김용준 著 『단원 김홍도』 해제 : 고독한 천재의 눈에 비친 사실주의 화가 김홍도

김미정(Kim, Mi jeong) 근대서지학회 2020 근대서지 Vol.- No.22

이 글의 목적은 김용준(金瑢俊, 1904~1967)의 『단원 김홍도』를 해제하고 김용준의 김홍도 연구가 지닌 미술사적 의의를 찾고자 함이다. 2018년 학계에 처음으로 소개된 『단원 김홍도』는 1955년에 북한에서 출판된 단행본이다. 이 책은 조선회화사 연구서를 통틀어 고전 화가를 개별 작가론으로 서술한 가장 이른 사례의 단행본으로 확인된다. 전체 분량은 51쪽으로, 앞표지는 김홍도의 인장과 신선도(神仙圖)로 꾸며졌다. 15점의 작품 이미지와 함께 수록된 작품해설에는 김용준의 빼어난 문장력과 더불어, 그림에 대한 자신의 감성을 충실하게 묘사하는 수필체 미술사 서술의 진면목이 드러난다. 1955년은 북한 미술사학계에서 비정(比定)한 김홍도의 생년에 따라 김홍도 탄생 195주년이 되는 해였다. 이 무렵 미술사 관련 출판물의 수가 늘어났고 각지에서 수집·발굴된 고서화와 문화유산을 소개하는 전람회도 개최되었다. 북한 미술계는 1955년을 전후해 민족 미술에 관한 인식의 변화와 함께 조선화에 적용할 내용과 형식의 변화를 모색했다. 이에 따라 『단원 김홍도』는 민족문화에 대한 관심이 촉발된 시기에 맞춰, 위인의 업적을 기려 대내외에 홍보하려는 목적에서 출판되었던 것이다. 월북 이후 김용준은 김홍도를 단일주제로 여러 편의 글을 저술했다. 일련의 글에서 그는 김홍도를 애국주의 화가이자, 18세기 사실주의 미술 발전의 핵심적 역할을 담당했던 화가로 평가했다. 또 김홍도의 신선도와 인물, 풍속 그림들의 필법에 주목했다. 김홍도의 인물화에서 인물형상의 조형적 특징을 찾으려고 했던 김용준은 전통 회화기법을 조선화 창작에 직접 적용했다. 그는 유려한 선조(線條)와 담백한 색채로 조선화를 창작해 여러 전람회에 출품하면서 조선화가 전근대적 산물이라고 보았던 1950년대 중·후반 북한 미술계의 인식을 개선하고자 몸소 실천했다. 조선회화에서의 독창성과 사실성 탐구에 집중했던 김용준의 미술사 연구는 1950년대 후반 북한미술이 조선화를 바탕으로 민족 형식의 전형을 확립해나가는데 밑거름이 되었다. The purpose of this article is to briefly describe ‘Danwon Kim Hong-do’ written by Kim Yong-jun (金瑢俊 1904~1967) and to understand the art historical implications of Kim Yong-jun’s studies on Kim Hong-do. ‘Danwon Kim Hong-do’ first introduced to academia in 2018 is a book of Korean art history published in North Korea in 1955 and is confirmed to be the earliest book that describes one of the most renowned classical painters based on an individual writer’s theory among all research papers as to the painting history during the Joseon Dynasty period. The year 1955 marks the 195th anniversary of Kim’s birth based on his birth year presumed by the North Korean art history academia. In this light, the publication of ‘Danwon Kim Hong-do’ apparently aimed to commemorate the great achievements of one of the most noteworthy painters in Korean art history at home and abroad at a time of soaring interest in national culture. Following his defection to North Korea, Kim Yong-joon wrote a number of articles dedicated to Kim Hong-do. In a series of his writings, he appraised Kim Hong-do as a patriotic painter who played a key role in developing the realism in the 18th century. He also noted Kim Hong-do’s brush stroke in his famous paintings, including Immortals, portraits, and customs paintings. Kim Yong-jun, who sought to identify the figurative characteristics of the figures in Kim Hong-do’s portraits, applied the traditional painting technique directly to creating the Joseon paintings. He made sincere effort to improve the awareness of the North Korean art academy in the mid- and late 1950s who found the Joseon paintings outdated as he created some Joseon paintings with elegant brush and plain colors and presented them to several exhibitions. Kim Yong-jun’s art history studies, which focused on seeking the originality and realism in Joseon paintings, served as a foundation for the North Korean art world to establish an exemplary model of national formality in the late 1950s based on the Joseon paintings.

소파 방정환에 의해 재창조된 번안동화의 작품세계 -『사랑의 선물』을 중심으로-

김미정 ( Mi Jeong Kim ),임재택 ( Jea Tack Lim ) 한국어린이문학교육학회 2010 어린이문학교육연구 Vol.11 No.2

본 연구의 목적은 방정환이 ‘소년운동’ 차원에서 기획한 번안동화집인 『사랑의 선물』중 임의로 선정한 총 4편을 원작과 비교하여, 원작이 ‘어떻게’, ‘얼마나’, ‘왜’ 다르게 번역되었는지 원작에 대한 번역 일치성 및 개작의 중재 전략을 알아보는 데 있다. 연구 결과 방정환은 번역자로서 내용의 의도적인 첨가, 삭제, 수정의 방법으로 원작을 개작하는 과정을 수행하였다. 또한 이러한 개작은 화합, 자국화, 윤색의 중재 전략이 사용되었는데, 방정환은 이러한 중재전략을 통하여 첫째, 순수한 동심의 세계 존중, 둘째, 외래문화에 대한 주체적 수용, 셋째, 문학적 감성과 상상력을 통한 애국 교육 등의 세계관을 뚜렷이 드러내었다. 이에 본 연구를 통하여 방정환은 『사랑의 선물』번안을 통하여 외국 동화가 문학텍스트로서 가지는 문학적·심리적 가치를 그대로 어린이에게 전달하는 동시에 유교 전통을 극복하고 우리나라 현실에 맞게 아동존중사상을 농축하여 표현한 문화변용의 주체였다는 사실을 알 수 있었다. Bang Jeong-Hwan tried to transfer foreign fairy tales in itself which was worth of literary and psychological value as a literary text to children and simultaneously express realistically condensed ideological contents of DongHak through the adaption of Sa-rang-ui-Suon-mul(A Gift of Love). This study chose four sub-titles of the Sa-rang-ui-Suon-mul to investigate how, how much different, why these translations(adaptions) were different from original on the base of the level of fidelity to original and the intervention strategy. As the results of this study, Bang Jeong-Hwan as a translator performed the process of these translations as a significant difference from original by introducing the method of intensely insertion, elimination, modification. Furthermore, Bang Jeong-Hwan could attain the following three purposes and express a distinguishing his outlook on the world through these adaptations: 1) the respect for the world of pure child mind 2) the creative and independent acceptance of foreign cultures 3) the patriotic education through a literary sensitivity and imagination. As results of this study, we surely knew that Bang Jeong-Hwan was a main agent of acculturation by means of maintaining the literary value of original and realizing an idea of children respect.

유방 부분 절제술 후 방사선 치료 시 TOMO Direct를 이용한 접선 조사의 선량적 유용성에 관한 고찰

김미정,김주호,김훈겸,조강철,전병철,조정희,Kim, Mi-Jung,Kim, Joo-Ho,Kim, Hun-Kyum,Cho, Kang-Chul,Chun, Byeong-Chul,Cho, Jeong-Hee 대한방사선치료학회 2011 대한방사선치료학회지 Vol.23 No.1

Purpose: Investigation of the clinical use of tangential fields technique using TOMO direct in comparison to conventional LINAC based radiation therapy after breast partial mastectomy. Materials and Methods: Treatment plans were created for 3 left-sided breast cancer patients who had radiation therapy after breast partial mastectomy by using wedged tangential fields technique, field in field technique (FIF), TOMO Direct, TOMO Direct intensity modulated radiation therapy (IMRT) under the normalized prescription condition ($D_{90%}$: 50.4 Gy/28 fx within CTV). Dose volume histogram (DVH) and isodose curve were used to evaluate the dose to the clinical target volume (CTV), organ at risk (OAR). We compared and analyzed dosimetric parameters of CTV and OAR. Dosimetric parameters of CTV are $D_{99}$, $D_{95}$, Dose homogeneity index (DHI: $D_{10}/D_{90}$) and $V_{105}$, $V_{110}$. And dosimetric parameters of OAR are $V_{10}$, $V_{20}$, $V_{30}$, $V_{40}$ of the heart and $V_{10}$, $V_{20}$, $V_{30}$ of left lung. Results: Dosimetric results of CTV, the average value of $D_{99}$, $D_{95}$ were $47.7{\pm}1.1Gy$, $49.4{\pm}0.1Gy$ from wedged tangential fields technique (W) and FIF (F) were $47.1{\pm}0.6Gy$, $49.2{\pm}0.4Gy$. And it was $49.2{\pm}0.4$ vs. $48.6{\pm}0.8Gy$, $49.9{\pm}0.4$ vs. $49.5{\pm}0.3Gy$ Gy for the TOMO Direct (D) and TOMO Direct IMRT (I). The average value of dose homogeneity index was W: $1.1{\pm}0.02$, F: $1.07{\pm}0.02$, D: $1.03{\pm}0.001$, I: $1.05{\pm}0.02$. When we compared the average value of $V_{105}$, $V_{110}$ using each technique, it was the highest as $34.6{\pm}9.3%$, $7.5{\pm}7.9%$ for wedged tangential fields technique and the value dropped for FIF as $16.5{\pm}14.8%$, $2.1{\pm}3.5%$, TOMO direct IMRT as $7.5{\pm}8.3%$, $0.1{\pm}0.1%$ and the TOMO direct showed the lowest values for both as 0%. Dosimetric results of OAR was no significant difference among each technique. Conclusion: TOMO direct provides improved target dose homogeneity over wedged tangential field technique. It is no increase the amount of normal tissue volumes receiving low doses, as oppose to IMRT or Helical TOMO IMRT. Also, it simply performs treatment plan procedure than FIF. TOMO Direct is a clinical useful technique for breast cancer patients after partial mastectomy.

CUDA를 이용한 초해상도 기법의 영상처리 속도개선 방법

김미정,Kim, Mi-Jeong 한국군사과학기술학회 2011 한국군사과학기술학회지 Vol.14 No.4

Although multi-frame super resolution algorithm has many merits but it demands too much calculation time. Researches have shown that image processing time can be reduced using a CUDA(Compute unified device architecture) which is one of GPGPU(General purpose computing on graphics processing unit) models. In this paper, we show that the processing time of multi-frame super resolution algorithm can be reduced by employing the CUDA. It was applied not to the whole parts but to the largest time consuming parts of the program. The simulation result shows that using a CUDA can reduce an operation time dramatically. Therefore it can be possible that multi-frame super resolution algorithm is implemented in real time by using libraries of image processing algorithms which are made by a CUDA.

The Effect of the IGF-I treated Gingival and Periodontal Ligament Fibroblast on Osteoblasts

김미정,양원식,Kim, Mi-Jeong,Yang, Won-Sik The Korean Association Of Orthodontists 2001 대한치과교정학회지 Vol.31 No.6

이 연구의 목적은 IGF-I의 골모세포에 대한 직접적 작용효과와 IGF-I이 섬유모세포에 작용된 후 섬유모세포에서 유리된 인자를 포함한 조절 배양액이 골모세포에 어떤 영향을 미치는지에 대해 각각 치주인대 섬유모세포와 치은 섬유모세포를 이용하여 알아본 후, 치조골의 반응을 외적자극과의 사이에서 매개하는 치주인대의 주세포군인 섬유모세포를 통한 IGF-I의 골모세포에 대한 영향을 알아보는 것이다. 이를 위해 치주인대 섬유모세포와 치은 섬유모세포를 6-8주된 백서(Sprague-Dawley rat)에서 채집하고, 골모세포는 태생 21일된 동종백서에서 채집하여 기본배양을 한 후, 각 군을 6군으로 분리하여 $1{\times}10^4$/we11, (1ml/well)세포수로 분주한 골모세포 배양접시에 IGF-I을 1,10,100ng/m1로 각각 농도를 달리하여 그 효과를 알아보았다. 각각의 군은 대조군, IGF-I을 직접 투여한 골모세포 배양군, 치주인대 섬유모세포의 조절배양액을 이용한 골모세포 배양군, IGF-I으로 처리한 치주인대 섬유모세포의 조절배양액을 이용한 골모세포 배양군, 치은 섬유모세포의 조절배양액을 이용한 골모세포 배양군, IGF-I으로 처 리한 치은 섬유모세포의 조절배양액을 이용한 골모세포 배양군이다. 조절배양액은 배양 36시간후(IGF-I 처리후 12시 간 배양 포함) 채집하였고, 마지막으로 IGF-I 및 조절배양액으로 처리한 후에 추가 24시간 배양한 후, Alkaline phoaphatase 활성도, Western blot 을 이용한 BMP발현, MTT를 이용한 세포증식, BCA kit을 이용한 총단백질량 측정, Western blot을 이용한 교원질 합성 계측 및 골결절의 생성을 관찰하였다. 본 연구의 결과는 다음과 같다. 1 Alkaline phosphatase활성은 10, 100ng/m1의 IGF-I으로 처리한 군과 치주인대 섬유모세포의 조절배양액을 이용한 군, IGF-I으로 처리한 치주인대 섬유모세포의 조절배양액을 이용한 군에서 대조군보다 더 높게 나타났다. 10, 100ng/ml의 IGF-I으로 처리한 치주인대 섬유모세포의 조절배양액을 이용한 실험군에서 유의성 있게 높게 나타났다. 2. 100ng/m1농도의 IGF-I으로 직접 처리한 군에서 골모세포증식이 유의성 있게 증가하였다. 3. 총단백질량은 IGF-I투여와 상관없이 대조군, 실험군 모두 유사하였다. 4. 모든 실험군에서 BMP2,4가 발현되었고, 대조군과 유의한 차이는 없었다. 이상의 결과에서 IGF-I의 투여여부와는 상관없이 치주인대 섬유모세포가 유리하는 물질이 골모세포의 활성을 증가시키는 것으로 나타났으며, IGF-I은 고농도일때만 유의성있게 골모세포 활성을 촉진함을 알 수 있었다. 따라서 이 연구를 통하여 치주인대 섬유모세포가 골모세포활성을 촉진 시키는 작용을 가지고 있음이 확인되었다. Insulin-like growth factor I (IGF-I) has the local tissue regulating actions. In bone, IGF-I increases the replication of osteoblastic lineage, probably preosteoblasts, and enhances osteoblastic collagen synthesis and matrix composition rates. The purpose of this study was to investigate the local regulatory effect of IGF-I on periodontium totally, both in an autocrine and paracrine manner. To examine the effect of IGF-I directly on osteoblast (OB) of test rats, and indirectlv on OB via periodontal ligament fibroblast (PDLF), and the effect of gingival fibroblast (GF) on OB via cellular paracrine manner for the understanding of humoral action of adjacent tissue, GF and PDLF were obtained from male Sprague-Dawley rats of six to eight weeks of age. OB was obtained iron frontal and parietal calvarial bone of Sprague-Dawley 21day-old-fetus. After each tell was Incubated 24 hours, for collecting conditioned medium, different concentrations of IGF-I (1,10,100 ng/ml,1ml/well) was adding in the GF, PDLF cells, and the supernatant from these cultures was put into the primary OB culture with $1{\times}10^4$cell/ml/well. The experimental group was divided into six groups control OB, IGF-I treated OB, OB culture with conditioned medium from PDLF, OB culture with conditioned medium from IGF-I treated PDLF, OB culture with conditioned medium from GF, OB culture with conditioned medium from IGF-I treated GF. After final IGF-I treatment, OB was Incubated for 24 hours, and alkaline phosphatase activity assay, BMP expression, cell proliferation measurement using MTT assay, total protein measurement, Collagen synthesis assay using western blot, and examination of bone nodule synthesis were done. Alkaline phosphatase expressions were increased in the group of PDLF-IGF-I supernatant treatment. Direct IGF-I treatment with concentrations of 100ng/m1 showed increased viable tell number measured by MTT assay. And IGF-I treatment did not increase total protein amount. The entire experimental group showed BMP2, 4 expression in western blot, and there was no significant difference between control and experimental groups. These results suggested that supernatant from PDLF effects on increasing cellular activities of OB regardless of IGF-I, and at high concentration, IGF-I increases OB tell proliferation.

병원직원들의 죽음 및 호스피스 인식에 관한 연구

김미정,Kim, Mi-Jeong 한국호스피스협회 2007 호스피스 학술지 Vol.7 No.2

The purpose of this study was to survey the hospital staff's perception of hospice and death and thereby, suggest the ways to help them have a mature attitude towards and a better understanding of death through an effective education on hospice. For this purpose, this study was designed to provide some data useful for the hospital staff not experienced in facing the dying patients to handle the desperate situation skillfully and engage themselves more effectively in their hospice services. For this study, the researcher conducted a questionnaire survey for the staff of 'C' hospital in Seoul about their hospice philosophy, attitudes towards hospice and perception of death for the period from February, 2006 to March, 2006. A total of 751 subjects responded effectively to the survey. The data collected were analyzed using the SF55 11.0 for ANOVA and T-test in order to test the relationships among subjects' perception of death, their demographic variables, their health condition, their hospice philosophy formed from their experiences of patients' death and hospice services and their attitudes towards hospice. Besides, the correlations among their hospice philosophy, perception of death and attitudes towards hospice were tested. The results of this study can be summarized as follows; First, as a result of testing the relationships among subjects' experiences of health consulting. their experiences of patients' death and hospice and their hospice philosophy, it was confirmed that their experiences of health and death consulting and their experiences of having been educated were relevant. Second, it was found that such variables as health condition, death, experience of hospice and attitude towards hospice were not significantly correlated with each other. Third, as a consequence of testing the relationships among health condition, death, experience of hospice and perception of death, it was disclosed that only the physical health condition was significant. Fourth, it was confirmed that subjects' hospice philosophy, perception of death and attitudes towards hospice were at the usual level on average. Fifth, hospice philosophy, perception of death and attitudes towards hospice were found correlated significantly with each other. Sixth, as a result of the stepwise variable adjustment for such variables as hospice philosophy, perception of death, attitudes towards hospice, it was found that the adjusted r-square value was 0.347 when departments, experience of having been requested by dying patient for consulting, experience of having been educated on hospice, religion and marital status were set as independent variables. And the estimated value of each variable was found significant. Seventh, as a consequence of conducting the multiple regression analysis by setting 'religion' as significant independent variable, it was found that the estimated value of physical health condition was not significant statistically. This, as a result of the simple regression analysis for 'religion' only, its explanatory power was found .197, while its adjusted r-square value was 0.20. Eight, it was found that subjects' attitude towards hospice was significantly correlated with such variables of experience of patient's or relative's death, experience of having been requested for consulting about death, gender, marital status and departments. As a result of the multiple regression analysis and the subsequent stepwise adjustment for this variable, it was found that only 'experience of having been requested for consulting' had some explanatory power: its adjusted r-square value was 0.089. As discussed above, this study tested the correlations among various variables including hospital staff's attitude towards hospice and perception of death and thereby, provided for the data useful for their education on hospice. This study may be significant in that it proved that it would be essential to educate hospital staff on hospice for more effective care of hospice pa

Prediction of Changes in Habitat Distribution of the Alfalfa Weevil (Hypera postica) Using RCP Climate Change Scenarios

김미정,이희조,반영규,이수동,김동언,Kim, Mi-Jeong,Lee, Heejo,Ban, Yeong-Gyu,Lee, Soo-Dong,Kim, Dong Eon Korean Society of Applied Entomology 2018 한국응용곤충학회지 Vol.57 No.3

Climate change can affect variables related to the life cycle of insects, including growth, development, survival, reproduction and distribution. As it encourages alien insects to rapidly spread and settle, climate change is regarded as one of the direct causes of decreased biodiversity because it disturbed ecosystems and reduces the population of native species. Hypera postica caused a great deal of damage in the southern provinces of Korea after it was first identified on Jeju lsland in the 1990s. In recent years, the number of individuals moving to estivation sites has concerned scientists due to the crop damage and national proliferation. In this study, we examine how climate change could affect inhabitation of H. postica. The MaxEnt model was applied to estimate potential distributions of H. postica using future climate change scenarios, namely, representative concentration pathway (RCP) 4.5 and RCP 8.5. As variables of the model, this study used six bio-climates (bio3, bio6, bio10, bio12, bio14, and bio16) in consideration of the ecological characteristics of 66 areas where inhabitation of H. postica was confirmed from 2015 to 2017, and in consideration of the interrelation between prediction variables. The fitness of the model was measured at a considered potentially useful level of 0.765 on average, and the warmest quarter has a high contribution rate of 60-70%. Prediction models (RCP 4.5 and RCP 8.5) results for the year 2050 and 2070 indicated that H. postica habitats are projected to expand across the Korean peninsula due to increasing temperatures. 기후변화는 곤충의 성장, 발육, 생존, 생식력, 분포범위 등 생활사의 변수들에 영향을 준다. 특히 외래곤충의 경우 생태계 정착 및 확산이 빨라지고 있으며, 생태계 교란, 토착종 감소 등 생물다양성을 감소시키는 직접적인 원인 중 하나이다. 알팔파바구미는 1990년대 제주도에서 처음 발견 후 남부지방에 대량 발생하여 농업해충으로 인식되었다. 최근 하면처로 이동하는 개체에 의한 밭작물의 피해와 여러 시군에서 서식이 확인되며 확산의 우려되고 있다. 본 연구에서는 기후변화가 알팔파바구미에 미치는 영향에 대해 파악하였다. 미래의 기후 시나리오 RCP 4.5와 RCP 8.5에서 알팔파바구미의 잠재적 분포를 추정하기 위해 MaxEnt 모델을 적용하였다. 모형의 변수는 2015~2017년까지 알팔파바구미의 서식이 확인된 66개 지점과 종의 생태특성 및 예측변수간 상관성을 고려한 6개(bio3, bio6, bio10, bio12, bio14, bio16)의 생물기후를 사용하였다. 예측된 모형의 적합도는 평균 0.765로 잠재력이 의미 있는 값이며, 최고 따뜻한 분기의 평균기온(bio10)이 60~70%로 높은 기여도를 나타냈다. 2050년과 2070년의 시나리오(RCP 4.5, RCP 8.5)에 대한 모형의 결과는 한반도 전역에서 알팔파바구미의 분포 변화를 보여 주었으며, 기온상승에 따른 전국적 확산이 예측되었다.

AHP를 이용한 사서교사의 북큐레이션 서비스 제공에 대한 우선순위 분석

김미정,이병기,임정훈,Kim, Mi-Jung,Lee, Byeong-Kee,Lim, Jeong-Hoon 한국도서관정보학회 2020 한국도서관정보학회지 Vol.51 No.3

This study aims to identify priorities in book curation service that the teacher librarians perceive important through the AHP (Analytic Hierarchy Progress) method by comparing the jobs of teacher librarians with those of curators and selecting the contents and areas of book curation service provided by school libraries. For the purpose, this study categorized the book curation service areas by class and analyzed the priorities in the book curation service areas in the school libraries by applying the AHP method on the teacher librarians who are the personnel in school libraries. As a result, the priorities in the upper-tier class were turned out to be information services, improvement of expertise, information resources, management, and promotion & marketing in that order. The priorities in the lower-tier evaluation areas were shown in the order of survey & research, Q&A, self-development, exhibition, budget allocation, connecting with experts, trend analysis, reading education, human resources, planning, collaboration class, marketing services, book status, online promotion, offline promotion, and facilities & environment. Based on the results, this study suggested the following plans to provide effective book curation services in school libraries: grasping characteristics of school library users, setting classification criteria for book curation, and finding reader participation-oriented book curation service. 본 연구는 큐레이터와 사서교사의 직무를 상호 비교·분석하여 학교도서관에서 제공하는 북큐레이션 서비스의 내용과 영역을 설정한 후, AHP(Analytic Hierarchy Progress) 방법을 통해 사서교사가 중요하게 인식하는 북큐레이션 서비스의 우선순위를 밝히는 데 목적이 있다. 이를 위해 북큐레이션 서비스 영역을 계층별로 나누고, 학교도서관 전담인력인 사서교사들을 대상으로 AHP 방법을 적용하여 학교도서관 북큐레이션 서비스 영역의 우선순위를 분석하였다. 분석결과 상위계층의 우선순위는 정보서비스, 전문성 신장, 정보 자원, 경영, 홍보 및 마케팅 순으로 나타났고, 하위계층의 우선순위는 조사 및 연구, 질의응답, 자기계발, 전시, 예산편성, 전문가 연계, 트렌드 분석, 독서교육, 인적자원, 기획, 협력수업, 마케팅 서비스, 소장, 온라인 홍보, 오프라인 홍보, 시설 및 환경 순으로 나타났다. 이를 토대로 학교도서관 북큐레이션 서비스를 효과적으로 제공하기 위한 방안으로 학교도서관 이용자의 특성 파악, 북큐레이션을 위한 분류기준의 설정, 독자 참여형 북큐레이션 서비스 모색의 필요성을 제시하였다.

치주인대세포와 치은섬유아세포의 단백질과 교원질 합성능에 대한 Transforming Growth $Factor-{\beta}$의 효과

김미정,이재목,서조영,Kim, Mi-Jeong,Lee, Jae-Mok,Suh, Jo-Young 대한치주과학회 1996 Journal of Periodontal & Implant Science Vol.26 No.2

Transforming growth factor $-{\beta}$ is one of the polypeptide growth factors that mediate the activity of mesenchymal cells and regulate wound healing process via cell proliferation, migration and extracellular matrix formation. The purposes of this study is to evaluate the effects of transforming growth factor $-{\beta}$ on the protein synthetic activity of human periodontal ligament cells and human gingival fibroblasts. The cells which were prepared were primary cultured gingival fibroblasts and periodontal ligament cells from humans, and the fourth or sixth subpassage were used in the experiments. Cells were seeded and at a confluent state, 0, 0.5, I, 2.5, 5, 10 ng/ml $TGF-{\beta}$ and $2{\mu]Ci/ml\;[^3H]$ proline were added to the cells and cultured for 24 hours. Then, 1 and 5 ng/ml concentrations were selected and added to confluent cells and cultured for 24 and 48 hours. They were labeled with $2{\mu}Ci/ml\;[^3H]$ proline for 24 hours and a collagen assay was done by the Peterkofsky and Diegelman method. The results were presented as the mean disintegration per minute (dpm) per well and S.D. of four determinations, The results were as follows. : The total protein, collagen and noncollagenous protein synthesis in periodontal ligament cells and gingival fibroblasts were increased dose- dependently by transforming growth factor-p to 2.5-5 ng/ml concentration and decreased at 10 ng/ml concentration. The percent of collagen was slightly changed according to the concentration of transforming growth factor-po The effect of transforming growth $factor-{\beta}$ was not specific for collagen synthesis since it increased the total, noncollagenous and collagenous protein, simultaneously. In the comparison of protein synthetic activity between the human periodontal ligament cells and human gingival fibroblasts, the human gingival fibroblasts had higher activities than the human periodontal ligament cells at all times and concentrations of $TGF-{\beta}$. In the comparison of protein synthetic activity between the 24 hour effect and the 48 hour effect of $TGF-{\beta}$, the 48 hour cultured cells' synthetic activity decreased more than the 24 hour cultured cells at human periodontal ligament cells and human gingival fibroblasts. In conclusion, $TGF-{\beta}$ has important roles in the stimulation of protein synthesis in human periodontal ligament cells and human gingival fibroblasts. Thus, it may be useful for clinical application in periodontal regenerative procedures.

BCG 접종에 의한 화농성 림프절염의 Rifampicin 국소 주입 요법

김미정,장성희,안영민,강미경,김상재,Kim, Mee Jeong,Jang, Seong Hee,Ahn, Young Min,Kang, Mi Kyoung,Kim, Sang Jae 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.4

목 적 : BCG접종 후에 소속 림프절에 발생하는 화농성 림프절염은 비교적 심각한 부작용 중 가장 흔하다. 대부분 치료를 하지 않더라도 결국은 퇴행되지만, 보통 몇 주 또는 몇 개월 동안 배농이 지속되어 매우 불편하고, 상당한 예에서 궤양으로 남게된다. Pan American Health Organization은 isoniazid 또는 rifampicin 국소 주입을 권장하였다. 이에 저자들은 BCG접종 후에 발생한 화농성 림프절염을 rifampicin 국소 주입으로 치료한 경험을 보고하고자 한다. 방 법 : 최근 3년간 대한결핵협회 결핵연구원 및 본원에서 BCG에 의한 림프절염으로 진단된 영아를 대상으로 하였다. BCG 림프절염은 동측의 액와부 또는 쇄골상부에 생긴 림프절염으로, BCG 접종 외에는 림프절염의 다른 원인이 없을 때 진단하였다. 화농하지 않고 림프절이 커져 있는 경우에는 자연 소실될 가능성이 있으므로 경과를 관찰하다가, 화농하면 자연적으로 파열되기 전에 주사기로 림프절을 흡인하고 rifampicin을 국소 주입하였다. 결 과 : BCG에 의한 림프절염 환아 37명을 경험하였다. 1) 림프절염의 양상 : 림프절염은 BCG를 접종한 후 대부분 4개월 이내에 발생하였다. 발생부위는 대부분 좌측 액와부였고, 쇄골상부에 생긴 예도 있었다. 크기는 대부분 2-3 cm였고, 5 cm 이상인 경우도 있었다. 2) 림프절염의 치료 : 37명 중 3명은 림프절염이 화농하지 않고 자연적으로 소실되거나 크기가 감소하였다. 화농하면 rifampicin을 주입하려고 경과를 관찰하다가 9명은 시술 전에 자연적으로 터져서 배농되어 드레싱만으로 치유되었다. 25명은 림프절염이 화농되어 주사기로 흡인한 후에 rifampicin을 국소로 주입하였다. 18명은 한번 시술해서 치유가 되었다. 7명에서는 한번 시술한 후에 다시 유동성이 생겨서 한번 더 시술하였다. 이중 1명은 두번 시술하였으나 크기가 더이상 감소하지 않아서 외과적 절제술을 고려하고 있다. Rifampicin 국소 주입 후 많은 경우에서 몇 일 이내에 배농이 없어지고, 그 이후 크기가 감소하였다. 림프절이 크면 일부에서 배농이 1-2개월 지속되었다. 결 론 : BCG에 의한 림프절염 중 일부는 자연적으로 소실된다. 화농성 림프절염으로 이행되면 침흡인 후에 rifampicin을 국소 주입하는 방법이 효과적이다. 즉 자연적 배농을 방지하고 비교적 빠른 시간 내에 림프절염이 치유된다. Purpose : Bacillus Calmette-$Gu\acute{e}rin$(BCG) lymphadenitis is one of the most common complications of BCG vaccination. The involved lymph nodes usually subside spontaneously, but they may become enlarged and form an abscess. Treatment of these infants is controversial. The Pan American Health Organization recommends local isoniazid or rifampicin instillation for patients with suppurative BCG lymphadenitis. Methods : The study group comprised 37 patients who presented with BCG lymphadenitis over the last three years. BCG lymphadenitis was diagnosed if the affected patient developed an ipsilateral axillary or supraclavicular lymphadenitis, with no other identifiable cause for the lymphadenitis. We used rifampicin instillation therapy for patients with suppurative BCG lymphadenitis. Results : Lymphadenitis regressed spontaneously in three patients. Thirty four patients showed a progression to abscess formation. Among 34 patients with suppurative lymphadenitis, drainage developed spontaneously during the follow-up period in nine patients before therapy. Twenty five patients received needle aspiration and local rifampicin instillation therapy. Reaspiration was performed in seven patients. One of these patients still has large lymph nodes after the second attempt. Conclusion : Needle aspiration and local rifampicin instillation therapy into the node is a safe and effective form of treatment for suppurative BCG lymphadenitis.