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전신홍반루푸스 환자에서 양측 가돌림 신경마비로 발현된 리스테리아 뇌수막염
황유미 ( You Mi Hwang ),곽승기 ( Seung Ki Kwok ),김지민 ( Ji Min Kim ),윤호성 ( Ho Sung Yoon ),주지현 ( Ji Hyeon Ju ),박경수 ( Kyung Su Park ),박성환 ( Sung Hwan Park ),김호연 ( Ho Youn Kim ) 대한류마티스학회 2009 대한류마티스학회지 Vol.16 No.4
Infection still remains a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). Patients with SLE are well known to have an increased risk of various opportunistic infections, which can be fatal. Central nervous system (CNS) infections such as meningitis are rare complications to SLE. On occasion, nonspecific neurologic manifestations of infectious meningitis in SLE patients can be confused with neuropsychiatric lupus. Listeria monocytogenes is a less-commonly identified organism causing meningitis in SLE patients. Here, we describe a case of Listeria monocytogenes meningitis presenting with bilateral abducens nerve (sixth cranial nerve) palsy in a patient with SLE, who was successfully treated with systemic antibiotics.
세균성 이질환자에 대한 Oxolinic acid의 치료 효과
정희영,김선무,한유식,김호연,김재희,백우현,이광언 대한감염학회 1980 감염 Vol.12 No.1
The emergence of antibiotic resistant strain in shigella bacilli made the treatment difficult and ampicillin which was used for several years is no more used in Korea. This study is a trial of treatment of antibiotic resistant strain with oxolinic acid which is a derivative of nalidixic acid. Eight patients of bacteriologically proved shigellosis administered oxolinic acid, 1.5g daily, showed excellent clinical response in all within 72hours of administration. Antibiotic sensitivity test performed by Kirby Bauer disc method with 37 clinical isolates showed resistant strains of; Penicillin 100%, Clindamycin 100%, Tetracycline 97.3%, Chloramphenicol 97.3%, ampicillin 94.6%, Erythromycin 100%, Cephalothin 46%, Kanamycin 32.4%, Gentamicin 27%, Carbenicillin 100%, Colistin 0%, Bacitracin 100%, Strptomycin 100%, Nalidixic acid 20%. MIC of oxilinic acid of 5 shigella strains tested were 0.16μg/ml except one with 10μg/ml and this one showed resistance to nalidixic acid too.