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RISS 인기검색어
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- 저자 : 권현민(Hyoun Min Kwon) (검색결과 2 건)
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실험적 급성 허혈성 신부전에서 칼슘 길항제의 투여가 신기능과 뇨 Prostaglandin E2 의 배설에 미치는 영향
조원용(Won Yong Cho),권현민(Hyoun Min Kwon),변현주(Hyoun Ju Byoun),구자룡(Ja Ryong Gu),이규백(Kyu Back Lee),김형규(Hyoung Kyu Kim),노정우(Jung Woo Noh) 대한내과학회 1991 대한내과학회지 Vol.40 No.5
N/A It has been proposed that calcium entry from the external medium increases intracellular free calcium to toxic levels during ischemic acute renal failure (ARF) thereby converting cellular injury from a potentially reversible to an irreversible state. Because verapamil impedes calcium entrance into cells via voltage-dependednt slow calcium channels, it has been suggested that this agent may block calcium entry into the kidney cells. This study was designed to determine whether systemic verapamil pretreatment protects renal function in experimental ischemic ARF in cats and whether verapamil influences prostaglandin, a compensatory system for an acute insult of kidney. For these purpose, creatinine clearance and urinary PGE2 were measured in 18 cats before and after ischemia. The experimental animals were divided into 3 groups. Group I (n=6) was ischemic ARF model by renal artery clamping for 60 minutes. Group II (n=5) was ischemic ARF with systemic verapamil pretreatment (5 μg/kg/min), and Group III (n=7) was the same as Group II with nonsteroidal antiinflammatory drug pretreatment (20 μg/kg/min). The results were as follows: 1) In Group I, creatinine clearance was 10.79±7.19 before clamping and decreased to 2.09±1.70ml/min/ kg, in Group II, 3.41±1.56 to 0.12±0.05ml/min/kg; and in Group III, 6.30±5.50 to 0.80±0.70ml/min/kg. 2) Creatinine clearance decreased significantly in Group II (96±2%) compared with Group I (61±30%). 3) Urine PGE2 in the preischemic period of Group I was 346±175, Group II; 159±102, Group III; 137±91 ng/ ml increased to Group I 355±114, Group II; 471±346, Group III; 355±114 ng/ml in postischemic period. Urine PGE2 excretion was relatively low in Group II and Group III, compared with Group I but not significant statistically. From these findings, it was suggested that systemic verapamil pretreatment exerts no protective effect to ischemic ARF and that it may compromise the compensatory mechanism of the prostaglandin system in ischemic ARF.
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말기 신부전 환자에서 안지오텐신 전환효소 유전자형에 대한 연구
김형규,윤종우,차대룡,조원용,조상경,권현민 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.4
An Insertion/deletion polymorphism in angiotensin converting enzyme gene has been considered the important regulator of ACE activity in plasma and tissue. The deletion allele of this gene is associated with higher ACE activity, which ultimately increased angiotensin ? formation. It is possible that alteration of ACE polymorphism might be contribute to development of end stage renal disease and cardiovascular disease where RAS system is implicated in disease process. This study determined the distribution of ACE genotype in 122 end stage renal disease patients and in a group of 101 healthy controls. Also we evaluated the difference of allele frequency in the hemodialysis patients with or without cardiovascular disease. ACE genotype was determined by polymerase chain reaction technique from the PBMC leukocytes of the patients. The results were as follows; 1)Patients population consisted of 122 hemodialysis patients and male to female ratio was 66:56, mean age was 54.3±12.8 years old. Mean duration of dialysis treatment was 52.5±37.5 months and the underlying disease of ESRD were diabetic nephropathy in 78 cases, chronic glomerulonephritis in 29 cases, hypertension in 8 cases, other disease in 7 cases. 2)In the contol patients, male to female ratio was 52:49, mean age was 46.1±15.1 years old. The age and sex distribution between ESRD and control group was not significantly different. 3)Of the total hemodialysis patients, 26.2% showed the II genotype, 35.2% of ID genotype and 38.6% of DD genotype. In the contol group, the frequency of each genotype was 20.8% of II, 55.4% of ID and 23.8% of DD genotype. The frequency of DD genotype was significantly higher in ESRD group than control group(p$lt;0.05). 4)In the ESRD patients, 72 patients(59%) had the LVH and 23 patients(18%) had the ischemic heart disease. The genotype distribution in ESRD patients according to the presence of LVH or ischemic heart disease did not show any significant difference. The frequency of each genotype in the patients with LVH showed 22.2%(II), 43.1%(ID), 34.7%(DD), and 32.8%(II), 37.5%(ID), 29.7%(DD) in the patients without LVH. In the aspect of ischemic heart disease, the frequency of ACE genotype was 27.3%(II), 45.5% (ID), 27.3%(DD) in the group of ischemic heart disease, compared with the ditribution of 31.5 %(II), 40%(ID), 32.6%(DD) in the patients without ischemic heart disease. From the above results, it was concluded that insertion/deletion polymorphism in angiotensin converting enzyme gene, especially DD genotype, may be important in the pathogenesis of progression to end stage renal disease. There was no significant difference in I/D polymorphism according to the presence or absence of cardiovascular complications.
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