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오늘 본 자료
PCI시술시 혈소판 당단백 GP IIb/IIIA 억제제(Abciximab) 투여의 경제적 가치
김진현,신상진,김은주,이영희,Kim, Jin-hyun,Shin, Sang-Jin,Kim, Eun-Ju,Lee, Young-Hee 대한약학회 2007 약학회지 Vol.51 No.3
This study was performed to analyse the economic value of abciximab which is used in PCI to prevent high-risk patients with ischemic complications. The effectiveness of abciximab was extracted from published clinical trials by search-ing CCIS, and the direct medical costs relevant to using abciximab were estimated from the NHI claims database. The results in terms of cost per life-year gained (LYG) and cost per QALY gained showed that abciximab was cost-effective enough to deserve its cost. Social net benefit resulting from abciximab in PCI was estimated to be 60-70 billion Won per year.
김진현,김태영,주명종,남기대 ( Jin Hyun Kim,Tae Young Kim,Myung Jong Ju,Ki Dae Nam ) 한국공업화학회 1996 공업화학 Vol.7 No.3
Sodium N-lauroyl-N-methyl taurate의 cmc에 대한 온도효과를 검토하였다. cmc값들은 처음 20℃∼40℃의 온도 범위에서는 감소하다가 더욱 온도가 증가되면 다시 증가하는 경향이었다. cmc에 대한 온도의 의존성으로부터 여러가지 열역학적 파라미터들(ΔH_m, ΔG_m, ΔS_m)을 산출하였다. Sodium N-lauroyl-N-methyl taurate의 cmc에 대한 여러 전해질들의 첨가효과를 또한 검토하였고, 소수성결합 형성에너지 및 미셀의 해리도를 log cmc와 log conc.의 곡선으로부터 산출하였다. ΔH_m값들은 온도가 증가함에 따라 감소하였고, 40℃∼50℃의 온도범위에서 부호가 양에서 음으로 변하였다. ΔG_m값들은 전해질 농도 및 온도가 증가할수록 감소하였다. The effect of temperature on the cmc of sodium N-lauroyl-N-methyl taurate was examined. The cmc values were found to be decreased initially but increased further with the increase of temperature. From the temperature dependence of cmc, various thermodynamic properties were calculated. The effects of various electrolytes on the cmc of sodium N-lauroyl-N-methyl-taurate were also examined. The free energy of hydrophobic bond formation and the degree of dissociation of the micelles were calculated from log cmc vs. log counter ion concentration plots. The ΔH_m values were decreased with increasing the temperature and changed their signs from plus to minus at 40℃∼50℃. The ΔG_m values were decreased with the increase of electrolyte concentration and temperature.
Erythrosine의 약리학적(藥理學的) 연구(硏究)
김진현,안영란,김학성,Kim, Jin-Hyon,Ahn, Young-Ran,Kim, Hack-Seang 한국약제학회 1982 Journal of Pharmaceutical Investigation Vol.12 No.3
The effects of erythrosine on motility of frog heart, rabbit duodenum and uterus isolated, and on mice intestinal motility and voluntary activity were investigated. The effect of erythrosine $2.3{\times}10^{-5}M$ on isolated frog heart showed a slight decrease of the amplitude of motility, and the heart motility stopped in $3.5{\times}10^{-4}M$. With the administration of erythrosine $3.4{\times}10^{-4}M$, the isolated rabbit duodenum showed a remarkable contraction and this effect was inhibited by atropine $1.4{\times}10^{-7}M$. The administration of erythrosine $2.3{\times}10^{-3}M$, produced a contractile effect on the isolated rabbit uterus, and the motility of $6.9{\times}10^{-3}M$ started to increase in contractions at first and finally stopped, keeping in continuous contractions. The effects of erythrosine 0.5, 1.0, 10, and 20mg/kg on mice intestinal motility were not significantly different from this of the normal control. With 20 and 40mg/kg of erythrosine, the effects on voluntary activity showed the decrease of 21 and 58% respectively, and voluntary activity of the mice pretreated with erythrosine 20 and 40mg/kg, induced by C. N. B. 30mg/kg showed the decrease of 57 and 78% respectively in contrast with the normal control group.
김진현,김은혜,김윤희,Kim, Jin-Hyun,Kim, Eun-Hye,Kim, Yoon-Hee 대한예방한의학회 2010 대한예방한의학회지 Vol.14 No.1
Objectives : This paper recommends a global budget based payment system for reimbursing oriental medical services in the national health insurance. Methods : We analyzed previous research outcomes related to oriental medical services and payment system We reviewed the experiences of other countries' global budget system in terms of their strength and weakness. In addition, we developed a reimbursement method for oriental medical services based on global budget. Results : Our reviews focused on global budget system of Germany, the Netherlands, the United Kingdom, Canada, France, and Taiwan. The estimation of global budget in the national health insurance was described in two scenarios. First scenario was to allocate oriental medical services in scale after signing a contract for global budget. In this case, 4.16% of the national health insurance expenditure was allocated for the oriental medical services. Second scenario was to estimate the global budget in a historical context. As a result, the first scenario in total budget was higher than the second, and we proposed a retrospective adjustment method for the gap between the budget and the actual expenditure Conclusions : The payment system for oriental medical services is recommended to shift from fee-for-service to global budget.
김진현,김철,김상균,장현철,한정민,예상준,송미영,Kim, Jin-Hyun,Kim, Chul,Kim, Sang-Kyun,Jang, Hyun-Chul,Han, Jeong-Min,Yea, Sang-Jun,Song, Mi-Young 대한예방한의학회 2009 대한예방한의학회지 Vol.13 No.3
Objectives : In this study, we survey papers about the combined therapy of oriental medicine and western medicine in oriental medicine viewpoint. Methods : First, we collected research papers on combined treatment, and we found 70 papers in the two internet sites, 'OASIS' and 'KISTI', using the keywords 'combined treatment', 'collaborated diagnosis', 'oriental-western medicine', and 'western-oriental medicine'. Then we analyzed them according to year, oriental-western medicine, diseases, research methods and subjects. Results & Conclusions : Researches for combined therapy had some problems as follows : First, studies have been made only for limited diseases like cancer, infection, stroke, etc. Second, methods of research are also limited. Some methods such as in vivo, in vitro and case-report are used repeatedly. Third, only the positive aspects of the combined therapy are proposed. We don't find the side effects of the combined therapy at all. To solve these problems, more objective and balanced studies such as RCT for various diseases should be performed.
김진현,Kim, Jin-Hyeon 한국자연공원협회 1990 한국자연공원 Vol.46 No.-
이글은 지난 1월15일부터 모스크바 소빈센터에서 열린 "인간생존을 위한 환경과 발전의 인류포럼"에 참가했던 필자의 글로서 1월24일 동아일보에 보도된바 있어 주목을 끌었는데 소련의 "지구적 교육프로"등 환경교육에 관한 미래상등을 다시한번 되새기길 바라면서 필자의 쾌락을 받아 싣게되었다.
바이오매스로부터 파클리탁셀 회수를 위한 전통적 용매 추출, 마이크로웨이브를 이용한 추출, 초음파를 이용한 추출 방법 비교
김진현,Kim, Jin-Hyun 한국화학공학회 2020 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.58 No.2
본 연구에서는 바이오매스로부터 파클리탁셀 회수를 위한 전통적 용매 추출(conventional solvent extraction, CSE), 마이크로웨이브를 이용한 추출(microwave-assisted extraction, MAE), 초음파를 이용한 추출(ultrasound-assisted extraction, UAE) 방법을 비교하였다. 추출 용매 종류(아세톤, 클로로포름, 에탄올, 메탄올, 메틸렌 클로라이드)에 따른 영향을 조사한 결과, 메탄올이 모든 추출 방법에서 가장 적합하였다. 메탄올을 이용한 MAE와 UAE의 경우, 단 1회의 추출로 대부분의 파클리탁셀 회수(>95%)가 가능하였다. 또한 MAE와 UAE의 경우 추출 온도(25-45 ℃), 마이크로웨이브 파워(50-150 W), 초음파 파워(180-380 W)의 증가에 따라 파클리탁셀 회수율이 증가하였다. 또한 SEM 분석을 통해 바이오매스 표면을 조사한 결과, 표면 구조가 CSE의 경우에는 조금 주름진 형태를 보인 반면 MAE와 UAE의 경우에는 강한 충격으로 매우 거칠고 파괴된 형태를 보였다. In this study, conventional solvent extraction (CSE), microwave-assisted extraction (MAE), and ultrasound-assisted extraction (UAE) were compared for the recovery of paclitaxel from biomass. As a result of investigating the effect of the extraction solvent type (acetone, chloroform, ethanol, methanol, methylene chloride), methanol was the most suitable for all extraction methods. In the case of MAE and UAE using methanol, most of the paclitaxel (> 95%) was recovered by only one extraction. The recovery rate of paclitaxel increased with the increase of extraction temperature (25-45 ℃), microwave power (50-150 W), and ultrasonic power (180-380 W) for MAE and UAE. In addition, SEM analysis showed that the biomass surface structure was slightly corrugated in CSE, while in the MAE and UAE, it was very rough and destroyed by strong impact.