분쇄기에 의한 얼굴 관통창 1례

강진아 ( Jin Ah Kang ),김강호 ( Kang Ho Kim ),백진휘 ( Jin Hui Paik ),홍대영 ( Dae Young Hong ),김지혜 ( Ji Hye Kim ),이경미 ( Kyoung Mi Lee ),김준식 ( Jun Sig Kim ),한승백 ( Seung Baik Han ) 대한외상학회 2006 大韓外傷學會誌 Vol.19 No.1

Penetrating facial wounds are uncommon and are usually life threatening because of the possibility of brain damage. There are three possible pathways for penetrating the cranium through the orbit: via the orbital roof, via the superior orbital fissure, or between the optic canal and lateral wall of the orbit. Brain injuries resulting from the penetrating wounds show extensive parenchymal damage, hemorrhage, and brain edema. Transorbital penetrating wounds can lead to diverse lesions of the optical apparatus, including the eye globe, the optical nerve, and the chiasm. Moreover, intracerebral structures may be hurt, and bleeding and infection may occur. Early diagnosis and prompt debridement are the fundamental factors affecting the outcome of a penetrating facial wound. An 87-year-old man was admitted to the emergency department with a grinder impacted into the medial aspect of the right eye. On presentation, the man was fully conscious with a Glasgow Coma Scale score of 15 and complained of a visual disturbance of the right eye. Computed tomography demonstrated a right orbital medial and inferior wall fracture, a frontal bone fracture, and a contusional hemorrhage in frontal lobe of the brain. A craniotomy with hematoma removal and repair of the orbital floor was done. He showed no neurological deficits except right visual loss. This appears to be the first report of a man with a penetrating facial wound caused by a grinder, who presented with a potentially disastrous craniocerebral injury that did not lead to any serious neurological seguelae. (K Korean Soc Traumatol 2006;19:89-92)

간장 ( 肝腸 ) 및 담도 ( 膽道 ) : 만성 B 형 활동성 간염 환자에서 Prednisolone 이탈요법후의 베타인터페론 병용투여의 치료효과

강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),박인서(In Suh Park),문영명(Yong Myung Moon),이상인(Sang In Lee),한광협(Kwang Hyub Han),전재윤(Chae Yoon Chon),김원호(Won Ho Kim),김경희(Kyung Hee Kim),신준한(Joon Han Shin) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3

N/A To evaluate the efficacy of a short course of prednisolone withdrawl followed by human B- interferon (HuIFN-B) treatment with chronic active hepatitis B(CAHB), 32 patients with peritoneoscopic liver biopsy proven CAHB were randomized to receive a 3 week tapered course of prednisolone followed by HuIFN-B or HuIFN-B alone. All patients were HBeAg positive and two groups were comparable with respect to age, sex and biochemical and histologic data. Interferon was administered in a dose of 6.0*10 IU per day for I week and 3.0*10 IU per day for successive 3 weeks by intravenous drip infusion. Treatment side-effects occurred in all treated patients but the treatred patients all tolerated and concluded treatment without serious side effects enough to give up the trials. The seronegative and seroconversion rates for the patients treated with prednisolone withdrawl+ HuIFN-B were 50.0% (10 cases out of 20) and 45.0% (9cases out of 20) respectively at last follow up after the treatment. These rates were apparently higher than seronegative rate of 25.0% (3 cases out of 12) and seroconversion rate of 16.7% (2 cases out of 12) in patients treated with HuINF-B alone. Sustained loss of serum HBV DNA & normalization of serum ALT was maintained in 65% (13 cases out of 20) at 6 month after steroid withdrawl+HuIFN-B treatment. Comparison of responders (n=9) to non-responders in patients with steroid withdrawl+ HuINF-B treatment indicated that there was no significant difference in age, sex and pretreatment ALT levels and HBV-DNA values. In conclusion, these results suggest that a short course of prednisolone withdrawl followed by HuINF-B can be more effective than HuIFN-B alone for the selected patients with HBeAg positive CAHB.

조건부 수요분석법을 적용한 공동주택의 용도별 상세 에너지사용량 추정모델 개발

강진경(Kang, Jin-Kyung),김성임(Kim, Sung-Im),진혜선(Jin, Hye-Sun),임수현(Lim, Su-Hyeon),임재한(Lim, Jae-Han),송승영(Song, Seung-Yeong) 한국건축친환경설비학회 2017 한국건축친환경설비학회 논문집 Vol.11 No.2

Establishing effective Action-Plan toward the reduction of energy consumption in apartment building units requires information on end-use energy consumption by usage ultimately consumed by residents, but relevant classification and definition by usage and the resulting data collection were not available in domestic circumstance. The purpose of this study is to develope estimation model of end-use energy consumption by usage in order to provide the data for end-use energy consumption by usage consumed ultimately by residents in apartment building units using the data on energy consumption by energy sources of the households. For this purpose, analyzed features on end-use energy consumption by usage by capitalizing on measurement data and household features, and based on the derived effective influence factors, estimation model was developed, and estimation regression equation was derived. This study can be utilized as fundamental material on data about estimating end-use energy consumption by usage by putting simple features of residents as input variables.

몇가지 관해유도요법제에 의한 급성임파구성 백혈병의 관해율

강진형(Jin Hyoung Kang),진종률(Jong Youl Jin),홍영선(Young Seon Hong),한치화(Chi Wha Han),박종원(Jong Won Park),김춘추(Choon Choo Kim),김동집(Dong Jip Kim),김학기(Hack Ki Kim) 대한내과학회 1987 대한내과학회지 Vol.32 No.5

N/A The case analysis of 74 patients, who were admitted to St. Mary's hospital from Jan, 1982 to Dec. 1986, and had a diagnosis as acute lymphocytic leukemia by bone marrow aspiration and biopsy was conducted. Of all the patients, the number of patients who were treated with VP regimens were 7, VPM regimens 6, VP, L-asp. regimens 4, L2, regimens 28, Modified L, regimens 15, miscellaneous regimens 3 for induction of complete remission. All of them were 63. We could find several interesting informations about the CR rate, duration of CR, survival rate between several prognostic factors. The CR rate in VP regimens was 42.9%, VP. L-asp. regimens 60.7%, L, regimens 67.9%, Modified L, regimen 93.3% According to the FAB classification, there were no difference in CR rate. (L1 76.2%, L2 70.3%, L3 80%) In patients who had CHOP regimen as consolidation, median, duration of CR was longer (6.6 months) than that in patients without CHOP (3.8 months). In the comparison of duration of survival between the immunologic classification, median duration of survival in C-ALL was 12 months and T-ALL was 4.5 months. We might come to conclusion as follows; 1) Modified L2 regimen is superior to other regimens to bring CR. 2) Early consolidation therapy give us more longterm disease free survival. 3) The survival rate of C-ALL is better than that of T-ALL.

간의 국소적 지방 침윤 1예

강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),정재복(Jae Bock Chung),한광협(Kwang Hyub Han),김원호(Won Ho Kim),박찬일(Chan Il Park),유형식(Hyung Sik Yoo),김중영(Joong Young Kim),한은경(Eun Kyung Han) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.2

N/A Focal fatty infiltration of the liver, a poorly characterized entity, was discovered incidentally at postmortem examination in the past, After both ultrasound and computed tomography (CT) have been extensively used over the past few years for imaging the hepatic parenchyma, it was possible to demonstrate focal fatty infiltration of the liver. Focal fatty infiltration of the liver may simulate mass lesions, so it is important to distinguish from space occupying lesions of the liver. Recently we encountered a case of focal fatty infiltration of the liver, which mimicked a liver tumor. It was detected by ultrasound and we performed abdominal CT, RBC liver scan, angiography and ultrasound guided needle biopsy. The diagnosis of focal fatty infiltration of the liver was established histologically.

국내 공동주택 단위세대의 전기에너지 사용 특성 분석

강진경(Kang, Jin-Kyung),진혜선(Jin, Hye-Sun),김성임(Kim, Sung-Im),최보혜(Choi, Bo-Hye),임재한(Lim, Jae-Han),송승영(Song, Seung-Yeong) 대한건축학회 2015 대한건축학회 학술발표대회 논문집 Vol.2015 No.-

공동주택 단위세대의 연간 전기기기 에너지사용 특성 분석

강진경(Jin-Kyung Kang),김성임(Sung-Im Kim),진혜선(Hye-Sun Jin),최보혜(Bo-Hye Choi),임재한(Jae-Han Lim),송승영(Seung-Yeong Song) 대한설비공학회 2016 대한설비공학회 학술발표대회논문집 Vol.2016 No.6

The purpose of this study was to analyze occupant behavior of electric appliances consumption and then interaction factors, to estimate end-use energy consumption of apartment units. To do this, samples from apartment units in Seoul were selected, and building energy end-use sub-metering systems were installed in 5 units and the data were measured for 12 months. Additionally in-depth questionnaire survey was conducted for data with occupant characteristics, building and M/E system of apartment units. Based on these, end-use characteristics of electricity consumption were analyzed for apartment housing.

국내 로타바이러스 감염의 역학

강진한 ( Jin Han Kang ) 대한소아감염학회 2008 Pediatric Infection and Vaccine Vol.15 No.1

Primary rotavirus gastroenteritis infection usually occurs in infants under 2 years of age worldwide regardless of level of hvgiene, quality of water, food or sanitation or type of behavior. In Korea, the diseases mostly occurred in infants under 2 years old, and usually in late fall to early winter with the highest incidence shown in November until early 1990s. However, since then, relatively the age incidence of this infection has increased in children over 2 years old, and it has mainly occurred in late winter to early spring with the highest incidence shown between February and March. And rotavirus gastroenteritis serotypes varied year to year as well as varied by year within the same region in our country. The comparison of severity scores between age groups in Korea showed that severity score was lowest in infants less than 3 months and highest in infants more than 6 months and less than 12 months, and hospitalization period between age groups was longest in infants older than 3 months and less than 6 months, In this aspect, rotavirus vaccines should be given to infants less than 2 years of age in whom the incidence of rotavirus gastroenteritis is the highest, and vaccination should be ideally started before 3 months considering hospitalization period and severity of rotavirus gastroenteritis. However, It should be careful for the introduction of new rotavirus vaccine, and the effectiveness of rotavirus Vaccines should be assessed by long-term post marketing surveillance. And we guess a multivalent vaccine may be an ideal rotavirus vaccine to prevent primary infection caused by variable rotavirus strains in Korea. In addition, clinical epidemiology studies on rotavivus gastroenteritis which evluate the age and serotypes related severity should be continuously conducted in various regions.(Korean J Pediatr Infect Dis 2008;15:5-11)

고지방식이 마우스에서 3,5-dicaffeoylquinic acid의 항비만 효과

강진용(Jin Yong Kang),박선경(Seon Kyeong Park),김종민(Jong Min Kim),박수빈(Su Bin Park),유슬기(Seul Ki Yoo),한혜주(Hye Ju Han),김대옥(Dae Ok Kim),허호진(Ho Jin Heo) 한국식품과학회 2019 한국식품과학회지 Vol.51 No.1

이연구는 고지방식이로 인한 비만 및 대사장애에 대한 3,5-diCQA의 효과를 확인하는 동시에 클로로겐산과의 상대적인 생리 활성을 확인하였다. 클로로겐산은 이전에 보고된 연구결과에서처럼 고지방식이를 섭취하는 쥐의 체중 증가를 효과적으로 억제하였으며, 3,5-diCQA와 비교하였을 때에도 그 효과가 상대적으로 우수하였다. 내장지방의 무게를 측정한 결과 3,5-diCQA와 클로로겐산 모두 내장지방의 축적을 효과적으로 억제하였으며, 이러한 이유는 두 샘플 모두 지방조직에서의 AMPK의 활성화가 증가된 것과 관련이 있는 것으로 보인다. 또한 이 두 샘플은 비만으로 인해 발생하는 산화적 스트레스로부터 간조직을 보호하는 효과가 있었다. 그러나 간조직에서의 지방축적을 확인한 결과에서 클로로겐산은 여전히 간의 지방축적을 억제하는 것으로 확인되었지만 3,5-diCQA는 오히려 간의 지방축적을 증가시킨 것이 확인되었다. 이러한 결과는 3,5-diCQA가 간조직에서 Akt의 활성을 증가시킨 것과 관련이 있는 것으로 보이며 이 증가된 Akt로 인해 3,5-diCQA 그룹의 내당능 개선이 클로로겐산 그룹보다도 우수하였지만 간에서의 지방 축적을 증가시킨 것으로 판단된다. This study was performed to confirm the influence of chlorogenic acid (CGA) and 3,5-dicaffeyolquinic acid (3,5-diCQA) intake on problems caused by high-fat diet. CGA was more effective in suppressing weight gain than 3,5-diCQA. In contrast, 3,5-diCQA was more effective in improving glucose tolerance than CGA. In the biopsy, it was confirmed that CGA inhibited visceral fat and liver fat accumulation. 3,5-diCQA also inhibited visceral fat accumulation, but 3,5-diCQA increased liver fat accumulation. The liver fat accumulation induced oxidative stress, but 3,5-diCQA reduced oxidative damage through its antioxidant activity. The increased liver fat accumulation was because a 3,5-diCQA greatly increased Akt phosphorylation and decreased AMPK phosphorylation in the liver. Consequently, CGA was effective in alleviating the problems caused by high-fat diets, while maintaining normal balance. 3,5-diCQA also showed a positive effect on problems caused by high-fat diets, but it increased liver fat accumulation and thereby had negative consequences.

신종·재출현 전염병 관리를 위한 새로운 백신 기술

강진한(Jin-Han Kang) 한국역학회 2006 Epidemiology and Health Vol.28 No.1

  Although the development of vaccines has been one of the most important contributions of immunology to medicine and public health, and despite vaccination having been proven as the most effective and cheapest medical practice to prevent infectious diseases, infectious diseases still remain the main cause of human deaths and new infectious diseases continue to emerge. Furthermore, we face an unprecedented succession of new pathogens able to jump species barriers and infect humans, even as we continue to be frustrated in our efforts to control devastating diseases such as HIV, malaria and tuberculosis. Hence the need to develop new vaccines and improve existing vaccines. Other challenges for scientists include rapid identification and response to emerging diseases and successful intervention in re-emerging infectious diseases.   Remarkable progress in molecular biology and biotechnology is making possible the development and improvement of new and old vaccines. Recombinant DNA technology, genetic attenuation of viral and bacterial pathogens and their use as vectors for heterologous proteins, naked DNA vaccines and peptide vaccines represent the most popular approaches hitherto adopted.   Reverse genetics and reverse vaccinology are now used to investigate new vaccines. Genome-based reverse vaccinology is very useful and a major tool in vaccine development. The rapid identification of the genome sequence to new pathogens enables the speedy development of diagnostic tools as well as recombinant expression of targets for vaccine.   Strengthening research and development in vaccines, including international cooperation, may be the most effective next step to control and prevent infectious diseases worldwide.