인진호(茵蔯蒿) 추출물이 과산화지질 투여한 쥐의 지질강하, 항산화효과 및 염증매개물질의 생산에 미치는 영향

공인표 ( In Pyo Kong ),이은 ( Eun Lee ),차윤엽 ( Yun Yeop Cha ) 한방재활의학과학회 2011 한방재활의학과학회지 Vol.21 No.1

Objectives: The present study investigated effects of Artemisia Capillaris Thunberg ethanol extract (EtOH ext). on lowering lipid, anti-oxidation and concentration of plasma inflammatory mediators using rat fed on high oxidized fat. Methods: We divided fat sprague-dawley rats fed on high oxidized into 4 groups. They were normal group, feed with 100 mg/kg Artemisia Capillaris Thunberg group, feed with 200 mg/kg Artemisia Capillaris Thunberg group and feed with 300 mg/kg Artemisia capilaris Thunberg group. They were administered for 4 weeks. We measured concentration of plasma free fatty acid(FFA), plasma triglyceride, plasma total cholesterol, and plasma low density lipoprotein-cholesterol(LDL-cholesterol), plasma high density lipoprotein-cholesterol(HDL-cholesterol), concentration of liver total cholesterol and liver triglyceride (TG), concentration of plasma thiobarbituric acid reactive substance(TBARS) and liver thiobarbituric acid reactive substance(TBARS), glutathione peroxidase (GSH-Px) activity, superoxide dismutase(SOD) activity and catalase(CAT) activity, plasma nitric oxide(NO), ceruloplasmin and α-glycoprotein. Results :1. The Artemisia Capillaris Thunberg EtOH ext. groups showed low concentration of plasma FFA, plasma triglyceride, plasma total cholesterol and plasma LDL-cholesterol compared to control group. However, concentration of plasma HDL-cholesterol was increased in the Artemisia Capillaris Thunberg EtOH ext. groups. 2. Concentration of liver total cholesterol and liver TG showed a significantly decrement in all Artemisia Capillaris Thunberg EtOH ext. groups than that of control group. 3. The Artemisia Capillaris Thunberg EtOH ext. groups showed lower values in concentration of plasma TBARS and liver TBARS than that of control group. The values of GSH-Px activity, SOD activity and CAT activity were increased in the Artemisia Capillaris Thunberg EtOH ext. groups. 4. The values of plasma NO, ceruloplasmin and α-glycoprotein were decreased in Artemisia Capillaris Thunberg EtOH ext. groups. Conclusions :Based on the results in this study, the Artemisia Capillaris Thunberg EtOH ext. showed a positive effect in lowering lipid, anti-oxidation and decrement of plasma inflammatory mediators.

五積散加味方이 고지방식이 유도 비만쥐의 지질대사, 항산화계 및 전염증성 cytokine 생산에 미치는 영향

공인표 ( In Pyo Kong ),박원형 ( Won Hyung Park ),차윤엽 ( Yun Yeop Cha ) 한방재활의학과학회 2011 한방재활의학과학회지 Vol.21 No.4

Objectives: This study was designed to examine the effects of extracts of Ojeoksangamibang(Wujisanjiaweifang) on the lipid lowering, anti-oxidation and concentration of proinflammatory cytokines and was investigated on hyperlipidemic rats. Methods: Male rats weighing 182.39±4.71 g were fed high fat diet for 8 weeks and 36 rats(above 400 g) were divided into 4 groups. Each of 9 rats was divided into a control group and experimental groups. We fed a control group of rats a basal diet and administered normal saline(100 mg/kg, 1 time/1 day) for 4 weeks. And we fed each experimental group of rats basal diet and administered an extract of Ojeoksangamibang(Wujisanjiaweifang) extracts(100 mg/kg, 200 mg/kg, 300 mg/kg, 1 time/1 day) for 4 weeks. At the end of the experiment, the rats were sacrificed to determine their chemical composition. We measured lipid of plasma and liver, concentration of proinflammatory cytokines, anti-oxidative activity and TNF-α, Apo-B, Apo-E and leptin gene expression. Results: 1. Concentration of plasma free fatty acid(FFA) showed no significant difference in all the treatment groups. Concentration of plasma triglyceride(TG) showed a significant decrement in the 300 mg/kg in Ojeoksangamibang(Wujisanjiaweifang) groups than that of control group. 2. Concentration of plasma total cholesterol showed a significant decrement in the 200 and 300 mg/kg in Ojeoksangamibang(Wujisanjiaweifang) groups than that of control group. Concentration of plasma low density lipoprotein(LDL)-cholesterol showed a significant decrement in the 300 mg/kg in Ojeoksangamibang(Wujisanjiaweifang) groups than that of control group. Concentration of plasma high density lipoprotein(HDL)-cholesterol showed a significant increment in the 300 mg/kg in Ojeoksangamibang(Wujisanjiaweifang) groups. 3. Concentration of liver total cholesterol showed a tendence to decrease in Ojeoksangamibang(Wujisanjiaweifang) groups. Concentration of liver TG showed a significant decrement in all Ojeoksangamibang groups than that of control group. 4. Concentration of plasma and liver thiobarbituric acid reactive substance(TBARS) showed a tendence to decrease in Ojeoksangamibang(Wujisanjiaweifang) groups. 5. The values of glutathione peroxidase(GSH-Px), superoxide dismutase(SOD) and catalase(CAT) activity showed a significant increment in all Ojeoksangamibang (Wujisanjiaweifang) groups than that of control group. 6. The values of plasma aspartate aminotransferase(AST) and alanine aminotransferase(ALT) activity showed no significant difference in all treatment groups. 7. Concentration of plasma interleukin(IL)-1β showed no significant difference in all the treatment groups. Concentration of plasma IL-6 showed a significant decrement in the 300 mg/kg in Ojeoksangamibang(Wujisanjiaweifang) groups than that of control group. Concentration of plasma tumor necrosis factor-α (TNF-α) a significant decrement in the 200 and 300 mg/kg in Ojeoksangamibang(Wujisanjiaweifang) groups than that of control group. However the concentration of plasma IL-10 in the 300 mg/kg Ojeoksangamibang(Wujisanjiaweifang) groups showed a significant increment than that of control group. 8. Concentration of liver IL-1β, TNF-α, IL-6 and IL-10 showed no significant difference in among treatment groups. 9. In the analysis of reverse transcription-polymerase chain reaction(RT-PCR), gene expression of TNF-α, Apo-B and Apo-E in the Ojeoksangamibang (Wujisanjiaweifang) groups showed a lower expression than that of control group. However the gene expression of leptin showed no difference in the treatment groups. 10. The ratio of TNF-α, Apo-B and Apo-E per β-actin expression in the Ojeoksangamibang(Wujisanjiaweifang) groups showed a significant decrement than that of control group. However The ratio of leptin expression per β-actin expression showed no significant difference among all the treatment groups. Conclusions: According to above results, in lowering lipid effect, anti-oxidation and control of pro-inflammatory cytokines production, Ojeoksangamibang(Wujisanjiaweifang) gives positive effect.

영양소 결핍으로 유도한 성장장애 흰쥐에서 龍玉膏가 성장 및 학습효과에 미치는 영향

공인표(In Pyeo Kong),차윤엽(Yun Yeop Cha) 한의병리학회 2008 동의생리병리학회지 Vol.22 No.3

Development of Simulation model for 2 kW class weeding robot power transmission system

I. P. Kong(공인표),S. Y. Baek(백승윤),J. H. Lee(이준호),M. J. Park(박민재),Y. J. Kim(김용주) 유공압건설기계학회 2022 유공압건설기계학회 학술대회논문집 Vol.2022 No.12

수치료(水治療) 중 온천요법의 한의학적 문헌고찰 및 효능에 대한 연구

김동건,허성규,김유진,허영진,공인표,한석훈,조영호,공경환,정수현,차윤엽,Kim, Dong-Gun,Heo, Seong-Kyu,Kim, Eu-Gene,Heo, Young-Jin,Kong, In-Pyo,Han, Seok-Hun,Cho, Young-Ho,Kong, Kyung-Hwan,Jeong, Su-Hyeon,Cha, Yoon-Yeop 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.2

Objectives : The purpose of this study is to consider the definition, history, classification and clinical effect of balneotherapy. Methods : We researched oriental documents and recent sources of balneotherapy. Results and Conclusions : 1. Balneotherapy is medical cure method which uses physical chemistry effects of water. 2. Records of balneotherapy are seen in oriental documents such as Hwangjenaegyeong(黃帝內經), Sinnongbonchogyeong(神農本草經), Jaebyoungwonhuron(諸病源候論), Youmoonsachin(儒門事親), Bonchogangmok(本草綱目) and Donguibogam(東醫寶鑑) etc. 3. Spa can classify eleven types according to ingredient. The types were as following. Simple thermal spirng, Common salt spring, Sodium bicarbonated spring, Sulfate spring, Radioactive spring, Acid spring, Sulfur spring, Carbon dioxide spring, Iron spring, Alum spring & Sulfate-iron spring, Bicarbonatealkaline spring. 4. Physical, chemical and environmental effect of spa therapy have effectiveness on the chronic and we akness disease more than acute disease. And balneotherapy have more effectiveness on digestive disease, pulmonary disease, metabolic disease, circulatory disease, muscle skeletal disease and dermatologic disease than any other diseases.

자주식 땅속 작물 수확기 개발을 위한 감자 수확 작업 간 소요동력 분석

박민종(M. J. Park),전현호(H. H. Jeon),공인표(I. P. Kong),백승민(S. M. Baek),김용주(Y. J. Kim) 유공압건설기계학회 2022 유공압건설기계학회 학술대회논문집 Vol.2022 No.12

한방비만치료의 여성노인환자 치험1례

김유진 ( Eu Gene Kim ),차윤엽 ( Yun Yeop Cha ),김동건 ( Dong Gun Kim ),허성규 ( Seong Kyu Heo ),허영진 ( Young Jin Heo ),한석훈 ( Seok Hun Han ),공인표 ( In Pyo Kong ) 한방비만학회 2007 한방비만학회지 Vol.7 No.1

This study was performed to evaluate the effect of oriental medical treatment on aged female obese patient. Methods : We experienced an aged female obese patient. We applied herbal medication(Choweseuncheng-tang), electrolipolysis, auricular acupuncture to her from 26th, March. 2007 to 25th, May. 2007. And we examined the changes of her weight, body composition, body size, skin resistance variability, visual analogue scale of knee pain. Results : 1. Her weight decreased from 73.5kg to 71.1kg and body mass index(BMI) decreased from 29.46kg/m2 to 28.11kg/m2. 2. Body fat mass(BFM) decreased from 25.7kg to 21.6kg but body muscle mass(BMM) increased from 45.1kg to 46.7kg. 3. Waist-hip ratio(WHR) decreased from 0.96 to 0.92. 4. Basal metabolic rate(BMR) increased from 1,273kcal to 1,314kcal. 5. The circumference of upper extremity decreased 1.03cm and lower extremity decreased 1.30cm but the circumference of the muscle of upper extremity increased 0.41cm and lower extremity increased 0.63cm. 6. The circumference of chest and hip are decreased. In addition to the circumference and fat of abdomen are decreased. 7. The visual analogue scale of knee pain is improved. Conclusions : According to above results, oriental medical treatment could be used safety to aged obese patients without loss of fat free mass. The study is more required to aged obese patient from now on.