Carboplatin의 용량 결정방법 분석

강효선,최수안,유순호,이병구,손인자 한국병원약사회 2002 병원약사회지 Vol.19 No.3

Carboplatin[cis-diamine(1, 1-cyclobutanedicarboxylato) platinum(Ⅱ), CBDCA] is a second-generation platinum-containing compound with proven activity against a range of malignant solid tumors. Carboplatin is much less nephrotoxic, neurotoxic, and emetogenic than it's parent compound cisplatin. It's dose-limiting toxicity is myelosuppression, particulary thrombocytopenia. Thrombocytopenia is strongly dependent on the area under the curve(AUC) of plasma carboplatin concentration as a function of time. Moreover, carboplatin AUC seems to correlate with therapeutic outcome. Carboplatin clearance is dependent on patient's renal function. So, carboplatin dosage is calculated using individual patient's renal function and AUC. Because carboplatin dosing method is different from other chemotherapeutic agents dosing methods, evaluation of accuracy of dosage calculation and pharmacist's dosage check may be necessary. The aim of this study was to be convinced of this. Also, at present in Seoul National University Hospital, they calculate carboplatin dosage by Calvert formula and Cockcroft & Gault equation based on body weight. We have attempted to evaluate the difference between the carboplatin dosages determined using actual body weight(ABW) and those determined using ideal body weight(IBW). The medical chart of sixty-five patients with non-small cell lung cancer(NSCLC), who received carboplatin, taxol regimen from January 2001 to October 2001 was reviewed retrospectively. Patients were ineligible for entry if they met the following criteria : (a) age>75 years; (b) origin is not lung. Data collection and analysis included ABW, IBW, renal function, calculated dosage, dosage determined using ABW and IBW. Sixty-five patients were entered into the study. There is no significant difference between dosages determined using ABW and IBW(t-test, p>0.01). This has no consideration for individual weight difference. We divide patients into two criteria; (1) patients: ABW>IBW(n=37), (2) patients : ABW<IBW(n=28) and analyze each criteria. The patient criteria (1) has significant difference of weight, creatinine clearance, calculated dose(t-test, p<0.01). Especially the patients that have more than 10% difference between ABW ad IBW have greater dosage determined using ABW than dosage determined using IBW. This is the same result as the patient criteria (2). In summary, carboplatin dosing for patients who have difference(≥10%) between ABW and IBW determined using IBW is necessary to minimize toxic effect and optimize carboplatin dosing.

교과 목표-평가의 유기적 연계 방안 탐색 : IB 교육과정 중등 프로그램(MYP) '개인과 사회'를 중심으로

강효선 제주대학교 교육과학연구소 2022 교육과학연구 Vol.24 No.1

This study aims to explore an alignment of subject objectives and assessment. In this study, IB MYP documents, subject guides and assessments from a sample MYP individuals and societies unit were analyzed. As a result of the analysis, first, the subject objectives correspond to assessment criteria. Second, MYP provide subject objectives and assessment criteria for years 1, 3 and 5. Each objective and criterion is elaborated by a number of strands which are an aspect or indicator of the learning expectation. The command terms which have been classified following Bloom’s taxanomy of educational objectives are part of objectives and assessment criteria. Lastly, MYP each criterion has nine possible level of achievement(0-8), divided into four bands. Each band has its own unique descriptors in terms of students’ progress and achievement which helps to clarify the expectation for assessment. 본 연구는 교과 목표-평가의 유기적 연계 가능성을 모색하기 위해 IB 교육과정의 중등 프로그램 MYP의‘개인과 사회’교과를 중심으로 고찰하였다. 이를 위해 IB 교육과정의 MYP 총론에 해당하는 문서들과 ‘개인과 사회’교과 해설서, 예시 교과서 단원의평가 문항들을 분석하였다. 분석 결과 MYP에서는 평가를 통해 교과 목표에 대한 도달도를 종합적으로 확인할 수 있는 다양한 장치를 마련하고 있다는 점을 확인하였다. 첫째, MYP에서는 교과의 목표를 구성하는 항목들과 평가 기준의 항목들을 일치시켜 평가를 통해 교과 목표에 대한 도달 정도를 명시적으로 파악할 수 있게 구조화하고 있었다. 둘째, MYP는 교과 목표와 평가기준에 근거해 학년군 목표와 학년군 평가기준을 별도로제시하고 있었다. 이러한 학년군 목표 및 평가기준 서술시에는 Bloom의 교육목표분류학에 근거해서 개발한 MYP 행동 동사인 지시어를 적극적으로 사용하여 학습의 위계성을드러내고 있었다. 마지막으로, 교과 목표와 평가기준을 구성하고 있는 각 항목들이 일반적으로 어떤 의미인지 설명하고 각 항목들의 구체화를 위해 항목별 세부영역들을 제시하고 있었다. 특히 평가기준에서는 각 세부영역에 대한 도달 정도를 8점 척도의 성취수준으로 진술하여 평가기준의 명세화를 통해 교육목표 도달도를 종합적으로 확인할 수있는 장치를 마련하고 있었다

중환자실 간호사들의 조직문화 유형이 직무몰입에 미치는 영향

강효선,박현주 한국산학기술학회 2023 한국산학기술학회논문지 Vol.24 No.12

This study was conducted to identify the organizational culture of intensive care unit (ICU) nurses and determine the impact of organizational culture on their job commitment. The participants of this study included 168 nurses working in the ICUs from 7 general hospitals with more than 300 beds. To analyze the data, descriptive statistics, t-test, one-way ANOVA, Scheffé test, Pearson's correlation, and hierarchical multiple regression were performed with using SPSS Statistics 24.0 Program. As a result of this study, among the organizational culture type, hierarchy-oriented culture had the highest score (3.41±0.51), and followed by the scores of relationship-oriented culture (3.24±0.67), innovation-oriented culture (3.22±0.62), and task-oriented culture (2.52±0.71). As a result of hierarchical multiple regression analysis to identify factors affecting job commitment, hierarchy-oriented culture, relationship-oriented culture, and work-oriented culture did not have significant effect on job commitment, and only innovation-oriented culture (β =.20, p =.028) had a significant effect. Additionally, among covariates, work unit and self-efficacy did not show significant effect on job commitment. Only self-leadership (β =.34, p <.001) were significant. The statistical model explained 40.0% of job commitment. Therefore, the job commitment of intensive care unit nurses would be improved if interventions are applied to spread innovation-oriented culture and increase nurses' self-leadership in intensive care units.

Enhanced Mechanical Properties of Poly(vinyl chloride) using Hexene-doping Graphitic Nanoplatelets

강효선,전인엽 한국고분자학회 2023 한국고분자학회 학술대회 연구논문 초록집 Vol.48 No.2

IB 교육과정 MYP 통합 수업 설계와 내용 체계

강효선 한국교육학회 2018 한국교육학회 학술대회 Vol.2018 No.-

유쾌하고 따뜻한 반란, 있ᄉ는잔치

강효선 도서출판여이연 2024 여성이론 Vol.- No.49

IB(International Baccalaureate) 교육과정의 핵심 개념 의미와 성격 탐색

강효선(Hyoseon Kang) 학습자중심교과교육학회 2020 학습자중심교과교육연구 Vol.20 No.4

본 연구는 IB(International Baccalaureate) 교육과정 MYP(Middle Years Programme)의 핵심 개념의 의미와 성격을 분석하여 한국 교육과정에 주는 시사점을 도출하는 데 목적을 두었다. 이를 위하여 MYP의 총론에 해당하는 ‘MYP의 원리와 실제(MYP: From principles into practice)’와 MYP의 8개 교과 해설서들을 집중적으로 분석하였다. 분석 결과, IB의 핵심 개념은 ‘교과와 과목을 가로지르는 광범위하고 구조화된 강력한 아이디어’로써, 범교과적인 성격을 지니고 있는 것으로 나타났다. 이러한 핵심 개념은 교과를 심층적으로 이해하고 지식의 전이를 가능하게 하며, 통합학습의 원리로써 작용하는 것으로 드러났다. 마지막으로 이러한 MYP의 교육과정 문서 분석 결과를 토대로 IB의 핵심 개념이 2015 개정 교육과정에 주는 시사점을 도출하였다. This study aims to analyze IB(International Baccarlaureate) MYP(Middle Years Programme) curriculum frameworks in terms of key concepts and found its implication on the framework of revision of 2015 Korean National Curriculum. To achieve these goals, IB publications which provide a guide to teaching and learning of the MYP has been reviewed. IB key concepts lead students towards deeper understanding of the subject group, integration with multiple disciplines appreciation of ideas that transfer and apply ideas and skills to new situations constructing meaning as they become able to create personal relevance and transfer knowledge and take responsibility for their own learning. The importance of principles and practices for achieving educational goals is highlighted. Thus the findings from this research have implications for the frameworks of 2015 revised national curriculum.

학습자의 심리적 거리에 따른 지역 변화의 인식과 반응

강효선 ( Kang Hoyseon ),김기남 ( Kim Kinam ) 한국지리환경교육학회 2017 한국지리환경교육학회지 Vol.25 No.2

본 논문은 환경의 변화가 예상되는 지역 개발 사업에 대한 학습자의 반응이 어떻게 달리 나타나는지를 알아보기 위한 실험 연구로 진행되었다. 제주도에 거주하는 학생들을 동일한 지역 개발 사업에 대해서 심리적 거리를 달리하는 조건으로 구분하였을 때 그 사업에 대해 해석수준(이해의 추상 수준)을 달리하여 이해하는지를 알아보는 연구였다. 해석수준은 기존의 연구들을 통해 구성된 행동개념화 척도 문항을 구성하여 측정하였다. 첫번째 실험에서 학생들은 같은 지역의 변화에 대해 아르헨티나로 인식했을 때보다, 제주도로 인식했을 때 보다 구체적으로 생각하고 반응했다. 두 번째 실험에서는 시간 거리와 공간 거리를 각각 달리하여 심리적 거리를 조정하였고 그에 대한 반응을 살펴보았다. 결과는 공간 거리에 따른 변인에 대해서만 해석수준이 다르게 나타나는 결과를 보였다. 지역 변화가 나타나는 시점을 달리한 것에 대해 학생들의 반응은 차이가 나타나지 않았다. This paper was conducted as an experimental study to investigate the different responses of learners to development projects in which environmental changes were expected. This study examined the differences in the construal level of students living in Jeju Island when students were differentiated by different psychological distance for the same regional development project. The level of interpretation was measured by the Behavior Identification Form, which was constructed by referring to previous studies. In the first experiment, the students responded to a lower level concretely when they recognized the changes in Jeju Island if they were asked to recognize the changes in Argentina for instance it would be abstract. In the second experiment, the psychological distances were manipulated so that the time distance and the spatial distance were different, and the response was examined. The results show that the interpretation level is different only for the variable depending on the spatial distance. The students did not react differently when the time of local change in Jeju Island changed.

Edward W. Said의 오리엔탈리즘에서 지역구분 방법의 한계와 그 한계를 극복하기 위한 방안

강효선 ( Hyo Seon Kang ) 서울대학교 지리교육과 2011 地理敎育論集 Vol.55 No.-

에드워드 사이드는 오리엔탈리즘(Orientalism)을 ``동양과 서양이라는 인식론적인 구별에 근거한 사고방식``이자, ``동양을 지배하고 재구성하며 억압하기 위한 서양의 제도 및 스타일``로 정의한다. 유럽의 동쪽에 퍼진 지리적 공간을 동양이라고 규정하는 수세기 동안의 낡은 방식은 정치적이기도 했고, 이데올로기적이기도 했다. 오리엔탈리즘의 지역구분의 한계는 인간과 지표현상의 다양성 보다는 동양과 서양이라는 두 대상의 차이에 주목한 결과이다. 이러한 오리엔탈리즘의 지역구분 방법의 한계를 지적하고, 이러한 한계의 극복을 통해서 인종적, 민족적, 국민적인 구별 이상으로 인간 사회를 조명할 수 있는 방법으로 지리학의 지역연구의 방법을 소개한다. Orientalism is a style of thought based upon ontological and epistemological distinctions made between the East and the West, and a form of invention used by the West to reinterpret the meaning of certain territories and to create discourses justifying the need for control over such reimagined places. From this perspective, Edward W. Said`s understanding of ``Orientalism`` caused political and ideological discourses. The limitations of the methods of regional division in ``Orientalism`` include Western authors` frequent use of the idea of ``the Orient`` as a screen upon which they could project their own vision of the East and what was ``varying`` being less important than its ``different`` significance. This paper aims to inspire further this pondering over the regional study and shed light on human society.

종합병원 중환자실 간호사의 노동조합 활동 경험

김민섭,강효선,이혜경,이동숙 대한질적연구학회 2024 대한질적연구학회지 Vol.9 No.1

Purpose: The study aim was to understand the experiences of intensive care unit (ICU) nurses in labor union activities. Methods: A descriptive qualitative study and content analysis were conducted. The participants included nine ICU nurses who shared their experiences with labor union activities. The data were collected through in-depth interviews. Results: The experiences of ICU nurses with labor union activities encompassed five themes: “The Initial Step in Union Activities”, “Benefits Derived from Union Participation”, “Concerns Regarding Union Activities”, “The Non-Omnipotence of Unions”, and “Achieving Mutual Benefits through Union Activities”. Conclusion: The study findings revealed that ICU nurses strive to improve their work and the nursing environment through labor unions, despite facing negative perceptions of union involvement.