백련초 (Opuntia ficus-indica var., saboten)의 Salmonella와 Escherichia coli O157 : H7에 대한 항균효과

김소현,권남훈,김지연,임지연,배원기,김준만,노경민,허진,정우경,박건택,이종은,라정찬,박용호,Kim, So-Hyun,Kwon, Nam-Hoon,Kim, J.Y.,Lim, J.Y.,Bae, W.K.,Kim, J.M.,Noh, K.M.,Hur, J.,Jung, W.K.,Park, K.T.,Lee, J.E.,Ra, J.C.,Park, Yong-Ho 한국식품위생안전성학회 2002 한국식품위생안전성학회지 Vol.17 No.2

항생제 및 항균 물질 등의 오, 남용으로 인하여 항생제 내성균들이 등장, 사회적으로 큰 문제가 되고 있으며, 최근에는 식물이나 probiotics 등과 같이 항생제를 대체할 수 있는 물질에 대한 연구가 활발히 진행되고 있다. 이에 본 연구에서는 국내에서 오래 전부터 민간 요법으로 사용되어 오던 백련초 (Opuntia ficus-indica var. saboten)를 이용하여 in vitro와 in vivo에서 Salmonella enteyica serova. Enteritidis (S. enteritidis), S. enterica serova. Typhimurium (S. Typhimurium) DT104 및 Escherichia coli O157:H7에 대한 항균능을 평가하였다 백련초의 수용액이 포함된 Moulter Hinton agar에 Salmonella spp. 및 S. coli O157:H7를 접종한 결과 이들 균에 대한 억제능(inhibitory activity)을 확인할 수 있었다. 백련초 제제를 경구투여한 군에서 분변으로 배출되는 S.typhimurium DT104의 수가 급격히 감소하였고, 낀 후에는 더 이상 분변으로 균이 배출되지 않았으며, intestinal IgA가 유의적으로 증가함이 확인되었다. 본 연구를 통하여 백련초가 in vitro에서 S. enteritis, S. Typhimurium DT104와 E. coli O157:H7대한 항균력을 나타낼 뿐만 아니라 마우스의 gastrointestinal tract에서 역시 Salmonella에 대한 항균력을 보임을 확인할 수 있었다. 본 연구를 통해 백련초 및 그 성분을 이용한 병원성 세균의 제거 및 면역 증진 효과 등과 같은 연구의 필요성이 확인되었고, 그 응용 가능성도 매우 높을 것으로 사료된다. With the incidence of antibiotic resistant bacteria there is increasing interest in natural products such as herb extract and probiotics to control antibiotic resistant bacteria. This study was focused on the determination of antimicrobial activity of Opuntia ficus-indica var. saboten against Salmonella enetrica serovar Enteritidis (S. enterifidis), S. enterica serovar Typhimurium (S. Typhimurium) DT 104 and Escherichia coli 0157:H7. Though bactericidal effect of 0. ficus-indica var. saboten was not observed, it had significant inhibitory activity against Salmonella spp. and E. coli O157:H7 on the Moulter Hinton agar containing its solution dissolved in deionized water. To investigate the antimicrobial activity in vivo, mice were challenged with 5. Typhimurium DT104 (3.7$\times$108 cfu/mouse) after pre-feeding 0. ficus-indica var. saboten solution. The fecal shedding of S. Typhimurium DT104 was more dramatically decreased and not detectable in feces and intestines 3 days after challenge in mice fed with 0. ficus-indica var. saboten. Antibody responses of the intestinal IgA were also significantly increased in mice fed with 0. ficus-indica var. saboten. These findings suggest that Opuntia ficus-indica var. saboten decreased the shedding of S. Typhimurium DT104 in vitro and also in the gastrointestinal tract in mice. In addition, administration of the product might enhance the mucosal immune response against S. Typhimurium DT 104. In conclusion, Opuntia ficus-indica var. saboten might be useful to control antibiotic resistant bacteria in vivo and in vitro.

대사체학의 연구 동향, 응용 및 국내 연구 활성화 방안

김소현,양승옥,김경헌,김영석,유광현,윤영란,이동호,이충환,황금숙,정면우,최기환,최형균,Kim, So-Hyun,Yang, Seung-Ok,Kim, Kyoung-Heon,Kim, Young-Suk,Liu, Kwang-Hyeon,Yoon, Young-Ran,Lee, Dong-Ho,Lee, Choong-Hwan,Hwang, Geum-Sook,Chung, Myeon 한국생물공학회 2009 KSBB Journal Vol.24 No.2

대사체학은 동 식물, 미생물뿐만 아니라 식품, 농업, 의약품에 이르기까지 다양한 분야에서 적용될 수 있으며, 최근 미래를 선도할 학문으로서 주목 받고 있는 분야이다. 하지만 우리나라의 대사체학 연구는 아직 기초적 단계이며, 대사체학에 대한 인식도 부족한 상황이다. 따라서 본 논문에서는 대사체 연구 방법에 대해서 간단히 소개하였고, 국내 외 대사체학 연구현황, 대사체 연구의 필요성과 활용방안, 대사체 연구 수행 활성화를 위한 전략들을 소개하였다. 대사체학은 활용 범위가 매우 넓은 것이 특징인데, 예를 들어 functional genomics, 생물의 계통 분류, 생물의 대사경로 규명, 생물을 이용한 유용물질 생산, 신약 및 신소재 개발, biomarker의 개발, 식품 및 천연물 제제의 품질관리, 그리고 환경 및 독성 모니터링 등에 활용될 수 있다. 그러나 국내 대사체학 연구는 초기단계에 머물러 있는 실정이므로 국내 대사체 연구의 발전을 위해서는 연구 주체간의 협력, 해외 선진 기술 습득, 연구 개발 투자, 대사체 분석 전문가 육성, metabolome database 구축 등이 필요하다. 대사체학 연구에 대한 이러한 지원이 이뤄진다면, 대사체학 분야에 있어서 국내수준과 세계수준의 격차는 줄어들 것이다. 또한 결과적으로 대사체학 연구의 발전은 한국 생명공학 분야 (BT)의 발전에도 크게 이바지할 것으로 사료된다. As one of the new areas of 'omics' technology, there is increasing interest in metabolomics, which involves the analysis of low-molecular-weight compounds in cells, tissues, and biofluids, and considers interactions within various organisms and reactions of external chemicals with those organisms. However, metabolomics research is still at a fundamental stage in Korea. Therefore, the purpose of this study was to establish a strategic long-term plan to revitalize the national metabolomics approach and obtain the elementary data necessary to determine a policy for effectively supporting metabolomics research. These investigations clarified the state of metabolomics study both in Korea and internationally, from which we attempted to find the potentiality and fields where a metabolomics approach would be applicable, such as in medical science. We also discuss strategies for developing metabolomics research. This study revealed that promoting metabolomics in Korea requires cooperation with metabolomics researchers, acquisition of advanced technology, capital investment in metabolomics approach, establishment of metabolome database, and education of metabolome analysis experts. This would reduce the gap between the national and international levels of metabolomics research, with the resulting developments in metabolomics having the potential to greatly contribute to promoting biotechnology in Korea.

표적 가림 예측에 의한 기억추적 알고리즘 개발 및 구현

김소현,장광일,권강훈,정진현,Kim, So-Hyun,Jang, Gwang-Il,Kwon, Kang-Hoon,Jung, Jin-Hyun 한국군사과학기술학회 2009 한국군사과학기술학회지 Vol.12 No.3

In this paper, the Autocoast algorithm is proposed for EOTS to overcome the target occlusion status. Coast mode, one of tracking modes, is to maintain the servo slew rate with the tracking rate right before the loss of track. The Autocoast algorithm makes decision of entering coast mode by the prediction of target occlusion and tries to refind target after the coast time. This algorithm composes of 3 steps, the first step is the prediction process of the occlusion by target-like background, the second one is the check process of the occlusion happened after background intensity variation, and the last one is the process of refinding target. The result of computer simulation, test under laboratory, and real test with EOTS shows the applicability for the automatic video tracking system.

백서 좌골신경의 압박손상에 대한 단기간 스테로이드 투여 시 복합근활동전위의 변화

김소현,박광원,백준석,정태영,김미리,박상준,Kim, So-Hyun,Park, Kwang-Won,Baek, Joon-Seok,Jung, Tae-Young,Kim, Mee-Lee,Park, Sang-Jun 대한악안면성형재건외과학회 2013 Maxillofacial Plastic Reconstructive Surgery Vol.35 No.1

Purpose: Many surgical procedures in oral and maxillofacial area can induce trauma to the peripheral nerve. The aim of the study is to evaluate the effects of short-term steroid therapy on nerve recovery after crush injury. Methods: Sixteen rats were randomly divided into two groups. The right sciatic nerves were exposed, crushed, and sutured. The control group was not given steroids. The test group was injected with dexamethasone disodium phosphate (2 mg/kg body weight/day) for 7 days. In all animals, compound muscle action potential (CMAP) was recorded before and at 1, 7, 14, 21, and 28 days after injury. Results: The amplitude of the CMAP before and at 1, 7, 14, 21, and 28 days after injury were $53.20{\pm}4.80$ mV, $20.12{\pm}5.38$ mV, $30.01{\pm}14.15$ mV, $31.14{\pm}13.56$ mV, $31.73{\pm}16.33$ mV, and $37.23{\pm}16.98$ mV in the control group, and $55.25{\pm}6.72$ mV, $18.62{\pm}6.26$ mV, $29.50{\pm}13.06$ mV, $32.90{\pm}13.226$ mV, $30.17{\pm}11.80$ mV, and $38.41{\pm}12.27$ mV in the test group, respectively. The nerve conduction velocity was $18.82{\pm}3.94$ m/s, $16.73{\pm}3.48$ m/s, $19.60{\pm}2.45$ m/s, $18.68{\pm}3.94$ m/s, $18.02{\pm}3.51$ m/s, and $19.25{\pm}3.88$ m/s in the control group, and $18.94{\pm}3.48$ m/s, $17.28{\pm}2.53$ m/s, $7.57{\pm}2.54$ m/s, $18.77{\pm}2.12$ m/s, $19.48{\pm}1.55$ m/s, and $19.22{\pm}2.97$ m/s in the test group, respectively. There was no significant difference between both groups (P>0.05). Conclusion: This study did not show any therapeutic effect of short-term administration of steroids on injured rat sciatic nerve. Further studies are needed.

부산백병원 응급실로 내원한 치과 응급환자에 대한 임상적 연구

김소현,김도영,백준석,정태영,박상준,Kim, So-Hyun,Kim, Do-Young,Baek, Joon-Seok,Jung, Tae-Young,Park, Sang-Jun 대한악안면성형재건외과학회 2012 Maxillofacial Plastic Reconstructive Surgery Vol.34 No.1

Purpose: Dental emergencies vary from toothaches to oral and maxillofacial traumas. Because the number of dental emergency cases has increased recently, we analyzed characteristics of patients seen during the last 2 years, in an effort to find a trend. Methods: This study was carried out with emergency room patients visiting the Department of Oral and Maxillofacial Surgery from 2009 to 2010. Results: The total number of patients studied was 1,162; the ratio of males to females was 1.73:1. The most frequent age group was 0 to 9 years, followed by 20 to 29 years. Trauma (58.7%) was the most frequent cause followed by acute toothache, oral hemorrhage, infection, and temporomandibular (TMJ) disorder. In the trauma group, injuries of soft tissue and alveolus were prevalent. The most common causes of soft tissue injury were falls, safety violations and assault. The highest incidence of emergencies was seen in patients 0 to 9 years old (41.8%). The most common causes of jaw fracture were falls, assaults, and traffic accidents in that order. In the acute toothache group, most patients had pulpitis (41.2%). In the infection group, most had buccal space abscesses (40.0%). In the hemorrhage group, post-operative bleeding cases (80.5%) were the majority, and hemostasis was obtained mostly by pressure dressings. For the TMJ disorder group, masticatory muscle disorder (65.4%) was more common than TMJ dislocation. Conclusion: In this study, trauma was the most frequent reason for patients who visited the emergency room. However, acute toothache, hemorrhage, infection and TMJ disorders were also seen frequently. Dental emergency patients could be better treated by understanding patterns of dental emergencies and performing proper diagnoses.

독자게시판

김소현,Kim, So-Hyeon 대한산업안전협회 2003 안전기술 Vol.68 No.-

HEVC CABAC 복호기의 문맥 모델러 설계

김소현,김두환,이성수,Kim, Sohyun,Kim, Doohwan,Lee, Seongsoo 한국전기전자학회 2017 전기전자학회논문지 Vol.21 No.3

HEVC (high efficiency video coding) exploits CABAC (context-based adaptive binary arithmetic coding) for entropy coding, where a context model estimates the probability for each syntax element. In this paper, a context modeler was designed and implemented for CABAC decoding. lookup table was used to reduce computation and to increase speed. 12 simulations for HEVC standard test sequences and encoder configurations were performed, and the context modeler was verified to perform correction operations. The designed context modeler was synthesized in 0.18um technology. Maximum frequency, maximum throughput, and gate count are 200 MHz, 200 Mbin/s, and 29,268 gates, respectively. HEVC(high efficiency video coding)의 엔트로피 코딩 방식인 CABAC(context-based adaptive binary arithmetic coding)에서는 각 구문 요소의 발생 확률을 추정하는 문맥 모델이 사용된다. 본 논문에서는 CABAC 복호화에 필요한 문맥 모델러를 설계하고 이를 구현하였다. 초기화에 필요한 연산 숫자를 줄이고 속도를 높이기 위해 참조 테이블을 사용하였으며, HEVC의 표준 테스트 영상 및 표준 부호기 구성에 대해 12가지의 시뮬레이션을 수행하여 모두 성공적으로 동작하는 것을 확인하였다. 설계된 문맥 모델러를 0.18um에서 합성하였을 때의 최대 동작 주파수, 최대 처리율 및 게이트 수는 각각 200 MHz, 200 Mbin/s, 29,268 게이트이다.

아는 사람들은 모브랜드와 비유사한 확장제품을 선호한다:소비자들의 지식수준이 브랜드 확장에 미치는 영향

김소현,황용철,Kim. SoHyun,Hwang. YongCheol 한국상품학회 2015 商品學硏究 Vol.33 No.2

본 연구는 소비자들의 사전지식의 정도에 따라서 선호하는 브랜드 확장 유형이 다른지 이론적 근거를 바탕으로 연구되었다. 실험 1에서는 실제 브랜드를 이용하여, 소비자들의 사전지식의 정도에 따라서 모브랜드와 유사하게 확장된 제품과 모브랜드와 비유사하게 확장된 제품 중 어떠한 제품을 더욱 긍정적으로 평가하고, 구매할 의향이 높은지 살펴보았다. 그 결과, 사전지식이 낮은 초보자는 유사하게 확장된 제품을 비유사하게 확장된 제품보다 상대적으로 호의적인 태도 및 구매의향을 보인 반면, 사전지식이 높은 전문가는 비유사하게 확장된 제품을 유사하게 확장된 제품보다 더욱 호의적인 태도 및 구매의향을 보였다. 실험 2에서는 가상브랜드를 이용하여, 실험 1의 결과 재현 및 이러한 현상이 나타나는 심리적 기제 (mechanism)가 무엇인지 살펴보았다. 이러한 결과는 브랜드 확장의 이론적 기여 및 기업의 신제품 개발 시 소비자의 유형 별 효율적인 브랜드 확장 방법을 제시해주고 있다. The current research investigated the effect of consumer' prior knowledge on brand extensions. In other words, it is difference that they prefer type of brand extension between novice and expert. In experiment 1, using real brand, when participants showed print advertisement about new product(brand extended product), novices evaluated favorable similar extended-product more than dissimilar extended-product, whereas experts evaluated favorable dissimilar extended-product more than similar extended- product. Also, novices purchased similar extended-product more than dissimilar extended-product, whereas experts purchased dissimilar extended-product more than similar extended-product. In experiment 2, using fictitious brand, replicated results of experiment 1 and investigated mechanism of this phenomenon. This is, experts have cognitive flexibility more than novices, so that experts prefer dissimilar extended product more than similar extended product. Applied to results of current research, marketers may be able to improve effectiveness of the marketing strategy such as brand extension in order for new product's development.

OTT 플랫폼 비즈니스 모델 개발을 통한 OTT 사업자 경쟁력 분석

김소현,임춘성,Kim, So-Hyun,Leem, Choon-Seong 한국디지털정책학회 2021 디지털융복합연구 Vol.19 No.10

본 연구는 OTT 산업에 특화된 분석틀을 개발하여 OTT 사업자들의 경쟁력 분석을 하는 데에 목적이 있다. 비즈니스 모델, 플랫폼 비즈니스 모델, OTT 특성에 관한 기존연구를 바탕으로 OTT 플랫폼 비즈니스 모델 프레임워크를 개발하였고 관련 자료, 문헌, 내부자료의 데이터를 토대로 사례 분석을 하여 국내 OTT 사업자들이 나아가야 할 방향을 제시하였다. 연구 결과, 국내 OTT 사업자들은 발전된 AI와 빅데이터 기술을 활용해 오리지널 콘텐츠를 제작하고 플랫폼의 인프라 및 서비스의 질을 향상해야 한다. 또한, 보유한 콘텐츠를 맞춤화된 추천 시스템을 통해 충분히 활용할 수 있어야 하고 이용자들이 선호할 해당 플랫폼만의 오리지널 콘텐츠에 아낌없는 투자가 지속되어야 한다. 본 연구는 급변하는 미디어 산업 속에서 OTT 사업자들이 자신만의 경쟁전략을 수립할 수 있는 분석틀을 제공하고 사례 적용을 통해 국내 OTT 사업자들이 나아가야 할 방향성을 제시했다는 점에서 의의가 있다. The purpose of this study is to analyze the competitiveness of OTT operators by developing an analysis framework specialized for the OTT industry. Based on existing research on business model, platform business model, and OTT characteristics, the OTT platform business model framework was developed, and case analysis was conducted based on data from related materials, literature, and internal data to suggest the direction for domestic OTT operators. As a result of the study, domestic OTT operators should use advanced AI and big data technologies to produce original content and improve the infrastructure and service quality of the platform. This study is meaningful in that it provides an analysis framework for OTT operators to establish their own competitive strategies and suggests the direction for domestic OTT operators through case application.

섭취 환경 조건이 나트륨 및 당 저감식품 기호도에 끼치는 영향

김소현,김의수,정서진,Kim, So Hyun,Kim, Eui-Su,Chung, Seo-Jin 한국식생활문화학회 2020 韓國食生活文化學會誌 Vol.35 No.4

This study investigated the possibility of reducing sodium and sugar intake in the Bulgogi bowl and yogurt, respectively, by utilizing food and non-food factors. Sodium and sugar replacers were the target food factors, and eating environment was the target non-food factor. The sodium content of Bulgogi bowls was reduced by 40%, and a flavor enhancer was applied to compensate for the reduced saltiness. Low calorie sweeteners, such as sucralose and stevia, were used to lower the sugar content of yogurt by 30%. Consumers were asked to evaluate the samples in one of the three eating environments: private booth evaluation, BOOTH; watching video clips during evaluation, VIDEO; conversation with friends during evaluation, FRIEND. The results showed that applying sodium or sugar replacers were effective in lowering sodium or sugar intake, respectively, without compromising the acceptance level of samples. Significant influences of the eating environment were observed on liking and perception of samples, but the influence patterns were not consistent between Bulgogi bowl and yogurt.