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단보 : α-Glucosidase 저해물질을 함유한 노랑느타리버섯(Pleurotus cornucopiae) 물추출물의 혈당상승 억제 효과
신자원 ( Ja Won Shin ),배상민 ( Sang Min Bae ),한상민 ( Sang Min Han ),이윤혜 ( Yun Hae Lee ),정윤경 ( Youn Kyung Jeong ),지정현 ( Jeong Hyun Ji ),이종수 ( Jong Soo Lee ) 한국균학회 2016 韓國菌學會誌 Vol.44 No.1
식용버섯 자실체를 이용하여 새로운 식후 혈당상승억제 물질을 개발하기 위하여 노랑느타리버섯 자실체에 함유되어있는 α-glucosidase 저해물질을 증류수로 추출하여 식후 혈당 상승억제효과를 조사하였다. α-Glucosidase 저해물질을 함유한 노랑느타리버섯 물추출물은 streptozotocin으로 당뇨를 유발시킨 당뇨 쥐에서 장기 30 mg/kg, 150 mg/kg 경구투여(2일)와 단기 500 mg/kg, 1,000 mg/kg 경구투여(120분)시 모두, 농도 의존적으로 식후 혈당상승억제 효과를 보였다. Following preparation of water extracts of Pleurotus cornucopiae fruiting body-containing α-glucosidase inhibitor, their antihyperglycemic effects were examined using streptozotocin-induced diabetic Sprague-Dawley (SD)-rats. The water extracts from Pleurotus cornucopiae showed dosage-dependant antihyperglycemic effects on the streptozotocin-induced diabetic SD-rats after oral administration to 120 min on the short time test and 4 days on the long time test, respectively. The water extracts from Pleurotus cornucopiae fruiting body showed dosage-dependent hypoglycemic action after administration to 120 min and 4 days in the SD-rat and streptozotocin-induced diabetic SD-rat.
신자경(Ja Kyoung Shin),박천욱(Chun Wook Park),김종민(Jong Min Kim),이철헌(Cheol Heon Lee) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.1
We report two cases of multiple neurilemmomas occured in a 17-year-old female and in a 76-year-old male. Both cases were histopathologically confirmed as neurilemmoma and immunohistochemical study showed S-100 protein in the tumor cells of case 1. (Kor J Dermatol 1993; 31(1): 139-142)
보문 : Aspergillus oryzae를 이용한 배 착즙박 누룩의 제조 및 막 걸리 발효특성
신자원 ( Ja Won Shin ),김영헌 ( Young Hun Kim ),김재호 ( Jae Ho Kim ),나광출 ( Kwang Chul Na ),이종수 ( Jong Soo Lee ) 한국균학회 2013 韓國菌學會誌 Vol.41 No.4
In order to develop new valuable pear marc nuruk and further, reduce environmental pollution by pear marc from pear juice processing, we prepared pear marc nuruk by incubation of Aspergillus oryzae into pear marc containing 50% of moisture at 30oC for 7 days. α-Amylase and glucoamylase activities of the pear marc nuruk were 320.2 IU and 442.8 IU, respectively and its acidic protease activity was showed 142.6 IU. After brewed makgeolli by using the pear marc nuruk, cooked rice and Saccharmyces cerevisiae, its physicochemical characteristics was investigated. Ethanol content of pear marc nurukmakgeolli was 6.8% after fermentation at 25oC for 10 days and also pear marc makgeolli showed 45.6% of antihypertensive angiotensin I-converting enzyme (ACE) inhibitory activity. In conclusion, pear marc nuruk had high amylase activity and pear marc-makgeolli had also good fermentation characteristics and antihypertensive ACE inhibitory activity. Therefore, it has the potential to become a new nuruk for brewing makgeolli.
Kikuchi병 ( Subacute Necrotizing Lymphadenitis )
신자경(Ja Kyoung Shin),이윤정(Yun Jeong Lee),안혜경(Hye Kyoung Ahn),박천욱(Chun Wook Park),이철헌(Cheol Heon Lee) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.5
Kikuchi's disease is a self-limiting lymphadenitis, predomin;intly of young women who present with cervical lymphadenopathy. We present a case of Kikuchis disease in a 18-year-old female, representing multiple tender subcutaneous mass on her neck, left eyelid and posteriarcuricle. Histopathologically, the biopsied mass was a lymph node showing architectural effacement by necrotic focicomposed of nucear karyorrhexis and mononucl ar cell proliferation. (Kor J Dermatol 1992;30(5):665-668)
신자경(Ja Kyoung Shin),장훈영(Hun Young Jang),박천욱(Chun Wook Park),이철헌(Cheol Heon Lee) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.4
Lymphangiectasia is a rsre occurrence, and may be due to an undgrlying disturbance of the lymph flow following surgery or irrediation. We present an unusual case of an extensive lymphangictasia of the vulva following radical abdominal hysterectomy and irradiation for cervical cancer. (Kor J Derrnatol 1994; 32(4): 744-748)
신자경(Ja Kyoung Shin),안혜경(Hye Kyoung Ahn),박천욱(Chun Wook Park),김종민(Jong Min Kim),이철헌(Cheol Heon Lee) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.5
A clinical and histologic survey was done on 71 cases of basal cel carcinoma(BCC) filed at Department of Clinical Fathology, Kang Nam, Han Kang, and Kang Dong Sacred Heart Hospital during past 13 year s from 1979 to 1991. The results were summerized as follows: 1. Of all malignant skin tumors BCC accounted for 31.6%. The frequency of BCC in the total number of outpatients visiting the Department of Dermatology was 0.06%. 2. The ratio of men to women with HCC was 1:1.03. 83.8% of the pat.ients with BCC were older than the age of l0 years with the mean age of 56.9 years. 3. 83.8% of the BCC appared in the face, especially on the nose(25.4%), eyelid(20.3%). 4. On the basis of classification of Lever et al, the solid type(66.7% ) was the most com mon histologic pattern, followed by the adenoid(8.8%), pigmented(8.8%), and etc. By the classification of Farmer et al, the nodulocystic type(35.1% ) was the most common histologic pattern followed by infiltrative(31.6%), adenoid(8.8%), pigmented(8.8% ), and etc. By the classification on Sexton et al, in the order of decreasing frequency, liistologic subtypes were the nodular(43.9%), mixed (22.8%), infiltrative(19.3%), supeficial(3.5%), morpheic(3.5%), and micronodular(3.5%). (Kor J Dermatol 1992;30(5):585-591)
신자경(Ja Kyoung Shin),강윤서(Yun Seo Kang),박천욱(Chun Wook Park),이철헌(Cheol Heon Lee) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.3
Tego (dodecylic aminoethyl glycine HCl) is an antiseptic detergent used abroad in hospitals, food industries, public baths, and for cleaning machinery. Allergic contact dermatitis may occur in hospital operating-room personnel, swimming instructors, and deep-sea divers. We present two cases of allergic contact dermatitis to Tego in two siblings after dressing the accidental abrasion with Tego . The patch test results showed a strong positive reaction to 0.1% Tego. (Kor J Dermatol 1992; 30(3): 385-388)