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제2형 당뇨병 환자의 영양소 섭취와 임상지표의 상관성에 관한 연구
권지영,정혜연,Kwon, Ji-Young,Chung, Hae-Yun 한국식품영양학회 2013 韓國食品營養學會誌 Vol.26 No.4
The objective of this study is to investigate the effects of dietary nutrient intakes for markers of blood glucose and inflammation which is important to the progress of type 2 diabetes and the development of its complications. For this study, 76 adults with diabetes (42 males, 34 females) were recruited from a group of patients who had visited the department of endocrine medicine. Data on anthropometric characteristics, clinical indices such as hemoglobin A1c (HbA1c) and C-reactive protein (CRP), and dietary nutrient intakes were collected. Our results have shown that 66% of subjects were either overweight or obese. Serum analysis indicates that levels of C-peptide, glucose, HbA1c, CRP, triglyceride, LDL-cholesterol were higher than normal range. Results from the dietary nutrient intake survey displayed that intakes of cholesterol and sodium were higher than Dietary Reference Intakes for Koreans. On the contrary, folate intake was lower than the guideline. Within the females, energy contribution from carbohydrate was higher than Korean Diabetes Association guideline. Statistical analysis has revealed a negative correlation between serum HbA1c level and dietary intakes of polyunsaturated fatty acid (PUFA), n-3 PUFA, ${\beta}$-carotene and vitamin E after adjustments for age, BMI, smoking habits, alcohol consumption, exercise and ingestion of diabetes mellitus medication (p<0.05). Serum CRP level was inversely associated with dietary intakes of carbohydrate, protein, vitamin C and fiber (p<0.05). Our results suggest that dietary nutrient intakes may influence the levels of HbA1c and CRP, and subsequently, it may help in the management/treatment of type 2 diabetes.
둔스 스코투스의 ‘윤리적 덕 없이 존립하는 실천적 지혜’
권지영(Kwon, Ji-Young) 서울대학교 철학사상연구소 2015 철학사상 Vol.56 No.-
토마스 아퀴나스가 윤리적 덕과 실천적 지혜의 필연적인 상호의존관계를 이야기할 때, 그는 ‘지성을 중심으로 통합된 인간의 완전성’과 ‘인간의 내적 충돌을 제거함으로써 그 완성을 가능케 하는 덕’을 염두에 두고 있었다. 그러나 둔스 스코투스는 ??정리집(Ordinatio)?? III권에서 실천적 지혜가 윤리적 덕에 의존하지 않는다고 주장한다. 이 글에서 나는 스코투스가 말하는 ‘윤리적 덕 없이 존립하는 실천적 지혜’의 의미와 그 함축을 검토한다. 스코투스의 실천적 지혜는 제일실천원리로부터 추론하는 지성의 습성이며, 그렇기 때문에 윤리적 덕과 분리된 채 성립하고 기능한다. 이는 궁극적으로 스코투스의 윤리학에서 중심 위치를 차지하는 것이 덕이 아님을 드러낸다. 주의주의 노선을 대표하는 철학자로서 스코투스는 내적 충돌을 제거하는 덕보다는 충돌 중에 자유롭게 그리고 창조적으로 선택하는 의지에 무게 중심을 두었다. 이런 맥락에서 나는 스코투스가 말하는 윤리적 인간은 통합된 인간보다는 ‘통합하는’ 인간이며, 따라서 그가 말하는 윤리적 행위는 충돌 없는 행위보다는 ‘충돌에서 창조하는’ 행위라고 이해한다. The aim of this thesis is to investigate the meaning and implication of “prudence without moral virtue” in Ordinatio III by Duns Scotus. Following Aristotle, Thomas Aquinas advocates the interdependence of prudence and moral virtue. This is based on his understanding of humans as intelligent beings, and of virtue as the principle of human completeness, whereby a conflict or clash between what reason (intelligence) commands and what desire carries out is removed. When Scotus claims that prudence can exist without moral virtue, he offers a different perspective on virtue, human beings, and moral actions. By analyzing his argumentation, I suggest that he means a “scientific, reasoning disposition” by prudence. According to Scotus, prudence is generated by correct judgment, reasoning from the first practical principle taken from some universal end particularly applied. It does not require a corresponding moral virtue in order to be a virtue. This implies Scotus’ voluntaristic view of human beings and human actions. In his moral theory, virtue as disposition is not something central but free will is. In this respect, I say that he regards man’s inner conflict as a critical element for his action to be free and moral. In conclusion, a moral action in Scotus’ theory can be interpreted as the creative result of a clash.
식물성 에스트로겐이 MC3T3 - E1 골아세포의 성장과 Insulin - like Growth Factor - I (IGF - I) 생성에 미치는 영향
권지영(Ji Young Kwon),남택정(Taek Jeong Nam) 한국식품영양과학회 2005 한국식품영양과학회지 Vol.34 No.6
식물성 에스트로겐은 에스트로겐의 대체물질로서 골 형성을 촉진하며, 다른 부작용 없이 폐경기 이후 여성의 골다공증 예방에 효과적인 물질로 주목받고 있다. 본 연구에서는 식물성 에스트로겐의 골 형성과 관련된 생리학적 기능을 확인하고자 식물성 에스트로겐인 genistein, daidzein 및 resveratrol을 각각 10^(-5) M 농도로 세포배양액에 첨가하여 MC3T3-E1 골아세포의 증식과 성장에 미치는 효과를 검토하였다. 그 결과 이들은 에스트로겐인 17β-estradiol과 마찬가지로 MC3T3-E1 골아세포의 증식과 성장을 향상시켰으며, daidzein과 resveratrol의 효과는 genistein의 효과보다 큰 것으로 나타났다. 골 형성 정도를 판단하는 생화학적 지표로 활용되고 골아세포의 증식과도 밀접한 관계를 가지는 alkaline phosphatase(ALP) 활성 또한 genistein, daidzein 및 resveratrol에 의해 증가하였다. 에스트로겐은 세포성장인자인 IGF-I의 국소적 생산과 분비를 촉진하며 간접적으로 골대사 촉진 효과를 유도해낼 수 있다고 보고되어 있었지만 식물성 에스트로겐의 투여에 의해 IGF-I의 농도가 증가하였다는 보고는 없었다. 그러나 본 실험 결과, 식물성 에스트로겐인 genistein, daidzein 및 resveratrol은 IGF-I의 단백질과 mRNA 수준을 증가시키는 것으로 나타났다. 이상의 연구결과들은 식물성 에스트로겐의 골 형성 촉진 효과를 증명하는 것으로서 이들의 유용한 약리학적 기능을 뒷받침하는 하나의 근거로 활용될 수 있으리라 사료된다. Estrogen is known to play an important role in maintaining bone mass, since the concentration of serum estrogen decrease after menopause and the estrogen deficiency results in bone loss. Phytoestrogens are plant compounds with estrogen-like biological activity. In this study, to investigate the bioactivities of phyto- estrogen, which act on bone metabolism, we examined the effect of selected food-borne phytoestrogens (ge- nistein, daidzein and resveratrol) on osteoblast proliferation and IGF-I production using MC3T3-E1 cells, a mouse calvaria osteoblast-like cell line. Cells were cultured in a serum free medium for 48 hr in the presence of genistein (10^(-5) M), daidzein (10^(-5) M) and resveratrol (10^(-5) M). The effects of genistein, daidzein and resveratrol on the cell proliferation and growth were evaluated by total cell numbers, MTS assay and cell migration assay. Their effect was compared with the 17β-estradiol. Genistein, daidzein and resveratrol exhibited stimulatory effects on the growth of MC3T3-E1 cells, and the most pronounced effect was shown with daidzein. In addition, these phytoestrogen increased alkaline phosphatase activity of MC3T3-E1 cells. These effects were similar to that of 17β-estradiol effects. Moreover, treatment with genistein, daidzein and resveratrol increased pro- duction of insulin like growth factor-I (IGF-I) in conditioned media, indicating that the growth promoting effects of these phytoestrogen were related to the changes in production of IGF-I by MC3T3-E1 cells. These results show that genistein, daidzein and resveratrol have a stimulatory effect on osteoblast function, and that these findings in a cell model may prove relevant to protecting against the loss of bone mass and the development of osteoporosis in human subjects.
권지영 ( Ji Young Kwon ),박큰바위 ( Kunbawui Park ),송기철 ( Ki Cheol Song ),오은경 ( Eun Gyoung Oh ),이희정 ( Hee Jung Lee ),조미라,김지회 ( Ji Hoe Kim ),손광태 ( Kwang Tae Son ) 한국수산과학회(구 한국수산학회) 2012 한국수산과학회지 Vol.45 No.5
From 1998 to 2008, the bacteriological quality of seawater in Kamak flay, Korea, was monitored. The total and fecal coliforms in seawater were monitored as bacterial indicators, and the level of fecal coliform contamination was used to evaluate seawater quality. In the southern shellfish growing area of Karnak Bay, the observed feeal coliform geometric mean (GM) and estimated 90th percentile did not exceed the quality standards for fecal coliforms in seawater in Korea and th USA (GM<l4 MPN/l00mL, 90th percentile<43 MPN/I00rnL). The GM and estimated 90th percentile of the fecal coliform levels in the adjacent northern area of Kamak Bay were higher than in the southern area. Stations near wastewater discharge sites and urban areas in the north had the lowest quality and did not meet the bacteriological seawater quality criteria. The high fecal coliform levels in the Seonso coastal region near wastewater discharges and northern urban areas declined significantly following dredging and operation of a sewage treatment plant.