가토에서 허혈후 뇌부종에 대한 Mannitol 및 Betamethasone의 효과

김법영,이영우 대한신경외과학회 1989 Journal of Korean neurosurgical society Vol.18 No.3

The study is to evaluate the effect of mannitol and betamethasone on postischemic brain edema. Brain ischemia was produced by transient occlusion of the both common carotid arteries with the vascular clip for duration of 3 minutes and 5 minutes. Each group was recirculated for 30 minutes, 1, 2, 3 and 6 hours after removing the clips from the arteries. Of 40 rabbits, twenty rabbits were untreated as control and the other twenty rabbits were treated with a combination of mannitol(2gm/㎏) and betamethasone(1mg/㎏) intravenously at 20 minutes before the occlusion. The water content, amount of Na and K were measured and compared with each group between the 3 minute and 5 minute occlusion groups, and between the control group and treated group with mannitol and betamethasone. The experimental results were summerized as follows ; 1) The water content of the treated group was significantly decreased comparing with the control group in both 3 and 5 minute occlusion group. The water content of the 5 minute occlusion group was much increased than that of the 3 minute occlusion group in the control group. 2) The amount of Na and K were significantly increased in the treated group comparing with the control group. 3) The amount of Na, K in relation to water content of the treated group were higher than that of the control group. With the above results, it might be concluded that postischemic brain edema(water content) was more significant in the prolonged occlusion group, and administration of mannitol and betamethasone is effective for the prevention and treated of postischemic brain edema.

후두개와 기형종

김법영,최창화,장병조,이영우 대한신경외과학회 1989 Journal of Korean neurosurgical society Vol.18 No.5

A rare case of teratoma occuring in the posterior cranial fossa is reported. The tumor was partially encapsulated, and a surgical removal was accomplished. Teratoma is defined as a true tumor, composed of several types of tissues representing more than one germinal layer, which are foreign to the part in which it arises. The literature on teratomas located in the posterior cranial fossa is reviewed.

토끼 경동맥 평활근에서 Isoproterenol의 이완작용에 미치는 Phorbol Esters의 효과

김법영,이영우 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.7

토끼 경동맥에서 phorbol estersr가 isoporterenol에 의한 혈관 긴장도의 조절에 미치는 protein kinase C(PKC)의 작용을 밝히기 위하여 경동맥환에서 등척성 수축을 기록하여 phorbol esters인 phorbol 12,13-di-butyrate(PDBu)와 phorbol 12-myristate 13-acetate(PMA)의 효과를 관찰하였다. β-Adrenergic agonist인 isoproterenol은 phenylephrine에 의한 수축을 이완하였으나 phorbol esters에 의한 수축에는 영향을 미치지 아니하였다. Isoproterenol에 의한 혈관 이완작용은 내피세포의 제거나 methylene blue나 nitro-L-arginine의 전처치에 의하여 감소하였다. 수축을 야기하지 않는 농도는 phorbol esters의 전처치는 내피세포 의존성 및 비의존성으로 isoproterenol에 의해 야기된 혈관이완을 억제하였다. Isoproterenol에 의해 야기된 혈관 이완작용에 대한 PDBu의 억제작용은 수축반응에서 보인 양상과는 달리 PMA의 억제작용보다 낮은 효과를 보였으나 PDBu의 수축효과는 PMA보다 더 강하게 나타났다. PMA는 forskolin의 농도반응에 영향을 미치지 않았다. 그리고 protein kinase C inhibitor인 staurosporine은 isoprocerenol에 의해 야기된 이완과 수축반응에 대한 이들 약물의 작용을 억제하였다. 이상과 같은 결과는 isoproterenol에 의해 야기된 혈관 이완작용은 protein kinase C의 활성제인 phorbol esters에 의해 억제되며, 이는 수축반응에 각기 다른 isozyme이 관여하는 것으로 사료된다. The effects of phorbol esters were studied in rabbit carotid artery to evaluate the action of protein kinase C on the regulation of vascular tone by isoproterenol. The vascular rings. 2 mm in width, were myographied isometrically in an isolated organ bath and the effects of phorbol 12,13-dibutyrate(PDBu) and phorbol 12-myristate 13-acetate(PMA) were determined. Isoproterenol a beta adrenergic agonist, relaxed the vessel which was precontracted by phenylephrine, but not that by phorbol esters. The action of isoproterenol was attenuated by removal of endothelium or pretreatment with methylene blue or nitro-L-arginine. The pretreatment with phorbol esters at concentrations which did not induce contraction, decreased isoproterenol-induced relaxation of vascular rings with or without endothelium. The action of PDBu on isoproterenol-induced relaxation was less effective than that of PMA, unlike those observed in contractile response. but the contractile effect of the former was more potent than that of the latter. PMA did not affect relaxant effect of forskolin, an activator of adenyl cyclase. Staurosporine, a protein kinase C inhibitor, inhibited the action of these drugs on both isoproterenol-induced relaxation and the contractile response. These results suggest that the relaxation induced by isoproterenol was reduced by the activation of protein kinase C. which may be isozyme different from that involved in contractile response.

전이성 흑색종 1예

이문태,김법영,장병조,이영우 釜山醫師會 1988 釜山醫師會誌 Vol.24 No.9

腦卒中에 對한 韓方治療法 硏究(證治醫學과 四象醫學) 및 韓方, 洋方, 洋·韓方 協診治療 效果에 關한 硏究

李仁仙,李元外,金法暎,金瑩均,張慶田,權貞南,金鍾元,朴東一,李仁善,宋昌元 동의대학교 한의학연구소 1998 동의ㆍ경산 한의학 학술대회 Vol.2 No.-

뇌졸중(腦卒中)에 대(大)한 한방치료법(韓方治療法) 연구(硏究)(증치의학(證治醫學)과 사상의학(四象醫學)) 및 한방(韓方), 양방(洋方), 양(洋)·한방(韓方) 협진치료(協診治療) 효과(效果)에 관(關)한 연구(硏究)

김종원,김영균,김법영,이인선,이인선,장경전,권정남,이원외,송창원,박동일,Kim, Jong-won,Kim, Young-kyun,Kim, Beob-young,Lee, In-seon,Lee, In-seon,Jang, Kyung-jeon,Gwon, Jeong-Nam,Lee, Won-oe,Song, Chang-won,Park, Dong-il 사상체질의학회 1998 사상체질의학회지 Vol.10 No.2

The Purpose of Study 1. Inspection of clinical application on TCD to CVA 2. Objective Comparement and analysis about treatment effect of Western-Medicine, Korean Medicine, Cooperative consultation of Korean and Western medicice for CVA The Subject of Study We intended for the eighty six patient of CVA who had been treated in the Oriental Medical Hospital at Dong Eui Medical Center from 1997. 8. I to 1998. 7. 31 1. View of CT, MRI : the patient of Cb infarction 2. Attack Time : The patient who coming hospital falling ill within the early one week The method of study 1. Treat four group of Korean medicine, Constitution medicine, Western medicine, cooperative consultation of Korean medicine and Western medicine. 2. Application of TCD Check the result for three times, immediatly after the attack, two months later, four months later 3. Comparative analysis of each treatment effect by clinical symptoms and pathologic examination 4. The Judgement of the patient The Result From 8/1/1997 to 7/31/1998, We have the following result by clinical analysis intended for CVA 86 patients who had been treated in the Oriental Medical Hospital at Dong Eui Medical Center from 1997. 8. 1 to 1998. 7. 31 in 1. Analysis according to Age The first stage of thirties, forties, seventies is heavier than forties, fifties in improvement and Index of improvement of symptom 2. Analysis according to sex We have no special relation in an average of symptom and improvement, Index improvement 3. Analysis according to Family History We have the better result in first stage and improvement, index improvement when no family history. 4. Analysis according to Past History We have no special relation in past history like hypertension, DM, heart problem 5. Analysis devided two group, above group and under group on the basis of the average in first stage of all patient. We have the better result when the first stage is light, that the first score of barthel index and CNS is high. 6. Analysis of the effect of treatment about Korean medical treatment, Western medical treatment, cooperative treatment. In this study, the highest group of rate of treatment at four contrast groups (Korean medicine, Constitution medicine, Western medicine, cooperative treatment according to dyagnosis and range of treatment was the patient group of doing dyagnosis and method of treatment based on constitution medicine theory. This is that of doing demostation, A-Tx, po-herb-medication according to dyagnosis and treat method of constitution of Lee Je-ma In case of left, the case of dyagnosis any disease according to doctor view but, normal in TCDwas 22-beginning of attack, 20- two weeks later, 11 case-four weeks later in case of right, 15-beginning of attack, 12-two weeks later, 9 case four weeks later. So left vessel compares to right vessel is more interference, in fact more than a 1/2 of the patients of MCA disease can't do dyagnosis. In rate of imparement, the state of pacient improved but there isn't the improved case of result in TCD. 7. In TCD dyagnosis, between the case of inconsus the doctor view specially MCA in brain blood vessel is in large numbers and in total 86's patient, impossible case of dyagnosis according to interferiance of temporal is 21 case. 7. Result study about application of Kreaan medical treatment 1) The impossible patient of observation MCA blood vescular for interference temporal bone happened in large numbers. 2) There is the case having difference result to CT,MRI, MRA result. 3) Because individual difference is large, excluding to ananalogy of symptom. This is normal numerical value that has possibility of being checked as abnormal numerical value 4) there are a lot of cases that the speed of normal part is as similarly measured as that of abnormal part. It means that we cannot judge the disease by this measure 5) It is rare that this measure represent degree of improvement in patient's condition of disease. When we observe patient's condition become better, but w

뇌졸중의 최근 역학적 동향

김경태,안재두,김법영,정재익,이성훈,이상찬 대한재활의학회 2003 Annals of Rehabilitation Medicine Vol.27 No.2

무선데이터 전송장치를 이용한 원격진료시스템개발

고창성,김태운,송종관,김법영,최경후 한국경영과학회 2000 한국경영과학회 학술대회논문집 Vol.- No.1

노인인구의 증가로 이에 대한 건강문제와 성인병의 증대 및 바쁜 일상생활로 인하여 본인의 건강상태를 수시로 스스로 확인할 수 있는 방안으로 무선데이터를 이용한 원격진료 시스템에 대한 요구가 크게 일어나고 있다. 이를 위해서 양방향 데이터 전송이 가능한 기기 (예를 들어 무선호출기나 휴대폰을 개량한 기기)를 이용해 실시간으로 혈당치나 혈압 측정치 등 종합적인 건강정보를 전송하고 이를 자동진단프로그램으로 위험여부를 판별해 경고하는 동시에 자신의 주치의에게 통보되는 시스템을 구현하고자 한다. 본 논문에서는 혈당치와 혈압 측정치의 데이터에 대하여 자동진단프로그램을 이용하여 관리도를 자동 생성하고 이를 전문의사의 지식에 의한 진단프로그램과 연계하여 관리 한계선을 벗어나면 위험을 알리게 되고, 전문가시스템을 도입한 1대 1 대화형으로 자체진단을 하게 하는 인터넷 기반 진단프로그램을 개발하여 고객의 건강상태를 진단하게 한다. 본 연구는 기존의 이동통신기술을 혈압측정기와 결합시켜 의료기관과 연결 시키는 데이터 전송기술을 응용하고, 의사가 실제 환자 앞에서 행하는 진료 과정을 원격으로 실시하는 원격 진료 시스템의 프로토다입 개발을 목표로 하고 있다.

혈압데이터 무선 전송에 의한 심혈관 질환의 예측시스템 구축

김태운,고창성,송종관,김법영 한국지능정보시스템학회 2000 한국지능정보시스템학회 학술대회논문집 Vol.1 No.1