동의보감에 수재된 방제의 현대 산업화를 위한 분류 연구

김윤경,김주호,오문수,박혜정,김은정,이제현,Kim, Yun-Kyung,Kim, Ju-Ho,Oh, Mun-Su,Park, He-Jung,Kim, Eun-Jung,Lee, Je-Hyun 대한한의학방제학회 2007 大韓韓醫學方劑學會誌 Vol.15 No.1

We re-classified traditional medicinal prescriptions in Dong-Eui-Bo-Gam for the modern application using Tradimed database. They could be devided into 6 categories by the definitions of the related laws. Herbal ethical drugs are the majority, 3926 items, account for 60.21% of total items. Herbal Health Functional Foods stands second, 1480 items, 22.70%, Herbal over the counter drugs are 893 items, 13.69%. These three categories are about 83% of total items. Herbal medical supplies are 158 items, 2.42%, Herbal medical tools are 44 items, 0.67%, Herbal cosmetics are 20 items, occupied 0.31 %. Therefore we have known that traditional medicinal prescriptions can be used not only as drugs, but also as funtional foods, cosmetics, and tools. So they should be developed as modern products to make best use of them. And we suggested that we need official criteria of herbs of careful use and higher standards for herbs which can be used as foods.

Group B β-hemolytic Streptococcus에 의한 소아 감염증의 임상상

김윤경,곽영호,김예진,정혜선,홍정연,이환종,Kim, Yun Kyung,Kwak, Young Ho,Kim, Yae Jean,Jung, Hye Sun,Hong, Jung Yeon,Lee, Hoan Jong 대한소아감염학회 1999 Pediatric Infection and Vaccine Vol.6 No.2

목 적 : 이전까지는 국내에서 발생 증례가 적었던 GBS 감염증이 최근에는 자주 접하게 되었다. 이에 최근 수년간의 발생 증례에 대한 고찰을 하여 그 임상적, 역학적 특성을 고찰하고자 하였다. 방 법 : 1985년 6월부터 1999년 6월까지 서울대학교 병원 소아과에서 균이 증명된 GBS 감염증 환아들을 대상으로 하였다. 이들의 의무 기록을 후향적으로 검토하였고, 분려된 일부 균주의 혈청형과 항균제 감수성을 경시하였다. 결 과 : 기간 별 증례 수를 비교해 보면, 1990년대 후반에 그 이전보다 증례가 많았다. 총 27례중 25례가 신생아 감염증이었고, 지발형이면서 뇌막염인 증례가 많았다. 혈청형은 III(6균주), Ib(6), Ia(1)와 II(1)였다. 검사된 10개의 항균제에 대하여 모든 균주가 감수성을 보였다. 결 론 : 국내에서 신생아 GBS 감염증은 증가하고 있는 추세이므로, 신생아 패혈증 또는 뇌막염의 원인균으로서 GBS의 가능성을 고려하여야 하며, 향후 빈도가 더욱 증가하면 산모에게 산전 검사와 예방적 항생제 요법 등을 고려해야 할 것으로 사료된다. Background : Group B ${\beta}$-hemolytic Streptococcus(GBS) has been the major pathogen of neonatal sepsis in western country. In contrast, GBS has played little role in neonatal sepsis in Korea. But recently, neonatal GBS infections are encountered more frequently. It is important to characterize the clinical and epidemiological features of GBS infection in Korean children. Methods: We reviewed retrospectively the medical records of twenty-seven infants and children with GBS infection experienced at the Seoul National University Children's Hospital during 14 year-period from June, 1985 to June, 1999. Fourteen strains isolated from blood and cerebrospinal fluid were serotyped. Minimum inhibitory concentrations of 10 strains were determined by agar dilution method for penicillin, ampicillin, ampicillin with sulbactam, cefarolin, cefuroxime, and cefuiaxone. Results: The numbers of cases with GBS infection increased in 1990s. Among twenty seven cases, twenty-five cases were under three months of age and both of two cases with underlying disease occurred at three years of age. All neonatal infections were late-onset type and meningitis predominated. Serotypes were III(6 strain), Ib(4), Ia(l) and V(2). All of the strain were susceptible to all of the antibiotics tested. Conclusion: GBS infections in infants were increasingly recognized. GBS should be considered as an etiological agent of neonatal sepsis or meningitis in Korea. Maternal screening and prophylactic antibiotic therapy may be considered.

한약제제의 권리보호에 대한 초보적인 고찰

김윤경,안상우,김홍준,최환수,Kim, Yun-Kyung,Ahn, Sang-Woo,Kim, Hong-Jun,Choi, Hwan-Soo 한국한의학연구원 2004 한국한의학연구원논문집 Vol.10 No.1

The discussion of intellectual property protection with TK, GR in WIPO begin Herbal medicines get a important basis in a development of modern new medicine. For the protection of intellectual property, we set up this study. For the protection of intellectual property with herbal medicines, We analyze as follows. First, we analyze the specific theory and character of traditional herbal medicines. Second, we analyze the existing system on protecting them in Korea. The intellectual property protection with herbal medicines must maintain the specific character of that. We must select the basic traditional herbal medicines. The next, we must protect from intellectual property on add and subtract, combine, create of the traditional herbal medicines. In order that we must construct database on the Herbal medicines.

임상투여용량에서 초오전탕액의 흰쥐에 대한 간독성연구

김윤경,이제현,송계용,박성규,김정숙,Kim, Yun-Kyung,Lee, Je-Hyun,Song, Kye-Yong,Park, Seong-Kyu,Kim, Chung-Sook 대한한의학방제학회 2005 大韓韓醫學方劑學會誌 Vol.13 No.1

Objective : This study was carried out to evaluate the liver toxicities of Wild Aconiti Tuber decoction. Methods : The amounts of aconitine in the methanol extract of Wild Aconiti Tuber was measured by HPLC. Safeties was studied by LD50 in mice. Liver toxicities were evaluated histologically and by CBC, blood chemistry after 2 weeks of 0.4g/kg/day clinical dosage oral administrations in rat. Results : 1. The amounts of aconitine in the methanol extract of Wild Aconiti Tuber is $1.697{\pm}0.052mg/g$. But aconitine was not detected in the water decoction of Wild Aconiti Tuber. 2. To evaluate LD50 and safeties of Wild Aconiti Tuber decoction, ICR mice were given high dose of 2, 5, 10g/kg for single time and were observed for 2 weeks. There were no dead animal and abnormal clinical sign and no abnormalities at the autopsy. So, LD50 was admitted to higher than 10g/kg. 3. After 2 weeks of 0.4g/kg/day clinical dosage oral administrations in rat, there was no significant change in the CBC and blood chemistry. 4. In the liver tissues of clinical dosage, mitotic figures, apoptosis and individual cell death were observed, but clear liver toxicities like fatty liver or necrosis were not observed. the liver tissues of high dose in mice, hydropic changes were getting severe as dose grows. Conclusions : According to the results, though aconitine was not detected in the Wild Aconiti Tuber decoction, 0.4g/kg/day 2 weeks p. o (clinical dosage) group showed weak changes in the liver tissues and high dose group showed liver toxicities like hydropic changes.

전통적인 한약의 전탕법과 복용법에 대한 현대적 고찰

김윤경,김정숙,최훈,Kim, Yun-Kyung,Kim, Chung-Seok,Cui, Xun 한국한의학연구원 2004 한국한의학연구원논문집 Vol.10 No.2

The decocting method of herbal medicines is various with a prescription or herbal medicine's characteristics. But it has common principles by which effective elements can be easily extracted with synergistic actions of herbs and which the therapeutic effect of a medicine is amplified. When decocting a herbal medicine, the volume of water is an important factor. Fire for decocting drugs and decocting time are also important factors. The excessive water and unproper decocting time and temperature can reduce the effect of the decoction. Besides a better decoction can be obtained by squeeze. According to herbal medicine's characteristics and prescription, there are herbs that should be treated after a specific method. For example, decoct first and decoct later. It also affects the therapeutic if a right taking method is not carried out. Methods of taking drugs include both the time and the method. We can confirm these decocting and taking methods in the ancient medical literatures of herbal medicine. This article deals with these things in detail.

생약제제의 의미 변천과 정책적 문제 검토

김윤경,조선영,김지연,강연석,Kim, Yun-Kyung,Cho, Sunyoung,Kim, Jiyeon,Kang, Yeonseok 대한한의학방제학회 2013 大韓韓醫學方劑學會誌 Vol.21 No.2

Objectives : The aim of this study is reviewing the past legal definition and regulations, to provide basis for the future desirable direction of Korean herbal pharmaceutical industry and national herbal drug policies. Methods : We reviewed how concept of herbal medicinal preparation has been utilized and changed along with various national laws and regulations. And this study also reviewed problems related herbal medicinal preparation policies. Results : Since 1990s, especially inauguration of Korea Food & Drug Administration (KFDA) at 1998, the concept of crude drug preparation has constantly expanded and distorted the scope of herbal medicinal preparations. This resulted in decline of herbal medicinal preparation industry. Conclusions : It means policies related herbal medicinal preparation which was driven steadily during this decade have lost their consistency. Also, it restricted the various medical options which can guarantee people's health rights.

정적분석을 이용한 자바 언어의 권한검사 시각화 시스템

김윤경,창병모,Kim, Yun-Kyung,Chang, Byeong-Mo 한국정보처리학회 2006 정보처리학회논문지 A Vol.13 No.5

Java 2에서 자원에 대한 접근 권한관리를 위하여 프로그래머는 프로그램 실행에 필요한 권한들을 정책파일(polic file)에 기술하고, 보안관 리자(Security Manager)를 설치하여 프로그램을 수행시킨다. 프로그램 실행 중에 자원에 대한 접근을 시도할 때마다. 보안관리자는 스택 인스펙션을 통해 접근 권한이 있는지 검사한다. 본 논문에서는 프로그래머가 안전한 보안정책을 세우는데 편의를 제공하고자 권한검사 관련 정보를 정적으로 분석하여 시각적으로 보여주는 시스템을 구현하였다. 권한김사 시각화 시스템은 정적 권한검사 분석에 기반하여, 각 메소드 별로 항상 성공하거나 항상 실패하는 권한검사를 계산한다. 프로그래머는 프로그램을 실행시켜보기 전에 권한검사와 스택 인스펙션이 어떻게 수행되는지 시각적으로 확인해 볼 수 있다. 이러한 정보를 토대로 안전한 보안정책을 세우기 위해 프로그램이나 정책파일을 수정할 수 있다. In Jana 2, to enforce a suity policy of a program, programmer writes permission sets required by the code at the policy file, sets Security Manager on system and executes the program. Then Security Manager checks by stack inspection whether an access request to resource should be granted or denied whenever code tries to access critical resource. In this paper, we develop a visualization tool which helps programmers enforce security policy effectively into programs. This system is based on the static permission check analysis which analyzes permission checks which must succeed or fail at each method. Based on this analysis information, programmer can examine visually how permission checks and their stack inspection are performed. By modifying program or policy file if necessary and examining analysis information repeatedly, programmer can enforce security policy correctly.

영화와의 상호작용에 따른 디지털 게임의 화면구성기법에 관한 연구

김윤경(Yun Kyung Kim) 한국디자인문화학회 2008 한국디자인문화학회지 Vol.14 No.4

As media, what digital games stands for other genre and form is interactivity allows the player to carry out various kinaesthetic actions, immersion. and so on. The advance of technology has, for example, enabled game designers to increase the visual detail of games, to make greater use of three-dimensional game worlds, and to provide players with improved means of interacting with games. Technology, however, is not the only factor that has determined the path and progress of games. Game designers have increasingly drawn on strategies employed in other media. Cinema has emerged as the most prominent influence on games. Cinema in particular has a very close relationship with digital games in terms of the similarities that the media share have meant that some artistic strategies can be transferred between the two. This study propose a enlargement of digital games by understanding the relationship between these two media, and outlines the outcomes of this interaction.

흰 쥐의 측두하악관절 통증모델에서 Triptolide와 N-nitro-L-arginine Methyl Ester의 통증조절효과

김윤경 ( Yun Kyung Kim ),이민경 ( Min Kyung Lee ) 한국치위생과학회 2015 치위생과학회지 Vol.15 No.6

The aim of this study was to investigate whether intracisternal administrations of triptolide and N-nitro-L-arginine Methyl Ester (L-NAME) are involved in the regulation of temporomandibular joint (TMJ) pain. The TMJ pain was induced by the injection of 5% formalin (30 -l) into TMJ capsule of rats. The pain behavioral responses was recorded the number of grooming or scratching on the left TMJ area for 9 successive 5 minutes intervals. Triptolide and L-NAME were administrated intracisternally 10 minutes before formalin injection. The intra-articular injection of formalin produced a biphasic pattern of pain response (first phase: 0∼10 minutes and second phase: 11∼45 minutes). The intracisternal administration of triptolide (1 μg/10 -l) and L-NAME (0.1 μg/10 μl) suppressed the TMJ pain behavior in each experiment. Co-administration of two drugs was shown the enhanced effect than the analgesic effect by single-administration of triptolide (1 μg/10 μl). The triptolide could be a useful analgesic agent for the treatment of TMJ pain, and it is expected to reduce the substantial amount of it via co-administration of synthetic chemical compound and natural products.

체감형 학습을 위한 매개 디바이스의 디자인 요구사항 -프로토콜 분석법을 통한 미취학 아동의 행동 패턴 분석

김윤경 ( Yun Kyung Kim ),김현정 ( Hyun Jeong Kim ),김명석 ( Myung Suk Kim ) 한국감성과학회 2010 감성과학 Vol.13 No.1

미취학 아동의 창의적 사고, 다양한 경험 기반의 학습 활동, 그리고 인성 및 감성 중심의 교육에 대한 욕구를 충족시켜줄 수 있는 새로운 교육 방식으로써 체감형 교육 방식의 보급이 활발해지고 있다. 체감형 학습은 사용자의 움직임이나 감각을 통해 디지털 교육 콘텐츠를 조작하는 인간-컴퓨터 인터랙션을 활용한 교육 방식이다. 그러나 사람의 움직임이나 목소리 같은 음성/영상 인식의 정확도가 높지 않아 실제 교육 시스템 적용에는 한계를 보인다. 이러한 한계점의 극복을 위해 인간과 서비스 콘텐츠 사이에 매개체를 두고 이를 통해 사람의 움직임을 가속도, 각속도와 같은 숫자 값으로 변환/전송하여 인터랙션 하는 매개 인터페이스 개념이 제안된다. 본 연구에서는, 교육 시스템의 대상인 미취학 아동의 행동을 관찰하고 프로토콜 분석을 통하여 사용자 중심의 매개 디바이스 디자인 요구사항을 제안한다. 분석 결과, 미취학 아동들은 물체를 조작하는 데 서툴고, 무의식적으로 물체를 만지작거리거나 기대는 행동을 보였다. 또한 물건을 사용할 때 그에 종속되어 행동의 부자연스러움을 보였다. 따라서 체감형 교육을 위한 매개 디바이스는 사용자의 익숙하지 않은 조작을 보조할 수 있어야 하며, 디바이스 사용 중에도 자연스러운 행동을 유지할 수 있도록 디자인되어야 한다. TPR(Total Physical Response) is a new representative learning method for children`s education. Today`s approach to TPR has focused on signals from a user which becomes input data in a human-computer interaction, but the accuracy of sensing from body signals(e. g. motion and voice) isn`t so perfect that it seems difficult to apply on an education system. To overcome these limits, we suggest a mediating interface device which can detect the user`s motion using correct numerical values such as acceleration and angular speed. In addition, we suggest new design requirements for the mediating device through analyzing children`s behavior as human factors by ethnography research and protocol analysis. As a result, we found that; children are unskilled in physical control when they use objects; tend to lean on an object unconsciously with touch. Also their behaviors are restricted, when they use objects. Therefore a mediating device should satisfy new design requirements which are make up for unskilled handling, support familiar and natural physical activity.