운동강도의 차이가 Streptozotocin-유도 당뇨쥐의 가자미근 GRP-78과 GLUT-4 발현에 미치는 영향

김양희,윤진환,Kim Yang-Hee,Yoon Jin-Hwan 한국생명과학회 2005 생명과학회지 Vol.15 No.1

본 연구에서는 Streptozotocin-유발 당뇨 쥐를 대상으로 8주 동안 운동 강도에 따른 혈당, 인슐린, 골격근 내 GLUT-4 발현 량과 GRP-78 발현량 변화를 관찰함으로써 당뇨 쥐의 혈당을 낮추는데 효과적인 운동 강도는 무엇이며, 기전적인 원인은 무엇인지를 밝히고자 실시되었다. 본 연구에서 Streptozotocin으로 당뇨를 유발시킨 흰쥐를 대상으로 운동 강도 처치에 따른 GLUT-4발현 량을 비교한 결과, 기본적으로 당뇨가 유발된 흰쥐의 GLUT-4 발현 량은 정상 쥐에 비해 현저하게 감소하는 것을 볼 수 있었다. 이중 8주 동안 저강도 운동 수행 한 쥐들의 경우는 정상 쥐 수준에 가까운 발현 량을 관찰 할 수 있었으며, 흰쥐 가자미 근 내 GRP-78 발현 량은 당뇨 유발 쥐의 경우 정상 쥐의 유의하게 증가한 것을 관찰할 수 있었고, 저강도 운동을 수행한 집단에서의 GRP-78 발현 량은 정상 흰쥐에서 발현되는 양에 비해 유의하게 높은 수준을 보이기는 했지만 당뇨 유발 대조군과 고강도 운동 군에 비해서는 유의하게 낮은 수준으로 나타났다. 결론적으로 저강도의 운동은 당뇨 질환자의 혈당을 낮추는 데 가장 효과적인 운동이라 할 수 있으며, 이러한 결과의 기전적인 원인은 저강도의 운동이 근육 내 GLUT-4의 증가로 세포내 당 유입을 촉진시킴으로 해서 나타난 사실이라 생각되며 이 같은 사실은 GRP-78의 발현 량의 감소로 확인할 수 있었다. This study investigated the response of GLUT -4 and GRP-78 expression in soleus muscle of streptozotocin-induced diabetic rats by imposing different exercise intensities. F344 rats were randomly divided into 4 groups (n=15 in each group): Control (Control), diabetes-operation (DO), diabetes with low intensity exercise (DLE) and diabetes with high intensity exercise (DHE). The rats in DLE and DHE groups were exercised for 8 weeks by treadmill running. Blood glucose levels in DO were significantly higher compared to that in NORMAL whereas DLE showed the most lowest level in blood glucose among diabetic groups. Diabetic groups exhibited significantly lower level in insulin change and DLE showed significantly higher insulin level among diabetic groups. GRP-78 in DO was significantly $(167.05\%)$ higher than that in Control. GRP-78 in DLE was $139.41\%$ which is significantly higher compared to Control but when compared to DO and DHE, it was significant low. GRP-78 in DHE was $194.64\%$ which doubled the protein level in Control and showed the most highest level in all groups. GLUT-4 in DO was significantly $(33.58\%)$ higher compared to Control. GLUT-4 in DLE showed $124.58\%$ which was significant high compared to Control, DO and DHE. GLUT-4 in DHE showed $26.91\%$ compared to Control and was the most lowest level among all groups. It seems clear that chiefly low intensity exercise benefits diabetic patients in controlling blood glucose. It was concluded that low intensity exercise induces translocation of GLUT-4 which results in increased blood inflow, thus GRP-78 expression is decreased.

회원작품 - 청양소방서

김양희,Kim, Yanghui 대한건축사협회 2018 建築士 Vol.587 No.-

경쟁작 - 공립어린이집 및 감성체험장

김양희,Kim, Yanghee 대한건축사협회 2018 建築士 Vol.597 No.-

공동주거단지 조경식재공사의 하자실태와 개선방안 연구

김양희,권영휴,Kim, Y.H.,Kwon, Y.H. 국립한국농수산대학교 교육개발센터 2008 현장농업연구지 = Journal of practical agricultural resear Vol.10 No.1

As the quality of life improves, people want to live in more pleasant environment with beautiful trees, clean air and water. They are keenly interested in environmental issues as well as living environment of apartment which is a trademark of modern life. With this situation, the function and roles of landscaping trees have been recognized as a critical factor to improve living environment. As people have asked for more demands on those trees, it has raised more issues on the defect of trees and is required the solution to those issues. So, the purpose of this study was to survey the reasons of defects and find out those solutions. The data on defects in 1990s was referenced to the reports issued by SH Corporation in 1994 and 1997. The data on defects in 2000s are collected from March, 2006 to May 2006 based on the survey for apartments already constructed by Korea Housing Corporation. The results of the survey were shown that, in the year of 1994, landscaping trees causing high rate of defects were Acer buergerianum (92%), Pinus densiflora(85.7%), Celtis sinensis(80%), Cydonia sinensis(75%) and Diospyros kaki(66.6%), and in the year of 1997, landscaping trees causing high rate of defect were Ziziphus jujuba(100%), Cornus alba(65.2%), Diospyros kaki(60%), Thuja occidentalis(60%), and Metasequoia glyptostroboides(42%). And, in the year of 2006, landscaping trees causing high rate of defect were Sophora japonica(100%), Taxus cuspidata(80%), Magnoila quinquepeta (75%), Acer palmatum(62.5%) and Ginkgo biloba(50%). Because the reasons of defects were various according to the conditions including the climate, location, time and landscaping trees carried into the work area, we present the problems and solutions to those defects. Since the landscaping trees are living creatures, the factors of defects were various and complicated according to the site condition. So, in the period of warranty, contractor should designate the tree manger who can recognize the situation and take suitable action within timely manner.

KISTI Home coming day-10.April

김양희,Kim, Yang-Hui 한국과학기술정보연구원 2006 지식정보인프라 Vol.22 No.-

아로마테라피 손 마사지가 입원 노인의 수면 및 우울에 미치는 효과

김양희,김영철,사공정규,Kim, Yang-Hee,Kim, Youn-Chul,SaKong, Jeong-Kyu 대한예방한의학회 2009 대한예방한의학회지 Vol.13 No.3

Objectives : To evaluate the effects of aroma hand massage on sleep disturbance and depression in hospitalized elderly patients. Methods : The data was collected using questionnaires from the subjects who were admitted to the G Medical Hospital in Daegu from 7 July to 12 July, 2008. A total of 23 subjects were selected. The subjects were applied with the aroma hand massage to both hands using a solution diluting four drops of lavender oil in jojoba oil 10cc. Aroma hand massage was given for 10 minutes, one time a day, during 5 days. Results : There was statistically significant improvement on the Korean sleep scale(t=-7.614, p=0.000) and on the Geriatric Depression Scale Short Korea Version(GDSSF-K)(t=3.444, p=0.002). Conclusions : aroma hand massage is an effective therapeutic intervention for decreased sleep disturbance and depression. Therefore, aroma therapy and hand massage by therapeutic intervention is recommended for improving psychological and physiological functions in hospitalized elderly patients.

PG-GAN을 이용한 패션이미지 데이터 자동 생성

김양희,이찬희,황태선,김경민,임희석,Kim, Yanghee,Lee, Chanhee,Whang, Taesun,Kim, Gyeongmin,Lim, Heuiseok 한국사물인터넷학회 2018 한국사물인터넷학회 논문지 Vol.4 No.2

이미지와 같은 고차원 데이터로부터 새로운 샘플 데이터를 생성하는 기술은 음성 합성, 이미지 변환 및 이미지 복원 등에 다양하게 활용되고 있다. 본 논문은 고해상도의 이미지들을 생성하는 것과 생성한 이미지들의 variation을 높이기 위한 방안으로 Progressive Growing of Generative Adversarial Networks(PG-GANs)을 구현 모델로 채택하였고, 이를 패션 이미지 데이터에 적용하였다. PG-GANs은 생성자(Generator)와 판별자(discriminator)를 동시에 점진적으로 학습하도록 하는데, 저해상도의 이미지에서부터 계속해서 새로운 레이어들을 추가하여 결과적으로 고해상도의 이미지를 생성할 수 있게끔 하는 방식이다. 또한 생성 데이터의 다양성을 높이기 위하여 미니배치 표준편차 방법을 제안하였고 GAN 모델을 평가하기 위한 기존의 MS-SSIM이 아닌 Sliced Wasserstein Distance(SWD) 평가 방법을 제안하였다. Techniques for generating new sample data from higher dimensional data such as images have been utilized variously for speech synthesis, image conversion and image restoration. This paper adopts Progressive Growing of Generative Adversarial Networks(PG-GANs) as an implementation model to generate high-resolution images and to enhance variation of the generated images, and applied it to fashion image data. PG-GANs allows the generator and discriminator to progressively learn at the same time, continuously adding new layers from low-resolution images to result high-resolution images. We also proposed a Mini-batch Discrimination method to increase the diversity of generated data, and proposed a Sliced Wasserstein Distance(SWD) evaluation method instead of the existing MS-SSIM to evaluate the GAN model.

전임 조영화 원장 이임식 및 제3대 양병태 원장 취임식

김양희,Kim, Yang-Hui 한국과학기술정보연구원 2006 지식정보인프라 Vol.23 No.-

Two-dimensional self-assembly behaviors of organic molecules on CVD-graphene

김양희,김윤정 ( Yun Jeong Kim ),안석훈 한국공업화학회 2022 한국공업화학회 연구논문 초록집 Vol.2022 No.-

논문편 : 학동기 자녀를 둔 맞벌이가족의 가족관계와 정책적 제언

김양희,박충선,서동인,신화용,조병은,최규련 ( Yang Hee Kim,Chung Sun Park,Dong In Suh,Hwa Yong Shin,Byung Eun Cho,Kyu Reon Choi ) 대한가정학회 1992 Human Ecology Research(HER) Vol.30 No.3