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1989 년 전북 서북부지역에서의 A 형 바이러스성 간염의 역학적 조사
임동석(Dong Suk Lim),조규혜(Kyoo Hye Cho),김학철(Haak Cheol Kim) 대한내과학회 1992 대한내과학회지 Vol.43 No.1
N/A Background: HAV was known as a water-borne disease and which was known aboiut a variable prevalence rate of specific antibody against hepatis A virus (anti-HAV) in differrent countries, and its prevalence of anti-HAV depend on the socio-economic state, hygiene, crowding and etc.. Method: A seroepidermiological study to detect anti -HAV was made with 802 randomly collected sera (1989) from heathy Korean who were residents in North -West area of Cheon-Buk province by radio-immuno assay (RIA, Abbort). Results: The prevalence rate of this area was high and closely related to age groups. The age-related prevalence rate was high in early infant period and then decreased after that period. The prevalence rate of anti -HAV of the period in 0-1/2 year was higher than that of 1/2-1 year. And then it was persisted untill preschool ages. But, it was sharply increased during school ages and adolescence period then plateued at>95% prevalence in young adult. The prevalence rate of ours were lower than that of Hong`s which was obserbed in Seoul Korea in 1979, especially in those age groups spanning spanning 6-18 years. Conclusion: North-West area of Cheon-Buk province might be an endemic area to HAV, and the anti-HAV that was transfered from the mother would be lost within 1 year. The infection to HAV might be occur chiefly in schoolage, The differrence suggest that there is changing of age-related prevalence rate of anti-HAV in Korea, and may be due to improvement of scioeconomic state and public health. And in furture, it might be increased the HAV susceptible popullation in Korea. The anti-HAV IgG in early infants that was transfered from their mothers might be lost within one year.
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