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논문 철회 : 고지방식이 비만마우스 모델에서 파키스탄산 및 중국산 마황으로 조성된 강지환(降脂丸)의 비알콜성 지방간질환 개선효과 비교
조주흠,장두현,정양삼,김종훈,김병출,석화준,유재상,구자룡,윤기현,노종성,안예지,이원경,윤미정,신순식,Jo, Ju-Heum,Jang, Du-Hyeon,Jeong, Yang-Sam,Kim, Jong-Hun,Kim, Byeong-Chul,Seok, Hwa-Jun,Yu, Jae-Sang,Gu, Ja-Ryong,Yun, Gi-Hyeon,No, Jong-Seong,A 대한한의학방제학회 2021 大韓韓醫學方劑學會誌 Vol.29 No.4
논문 철회 : 고지방식이 비만마우스 모델에서 강지환(降脂丸)과 강지환(降脂丸)+가미소체환(加味消滯丸)의 비알콜성 지방간질환 개선효과 비교
장두현,정양삼,김종훈,김병출,석화준,유재상,구자룡,윤기현,조주흠,이혜림,노종성,윤호영,윤미정,신순식,Jang, Du-Hyeon,Jeong, Yang-Sam,Kim, Jong-Hun,Kim, Byeong-Chul,Seok, Hwa-Jun,Yu, Jae-Sang,Gu, Ja-Ryong,Yun, Gi-Hyeon,Jo, Ju-Heum,Lee, Hye-Rim,No, 대한한의학방제학회 2021 大韓韓醫學方劑學會誌 Vol.29 No.4
실험적 급성 허혈성 신부전에서 Verapamil 이 혈중 Polyamine 동태에 미치는 영향
원동준(Dong Jun Won),권현민(Hyun Min Kwon),김용섭(Yong Seop Kim),구자룡(Ja Ryong Gu),권영주(Young Ju Kwon),조원용(Won Yong Cho),김형규(Hyung Kyu Kim) 대한내과학회 1991 대한내과학회지 Vol.40 No.6
N/A It has been proposd that calcium entry from an external medium increases intracellular free calcium to toxic levels during ischemic acute renal failure, and verapamil (ARF) has been suggested as the agentblocking calicium entry into renal cells and protecting renal function during ischemic injury. Polyamines, anorganic cations that play various roles in normal cellular proliferation and differentiation, accumulate in renal failare. Alsa it has been suggested tht the synthesis and metabolism of polyamine are influence by acute changes of the general condition, such as acute renal failure, and are mediated by a calcium influx into the cells. The study was designed to study the protective effects of systemic verapamil pretreatment on renal function and the influence on polyamine metabolism in experimental ischemic ARF in cats. For these purpose, the experimental animals were divided into 2 groups. While Group I (n=5) was an ischemic ARF model by renal artery clamping for 60 minutes, Group II (n=5) was ischemic ARF with systemic verapamil (5 ml/min/kg) pretreatment. The creatinine clearance and plasma and urinary polyamine were measured in each group before and after the renal artery clamp. The results were as follows: 1) Creatinine clearance before and after the renal artery clamp were 10.64±7.18 ml/min/kg and 2.09±1. 70 ml/min/kg in Group I, 4.47±3.38 ml min/kg and 0.60±0.79ml/min/kg in Group II, respectively, So creatinine clearance decreased more significantly in Group II campared with Group I. 2) Plasma polyamine increased after ischemia in Group I. In group I, plasma levels of putrescine, spermidine, and spermine before ischemia were 4.75±0.40 nmol/ml, 0.69±0.09 nmol/ml, and 0.83±0.63 nmol/ml, were elevated to 7.17±2.91 nmol/ml, 9.83±1.46 nmol/ ml, and 2.64±1.14nmol/ml after ischemia. But in Group II, the plasma level of polyamine was not changed, and especially, spermine decreased significantly from 0.83±0.27 before ischemia to 0.49±0.23 nmol/ml after ischenmine (p=0.033). 3) Urine polyamine excretion decreased after ischemia in Group I and Group II. In Group II, urinary excretion of spermidine and spermine before ischemia, 0.13±0.10 nmol/min and 0.17±0.13nmol/min, decreased after ischemia to 0.01±0.01nmol/min (p=0.019) and 0.032±0.26 nmol/min (p=0.0257). 4) In renal tissue, spermine content vas highest. In Group II, preischemic spermine were 397.20 nmol/g and increased to 646.66nmol/g after ischema, But there were no significant changes in the polyamine contents in Group II. From these data, it was suggested that systemic verapamil pretreatment exerts no protective effect on ischemic ARF. Plasma polyamines are elevated in ischemic ARF, and verapamil may protect these elevations.
실험적 급성 허혈성 신부전에서 칼슘 길항제의 투여가 신기능과 뇨 Prostaglandin E2 의 배설에 미치는 영향
조원용(Won Yong Cho),권현민(Hyoun Min Kwon),변현주(Hyoun Ju Byoun),구자룡(Ja Ryong Gu),이규백(Kyu Back Lee),김형규(Hyoung Kyu Kim),노정우(Jung Woo Noh) 대한내과학회 1991 대한내과학회지 Vol.40 No.5
N/A It has been proposed that calcium entry from the external medium increases intracellular free calcium to toxic levels during ischemic acute renal failure (ARF) thereby converting cellular injury from a potentially reversible to an irreversible state. Because verapamil impedes calcium entrance into cells via voltage-dependednt slow calcium channels, it has been suggested that this agent may block calcium entry into the kidney cells. This study was designed to determine whether systemic verapamil pretreatment protects renal function in experimental ischemic ARF in cats and whether verapamil influences prostaglandin, a compensatory system for an acute insult of kidney. For these purpose, creatinine clearance and urinary PGE2 were measured in 18 cats before and after ischemia. The experimental animals were divided into 3 groups. Group I (n=6) was ischemic ARF model by renal artery clamping for 60 minutes. Group II (n=5) was ischemic ARF with systemic verapamil pretreatment (5 μg/kg/min), and Group III (n=7) was the same as Group II with nonsteroidal antiinflammatory drug pretreatment (20 μg/kg/min). The results were as follows: 1) In Group I, creatinine clearance was 10.79±7.19 before clamping and decreased to 2.09±1.70ml/min/ kg, in Group II, 3.41±1.56 to 0.12±0.05ml/min/kg; and in Group III, 6.30±5.50 to 0.80±0.70ml/min/kg. 2) Creatinine clearance decreased significantly in Group II (96±2%) compared with Group I (61±30%). 3) Urine PGE2 in the preischemic period of Group I was 346±175, Group II; 159±102, Group III; 137±91 ng/ ml increased to Group I 355±114, Group II; 471±346, Group III; 355±114 ng/ml in postischemic period. Urine PGE2 excretion was relatively low in Group II and Group III, compared with Group I but not significant statistically. From these findings, it was suggested that systemic verapamil pretreatment exerts no protective effect to ischemic ARF and that it may compromise the compensatory mechanism of the prostaglandin system in ischemic ARF.
김형규,이은주,구자룡,정동국 대한내과학회 1989 대한내과학회지 Vol.36 No.2
A percutaneous renal biopsy was done in a patient with diabetes mellitus, who had severe renal symptoms, such as edema and azotemia. The histologic findings suggested the features of immune complex glomerulonephritis complicating diabetic nephropathy. With hemodialysis, the renal symptoms improved.