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Propionibacterium acnes에 의해 유도된 염증에 대한 Chitosan-phytochemical Conjugates의 항염증 효과
김지훈 ( Ji-hoon Kim ),제재영 ( Jae-young Je ),김영목 ( Young-mog Kim ) 한국수산과학회(구 한국수산학회) 2016 한국수산과학회지 Vol.49 No.5
Propionibacterium acnes infection in skin tissue often causes acne vulgaris, commonly characterized by inflammatory papules, pustules, and nodules. Chitosan and its derivatives possess strong anti-inflammatory effects. In this study, the anti-inflammatory activity of chitosan-phytochemical conjugates on P. acnes-infected human skin keratinocytes (HaCaT) was evaluated. We designed a model of P. acnes-induced inflammation in viable HaCaT cells. Nitric oxide (NO), an inflammatory marker, was successfully elevated by P. acnes infection in HaCaT cells in a dose-dependent manner. Furthermore, the levels of NO were reduced by treatment with chitosan-phytochemical conjugates (chitosan-caffeic acid, -ferulic acid and -sinapic acid) in a dose-dependent manner. Among these conjugates, chitosan-caffeic acid exhibited the strongest NO suppression in HaCaT cells infected with P. acnes. The results obtained in this study suggest that chitosan-phytochemical conjugates could be used as a potential therapeutic agent against acne vulgaris.
한국어판 Eating Disorder Inventory의 요인구조
김철민 ( Cheol Min Kim ),박제민 ( Je Min Park ),김성곤 ( Sung Gon Kim ),김명정 ( Myung Jung Kim ),강철중 ( Cheol Joong Kang ),김지훈 ( Ji Hoon Kim ) 한국정신병리진단분류학회 2005 精神病理學 Vol.14 No.1
Objective: As a pilot study to develop a screening tool for eating disorders(EDs), the authors delineated factor structure and discriminant validity of the 64-item Korean version of Eating disorder inventory(EDI). Method: The EDI was administered to 1,217 Korean girls` high school students. Principal component analysis, one-way ANOVA and Receiver operating characteristic(ROC) curve analysis on EDI total and subscale scores were done. Diagnosis of EDs was based on a self report questionnaire derived from the Structured interview for DSM-IV. Result: Thirteen factors were extracted, explaining 58% of total variance but could be restructured into nine. Item construction was comparable with the Garner et al`s report except Interoceptive awareness subscale. Significant differences were noticed among diagnostic groups in the EDI total scores and subscale scores of drive for thinness, body dissatisfaction, bulimia/overeating and emotional/interpersonal problem. Other subscales such as interoceptive awareness, perfectionism, fear of maturity, interpersonal distrust and personal ineffectiveness failed to differentiated diagnostic groups. ROC curve analysis revealed dissatisfactory sensitivity and specificity of EDI as a screening tool. Moreover, EDI failed to detect AN type of EDs, showing greater usefulness for BN type. Conclusion: These data suggest that a new screening tool comprising ED- specific subscales would prove enhanced sensitivity and specificity for detecting different diagnostic groups of EDs for non-clinical population.
손제현(Je Hyun Sohn),이영민(Young Min Lee),박제민(Je Min Park),이병대(Byung Dae Lee),문은수(Eun Soo Moon),정희정(Hee Jeong Jeong),김수연(Soo Yeon Kim),이강윤(Kang Yoon Lee),김지훈(Ji-Hoon Kim),정영인(Young-In Chung) 대한노인정신의학회 2017 노인정신의학 Vol.21 No.2
Objective:The purpose of this study is to investigate the difference on regional volume in temporal lobe between Alzheimer’s disease patients with psychosis (AD+P) and Alzheimer’s disease patients without psychosis (AD-P). Methods:Altogether, 24 AD+P and 25 AD-P matched age, gender, and clinical dementia rating sum of box (CDR-SOB) were include from a Memory impairment clinics of Pusan National University Hospital in Korea. AD+P were diagnosed according to Jeste and Finkel’s proposed diagnostic criteria for psychosis of Alzheimer’s disease. Grey matter volume of temporal lobe was measured with 3-tesla magnetic resonance imaging and freesufer analysis. Analysis of variance was used to investigate the association between temporal lobe and AD+P after controlling age, gender, education years, CDR-SOB and total intracranial volume. Results:We found an association between AD+P and reduced grey matter volume in total temporal lobe as well as in specific temporal regions such as left middle temporal lobe, left inferior temporal lobe, both hippocampus and both fusiform. Conclusion:Our findings suggest that AD+P are associated with reduced grey matter volume of temporal lobe.
성인 입원 환자에서의 영양치료 관련 합병증: 국내 다기관 연구
설은미 ( Eun-mi Seol ),권계숙 ( Kye Sook Kwon ),김정구 ( Jeong Goo Kim ),김정태 ( Jung-tae Kim ),김지훈 ( Jihoon Kim ),문선미 ( Sun-mi Moon ),박도중 ( Do Joong Park ),박정현 ( Jung Hyun Park ),박제훈 ( Je Hoon Park ),박지영 ( Ji Y 한국정맥경장영양학회 2019 한국정맥경장영양학회지 Vol.11 No.1
Purpose: Nutritional therapy (NT), such as enteral nutrition (EN) or parenteral nutrition (PN), is essential for the malnourished patients. Although the complications related to NT has been well described, multicenter data on symptoms in the patients with receiving NT during hospitalization are still lacking. Methods: Nutrition support team (NST) consultations, on which NT-related complications were described, were collected retrospectively for one year. The inclusion criteria were patients who were (1) older than 18 years, (2) hospitalized, and (3) receiving EN or PN at the time of NST consultation. The patients’ demographics (age, sex, body mass index [BMI]), type of NT and type of complication were collected. To compare the severity of each complication, the intensive care unit (ICU) admission, hospital stay, and type of discharge were also collected. Results: A total of 14,600 NT-related complications were collected from 13,418 cases from 27 hospitals in Korea. The mean age and BMI were 65.4 years and 21.8 kg/m<sup>2</sup>. The complications according to the type of NT, calorie deficiency (32.4%, n=1,229) and diarrhea (21.6%, n=820) were most common in EN. Similarly, calorie deficiency (56.8%, n=4,030) and GI problem except for diarrhea (8.6%, n=611) were most common in PN. Regarding the clinical outcomes, 18.7% (n=2,158) finally expired, 58.1% (n=7,027) were admitted to ICU, and the mean hospital days after NT-related complication were 31.3 days. Volume overload (odds ratio [OR]=3.48) and renal abnormality (OR=2.50) were closely associated with hospital death; hyperammonemia (OR=3.09) and renal abnormality (OR=2.77) were associated with ICU admission; “micronutrient and vitamin deficiency” (geometric mean [GM]=2.23) and volume overload (GM=1.61) were associated with a longer hospital stay. Conclusion: NT may induce or be associated with several complications, and some of them may seriously affect the patient’s outcome. NST personnel in each hospital should be aware of each problem during nutritional support.