Fanconi 증후군 치료 후 골동통이 호전된 다발성 골수종

권혜리 ( Hye Lee Kwon ),조성진 ( Seung Jin Cho ),송영수 ( Young Soo Song ),송헌호 ( Hun Ho Song ),오지은 ( Ji Eun Oh ),김수진 ( Soo Jin Kim ),김형직 ( Hyeong Jik Kim ),노정우 ( Jeong Woo Noh ) 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.4

Adult Fanconi syndrome is characterized by variable abnormalities caused by renal proximal transport defects, resulting in glycosuria, aminoaciduria, bicarbonaturia, uricosuria and phosphaturia. A 57-year-old man with κ-light chain multiple myeloma, undergoing chemotherapy with prednisolone and melphalan for 17 month, was admitted with spontaneous femoral neck fracture and was consulted due to polyuria and refractory metabolic acidosis immediately after hemiarthroplasty. The laboratory values showed normal anion gap metabolic acidosis with normal urinary anion gap, hypokalemia, hypouricemia, hypophosphatemia at the time of consultation. After partial correction of acidemia, the fractional excretion of HCO3-was 11.9%, it was interpreted as proximal renal tubular acidosis. 24-hour urine collection showed increased level of excretion for most aminoacids. Diffuse osteopenia and multiple compression fractures on spine were detected on radiological examinations. Also, osteoporosis and osteomalacia was suggested during his clinical course. After the diagnosis of Fanconi syndrome was made, treatment was started with sodium bicarbonate, potassium citrate, calcitriol, calcium carbonate along with phosphate rich diet. Laboratory abnormalities were corrected and refractory multiple bone pain was ameliorated with these treatment.

비례의 원리와 질감 테크닉을 응용한 헤어디자인 연구

권혜지 ( Hye-ji Kwon ),김태숙 ( Tae-sook Kim ),진용미 ( Yong-mi Jin ) 한국미용예술경영학회 2011 미용예술경영연구 Vol.5 No.1

In modern times, the concept of beauty treatment is accepted as a form of artistic expressions to deliver our own emotion and imagery. In order to grow as an specialist suited for the high -quality beauty culture era, the systematical process to make beauty as study is required in the perspective of designing activities. Thus, in this study, the viewpoint of design is grafted onto hair and 5 haircut works, applying the proportion among the design principles, have been produced, based on the theoretical study on hair cutting. And then the concept of texture out of design elements have been applied. As a result producing 5 works, it had been identified that the weightiness and the movement of forms and haircut design could change according to the selection for the proportion and the expression of texture in the development process of hair, and diverse cutting designs were available by using this. Through this study, the basic data for hair design based on design principles is provided and, as a result, the foothold for creating new design, thorough the introduction of practical development process. At the same time, this study is expected to contribute the development of the hair design field.

통계적 모형을 이용한 대기중 망간 농도 예측

권혜지,김용구,Kwon, Hye Ji,Kim, Yongku 한국데이터정보과학회 2016 한국데이터정보과학회지 Vol.27 No.3

최근 국내에서도 환경보건에 관한 관심이 급증하고 있는데, 특히 중금속은 발암의 특성이나 독성의 비임계성에서 대기오염물질과 구분이 되며, 낮은 수준일지라도 장기간 노출되면 호흡기계, 순환기계, 신경계 및 정신적 질환을 유발하는 것으로 알려져 있다. 이들 중금속 중 망간은 인체에 유해하지만 발암물질로 분류되지 않은 탓에, 망간 자체에 대한 연구는 미비한 편인고, 특히 망간은 자동측정장치 (AWS)를 통한 측정이 불가능하고 측정 및 분석에 고난도의 기술이 요구되어서 예산 등 비용효율성의 문제로 지속적인 관측이 불가능하다. 그러한 이유로 우리나라에서는 계절별로 10~12일 정도만 관측이 이루어지고 있다. 본 논문에서는 자동측정이 가능한 기온, 강수, 풍속 등 기상인자와 관측된 $SO_2$, $PM_{10}$, $O_3$ 등 대기질 물질을 이용한 망간 농도에 대한 통계 모형을 설계하고 이를 통해 부분적으로 관측된 망간 농도를 추정하여 망간의 위해성평가에 대한 정확도를 향상 시키고자 한다. 이를 위해 제안된 모형을 시화 반월 공업지역에서 관측된 자료를 적용하였다. Hazardous air pollution caused by heavy metals in the air is at a serious level. Although manganese(Mn), one of the heavy metals, is a non-carcinogenic substance, it has a harmful influence on the human body. It is partially measured because automatic monitoring technologies have not yet be fully established. We introduced a statistical model for the daily concentration of manganese. Incorporating a linkage between Mn and meteorology, the proposed model is formulated in way to identify meteorological effects and to allow for seasonal trends, enabling not only accurate measurement of manganese concentration, but also information about the evaluation on a Hazard Quotient (non-cancer risk).

한국지역 집중호우에 대한 반환주기의 베이지안 모형 분석

이정진,김남희,권혜지,김용구,Lee, Jeong Jin,Kim, Nam Hee,Kwon, Hye Ji,Kim, Yongku 한국통계학회 2014 응용통계연구 Vol.27 No.6

Understanding extreme precipitation events is very important for flood planning purposes. Especially, the r-year return level is a common measure of extreme events. In this paper, we present a spatial analysis of precipitation return level using hierarchical Bayesian modeling. For intensity, we model annual maximum daily precipitations and daily precipitation above a high threshold at 62 stations in Korea with generalized extreme value(GEV) and generalized Pareto distribution(GPD), respectively. The spatial dependence among return levels is incorporated to the model through a latent Gaussian process of the GEV and GPD model parameters. We apply the proposed model to precipitation data collected at 62 stations in Korea from 1973 to 2011. 집중호우의 특성을 이해하는 것은 수문관리 및 재해방재 등에서 매우 중요하다. 특히 반환주기는 이러한 집중호우의 특성을 나타내는 측정치로 자주 사용된다. 본 논문에서는 베이지안 계층적 모형을 이용하여 강우의 반환주기에 대한 공간구조를 분석하였다. 먼저 국내 62개 지점에서 측정한 강우 강도을 기초로 하여 연간 일일 최대강우량과 특정한 수준을 초과하는 강우량에 대해서 generalized extreme value(GEV)와 generalized Pareto distribution(GPD)를 각각 가정하여 추정하였다. 집중호우 반환주기에 대한 공간구조는 이 GEV 분포와 GPD 분포의 모수에 공간구조를 가지는 다변량 정규분포를 이용하여 설명하였다. 제안된 모형을 국내 76개 지역에서 39년간 측정된 일별 강우량 관측자료에 적용하였다.

전문심장소생술 시뮬레이션 실습교육 경험 만족도에 관한 연구

유순규(You, Soon-Kyu),권혜지(Kwon, Hye-Ji) 한국산학기술학회 2015 한국산학기술학회논문지 Vol.16 No.10

본 연구는 응급구조학과 학생대상 한국판 시뮬레이션 경험 만족도 측정도구 분석을 목적으로 응급구조학과 학생 총 111명을 대상으로 ACLS시뮬레이션 실습교육 후 학생들이 느끼는 만족도를 측정 후 분석하였다. 또한 시뮬레이션 교육에 대한 호감도, 필요성, 전문심장소생술 이론 성적이 시뮬레이션 실습교육 만족도에 미치는 영향 및 상관관계를 확인하고자 한다. 측정된 만족도는 일원배치분산분석을 통하여 분석하였으며, 그 결과 대부분의 학생들이 높은 만족도를 나타냈다. 시뮬 레이션 교육에 대한 호감도 및 필요도가 높을수록 만족도 측정도구의 세 가지 요인 모두에서 높게 나타났으나, ACLS이론 성적과 만족도의 상관관계는 성립되지 않았다. 향후 ACSL 시뮬레이션을 통한 교육법은 유지되어야 하며 지속적으로 발전해 야 한다. The purpose of this study was to analysis a Korean version of Satisfaction with Simulation Experience(SSE) Scale by paramedic students. Total number of 111 students majoring in the EMT-paramedic education area have taken part in the survey after completing the professional cardiac resuscitation simulative training, using the standardized simulation satisfaction evaluation method (SSE scale). Through the scale, one’s preference, necessity, ACLS theory grade, and satisfaction rate per year regarding the training were measured. To analyze one’s preference, necessity, ACLS theory grade, and satisfaction rate per year in regards to the training, one-way ANOVA was used. The result reveals that the overall satisfaction rate was generally quite high. When one’s preference and necessity rate is high, the satisfaction rate also seems to increase. The result indicates that the simulation training will enhance the students’ clinical skill, patient evaluation, and treatment capability as well as one’s field adaptation skill at the time of an emergency occurrence. Eventually, training through the ACLS simulation will be used in the future for the benefit of encouraging students from emergency rescue to adapt to the site of an emergency. Therefore, such an education method should be maintained and further developed.

저영향개발 (Low Impact Development) 침투기술에 의한 토양 오염정화능력 향상에 미치는 영향에 대한 연구

이나리 ( Na Ri Lee ),황서윤 ( Seo Yun Hwang ),김종모 ( Jong Mo Kim ),권혜지 ( Hye Ji Kwon ),이윤규 ( Yun Kyu Lee ),최한나 ( Han Na Choi ),김한용 ( Han Yong Kim ),박준홍 ( Joon Hong Park ) 한국물환경학회(구 한국수질보전학회) 2015 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2015 No.-

고추(Capsicum annuum) callis와 검은 무늬병 유발균의 elicitor를 이용한 항균물질 생산

박지은,구부연,박재영,권혜인,문슬아,조은별,이인순,박흠대 대구대학교 산업기술연구소 2014 産業技術硏究 Vol.25 No.1

We described the effects of antimicrobial activity on a produced material by the co-culture of elicitor inducing black rot's disease and callus of Capsicum annuum that callus was induced in MS medium containing IAA 0.5 mg/ml and kinetin 2.0 mg/ml. the bacterial elicitor used 0.5% Yeast extract and the fungal elicitor made by Alternaria alternata KACC 40019 with PDB medium. In order to produce antimicrobial agent protective balck rot's disease, we co-cultured the fungal elicitor or bacterial elicitor with the red pepper callus tissue for 7days repectively. The result, an antifungal agent was produced extracellular materials into medium during co-culture red pepper callus with the fungal elicitor. The antifungal activity of the extracellular material was showed 23% inhibition rate on Alternaria alternata KACC 40019 on the other hand the intracellular material was showed 2% inhibition rate. A chitinase activity of extracellular material was also showed higher value than a chitinase of the intracellular material. The extracellular material produced by elicitor was had more 15% of andtibacterial activity than the intracellular material. As a result, a biotic stress as a fungal elicitor and a bacterial elicitor brings a defence system in the red pepper callus and induce to synthesis in extracellular material an antimicrobial agent as a chitinase and phytoalexin.