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권오찬,황호정,김정필,지윤성,전옥성,설용건 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
Lithium ion battery is a technology on its way of closing on its theoretical bounds. In this sense, secondary zinc air batteries are a strong contender as a next generation power source. As great possibilities are hidden in this particular system as their beneficial properties include: larger energy density, lesser tariffs on the environment and cheaper materials. Although with such aspects, the cyclic stability has been a constant undermining factor. Preceding works have been on the understanding of the electrode properties, but not much insight has been given to the intermediate components; the electrolyte and the separator. Herein the presented work shows some light to the influential effects of the zincate ion. It has been observed that the crossover of the zincate ion is a significant factor effecting the life of a secondary zinc air battery. Furthermore a facile mitigation strategy has been providing using a anion exchange membrane.
Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis
권오찬,김수현,홍석찬,이창근,유빈,장은주,김용길 대한면역학회 2018 Immune Network Vol.18 No.3
IL-32 acts as a pro-inflammatory cytokine by inducing the synthesis of inflammatory molecules as well as promoting the morphological changes involved in the transformation of monocytes into osteoclasts (OCs). Evaluation of the functions of IL-32 has mainly focused on its inflammatory properties, such as involvement in the pathogenesis of various autoimmune diseases. Recently, IL-32 was shown to be involved in bone metabolism, in which it promotes the differentiation and activation of OCs and plays a key role in bone resorption in inflammatory conditions. IL-32γ also regulates bone formation in conditions such as ankylosing spondylitis and osteoporosis. In this review, we summarize the results of recent studies on the role of IL-32γ in bone metabolism in inflammatory arthritis.
권오찬,전태주,박민찬 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.9
Purpose: To evaluate whether vascular uptake on 18F-fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT) during the clinically inactive state of Takayasu arteritis (TAK) is associated with disease relapse. Materials and Methods: Patients with TAK who underwent 18F-FDG PET/CT during the clinically inactive state of the disease between2006 and 2019 were included. Clinically inactive disease was defined as a status not fulfilling the National Institutes of Health(NIH) criteria for active disease in TAK. Relapse was defined as recurrence of clinically active disease after a clinically inactive period,requiring change in the treatment regimen. Vascular uptake on 18F-FDG PET/CT was assessed using target/background ratio(TBR), calculated as arterial maximum standardized uptake value (SUV)/mean SUV in venous blood pool. Multivariable Coxregression analysis was performed to identify factors associated with relapse. Results: A total of 33 patients with clinically inactive TAK were included. During a median observation period of 4.5 (0.9–8.1)years, relapse occurred in 9 (27.3%) patients at median 1.3 (0.7–6.9) years. Notably, TBR [1.5 (1.3–1.8) vs. 1.3 (1.1–1.4), p=0.044]was significantly higher in patients who relapsed than in those who did not. On multivariable Cox regression analysis, the presenceof NIH criterion 2 [adjusted hazard ratio (HR): 7.044 (1.424–34.855), p=0.017] and TBR [adjusted HR: 11.533 (1.053–126.282),p=0.045] were significantly associated with an increased risk of relapse. Conclusion: Vascular uptake on 18F-FDG PET/CT and the presence of NIH criterion 2 are associated with future relapse in patientswith clinically inactive TAK.
권오찬,박정환,이상원,송정식,박용범,박민찬 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.11
Purpose: To compare the clinical characteristics and renal outcomes between patients who initially had lupus nephritis (LN) atthe onset of systemic lupus erythematosus (SLE) (initial-onset LN) and those who developed LN within 5 years after SLE onset(early-onset LN). Materials and Methods: SLE patients with biopsy-proven LN were retrospectively reviewed. The clinical parameters and renaloutcomes were compared between initial-onset and early-onset LN groups. We used Cox regression analysis to estimate risk ofworse renal outcomes according to the onset time of LN. Results: Of all 136 LN patients, 92 (67.6%) and 44 (32.4%) patients were classified into the initial-onset and early-onset LN groups,respectively. The initial-onset LN group had higher prevalences of class IV LN (54.3% vs. 34.1%, p=0.027), impaired renal function(34.8% vs. 11.4%, p=0.004), microscopic hematuria (73.9% vs. 54.5%, p=0.024), and higher urine protein/creatinine ratio [4626.1(2180.0–6788.3) mg/g vs. 2410.0 (1265.0–5168.5) mg/g, p=0.006] at LN diagnosis. Renal relapse (46.3% vs. 25.7%, p=0.039) andprogression to chronic kidney disease (CKD) or end-stage renal disease (ESRD) were more common (24.4% vs. 8.3%, p=0.042) inthe initial-onset LN group. In Cox regression analysis, the initial-onset LN group had higher risks of renal relapse [adjusted hazardratio (HR) 3.56, 95% confidence interval (CI) 1.51–8.35, p=0.004] and progression to CKD or ESRD (adjusted HR 4.57, 95% CI1.03–20.17, p=0.045), compared with the early-onset LN group. Conclusion: Patients with LN at SLE onset may have more severe renal presentations and experience worse renal outcomes thanthose who develop LN within 5 years.
Enhancement of Cyclic Stability in Secondary Zinc Air Batteries by Selective Ion Transport Separator
권오찬,황호정,이진구,설용건 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
Elongating the cycle stability has been the holy grail of all secondary ZAB research. While much of the precedent work has been focused on developing catalysts for the air cathode and indeed, found thirst quenching success, not much attention has been focused on separators and extracting their potential. The control of zincate ions is a major factor in durability. In this aspect, former membranes which are widely used in research is insufficient. The micropores of the commercial membrane allow nonspecific flow of ions, thus results in zincate migration which deteriorates the cathode by ZnO formation or decreases the conductivity of the separator/electrolyte. By applying a coating of PEBIH-PBMA polymer, we eliminate existing pores while conserving the ionic conductivity of the membrane. This allows selective hydroxyl ion transportation and limits the free diffusion of zincate ion by the preferred solubility of hydroxyl ions in the ionic liquid copolymer and the size exclusion effect.