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지역사회에 거주하고 있는 노인의 우울증과 삶의 질을 평가하는 도구로 한국판 WHO-5의 유용성
김현지(Hyun Ji Kim),문유선(Yoo Sun Moon),손봉기(Bong Ki Son),이상규(Sang Kyu Lee),노현진(Hyun Jin Rho),김도훈(Do Hoon Kim) 대한노인정신의학회 2010 노인정신의학 Vol.14 No.2
Background and Objectives : Recently the number of geriatric depressed people has been increasing tremendously. Among many factors affecting depression, quality of life seems to be closely related to depression. Thus, a screening tool for assessing both geriatric depression and quality of life is needed. The purpose of this study is to estimate the utility of the Korean version of the WHO-Five Well-Being Index (WHO-5) in evaluating geriatric depression as compared with SGDS-K (Short Geriatric Depression Scale of Korean version) that is being used widely and quality of life. Methods : A sample of 244 subjects over 65-year old living in Yanggu and Inje area in Gangwon Province, Korea were interviewed and responded to scales, including WHO-5, SGDS-K, MMSE-KC (Mini Mental Status Examination in the Korean version of the CERAD assessment packet) and GQOL-D (Geriatric Quality of Life-Dementia). The total score of WHO-5 below 13 indicates low well-being. Results : The WHO-5 inversely correlated with SGDS-K and positively with GQOL-D, but showed no significant correlation with MMSE-KC. The SGDS-K negatively correlated with WHO-5, MMSE-KC, and GQOL-D. Low well-being group (WHO-5 score<13) had lower GQOL-D score (t=1.9698, p<0.05) and higher SGDS-K score (t=1.9798, p<0.05) than high well-being group. In multiple regression analysis, WHO-5 was significantly associated with GQOL-D and SGDS-K (r2=0.29422, p=0.0000). Conclusion : The Korean version of WHO-5 was very useful to evaluate both depressive symptoms and quality of life in the aged dwelling in community.
p-phenylenediamine에 노출된 마우스의 피부조직에서 케모카인과 케모카인 수용체의 발현 변화에 관한 연구
김현지 ( Hyun Ji Kim ),김영희 ( Young Hee Kim ),김민정 ( Min Jeong Kim ),김기석 ( Ki Sok Kim ) 한국미용학회 2010 한국미용학회지 Vol.16 No.1
p-phenylenediamine(PPD)은 피부조직에서 접촉성 민감반응을 일으킬 수 있는 물질로 알려져 왔으나 피부 감작기 동안 사이토카인 유전자의 발현에 미치는 영향과 관련된 연구결과는 거의 없는 실정이다. 따라서 본 연구는 PPD에 노출된 마우스의 피부조직에서 사이토카인과 사이토카인 수용체의 유전자 발현을 규명하기 위해 수행되었다. 이를 위해 BALB/c계 마우스에 50mg/kg 용량의 PPD를 피부에 3회 도포한 후 PPD에 노출된 마우스와 용매에 노출된 대조군에서 등피부 조직을 분리하였다. 이 조직을 real time polymerase chain reaction(PCR) 분석방법을 통해 피부조직에서 발현되는 유전자의 양을 정량분석하였다. 그 결과 전반적으로 PPD에 노출된 BALB/c 마우스의 등피부 조직에서 몇몇 사이토카인과 사이토카인 수용체에 대한 유전자의 발현이 증가되었다. 특히, CCL3, CCL4, CCR6, CCR7, CCR8, CXCL5, CXCL15, CXCR3, CXCR5 유전자가 대조군에 비해 PPD를 처리한 피부조직에서 유의하게(3배 이상) 증가되었다. 이러한 결과는 사이토카인과 사이토카인 수용체의 발현 증가가 알러지성 접촉피부염의 발생과 관련되어 있기 때문에, 본 연구에서 유의하게 변화를 나타낸 유전자들이 PPD에 의한 피부 병변에서 나타나는 초기 면역학적 반응에 관련되어 있다는 것을 시사한다.
간호 대학생의 환자 프라이버시 보호행동, 간호윤리의식 및 자아존중감의 관계
성기월 ( Ki Wol Sung ),김다솜 ( Da Som Kim ),한민영 ( Min Young Han ),곽은영 ( Eun Yeong Gwak ),김근영 ( Geun Yeong Kim ),김언주 ( Eon Ju Kim ),김현지 ( Hyun Ji Kim ),류선영 ( Sun Young Ryu ),문성은 ( Seong Eun Moon ),한선미 ( Seo 대구가톨릭대학교 사회과학연구소 2011 사회과학논총 Vol.10 No.-
The purpose of this study is to understand correlation between patient privacy act, nursing ethics, and self-esteem in nursing students. Subjects of the study include 234 students in third and fourth year of four-year nursing course in universities in Daegu and the period of collecting data was between 19 and 28 September, 2011. Patient privacy act was measured by using a tool created by Lee Miyeong (2005) but revised and supplemented so that it is suitable for students nurses who are the subjects of this research. Nursing ethics was measured by the tool created by Lee Yongsook (1990) and revised by Choi Yongran (2001). Rosenberg Self-Esteem Scale (RES) developed by Rosenberg (1965) and revised by Jeon Byeongjae (1974). The collected data was analyzed by Frequency Analysis, average and standard deviation, range and t-test, one-way ANOVA, Pearson`s Correlation, Stepwise Multiple Regression. Followings are the study result. 1) The average score of patient privacy act of student nurses was over the middle mark (81.48±12.36), and the average score of nursing ethics was the middle mark (72.40 ±8.29). The average score of self-esteem was over the middle mark (31.71±3.65). 2) The significant differences of the patient privacy act were grade (p=.013) and third year students. 3) In nursing students patient privacy act was positively related to nursing ethics. 4) The significant predictors of the patient privacy act were nursing ethics, self-esteem, and grades explaining 16.9% of patient privacy act. There should be a need of educational development which can raise student nurses` nursing ethics and self-esteem in order to improve student nurses` patient privacy act based on the result of the research.
족배동맥 유리피판술을 이용한 수부 재건: 공여부 이환율 최소화 방법
손대구,김현지,김준형,한기환,Son, Dae Gu,Kim, Hyun Ji,Kim, Jun Hyung,Han, Ki Hwan 대한미세수술학회 2004 Archives of reconstructive microsurgery Vol.13 No.1
One of the major advantages of microsurgical reconstruction for defects of the hand is that these techniques allow for selection of the most ideal tissue to reconstruct a particular defect, thus optimizing the functional and aesthetic outcome. The dorsalis pedis free flap is an excellent reconstructive tool for various hand reconstructions. It has a reliable vasculature with vessels that are relative large on a long pedicle. It provides thin pliable tissue and be innervated by deep peroneal nerve. Coupled with its thinness and pliability, it is ideal for innervated cover of critically sensitive area, especially such as the hand. Thus it can be used as a cutaneotendinous flap, or an osteocutaneous flap. Otherwise, the major criticism with this flap is related to its uncertain vascularity and the donor defect. It is the purpose of this paper to outline our technique of flap elevation and donor site closure and to indicate our current use of this flap in hand reconstruction. We have treated 10 cases (6 burn scar contracture cases, 4 acute hand trauma cases) of hand reconstruction from Dec. 3, 1997 to Mar. 4, 2004 using dorsalis pedis free flap. The key points for sucess in terms of a viable flap and acceptable donor site are the preservation of the critical dorsalis pedis-first dorsal metatarsal vascular axis and the creation of a viable bed for grafting. In addition, we substituted preserved superficial fat skin graft for split thickness skin graft and wet environment was offered for good graft take. Preserved superficial fat skin is defined as composite graft containing epidermis, dermis and superficial fat layer. With sufficient care in flap elevation and donor site closure, a good graft take of preserved superficial fat skin under wet environment can be achieved with no functional disability and minimal cosmetic deformity in donor site. This flap has proved itself to be a best choice for hand reconstruction.
지방분화시 PPARγ에 의한 microRNA-17의 발현 조절
배인선(In-Seon Bae),김현지(Hyun-Ji Kim),정기용(Ki Yong Chung),최인호(Inho Choi),김상훈(Sang Hoon Kim) 한국생명과학회 2014 생명과학회지 Vol.24 No.3
MicroRNA는 21~25개의 뉴클레오티드로 이루어진 단일 염기가닥의 RNA로 지방분화를 포함한 세포내 여러 생리학적 기전에 영향을 미친다. MicroRNA-17 (miR-17)은 지방전구세포의 지방분화를 촉진하고, 세포 내 지방을 축적시킨다. 그렇지만, 지방분화시 miR-17 전사조절 기전은 알려진 것이 없다. 본 연구에서는 PPARγ 전사인자가 miR-17의 전사를 조절하는지 여부를 조사하였다. 먼저 지방전구세포의 분화를 유도한 다음 PPARγ와 miR-17의 발현을 조사한 결과 두 유전자 모두 분화 이후 발현이 증가하였다. 또한 miR-17 프로모터 부위에는 PPARγ 반응하는 부위(PPRE)가 세 군데 발견되었다. Chromatin immunoprecipitation과 luciferase assay을 실시한 결과, miR-17 프로모터의 PPRE3 (-677/-655) 부위가 PPARγ와 직접 결합함을 관찰하였다. 이러한 연구 결과는 3T3-L1 세포주에서 PPARγ가 miR-17의 전사를 활성화 시키고 있음을 나타낸다. 향후 PPARγ에 의한 표적 microRNA을 대량 발굴한다면 비만과 관련한 PPARγ의 기능을 보다 구체적으로 파악하는데 중요한 정보를 제공할 수 있을 것으로 생각된다. MicroRNAs comprise a family of small noncoding RNAs that modulate physiological processes, including adipogenesis. MicroRNA-17 (miR-17) promotes adipocyte differentiation and enhances lipid accumulation. The transcriptional regulation of miR-17 during adipogenesis remains unknown. In this study, we investigated whether miR-17 is a target of peroxisome proliferator-activated receptor γ(PPARγ), which is a key regulator of adipogenesis. The levels of miR-17 and the expression of PPARγ increased after the induction of adipocyte differentiation. Three putative peroxisome proliferator response elements (PPREs) were identified in the miR-17 promoter region. Using chromatin immunoprecipitation and luciferase reporter assays, we observed the interaction of PPARγ with the miR-17 promoter. Mutagenesis experiments showed that the -677/-655 region of the miR-17 promoter could function as a PPRE site. These results suggest that PPARγ is essential for transcriptional activation of the miR-17 gene, thereby contributing to understanding the molecular mechanism of adipogenesis in adipocytes.
간호대학생의 임상실습스트레스, 교수효율성이 임상수행능력에 미치는 영향
구상미(Koo, Sang-Mee),김현지(Kim, Hyun-Ji),기은정(Ki, Eun-Jeong) 학습자중심교과교육학회 2018 학습자중심교과교육연구 Vol.18 No.17
The purpose of this study was to investigate the effect of clinical practice stress and teaching efficacy on clinical performance of nursing students. The subjects of the study were 290 nursing students and data collection period was from September 1, 2017 to October 30, 2017. As a result, the clinical practice stress of the nursing college students was 3.1 out of 5 points. The efficiency of teaching was 3.5 out of 5 points and clinical performance was 3.48 points. The general characteristics of the subjects who showed significant differences in clinical practice stress, teaching efficacy, and clinical performance were collegial relationship and major satisfaction. As a result of examining the effects of teaching efficacy and clinical practice stress on clinical performance, two variables showed 13% explanatory power. The results of this study can be used as a basic data for developing a program that lowers the clinical practice stress of nursing college students and strengthens clinical performance. 본 연구는 간호대학생의 임상실습스트레스, 교수효율성이 임상수행능력에 미치는 영향을 파악하고자 실시되었다. 연구대상자는 간호대학생 290명이었으며, 자료수집기간은 2017년 9월 1일부터 10월 30일까지이었다. 연구결과 간호대학생의 임상실습 스트레스는 5점 만점에 3.1점이었으며, 교수효율성은 5점 만점에 3.5점, 임상수행능력은 3.48점이었다. 본 연구에서 임상실습스트레스, 교수효율성, 임상수행능력에 유의한 차이를 보인 대상자의 일반적인 특성은 동료관계와 전공만족도로 나타났다. 교수효율성과 임상실습스트레스가 임상수행능력에 미치는 영향을 살펴본 결과 두 변수가 임상수행능력을 13% 예측, 설명하는 것으로 확인되었다. 본 연구 결과는 간호대학생의 임상실습스트레스를 낮추고, 임상수행능력을 강화하는 프로그램을 개발하는 기초 자료로 활용할 수 있을 것으로 생각한다.