물검사실에 항산균 도말 및 배양 검사가 의뢰되어 도 Background : Nontuberculous mycobacterial (NTM) infections are increasingly being recognized as a cause of chronic pulmonary disease. This study describes the prevalence of NTM species from clinical specimens and the clinical characteristics of NTM pulmon
알레르기 염증에서의 비만세포 역할과 비만세포 관련 질환
김희규 ( Hee-kyoo Kim ) 대한천식알레르기학회(구 대한알레르기학회) 2017 Allergy Asthma & Respiratory Disease Vol.5 No.5
Mast cells, which are major effector cells in allergic reactions, are found in the perivascular spaces of most tissues and contain pro-in-flammatory and vasoactive mediators. These mediators are released after IgE receptor cross-linking induced by allergens or other stimuli, including anaphylatoxins (C3a and C5a), aggregated IgG, certain drugs, venoms, and physical stimuli (pressure and tempera-ture changes), as well as cytokines and neuropeptides. The excess release of these mediators can cause variable allergic symptoms and signs, such as bronchospasm, itching, flushing, nausea, vomiting, diarrhea, abdominal pain, vascular instability, and anaphylaxis. Furthermore, mast cell disorders may involve either excessive proliferation of mast cells or abnormal mast cell reactivity. Mast cell disorders can be broadly divided into 3 types: primary, secondary, and idiopathic. All of these disorders present with signs and symp-toms of mast cell activation and differ in severity and involvement of various organ systems. The best characterized primary disorder is mastocytosis. Systemic and cutaneous forms of the disease are well described. Secondary disorders include typical allergic dis-eases and some types of urticarial diseases. In this article, the biochemical characteristics of mast cells and the role of mast cells in al-lergic inflammation, as well as the classification, diagnosis, and management of mast cell-related disorders, will be reviewed. (Allergy Asthma Respir Dis 2017;5:248-255)
천식 환자에서 메타콜린 기도 과민성에 미치는 임상적 인자 평가
김희규 ( Hee Kyoo Kim ),이현승 ( Hyun Seung Lee ),이상민 ( Sang Min Lee ),송우정 ( Woo Jung Song ),손성욱 ( Seung Wook Sohn ),박창한 ( Chang Han Park ),김경묵 ( Kyung Mook Kim ),박흥우 ( Heung Woo Park ),김상헌 ( Sang Heon Kim 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.1
Background: Airway hyperresponsiveness (AHR) is a key phenotype of asthma. The expression of AHR is known to be variable in asthma patients, but the underlying mechanisms are poorly understood. Objective: The aim of this study was to evaluate the relationship of clinical characteristics such as smoking history, duration, atopy, total IgE levels, basal lung function, disease severity, and airway inflammation with methacholine AHR in patients with asthma. Method: A total of 109 asthma patients underwent spirometry and methacholine bronchial provocation test (MBPT). According to PC20, asthma patients were classified by mild AHR group (PC20 between 4 to 25 mg/mL) and by severe AHR group (PC20 of less than 4 mg/mL). They gave induced sputum for airway inflammation and serum for total IgE, and atopy were evaluated by the skin prick test to common aeroallergens. Result: Atopy and serum total IgE levels were not significantly different between the two groups. Basal FEV1 was significantly higher in mild AHR group (87.5±14.7%) than in severe AHR group (80.5±17.4%)(P=0.023). In addition, frequencies of severe severity were higher in severe AHR group than in mild AHR group (5.8% vs. 19.3%; P=0.002). The number of neutrophils and eosinophils in induced sputum was enhanced in the former group than in the latter group, although the statistical significances were not found (18.9±88.0 vs. 8.2±8.8×105/g; 7.1±16.6 vs. 2.8±5.9×105/g, respectively). Conclusion: Basal airway obstruction and asthma severity were positively associated with severity of methacholine airway responsiveness in asthma patients. (Korean J Asthma Allergy Clin Immunol 2006;26:59-63)
원저 : 폐암 환자에서 촉진되지 않는 경부 림프절에 대한 초음파 유도 하 세침흡인 세포검사의 유용성
김희규 ( Hee Kyoo Kim ),하승인 ( Seung In Ha ),김유리 ( Yu Ri Kim ),박찬복 ( Chan Bog Park ),옥철호 ( Chul Ho Oak ),장태원 ( Tae Won Jang ),정만홍 ( Maan Hong Jung ),오경승 ( Kyung Seung Oh ),천봉권 ( Bong Kwon Chun ),이민기 ( Min 대한결핵 및 호흡기학회 2004 Tuberculosis and Respiratory Diseases Vol.56 No.5
이트라코나졸(itraconazole)액의 첨가물에 의해 발생한 지연형 두드러기 및 혈관부종 1예
김수영 ( Soo Young Kim ),최길순 ( Gil Soon Choi ),김희규 ( Hee Kyoo Kim ),김제훈 ( Je Hun Kim ),김철수 ( Cheol Su Kim ),양정욱 ( Joung Wook Yang ),유가인 ( Ga In You ),이진영 ( Jin Young Lee ) 대한천식알레르기학회(구 대한알레르기학회) 2014 Allergy Asthma & Respiratory Disease Vol.2 No.2
Itraconazole, new triazole agent with a broader antifungal spectrum than fluconazole, has been prescribed widely in the treatment and prophylaxis for fungal infection. Itaconazole has been reported to have gastrointestinal disturbance (4%) and headache (1%) as its most common side-effects. However, allergic reactions caused by this drug are rare. A 53 year-old woman with myelodysplastic syndrome received prophylactic antibiotic therapy including itraconazole solution before chemotherapy. She complained of hive on the face with angioedema at 6 hours after taking them. The symptoms were more aggravated on the next day and reversed by stopping itraconazole solution and injection of antihistamine and steroids. Skin prick tests with itraconazole solution, itraconazole tablet, and ketoconazole showed all the negative responses. The oral challenge test with itraconazole solution was performed and resulted in urticaria and angioedema 6 hours later. Next, the oral challenge test with intraconazole tablet was performed and showed negative response. The patient was finally diagnosed as adverse reaction by additives contained intraconazole solution. We report, a case of delayed onset urticaria and angioedema caused by components of itraconazole solution. (Allergy Asthma Respir Dis 2014;2:138-141)
천식 및 알레르기비염으로 진단된 소아, 청소년 및 성인에서의 흡입 알레르겐에 대한 감작률 비교
이나겸 ( Na Gyeom Lee ),김희규 ( Hee-kyoo Kim ),최길순 ( Gil Soon Choi ) 대한천식알레르기학회(구 대한알레르기학회) 2021 Allergy Asthma & Respiratory Disease Vol.9 No.3
Purpose: Inhalant allergens are known as a major factor for respiratory allergic diseases. There are many differences in sensitization rates of inhalant allergens, depending on the environment and demographic factors. This study aimed to compare the cross-sectional differences in sensitivity patterns to inhalant allergen between children, adolescents, and adults. Methods: We analyzed the results of 449 patients with asthma or allergic rhinitis who underwent the inhalant allergen skin prick test at our university hospital in 2016. The subjects were classified 5 groups according to age: children (≤12 years), adolescents (13-17 years), young adults (18-30 years), middle adults (31-64 years), and elderly group (≥65 years). Positive responses skin prick test for allergens were defined as allergen-to-histamine wheal ratio ≥1. Results: The sensitization rate (SR) to house dust mites (HDM) was 52.1% on average, showing the highest SR in all groups, especially in children (64.2%). Children and adolescents showed high SRs to cockroach along with tree pollen, animal fur, and adults showed high SR to weed pollen along with them. Among the tree pollen, the SRs to oak, alder, birch, and beech were high in all groups; in children, the SR to plain and willow tended to be high, and in adults the SR to hazel was high. SRs to Timothy pollen (9.9%) and Alternaria (8.6%) tended to be higher in children than in the other groups. Conclusion: Although HDM is still the major allergen in children and adults with respiratory allergy, our study suggests various differences in the sensitization pattern to inhalant allergens according to age even in the same area. Further studies are needed to explain these differences in sensitization patterns. (Allergy Asthma Respir Dis 2021;9:148-155)
암 환자에서의 자발적 보고자료를 통해 수집된 약물유해반응 분석
전해수 ( Hae-soo Jeon ),김희규 ( Hee-kyoo Kim ),최길순 ( Gil-soon Choi ) 대한내과학회 2020 대한내과학회지 Vol.95 No.2
Background/Aims: Although the number of domestic adverse drug reactions (ADRs) reported in Korea is rapidly increasing, the analysis of ADRs in cancer patients remains limited. We sought to investigate the clinical features of ADRs in cancer patients. Methods: ADR data were collected from a spontaneous reporting system at single university hospital, between July 2010 and June 2015. ADR cases assessed to be “unlikely” or “unclassifiable” as per the criteria of the World Health Organization-Uppsala Monitoring Center were excluded. Additional medical information was retrospectively collected from chart reviews, and clinical features of ADRs were analyzed. Results: In total, 1,455 cases were reported. Of these, 822 ADRs (52.1%) were observed in cancer patients. The mean age of cancer patients was 60.8 years (range, 17-90 years), and 45.9% were male. The most prevalent clinical features were gastrointestinal abnormalities (32.6%), such as nausea and vomiting, followed by skin (28.5%) and neurologic manifestations (26.0%). Fifty-one (6.2%) and 296 cases (36.0%) were classified as severe and moderate, respectively. The most common causative agents were parenteral nutrition (PN) supplements (40.4%), followed by antibiotics (17.8%), analgesics (16.7%), iodinated contrast media (ICM, 10.6%), and vitamins (3.9%). Antineoplastic agents were responsible for 2.9% of cases. PN supplements were commonly associated with severe reactions. Conclusion: Although it is well known that antibiotics, ICM, and analgesics induce ADRs, PN supplements, vitamins, and antineoplastic agents should also be considered as common causes of ADRs in cancer patients. Further investigation and monitoring to determine the causality associated with these agents is required. (Korean J Med 2020;95:104-113)
MLE12 및 RAW264.7세포에서 Alternaria와 Alternariol Mycotoxin의 알레르기 염증반응 효과
최길순 ( Gil Soon Choi ),김희규 ( Hee Kyoo Kim ) 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.4
Background: Alternaria and their secondary metabolites, alternariol mycotoxins, may cause respiratory symptoms and asthma. Moreover, microbial compounds, such as bacterial endotoxins, act as potential contributors in such situations. Alveolar epithelial cells and macrophages appear to initiate airway inflammation through proinflammatory cytokines after exposure to aeroallergens or toxic materials. The present study investigated the effects of Alternaria and alternariol mycotoxins on inflammatory cytokines secreted from airway epithelial cells and macrophages, especially interleukin-33, interleukin-6 and tumor necrosis factor-α, which were assessed association with lipopolysaccharide. Methods: In vitro MLE12 cells and RAW264.7 cells were treated with Alternaria, alternariol monomethyl ether and alternariol at different doses for 24 hour. The levels of interleukin- 33, interleukin-6, and tumor necrosis factor-α in each cell supernatants were measured by ELISA. Then, each mycotoxin (100 ng/mL) was added to lipopolysaccharide stimulated cells and incubated with them. Cell viability was measured by flow cytometry. Results: Alternaria and alternariol mycotoxin-treated cells released pro-inflammatory cytokines partly in a dose-dependent manner. Moreover, lipopolysaccharide induced the synergic effect of mycotoxins on cytokine production by RAW264.7 cells. However, the different cytokine productions among groups were not related to cell viability. Conclusion: This study suggests that alternariol mycotoxins, such as Alternaria, would provoke airway inflammation through interleukin-33, interleukin-6 and tumor necrosis factor- α uction from epithelial cells and macrophages.