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김영묵 ( Young Mook Kim ),이주용 ( Jue Yong Lee ),이명구 ( Myung Goo Lee ),이창률 ( Chang Youl Lee ),김고운 ( Go Woon Kim ),손경민 ( Kyoung Min Sohn ),양하나 ( Ha Na Yang ),김대용 ( Dae Yong Kim ),최현희 ( Hyun Hee Choi ),김형수 ( 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.63 No.6
The incidence of acute respiratory distress syndrome (ARDS) has been estimated worldwide to range from 1.7 to 75 cases per 100,000. There are many treatments for ARDS, but only the low tidal volume strategy is based on strong clinical evidence from randomized clinical trials. The efficacy of extracorporeal life support (ECLS) in adults remains controversial. Ongoing clinical trials and research have shown a benefit for its use to salvage severe ARDS patients that are in failure with conventional treatment. We encountered a 41-year-old woman who developed ARDS induced by pneumococcal pneumonia. Despite conventional mechanical ventilation in the emergency room, severe hypoxia remained. We treated the patient immediately with ECLS. The patient has almost fully recovered, and was discharged from a 177-day stay at our hospital. (Tuberc Respir Dis 2007;63:526-530)
춘천 지역의 위식도 역류질환과 역류성 식도염의 특징 -건강 검진자 연구-
이주용 ( Jue Yong Lee ),홍원기 ( Won Ki Hong ),손경민 ( Kyung Min Sohn ),김대용 ( Dae Yong Kim ),김영묵 ( Young Mook Kim ),최현희 ( Hyun Hee Choi ),최창순 ( Chang Soon Choi ),김성중 ( Seong Jung Kim ),백광호 ( Gwang Ho Baik ),김 대한내과학회 2008 대한내과학회지 Vol.74 No.4
목적: 춘천을 중심으로 강원도 북서 지역의 건강 검진자를 대상으로 하여 위식도 역류 증상의 종류별 빈도와 역류식도염, 내시경적으로 의심되는 바렛 식도의 빈도를 알아보고자 하였다. 증상의 종류별로, 내시경적 역류식도염의 유무로 분류하여 각각에서 바렛 식도, 위궤양, 십이지장궤양, 식도 열공, 흡연 및 음주 등의 생활 습관의 차이가 있는지 연구하였다. 방법: 2005년 7월 1일부터 2006년 6월 30일까지 내시경을 포함한 건강검진을 받은 총 1,011명을 연구대상으로 하였다. 설문지를 통하여 증상, 흡연, 음주, 성별, 나이, 과거 HP 치료력을 얻었으며 내시경을 통해 역류식도염, 바렛 식도, 위궤양, 십이지장궤양, 식도 열공 등을 관찰하였다. 증상 종류별로 전형적 증상군, 비전형적 증상군, 증상이 없는 무증상군과 증상의 빈도가 낮아 불편감 없는 군으로 분류하였고, 내시경적 역류식도염의 유무로 분류하여 각 군 간의 임상적 차이를 알아보았다. 결과: 춘천을 중심으로 강원 북서 지역에서 건강 검진자중, 일상 생활에 지장을 주는 정도의 가슴 쓰림과 위산 역류의 증상을 호소하는 경우는 7.5%였으며 내시경적으로 역류 식도염은 9.7%에서 관찰되었다. 바렛 식도는 6.8%에서 내시경적으로 의심되었다. 증상의 유무에 따라 내시경적 역류식도염의 유병률에 통계적 차이를 나타냈으며 성별에 의한 뚜렷한 차이를 관찰할 수 있었다. 내시경적 역류식도염의 성별에 의한 차이가 2.8:1로 남자에서 많은 것으로 관찰되었으며 이와 함께 식도 열공과 음주, 흡연, 기침도 남자에게서 보다 빈번했으며 가슴 쓰림, 속 쓰림, 기타 증상은 여자에게서 빈번히 나타났다. 결론: 증상이 있는 군에서 증상 종류에 따라 연구에 포함된 모든 항목에서 통계적인 차이가 없었고, 증상의 정도 및 빈도는 내시경적 역류식도염과 연관성이 없었다. 그러나 증상의 유무와 역류식도염과는 연관성이 있었다. 이번 연구로 춘천을 중심으로 한 강원 북서 지역의 위식도 역류병의 일면을 보았고 향후 일반 인구집단에 대한 위식도 역류병의 유병률 조사가 필요하겠다. 내시경적 역류식도염에서 지역적 유병률의 차이, 관찰자간 차이 및 실제적 증가가 있는지에 대한 연구가 필요할 것으로 보인다. Background/Aims: The aims of this study were to estimate the frequency of symptoms of gastroesophageal reflux disease and reflux esophagitis, to evaluate the difference in characteristics among groups subdivided by symptoms, and to compare clinical features between a reflux esophagitis group and a non-reflux esophagitis group in Chuncheon City. Methods: A total of 1,011 persons who underwent endoscopy for health check-up were enrolled between July 1, 2005, and June 30, 2006. All persons were given a validated, self-reported questionnaire, which inquired about the presence, frequency, and severity of typical symptoms (heartburn and acid regurgitation) and atypical symptoms. The questionnaire also inquired about smoking, alcohol intake, and Helicobacter pyroli eradication. The subjects were subdivided into typical symptomatic, atypical symptomatic, no discomfort, and asymptomatic groups. Results: The prevalence of heartburn and acid regurgitation occurring at least weekly was 7.5%. Reflux esophagitis, hiatal hernia, smoking, and alcohol intake were more common in males (p<0.05). Ninety-eight cases (9.7%) were endoscopically diagnosed as reflux esophagitis, and sixty-nine cases (6.8%) were endoscopically suspected esophageal metaplasia (ESEM). Subjects in the symptomatic group more frequently manifested reflux esophagitis than subjects in the asymptomatic group (p<0.05). Conclusions: The presence of reflux-induced symptoms is related to reflux esophagitis, but the intensity and frequency of symptoms are poor predictors of the presence or severity of endoscopic mucosal breaks.(Korean J Med 74:385-390, 2008)
뇌하수체 선종과 동반된 갑상선호르몬 저항성 증후군 1예
김대용 ( Dae Yong Kim ),김영묵 ( Young Mook Kim ),최현희 ( Hyun Hee Choi ),이주용 ( Joo Yong Lee ),한재필 ( Jae Pil Han ),이성진 ( Seong Jin Lee ),최문기 ( Moon Gi Choi ) 대한내과학회 2008 대한내과학회지 Vol.74 No.1
저자들은 갑상선자극호르몬분비호르몬 자극검사, 갑상선자극호르몬 α-아단위 측정, 뇌하수체 자기공명영상, 갑상선호르몬 수용체 β 유전자 검사로 진단한 비기능성 뇌하수체미세선종과 동반된 뇌하수체성 갑상선호르몬 저항성 증후군 증례를 국내에서 처음으로 경험하였기에 문헌고찰과 함께 보고하는 바이다. Resistance to thyroid hormone (RTH) is an autosomal dominant disorder that`s characterized by inappropriate normal or elevated TSH levels despite of the elevated thyroid hormone levels. RTH is distinguished from the TSH secreting pituitary adenoma by performing the TRH stimulation test, TSH alpha-subunit measurement and sellar MRI. A 23-year old woman visited our hospital complaining of fatigue, palpitation and heat intolerance and she had an anterior neck mass. She had elevated total T3, free T4 and TSH levels. The serum TSH levels were increased during the TRH stimulation test before and after T3 suppression. The serum TSH alpha-subunit showed a normal response and the serum TSH alpha-subunit/TSH molar ratio did not increase over 1.0 with TRH stimulation. Thyroid hormone receptor β gene mutation was identified. Although a left pituitary microadenoma was revealed on sellar MRI, the patient was diagnosed as having pituitary RTH with a nonfunctioning pituitary microadenoma. We report here on a patient with pituitary RTH and a nonfunctioning pituitary microadenoma, and this is the first such case in Korea.
초생추 각장기에 있어서 이중투여에 의한 P32 및 Ca45 분포에 관한 실험적 연구
이용빈 ( Yong Bin Lee ),정영채 ( Yang Chai Chung ),김영묵 ( Yong Mook Kim ),성재기 ( Jae Ki Sung ),권종국 ( Jong Kuk Kwun ) 한국축산학회 1967 한국축산학회지 Vol.9 No.1
The distribution of double labeled P^(32) and Ca^(45) in the various tissues were investigated in fourty chicken. The results obtained were as follows: 1) The highest differences were observed in the thyroid gland between the sex in 24 hrs. after double administration of P^(32) and Ca^(45). 2) Generally, the distribution of double administrated P^(32) and Ca^(45) were higher in 24 hours than in one hour. 3) The sequence of the distribution of P^(32) and Ca^(45) in Various tissue were, thyroid gland, femur, adrenal, genital organs, pituitary, kidney, liver, spleen, brain, and G-muscle.
가금의 인 및 칼슘 대사에 관한 연구 ; 제5보 : 초생추 각장기에 있어서 이중투여에 의한 P32 및 Ca45 분포에 관한 실험적 연구
이용빈 ( Yong Bin Lee ),정영채 ( Yang Chai Chung ),김영묵 ( Yong Mook Kim ),성재기 ( Jae Ki Sung ),권종국 ( Jong Kuk Kwun ) 한국축산학회 1967 한국축산학회지 Vol.9 No.1
The distribution of double labeled P^(32) and Ca^(45) in the various tissues were investigated in fourty chicken. The results obtained were as follows: 1) The highest differences were observed in the thyroid gland between the sex in 24 hrs. after double administration of P^(32) and Ca^(45). 2) Generally, the distribution of double administrated P^(32) and Ca^(45) were higher in 24 hours than in one hour. 3) The sequence of the distribution of P^(32) and Ca^(45) in Various tissue were, thyroid gland, femur, adrenal, genital organs, pituitary, kidney, liver, spleen, brain, and G-muscle.
최현희 ( Hyun Hee Choi ),김영묵 ( Young Mook Kim ),김대용 ( Dea Yong Kim ),이주용 ( Jue Yong Lee ),윤인상 ( In Sang Yun ),한상진 ( Sang Jin Han ),홍경순 ( Kyung Soon Hong ) 대한내과학회 2008 대한내과학회지 Vol.74 No.3
Transient left ventricular apical ballooning syndrome is also known as takotsubo cardiomyopathy, and this is characterized by transient wall-motion abnormalities involving the left ventricular apex without significant stenosis on the coronary angiogram. We report here on a new variant of transient left ventricular ballooning in which only the mid-ventricle was affected. The patient initially presented with dyspnea and she had wall-motion abnormalities involving the mid-ventricle with hypercontractility of the apical and basal segments in the absence of a significant coronary artery stenosis. Emotional or physical stress or other preceding triggering factors might play a key role in this cardiomyopathy, but the precise etiology remains unknown. So far, the cases of this syndrome have been reported only among the North America Caucasian population and the Japanese population. (Korean J Med 74:321-324, 2008)
이용빈,김영묵,정영채 한국축산학회 1966 한국축산학회지 Vol.8 No.1
Using 24 Guinea pigs which were divided into 4 group, and each group was subcutaneously injected 35, 70, 140 and 280 μc of I^(131) per ㎏ cf body weight and then thyroidal I^(131) uptake rate and P.B.I^(131) conversion ratio were observed. 1) In 16 hrs after injection of I^(131) the external count of thyroidal uptake rate showed maximum value in all group. The values of each group were 1.37×10³ cpm, 2.72×10³ cpm. 5.66×10³ cpm and 10.97×10³ cpm, and there was highly significant differences (p$lt;0.01) among treatments. 2) The I^(131) uptake rates of removed thyroid gland were 2.76×10³ cpm, 7.35×10³ cpm, 14.23×10³ cpm and 21.38×10³ cpm in 24 hrs. after injection of I^(131). Generally, the rates were Proportionally increased to the injected dose of I^(131), but they shoved highly significant difference in that treatment (P$lt;0.01), 3) The concentrations of I^(131) in blood serum were 8.91×10³ cpm, 27.32×10³ cpm, 35.15×10³ cpm and 45.45×10³ cpm in 24 hrs. after injection of I^(131), and there were highly significant difference among the concentrations. 4) The activities of P.B.I^(131) in serum in 24 hrs. after injection of I^(131) were 0.81×10³ cpm for 35μc group, 108×10³ cpm for 70μc group, 1.21×10³ cpm for 140μc group, and 1.21×10³ cpm for 280μc group, respectively In 35 and 70μc group, the P.B.I^(131) activities were increased, but in 140μc and 280μc group, the activities were not increased according to the dose of I^(131) injected. 5) The highest conversion ratios of P.B.I^(131) were 3.48% in 70 μc group and were 3.19% in 140μc group, 2.55% in 35μc group, and 2.42% in 280μc group.
최정숙,이충원,김영묵,권기호,최한용,황순철,서보정,박양훈,이복근 대한내과학회 1994 대한내과학회지 Vol.47 No.4
'h A 50-year old female patient admitted with a 1-week-istory of pain and bulging in the left lower abdominal area following a bout of coughing. The pain was exacervated when a Valsalva's manuver was performed and was somewhat relieved by lying supine. The patient reported a 10-day history of severe coughing, but no fever. She had been taking antitussive for 10 days, but no aspirin and anticoagulant. She had been suffered from bronchial asthma for 8 years. The ultrasound, CT & needle aspiration confirmed the diagnosis of a hematoma between the internal oblique & external oblique muscle of abdominal wall. She was treated conservatively with a heating pad, analgesics, elastic bandages, and instructed to rest. Her bronchial asthma was treated with antitussives, aminophilline, B2 agonist inhalator, and prednisolon. This case report describes the association between relative minor strain and the formation of a hematoma of anterior abdominal wall. A review of the literature was undertaken to discuss the cause, diagnosis, and treatment of a anterior abdominal wall hematoma.