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이동우(Dong Woo Lee),강제욱(Je Wook Kang),유승호(Seung Ho Ryu),이강준(Kang Joon Lee),한은주(Eun Joo Han),정한용(Han Yong Jung) 대한노인정신의학회 2006 노인정신의학 Vol.10 No.1
Objectives : The rapid increase of elderly people with dementia poses a strategy for effective management of dementia. The recent progress in pharmacotherapy of dementia have overcome the past therapeutic nihilism, and gives the hope that dementia can be managed by early diagnosis and early intervention. Accordingly, the use of comprehensive neuropsychological test for early diagnosis is emphasized. Methods : In this study, we tried to evaluate the necessity and the usefulness of comprehensive neuropsychological tests in the diagnosis of dementia, by reviewing the guidelines for dementia, the researches about comprehensive neuropsychological tests, and by asking the experts about the necessity and the usefulness of comprehensive neuropsychological tests. Results : As a result we came to know that there are many tests which comprehensively covers the cognitive domains, and can be performed in relatively short time. The guidelines recommend that the use of comprehensive neuropsychological tests should be decided by the clinician. Many experts were the same opinion. Conclusion : There are many useful comprehensive neuropsychological tests, the use of which should be decided by the clinician.
김지순(Ji-Soon Kim),유희정(Hee-Jeong Yoo),조인희(In-Hee Cho),박태원(Tae-Won Park),손정우(Jung-Woo Son),정운선(Un-Sun Chung),신민섭(Min-Sup Shin),김붕년(Bung-Nyun Kim),김재원(Jae-Won Kim),양영희(Young-Hui Yang),강제욱(Je-Wook Kang),송숙 대한소아청소년정신의학회 2011 소아청소년정신의학 Vol.22 No.3
Objective:A significant proportion of children with autism spectrum disorders (ASD) have regression characterized by loss of previously acquired skills. The purpose of this study was to compare demographic, clinical characteristics and autism-related symptomatology of the children who have regression with children who don’t have regression. Methods:The subjects with ASD and their unaffected siblings (SIB) were recruited from the Korean Autism Genetic Study Consortium. Typically developing children (TC) were volunteered from community. The subjects were administered the Korean version of Autism Diagnostic Interview-Revised (K-ADI-R) and the Korean version of Autism Diagnostic Observation Schedule (K-ADOS) to diagnose or exclude ASD. Regression was defined on the basis of K-ADI-R data. The Korean version of Vineland Adaptive Behavior Scale (K-VABS), Aberrant Behavior Checklist (K-ABC) and Social Responsiveness Scale (K-SRS) were obtained from their parents. Results:Regression occurred in 8.33% (n=14) of children with ASD (n=168). Any SIB (n=166) and TC (n=53) did not experience regression. Regression was associated with lower IQ and lower score of K-VABS. There was no difference in autism symptom severity and K-ABC, K-SRS scores, between children with ASD who experienced regression and who did not. Conclusion:Regression seems to be a distinctive feature of ASD. Regression is associated with cognitive and more general functions, rather than symptoms specific to autism.
주의력결핍 과잉행동장애의 신경생물학과 오로스 메칠페니데이트의 작용기전
구영진(Young-Jin Koo),이문수(Moon-Soo, Lee),신동원(Dong-Won Shin),김의정(Eui-Jung Kim),강제욱(Je-Woo Kang),조수철(Soo-Churl Cho) 대한소아청소년정신의학회 2012 소아청소년정신의학 Vol.23 No.S
This article is to review neurobiology of attention-deficit/hyperactivity disorder (ADHD) and pharmacological properties of Osmotic-Controlled Release Oral delivery System Methylphenidate (OROS MPH)(Concerta Oros<SUP>R</SUP>) in celebration of its one-decade clinical experiences in Korea. ADHD is a highly heritable neurodevelopmental disorder, characterized by age-inappropriate inattention, hyperactivity and impulsiveness. The symptoms of ADHD are consistent with dysfunction of the prefrontal cortex (PFC). The PFC functions such as working memory and executive function are powerfully modulated by the catecholamine neurotransmitters, dopamine (DA) and norepinephrine (NE). Methylphenidate (MPH) is a first line treatment for children and adolescents with ADHD in Korea. MPH improves the PFC functions with the mechanism of action being modulation of DA and NE tones by blocking both dopamine transporter (DAT) and norepinephrine transporter (NET). Stimulation of D1 and NE α<SUB>2</SUB> receptors on the postsynaptic neurons may be its main mechanisms of action which improve working memory and behavioral inhibition in patients with ADHD. OROS MPH, one of long-acting MPH, employs an osmotic-releasing oral system (OROS), which has been designed to have 12 hour duration of effect, which permits oncedaily dosing, which has been shown to be as effective as 3-times-a-day immediate-release formulation of MPH (IR MPH). Recently there is growing evidence that OROS MPH has positive effects even on adults with ADHD, in multidimensional aspects; cognitively, emotionally and functionally.
남보라(Bo-Ra Nam),유희정(Hee-Jeong Yoo),조인희(In-Hee Cho),박태원(Tae-Won Park),손정우(Jung-Woo Son),정운선(Un-Sun Chung),신민섭(Min-Sup Shin),김붕년(Bung-Nyun Kim),김재원(Jae-Won Kim),양영희(Young-Hui Yang),강제욱(Je-Wook Kang),송숙형( 대한소아청소년정신의학회 2010 소아청소년정신의학 Vol.21 No.3
Objectives:The purpose of this study was to evaluate the prenatal, perinatal, and infancy history of children with autism spectrum disorder (ASD) as compared to unaffected siblings (SIB) and typically developing children (TC). Methods:Subjects with ASD, their SIB, and TC were recruited. All subjects were assessed using both the Korean version of Autism Diagnostic Interview-Revised (K-ADI-R) and the Korean version of Autism Diagnostic Observation Schedule (K-ADOS) and were subsequently identified as affected or unaffected. Prenatal, perinatal, and infancy history was obtained from the primary caregivers and each facet was compared in those with ASD, the SIB, and the TC groups using SPSS ver. 17.0 (p<.05). Results:70 individuals with ASD (63 males, 87.94±37.8months), 53 SIB (27 males, 85.40±48.06 months), and 32 TC (19 males, 104.19±23.409 months) were analyzed. The ASD group showed significantly higher rates of insufficient vaccination as they aged age (χ²=15.54, p=.000). Among the scheduled vaccinations, the DPT vaccination (χ²=10.08, p=.006) was insufficient in ASD groups. The ASD group also showed higher rates of sleep disturbances from infancy. Differences in maternal/paternal age at conception, gestational age, and growth parameters at birth were not significantly difference among the three groups. Conclusion:These results do not support the previous controversies regarding the relationship between prenatal/perinatal complications and ASD. However, these results indicate that perinatal and prenatal factors may contribute to the development of ASD.
항정신병약물을 처음으로 사용하는 초발 정신증 환자에서 나타나는 체중 및 대사성 지표의 변화 : 후향적 연구
김우진,심주철,공보금,강제욱,문정준,김정은,김민걸,박민경,김성진,김현정,정도운 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2
Objectives:This study was to identify weight & metabolic changes in first-episode psychotic patients with antipsychotics use and investigate the differences of weight & metabolic changes between first-episode psychotic patients and controls with antipsychotics use. Method:In this retrospective study, twenty eight first-episode psychotic patients and twenty eight controls with schizophrenia, schizoaffective or bipolar disorder defined by DSM-IV criteria were included. Information about demographic and clinical characteristics of the subjects was gathered from the medical records. Also body weight, sBP, dBP, fasting glucose, lipid profile and WBC count were evaluated before and after antipsychotics use. Rogistic regression was conducted to assess factors associated with weight gain. Results:First-episode psychotic patients showed more weight and BMI changes than controls after antipsychotics use, and these changes continue over 12 months. On the other hand, there were no significant factors associated with weight gain. Conclusion:The results of present study suggest that antispychotics is one of the major causes inducing weight gain of psychotic patients and antipsychotics-induced weight gain is more vulnerable to drug-naive first-episode psychotic patients.