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윤영석(Young Suk Yoon),구완서(Wan Suh Koo),박인석(In Suk Park),김석영(Suk Young Kim),최의진(Euy Jin Choi),방병기(Byung Kee Bang) 대한내과학회 1991 대한내과학회지 Vol.41 No.2
N/A To investigate a possible association between intracellular free calcium and blood pressure in normotensive subjects and patients with essential hypertension, intraplatelet free calcium was measured with intracellularly trapped fluorescent indicator Fura 2-AM. The results were as follows: 1) Intraplatelet free calcium levels were significantly higher in patients with essential hypertension than in normotensive subjects (222.4±58.0 vs. 119.6±10.9 nM; p < 0.0001). 2) There was a close correlation between the intraplatelet free calcium levels and the systolic, diastolic and mean blood pressure (n=45; r=0.817 for SBP, 0.728 for DBP, 0.800 for MBP; p<0.0001, respectively). 3) Antihypertensive treatment with calcium channel blookers or beta-blockers resulted in a reduction in both blood pressure and intraplatelet free calcium(p<0.0001). 4) There was a significant correlation between intraplatelet free calcium and serum cholesterol concentration (r=0.462, p<0.05). Based on the above findings, there was a close correlation between the free calcium level in platelets and blood pressure, and the serum cholesterol concentrations. Antihypertensive treatment with calcium channel blockers or beta blockers resulted in a reduction in free calcium, which correlated with the fall in blood pressure.
김동욱(Dong Uk Kim),홍관수(Kwan Su Hong),김석영(Suk Young Kim),구완서(Wan Suh Koo),최외진(Euy Jin Choi),장윤식(Yoon Sik Chang),윤영석(Young Suk Yoon),방병기(Byung Kee Bang) 대한내과학회 1987 대한내과학회지 Vol.34 No.1
N/A A clinical analysis was made of 8 cases of renal tubular aciosis diagnosed between January 1984 and May 1987 at Internal Medicine Department of Catholic University Medical College. The results are as followings. 1) Clinical diagnosis were Type 1 RTA, 7 cases; Type 2 RTA, 1 case. 2) Patients age ranged from 13 to 50 years with more than 60% of the patients in the 10 years and 20 years of age. 3) The male and female ratio was 1:3. 4) The major clinical problems at initial presentation were numbness or paralysis (50%), uremic symptoms (37.5%), short stature (25%), tetany (12.5%). 5) The major electrolytes abnormalities at initial presentation were hypokalemia (75%), hyperchloremia (50%), 6) The patients were treated by a mixture of potassium chloride and sodium bicarbonate with good reponse.
송춘익(Choon Eck Song),심규식(Kyu Sik Shim),구완서(Wan Suk Koo),박동준(dong JUne Park),김철민(chul Min Kim),하현권(Hyun Kwon Ha),허미경(Mi Kyung Hur),강문원(Moon Won Kang) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
This is a report of two cases of adenocarcinoma in ileum of the small intestine. Ileal adenocar- cinoma has been noted at its rarity, etiology, distribution, and poor prognosis. Recently we experi- enced two interesting cases. One dveloped in 25 year-old rnan, and the other in 42 year old man, vho had treated by segmental resection and chemotherapy, was followed by development of gastric carcinoma after 8 year-survival.
동위원소 ( 99mTc - DTPA ) 를 이용한 신사구체 여과율 측정의 유용성
추원오(Won Oh Choo),우제영(Je Young Woo),김용수(Yong Soo Kim),구완서(Wan Suh Koo),장윤식(Yoon Sik Chang),윤영석(Young Suk Yoon),방병기(Byung Kee Bang),정수교(Soo Kyo Chung) 대한내과학회 1992 대한내과학회지 Vol.43 No.6
N/A Background: Although creatinine clearance is most commonly used to evaluate renal function, it overestimates glomerular filtration rate and needs 24 hour urine collection. In the last several years, it was reported that glomerular filtration rate using radioisotope has advantages of creatinine clearance. Methods: Glomerular filtration rate estimated by fractional accumulation of 99mTc-DTPA (CDTPA), creatinine clearance (Ccr), predicted creatinine clearance estimated by the formula devised by Cockcroft and Gault (PCcr) and 100/serum creatinine (100/Scr) were measured simultaneously in 89 medical outpatients whose serum creatinines ranged from 0. 6 mg/dl to 11, 2 ma/dl. Results: 1) CDTPA were closly correlated to Ccr (r=0.84), PCcr (r=0.88) and 100/Scr (r=0.86). 2)CDTPA were inversely correlated to Scr. 3) In patients with normal renal function (Scr<1.2 mg/dl) or mild to moderate renal insufficiency (1,2< Scr < 4. 0 mg/dl), CDTPA A were significantly lower than Ccr and 100/Scr, and simmilar to PCcr. 4) In patients with severe renal insufficiency (Scr>4. 0 mg/dl), CDTPA were significantly higher than Ccr, PCcr and 100/Scr. 5) Cm of left kidney were closely correlated to those of right kidney (r=0.91). The absolute differences of CDTPA between right and left kidneys were 5,1±4.9ml/ min/l. 73 M2, which were not significant statistically. 6) In 4 patients who had a past history of unilateral nephrectomy, DDTPA were measured falsely by 7.4±4.9 ml/min/1,73 M2 in nephrectomized side. 7) This procedure needs only 6 minutes of patient time. Conclusion: These observations suggest that determining glomerular filtration rate using 99mTc-DTPA is a rapid, accurate method in patients with normal or mild to moderate renal insufficiency, both as a total value and individually for each kidney. But it overestimates glomerular filtration rate in patients with severe renal insufficiency.
신조직검사를 시행한 Acute Focal Bacterial Nephritis 1예
민창기,이숙영,우제영,구완서,윤영석,방병기,김희나 대한내과학회 1992 대한내과학회지 Vol.42 No.3
당뇨병을 갖고 있으면서 발열과 측복통을 주소로 내원한 환자에서 요분석 및 배양검사와 방사선학적인 검사로 AFBN으로 진단된 경우 신조직 검사를 시행한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. AFBN is a form of acute pyelonephritis. Many of the patients in this series had either a history of diabetes or reflux nephropathy. On Sonograpnhy or CT scanning, it was poorly marginated lower density mass which significantly responded to the administration of antibiotics. It is important not to confuse AFBN with renal abscess of neoplasm, which it may simulate, as this might lead to inappropriately surgical therapy. Histologically, the disease is characterised by chronic narture such as fibrosis and monouclear cell infiltration, being admixed with acute and chronic inflammation.
김용수,박인석,김석영,우제영,윤영석,방병기,구완서,장윤식 대한신장학회 1990 Kidney Research and Clinical Practice Vol.9 No.4
Carpal tunnel syndrome (CTS) is a late complication of chronic hemodialysis. This complication results from the deposition of ?2-microglobulin as an amyloid-like substance. CTS results from entrapment of the medial nerve at the wrist. ?2-microglobulin deposits have been reported in bones, kidney, liver, bowels, and vasculature. We report here our experience with carpal tunnel syndrome in 47-year-old women treated exclusively with hemodialysis over a period of 14 years. She showed pain/paresthesia at night, weakness, burning pain in palm of right hand and right shoulder pain. Also, she showed decreased sensation to light touch and pin prick, positive Tinnels sign of the right hand. Nerve condnction studies showed an increased terminal latency of the right median nerve. Management of the carpal tunnel syndrome have not been altogether satistactory. Surgical decompression of the median nerve has been of the greatest benefit to patients with marked disability and pain from the carpal tunnel syndrome. A brief review of the literature was made.