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Glucocorticoid Regulation of Gene Expression in Hippocampal CA3 and Dentate Gyrus
김동섭,안순철,김영진,박병권,안용태,김지연,허송욱,Kim, Dong-Sub,Ahn, Soon-Cheol,Kim, Young-Jin,Park, Byoung-Keun,Ahn, Yong-Tae,Kim, Ji-Youn,Kyoji, Morita,Her, Song Korean Society of Life Science 2007 생명과학회지 Vol.17 No.3
글루코코르티코이드는 해마 조직에서 대사, 스냅신 형성, apoptosis, 신경세포 생성과 세포에 있어서 수지상의 형태에 영향을 준다. 글루코코르티코이드 호르몬에 의한 해마조직의 생리학적 조절을 이해하기 위하여, CA3와 DG (dentate gyrus)에서 유전자 발현에 대하여 조사하였다. Lewis 쥐에 9.5mg의 코르티코스테론 알약 또는 플라시보 알약을 20일 동안 처리한 후에 올리고머 유전자 칩을 이용하여 유전자 발현을 조사 하였다 (Rat Neurobiology U34 Arrays, Affymetrix). 플라시보 알약을 처리한 쥐에서 32 유전자들이 DG보다 CA3에서 발현이 높았으며, 3개 유전자는 CA3보다 DG에서 높은 발현을 보였다. 코르티코스테론 호르몬 처리에 의한 해마조직의 유전자 발현 형태는 해부학적 구조의 차이를 보였다. 특히, CA3에서 6개의 유전자와 DG에서 41 개의 유전자가 호르몬에 의하여 조절 받았으며, 이중 43개의 유전자가 상승 발현하였으며, 4개의 유전자가 하강 발현 하였다. 이들 유전자를 기능에 의해 분류하면, 13개의 신경전달물질관련 유전자, 5개의 이온채널,4개의 전사인자, 3개의 neurotrophic인자, 1개의 각 사이토카인과 apoptosis관련 유전자, 그리고 5개의 스냅신형성관련 유전자가 해마조직에서 발현의 변화를 보였다. 특히, 스트레스 호르몬에 의하여 CA3에서 BDNF의 감소를 볼 수 있었다. 이러한 결과는 호르몬에 의하여 해마구조의 생리학적인 다양성을 내포 하고 있다. Glucocorticoids (GCs) alter metabolism, synaptogenesis, apoptosis, neurogenesis, and dendritic morphology in the hippocampus. To better understand how glucocorticoids regulate these aspects of hippocampal biology, we studied gene expression patterns in the CA3 (Hippocampal pyramidal cell field CA3) and dentate gyrus (DG). Litter-matched Lewis inbred rats treated for 20 days with either 9.5 mg per day sustained-release corticosterone or placebo pellets were compared with high-density oligonucleotide microarray analysis (Rat Neurobiology U34 Arrays, Affymetrix). In placebo-treated rats, 32 genes were expressed at greater levels in CA3 than DG, whereas 3 genes were expressed at great levels in DC than CA3. Regional differences were also apparent in corticosterone-induced changes in the hippocampal transcriptome. Six genes in CA3 and 41 genes in DC were differentially regulated by corticosterone. As per the glucocorticoid effects on gene transcription in the brain, forty three of these genes were upregulated, and 4 genes were downregulated. Genes differentially expressed in hippocampus included those for 13 neurotransmitter proteins, 5 ion channel related proteins, 4 transcription factors, 3 neurotrophic factors, 1 cytokine, 1 apoptosis related protein, and 5 genes involved in synaptogenesis. Interestingly, GCs can have suppressive effects on brain BDNF mRNA transcription, one of the neurotrophic factors. These results indicate the diversity of targets affected by chronic exposure to corticosterone and highlight important regional differences in hippocampal neurobiology.
김동섭,조은철,조영현,민요셉,이수홍,Kim, D.S.,Cho, E.C.,Cho, Y.H.,Ebong, A.U.,Min, Y.S.,Lee, S.H. 한국태양에너지학회 1997 한국태양에너지학회 논문집 Vol.17 No.2
단결정 실리콘 태양전지는 PESC(Passivated Emitter Solar Cell), PERC(Passivated Emitter and Rear Cell), Point Contact Cell, PERL(Passivated Emitter and Rear Locally-Diffused Cell) 형태로 기술적인 발전을 해왔다. BCSC(Buried Contact Solar Cell)는 낮은 제조 단가로 높은 효율을 얻을 목적으로 개발되었으며 개량된 형태인 DSBC(Double Sided Buried Contact Cell)는 양면으로 빛을 흡수할 수 있는 장점이 있다. Since PESC(passivated emitter solar cell) was developed in 1985, high efficiency silicon solar cell technology based on planar technology has been improved in the order of PERC, Point Contact Solar Cell, PERL. BCSC and DSBC, which do not require photolithography, are expected to replace commercial screen printed cells because of its potential for low cost and high efficiency. In this paper, history and characteristics of each type of cells are reviewed.
김동섭,김범철 ( Dong Sup Kim,Bom Chul Kim ) 한국하천호수학회 1990 생태와 환경 Vol.23 No.3
Primary production of phytoplankton and macrophytes were measured in a reservoir on the Han River, Lake Paldang. The primary productivity of phytoplankton was measured by photosynthesis-irradiance (P-I) model method and the primary production by macrophytes was claculated from the harvestable above ground biomass. Daily productivity of phytoplankton per unit surface area was 500∼1,000 mgC㎡/day, falling in the range of eutrophic lakes. The initial slope of P-I curves (α) showed 6.1∼9.6 gC㎡/gChl/E of 50% percentile range and the photoinhibition coefficient (β) showed 0∼0.057 gC㎡/gChl/E of 50% percentile range. The seasonal variations of P-I model parameters were small compared with the reports in other lakes, which means that in Lake Paldang the seasonal variation of light intensity which phytoplankton is adapted to was small, because Lake Paldang is well mixed all the year round and the seasonal variation of mixed zone is small except only two or three months. The assimilation number showed 2.7∼4.7 gC/gChl/hr of 50% percentile range. 64% of total annual primary production was contributed by phytoplankton and 36% by macrophytes. Though the productivity per unit area is much higher for macrophytes, the total production of phytoplankton is larger because the macrophytes production is confined to narrow littoral zone along the shore.
가스터빈의 설계 성능과 부분부하 성능 사이의 상관관계 분석
김동섭,Kim, Dong-Seop 대한기계학회 2002 大韓機械學會論文集B Vol.26 No.8
This study analyzed the dependence of part load performance of simple cycle gas turbines on their design performance. Various parametric calculations were carried out to examine effects of design temperature ratio, pressure ratio and component efficiencies using a simplified analysis. In addition, a more practical analysis was done for realistic design conditions with the aid of a comprehensive performance analysis program. The results show that gas turbines with higher design performance exhibit less efficiency degradation during part load operation. The influence of power control method (fuel only centre) and air flow control) on part load performance was examined as well.