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Physostigmine 과 Procyclidine 으로 구성된 복합예방제의 유기인제 해독효능
허경행(Gyeung Haeng Hur),천기철(Ki Cheol Cheon),피택산(Taek San Phi),김지천(Jee Cheon Kim),홍대식(Dea Sik Hong),박훈(Hoon Park),정창희(Chang Hee Jung),이용한(Yong Han Lee),김윤배(Yun Bae Kim) 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.1
N/A Antidotal efficacy of combinational prophylactics composed of physostigmine plus procyclidine, alone or in combination with antidotes such as atropine plus 2-pralidoxime or atropine plus HI-6, was evaluated in rats. Physostigmine (0.1 mg/kg) plus procyclidine (3 mg/kg), pretreated subcutaneously 30 min prior to subcutaneous exposure to organophosphates of militarily importance, exerted protection ratios of 7.2, 6.5, 4.0, 2.9 and 8.0 fold for tabun, sarin, soman, cyclosarin and V-agent, respectively. In comparison, low effects (1.7 fold for soman and 1.3 fold for cyclosarin) were achieved with the traditional antidotes atropine (17.4 mg/ kg) plus 2-pralidoxime (30 mg/kg) administered intramuscularly immediately after organophosphate, in contrast to high effects (5.5 fold for soman and 160.0 fold for cyclosarin) with atropine (17.4 mg/kg) plus HI-6 (125 mg/kg), although the protection ratio markedly decreased when treatment of antidotes was delayed. Noteworthy, the combinational prophylactics markedly potentiated the effects of antidotes to higher than 5.0 fold in all cases. In addition, the combinational prophylactics fully prevented the seizures and excitotoxic brain injuries induced by a high dose (100 mg/kg, 1.3 LD_(50)) of soman. Taken together, it is suggested that the prophylactics composed of physostigmine and procyclidine, in combination with posttreatment antidotes, could be a promising regimen for the prevention of lethality, seizures and brain injuries induced by organophosphates possessing diverse properties.
유기인제 중독의 복합예방제로서의 physostigmine과 procyclidine이 랫드의 학습 및 기억에 미치는 염향
조순옥(Soon Ock Cho),박우규(Woo-Kyu Park),이선애(Sun Ae Lee),조영(Young Cho),허경행(Gyeung-Haeng Hur),김왕수(Wang-Soo Kim),천기철(Ki-Cheol Cheon),하연철(Yeon-Cheol Ha),연규백(Gyu-Baek Yeon),김지천(Jee-Cheol Kim),김형규(Hyong-Kyu Kim 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.4
The effects of physostigmine and procyclidine, as a combinational prophylactic regimen for organophosphate poisoning, on learning and memory process were examined in rats administering subcutaneously. Procyclidine at doses of 3 through 10 ㎎/㎏ produced significant impairment of learning and memory process in step-through passive avoidance test. However, this harmful effect of procyclidine (3 and 5 ㎎/㎏) was reversed by simultaneous injection of physostigmine (0.1 ㎎/㎏). Procyclidine at doses of 7 and 10 ㎎/㎏ produced reversible inhibition of learning and memory process in Morris water maze test. Physostigmine (0.1 ㎎/㎏) recovered the memorial impairment induced by procyclidine in this test. In conclusion, procyclidine can affect learning and memory process at the doses not less than 3 ㎎/㎏, and the dose of procyclidine to influence the learning and memory process in rats might be increased to more than 5 ㎎/㎏ by the simultaneous administration of physostigmine (0.1 ㎎/㎏).