Outcomes of Therapeutic Modalities for Intractable Childhood Epilepsy

Hoon Chul Kang(강훈철),Ji Won Kwon(권지원),Yong Soon Hwang(황용순),Heung Dong Kim(김흥동),Sang Keun Park(박상근) 대한소아신경학회 2005 대한소아신경학회지 Vol.13 No.2

목 적 : 난치성 소아 간질 치료를 위해, 최근 개발된 항간질 약물, 프레드니솔론, 케톤생성식이요법, 간질수술, 미주신경자극술의 임상적 결과를 평가하였다. 방 법 : 1995년 7월부터 2003년 4월까지 상계백병원 간질센터에서 치료한 난치성 간질 환아 297명의 임상 결과를 후향적으로 분석하였다. 결 과 : 최근 개발된 항간질 약물이 투여된 290명 환아에서 20명(6.9%)에서만 추적 관찰기간 중 간질 완해물 유지하였다. 프레드니솔돈을 투여한 138명 환아에서 58명(42.0%)에서 약물 투여 중 간질 완해를 보였으나, 41명 환아에서 약물 중단 후 재발되었다. 케톤생성 식이요법은 162명에서 시도되어 74명(45.7%)에서 12개월 이상 식이요법을 유지하였으며, 간질 완해를 보인 37명(22.8%)을 포함하여 68명(42.0%)에서 50% 이상의 간질 횟수의 감소를 보였다. 간질 수술은 38명에서 시행되었으면 25명(65.8%)에서 Engel 구분 Ⅰ을 보였다. 미주신경자극술은 5명 환아에서 시행되어 2명에서만 50% 이상의 간질 횟수 감소를 보였다. 결 론 : 케톤생성 식이요법과 간질수술은 난치성 소아 간질 치료에 상당히 효과적인 치료였으나 프레드니솔론은 잦은 재발을 보였고 새로 개발된 항간질 약물은 난치성 간질의 완해를 유지함에 있어 한계가 있었다. Purpose : This study sought to evaluate the clinical outcomes of various therapeutic modalities, including newly-developed anti-epileptic drugs (AEDs), prednisolone, ketogenic diet (KD) epilepsy surgery, and vagus nerve stimulation (VNS), in treating intractable childhood epilepsy. Methods : Data of refractory epilepsy patients (n=297) treated from July 1995 through April 2003 at the epilepsy center of Sanggye Paik Hospital were retrospectively analyzed. Results : Newly-developed AEDs were primarily prescribed to 290 patients, although only 20 patients (6.9%) maintained a seizure- free state. Of 138 patients for whom prednisolone was prescribed, 58 patients (42.0%) showed complete seizure controls while 41 patients experienced relapse. KD was attempted and evaluated at 12 months in 162 patients, at which time 74 (45.7%) remained on the diet and 68 (42.0%) showed seizure reduction of greater than 50%, including 37 (22.8%) who were completely seizure free. Epilepsy surgery was undergone in 38 patients, and Engel class I was identified in 25 (65.8%) patients. VNS was administered to five patients, only two of whom obtained a seizure reduction of more than 50%. Result : Taken together, these findings suggest that considerable controls over intractable childhood epilepsy can be gained through KD and epilepsy surgery, whereas prednisolone treatment leads to somewhat more frequent relapses, and newly-developed AEDs are comparatively limited in their controls of refractory epilepsy.

전자광학추적장비와 레이더 사이의 표적탐지영역의 차이보상방법 개선

유형곤,권강훈,김영길,Yoo, Hyeong-Gon,Kwon, Kang-Hoon,Kim, Young-Kil 한국정보통신학회 2013 한국정보통신학회논문지 Vol.17 No.12

일반적으로 함정은 표적을 탐지하고 추적하는 기능을 하는 다양한 장비를 보유하고 있으며 각 장비들 간의 정보교류를 통해 보다 정확하고 신속하게 대상 표적을 추적하고 있다. 이런 장비들은 대체로 유사한 표적탐색영역(FOV)을 보유하지만 일부는 해당 장비의 오차범위(Resolution) 한계로 인해 장비간의 차이가 발생하기도 한다. 본 논문에서는 전자광학추적장비(Electro Optic Tracking System)와 레이더 시스템 간의 표적탐색영역(FOV) 차이를 보상하기 위해 사용된 전자광학추적장비 표적탐색 방식을 랜덤한 표적정보를 기준으로 다양한 방법을 통해 탐색시간을 단축하고, 자동으로 표적을 탐지/추적할 수 있는 방법에 대해 연구하였다. This is an example we generally have a variety of equipment that can detect and track the targets and track them quickly and accurately through the information exchange among each piece of equipment. These equipment have similar detection areas (FOV), but some are different due to the limit of the resolution of the equipment. In this paper, we studied the method of reducing detection time and tracking the targets automatically.

표적 가림 예측에 의한 기억추적 알고리즘 개발 및 구현

김소현,장광일,권강훈,정진현,Kim, So-Hyun,Jang, Gwang-Il,Kwon, Kang-Hoon,Jung, Jin-Hyun 한국군사과학기술학회 2009 한국군사과학기술학회지 Vol.12 No.3

In this paper, the Autocoast algorithm is proposed for EOTS to overcome the target occlusion status. Coast mode, one of tracking modes, is to maintain the servo slew rate with the tracking rate right before the loss of track. The Autocoast algorithm makes decision of entering coast mode by the prediction of target occlusion and tries to refind target after the coast time. This algorithm composes of 3 steps, the first step is the prediction process of the occlusion by target-like background, the second one is the check process of the occlusion happened after background intensity variation, and the last one is the process of refinding target. The result of computer simulation, test under laboratory, and real test with EOTS shows the applicability for the automatic video tracking system.

드라베 증후군의 SCN1A 유전자 변이 양상

조민정(Min Jung Cho),권순성(Soon Sung Kwon),이승태(Seung Tae Lee),김흥동(Heung Dong Kim),정희정(Hee Jung Chung),이준수(Joon Soo Lee),이영목(Young Mock Lee),김세희(Se Hee Kim),강훈철(Hoon Chul Kang) 대한소아신경학회 2017 대한소아신경학회지 Vol.25 No.1

Purpose: The aim of this study is to examine the SCN1A variants in Korean patients with Dravet syndrome. Methods: We conducted a retrospective study of clinically confirmed thirty-nine patients with Dravet syndrome who visit our hospital from January 2007 to May 2015. We analyzed the SCN1A variants by direct sequencing. We analyzed and classified SCN1A variants according to ACMG/AMP (American College of Medical Genetics and Genomics and the Association for Molecular Pathology) guideline. Results: : A total thirty-nine patients (female 22, male 17) were included. Among them, twenty patients (51.2%) with Dravet syndrome had pathogenic or likely pathogenic SCN1A mutations including fifteen truncating mutations (12 nonsense and 3 splice region mutations), 5 missense mutations. The remained variants in nineteen patients with Dravet syndrome classified into ten variants of unknown significances, and 9 benign variants. In our study, truncation mutations are located whole span of SCN1A protein, while half of missense mutations are located at higher density on pore loop (S5-S6) regions. Conclusion: Unlike previous known study, lower positive rate of SCN1A mutation of Dravet syndrome was revealed in our study. The importance of parental test (trio test) and other additional tests have been emphasized. 목적: 이 연구는 드라베 증후군으로 진단받은 소아 환자들을 대상으로 SCN1A 돌연변이의 특성에 대해 살펴보고자 하였다. 방법: 2007년 1월부터 2015년 5월까지 임상적으로 드라베 증후군으로 확진된 환자 39명을 대상으로 후향적 연구를 진행하였다. SCN1A 변이는 직접 염기 서열 분석법을 이용하여 분석하였고 ACMG/AMP 가이드라인에 따라 분류하였다. 결과: 39명의 환자가 포함되었으며 여아는 22명, 남아는 17명이었다. 총 20명(51.2%)의 드라베 증후군 환자에서 SCN1A 병적 돌연변이가 발견되었으며 그 중 15명이 결절 돌연변이, 5명이 과오 돌연변이를 가지고 있었다. 나머지 19명의 드라베 증후군 환자들은 10명에서 임상적 의미를 알 수 없는 변이가 관찰되었고 9명에서 양성 소견을 가지고 있었다. 결절 돌연변이는 SCN1A 단백질의 전체 구역에 분포하고 있지만, 과오 돌연변이는 pore loop (S5-S6) regions에 좀 더 높은 비율로 위치하고 있었다. 결론: 기존의 연구와 달리 본 연구에서는 드라베 증후군 환자의 SCN1A 돌연변이의 양성률이 낮게 나왔다. 부모 검사(trio test) 및 추가적인 검사의 중요성이 강조된다.

전자광학장비 표적좌표추정 알고리즘 개발

문성만(Seong-Man Moon),김성수(Sung-Su Kim),권강훈(Kang-Hoon Kwon),임정빈(Jeong-Bin Yim) 대한전자공학회 2010 대한전자공학회 학술대회 Vol.2010 No.6

Target pointing is a function that maintains LOS(Line of Sight) toward a fixed ground target by controlling azimuth and elevation angles of electro-optical systems which are calculated from navigation data of aircraft and target coordinates. It is useful when pilots wish to observe the target continuously under dynamic maneuvering of the aircraft. To guarantee the target pointing performance, target coordinates have to be estimated accurately. There are several error factors for computing the target coordinates such as alignment error, sensor measurement error control error, and so on. Especially, transmission time delay of the navigation data is a major factor. This paper describes the target coordinates estimation algorithm and shows its experimental results.

건강한 성인에서 알콜섭취와 혈중지질농도와의 관계

조정진,강훈일,권선영 대한가정의학회 1999 Korean Journal of Family Medicine Vol.20 No.10

통근교통 수단선택에 대한 연구

임채문,권강훈,구경남 대구대학교 과학기술연구소 1999 科學技術硏究 Vol.5 No.5

The growth of auto ownership which was resulted by a rapid growth of economy and population caused a terrible transportation problem. This problem will not be improved by the supply of transportation facility. These days, it is natural for every foreign country to give a priority to the public transportation. Namely, it is necessary that the policy for travellers to attract from auto to public transportation is needed. Therefore, the purpose of this study is to find a basic idea for attracting auto users to public transportation. This study is largely divided into 3 parts. First, a travel mode choice model was estimated by using which is all the sample. Second, the mode choice models were estimated with the market segmentation divided by residential and work location. Third, the policy analysis was performed by using the estimated model.

都市街路의 遲滯度推定에 관한 硏究

임채문,권강훈,이주호,김태형 대구대학교 과학기술연구소 2001 科學技術硏究 Vol.8 No.1

This study suggested input variables whose effects have been considered by adjusting various input variables in the TRANSYT-7F and NETSIM, the Simulation programs employed in calculating the delay time at street sections. The results can be summarized as follow. 1. Among the input variables in the TRANSYT-7F needed to calculate the delay time at street sections, the excluded are those which effect the most on time delay, such as bus stops, pedestrian crossings and on/off ramps. Among the input variables the most affecting factors are Saturation flow rate and time delay whose suggested quotients are well summarized in the text of this study. 2. There are variables which affect the change of time delay in the NETSIM, such as bus stop, pedestrian crossing, bus appearance period, and departure time delay. This study did the Simulation program using those variables except pedestrian crossing because, as the result of the correlation analysis suggests, there is a strong correlation between bus stop and pedestrian crossing. In this study, the survey had been done in the morning and afternoon except the Peak time, so heavily congested sections were excluded. And both sides of three street sections were surveyed. Therefore, there should be further studies on heavily congested situations and many other street sections.

도로설계요소에 대한 운전자 인식도 분석

임채문,박준,권강훈,홍익상 대구대학교 과학기술연구소 1998 科學技術硏究 Vol.5 No.3

This study presents fundamental data to design for the safe and comfortable road. and to reduce traffic accidents by performing cognition analysis and Factor Analysis of drivers. The results obtained are summarized as follow : 1. According to analysis of investigated road design elements, most drivers have low cognition level in alinement elements of road design. So drivers have to get more information than now about alinement elements of road design, 2. When we design road, it is proved that alinement as well as safety is so important to drivers. Therefore we should design road considering drivers` characteristics.

적정 예비 신호등 설치에 관한 연구

임채문,박관,권강훈,정만표 대구대학교 과학기술연구소 1998 科學技術硏究 Vol.5 No.4

In this study, the crosswalk at Hayaong-Yungchun arterial located in Kyungbuk province were chosen as the subject, and the reaction patterns of drivers were analyzed by the survey of the approach velocity of cars, know-reaction time and the geometric structure of crosswalk, and the substitute about the installation of pre-traffic signal at moderate distance for the prevention of the disturbing zone (dilemma zone, option zone) to drivers' pass-stop decision at the yellow-signal-situation was presented. The results are summarized as follows 1. The know-reaction time which is applied to the calculation of the yellow signal time is 1 second in korea generally, but the average time was 1.67 second and the standard variation was 0.38 second at 95 samples of the analyzing area. 2. The comparison between the calculation formula of the yellow signal time which is used in korea and the actual time has 1 second difference.