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유기인제 중독의 복합예방제로서의 physostigmine과 procyclidine이 랫드의 학습 및 기억에 미치는 염향
조순옥(Soon Ock Cho),박우규(Woo-Kyu Park),이선애(Sun Ae Lee),조영(Young Cho),허경행(Gyeung-Haeng Hur),김왕수(Wang-Soo Kim),천기철(Ki-Cheol Cheon),하연철(Yeon-Cheol Ha),연규백(Gyu-Baek Yeon),김지천(Jee-Cheol Kim),김형규(Hyong-Kyu Kim 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.4
The effects of physostigmine and procyclidine, as a combinational prophylactic regimen for organophosphate poisoning, on learning and memory process were examined in rats administering subcutaneously. Procyclidine at doses of 3 through 10 ㎎/㎏ produced significant impairment of learning and memory process in step-through passive avoidance test. However, this harmful effect of procyclidine (3 and 5 ㎎/㎏) was reversed by simultaneous injection of physostigmine (0.1 ㎎/㎏). Procyclidine at doses of 7 and 10 ㎎/㎏ produced reversible inhibition of learning and memory process in Morris water maze test. Physostigmine (0.1 ㎎/㎏) recovered the memorial impairment induced by procyclidine in this test. In conclusion, procyclidine can affect learning and memory process at the doses not less than 3 ㎎/㎏, and the dose of procyclidine to influence the learning and memory process in rats might be increased to more than 5 ㎎/㎏ by the simultaneous administration of physostigmine (0.1 ㎎/㎏).
유기인제 중독의 복합예방제로서의 Procyclidine과 Physostigmine의 일반약리작용
이선애(Sun Ae Lee),조순옥(Soon Ock Cho),이보영(Bo Young Lee),반주연(Ju Yeon Ban),조영(Young Cho),허경행(Gyeung-Haeng Hur),김왕수(Wang-Soo Kim),김지천(Jee-Cheon Kim),김윤배(Yun-Bae Kim),성연희(Yeon Hee Seong) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.3
General pharmacological properties of procyclidine and physostigmine, as a combinational prophylactic regimen for organophosphate poisoning, were investigated in experimental animals and in vitro test system. Procyclidine and physostigmine were administerd by subcutaneous injection or miniosmotic pumps for sustained release. Procyclidine had no effects on general behavior, spontaneous motor activity, pentobarbital sleeping time, motor coordination and normal body temperature at the doses of less than 30 ㎎/㎏ or 1728 ㎍/㎏/hr. Gastric secretion and intestinal motility in rats were not influenced by the sustained release of procyclidine at dose of 1296 ㎍/㎏/hr. Procyclidine up to 40 ㎎/㎏ did not change the mean arterial blood pressure and heart rate in conscious rats. Procyclidine had no effect on the respiratory rate at the same doses when given to anesthetized rats. In in vitro experiments, procyclidine at the concentration of more than 0.1 and 1 ㎎/ℓ showed significant inhibitory action on the acetylcholine-and histamine-induced contractions, respectively, in the isolated ileum of guinea-pig. In the isolated guinea-pig tracheal muscle, procyclidine did not affect the histamine-induced contractions at the dose of 5 ㎎/ℓ, but showed partial inhibition on the acetylcholine-induced contractions at the doses of 3 and 5 ㎎/ℓ. Physostigmine at the concentration of 0.05 ㎎/㎏ or 36 ㎍/㎏/hr neither produced significant change of the normal physiological activity of rats, nor completely recover the inhibitory effect of procyclidine on the gastrointestinal tract. Based on these results, it was concluded that procyclidine and physostigmine did not induce marked adverse effects in experimental animals except the significant inhibitory effect on the gastrointestinal system.