http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
조혈제에 관한 연구 II 특효성 조혈제 제조에 관한 연구
김양배,홍문화 대한약학회 1964 약학회지 Vol.8 No.4
Sustained-release dosage form of ferruginous hematinics which can be absorbed effectively without forming "iron block" that caused by high concentration of Iron in the gastrointestinal tract, was studied. Gelatinized micropellets containing medicament were prepared according to the method of N. Tanaka et al. and hardened in 10% formalin-isopropanol in various time. Gelatinized micropellets were digested with artificial gastric juice and prepared a graph of iron concentration determined by Hong's method. As a result, it is assumed that gelatinized sustained-release dosage form can be a good ferruginous hematinics and it is shown that the preparation of 72-hour-hardening in 10% formalin-isopropanol has a suitable sustained release.d release.
마늘(Allium sativum L .) Polyphenol Oxidase 의 특성
김양배,이종욱,김동연 한국농화학회 1981 Applied Biological Chemistry (Appl Biol Chem) Vol.24 No.3
Crude enzyme of polyphenol oxidase was obtained from garlic. This enzyme actively oxidized triphenols such as pyrogallol and gallic acid, although it showed very weak activity on diphenols such as catechol and chlorogenic acid among the phenolic compounds tested. The optimum pH of the enzyme was 6.5 which was slightly higher than that of the garlic itself (pH 6.0). The enzyme was stable relatively at heat treatment. Sodium metabisulfite inhibited the enzyme activity at the concentration of 1mM, and KCN, L-ascorbic acid and thiourea also inhibited the enzyme action. Mg^(++) activated the enzyme activity. Cu^(++) activated slightly the enzyme action at low concentration (1mM), but inhibited at high concentration (10mM).
히드록시프로필셀룰로오스와 카르보폴을 사이클로옥시게나제의 작용부위 모델
김양배,박일영,정우태 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.3
The active site of cyclooxygenase was modeled by complementary receptor-cavity mapping procedure using 3D structures of the non-steroidal antiinflammatory drugs (NSAIDs). A total of 50 NSAIDs were chosen as data ligands which compete the same site on the enzyme. Partial atomic charges were estimated, and the energetic differences for various conformations were calculated so as to meet the need for a most efficient overlapping of the probably-equivalent functional groups of the ligand molecules. The structure activity relationships of the NSAIDs, if available, were fully considered throughout the modeling. The overall shape of the model obtained is similar to a boot-without-bottom. Most of inner surface of the cavity appeared as hydrophobic: two polar counterparts except the carboxyl-binding position were found. By this model, some clear explanations could be given on the experimental observations which were not satisfiably understood yet.