1945-60년대 보건소 체계 형성과 예방·치료사업

강재구 한국역사연구회 2023 역사와 현실 Vol.- No.130

Given that public hospitals in South Korea had not performed well due to a lack of funding since the country’s liberation from Japanese rule, the nationwide system of public health centers, which provided primary care and disease prevention measures, was the main channel through which the state could intervene in the health of the population. By examining the process of establishing the Korean health center system, this article aims to understand the process by which post-liberation Korea has shaped the role of the state in the healthcare system. After liberation, under the influence of the U.S. military regime and the criticism of the Japanese sanitary administration, the Korean medical community sought a democratic and proactive preventive role for the state. For the medical community, preventive health centers were the means to achieve this goal. Foreign aid organizations such as WHO, UNKRA and ICA also planned to establish a system of preventive medicine-oriented health centers in Korea. However, unlike the medical community, the rural people wanted the state to focus on the role of treatment through health centers, and this orientation was partially realized during the Korean War, frustrating the preventive medicine orientation of the medical community. In addition, the South Korean government wanted to keep health center programs at a low level that would not hinder national development. In the 1960s, as the national economic development projects progressed, the health center system, under the strong influence of the government, was oriented to support national development based on low-level curative and centralized disease prevention programs. The different orientations for the public health center system have converged within the framework of development.

좋은 의사는 어떤 사람인가?

강재구,Kang, Jaeku 연세대학교 의과대학 2016 의학교육논단 Vol.18 No.2

고혈압성 소뇌출혈의 예후인자에 대한 고찰

강재구,최하영,김철진,김재은,이정청 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.3

1987년 1월부터 1990년 12월까지 4년동안 뇌전산화 단층촬영을 이용하여 진단받은 고혈압성소뇌출혈 28예를 대상으로 임상적 소견과 방사학적 소견, 그리고 예후를 분석한바 다음의 결론을 얻었다. 1) 사구체조의 모양이 정상인 경우 7예중 6예(85%)에서 좋은 예후를 보였다. 그중 수두증이 없었거나 출혈후 48시간내에 수두증에 대한 shunt시행을 받았던 5예 모두에서(1예에서만 혈종제거술 시행)좋은 예후를 보였다. 반면 48시간후 shunt 시행한 2예중 1예에서 좋은 예후를 보였다. 따라서 폐쇄성 수두증이 존재하면 조기에 이를 호전 시켜야 하며 혈종 제거술은 불필요한 것으로 여겨진다. 2) 사구체조가 부분 폐쇄된 경우 9예중 7예(78%)에서 좋은 예후를 보였다. 그 중 수두증이 없거나 출혈후 48시간내 수두증에 대한 shunt시행을 받었던 6예중 5예(83%)에서 좋은 예후를 보였으며, 혈종제거술을 함께 시행하였던 4예는 모두 좋은 예후를 보였으나, 혈종제거술을 시행치 않았던 2예중 1예에서만 좋은 예후를 보였다. 반면 48시간후 수두증에 대한 shunt를 시행한 경우는 3예중 2예(67%)에서만 좋은 예후를 보였다. 따라서 조기에 혈종제거술과 수두증이 있다면 48시간내에 shunt를 시행해 주는 것이 좋을 것으로 여겨진다. 3) 사구체조의 완전폐쇄된 경우 12예 모두에서 혈종제거술과 수두증 호전과 관계없이 좋지 않은 예후를 보였다. 4) 이상을 연구 결과 뇌 전산화 단층 촬영상 사구체조의 폐쇄정도는 환자의 예후에 대한 지침과 치료방법을 선택하는데 유용하다고 생각되었다. The authors analyzed 28 cases with hypertensive cerebellar hemorrhage, diagnosed by computerized tomography(CT), between 1987 and 1990, in Chonbuk National University Hospital. The authors assessed the relationship of outcome to the CT appearance of the quadrigeminal cistern, which in some cases was obliterated by rostral displacement of the vermis resulting from the cerebellar mass. Obliteration of the quadrigeminal cisterns was classified on the CT scans into three grades : Normal (Grade Ⅰ), Compressed (Grade Ⅱ), or Absent (Grade Ⅲ). There were 7 cases with Grade Ⅰ, 9 with Grade Ⅱ, and 12 with Grade Ⅲ cisterns. Of the 28 cases, 6(85%) of those with Grade Ⅰ, 7(78%) of those with Grade Ⅱ, and none of those with Grade Ⅲ cisterns respectively returned to their previous activities at 6 months or more after onset. A Grade Ⅰ cisterns predicted a good outcome whether the hematoma was evacuated or not, as long as obstructive hydrocephalus, if present, was relieved early. However, a Grade Ⅱ cisterns was not predictive of a good outcome unless the hematoma was evecuated within 48 hours after onset of the hemorhage. A Grade Ⅲ cisterns predicted an unfavorable outcome. Taken together, these results strongly suggest that the CT grade of quadrigeminal cistern obliteration may be an indicator of outcome and may be useful in selecting treatment for patients with cerebellar heorrhage.

척추 전방전위증 환자에서 V.S.P(Variable Screw Placement) plate 사용에 대한 임상적 고찰

강재구,김재은 의과학연구소 1991 全北醫大論文集 Vol.15 No.3

From December 1989 to may 1991, 12 patients with spondylolisthesis were operated application of V.S.P(variable screw placement) spinal plate with total laminectomy in Department of Neurosurgery of Chonbuk national university hospital. Main symptoms were severe low back pain and lower extrenity radiating pain. Male to female ratio was 1:3. The age of patient was from 4th decade to 7th decade with the largest number in 4th decade. The result of operation were considered excellent in 7cases, good in 3cases and poor in 2cases.

CJ-50001 (rG-CSF)에 대한 변이원성시험

강재구,백남진,김달현,하석훈,김제학,김현수 한국독성학회 1997 Toxicological Research Vol.13 No.3

In order to evaluate the mutagenic potential of CJ-50001 (recombinant human granulocytecolony stimulating factor), 3 sets of mutagenicity tests were performed. In the reverse mutation test using Salmonella typhimurium TA1535, TA1537, TA98 and TA100, CJ-50001 did not increase the number of revertant at any of the concentration tested in this study (500, 250, 125, 62.5 and 31.3 $\mu\textrm{g}$ plate). CJ-50001, at the doses of 200, 100 and 50 $\mu\textrm{g}$ /ml, did not increase the number of cells having structural or numerical chromosome aberration in cytogenetic test using Chinese Hamster Lung cells. In mouse micronucleus test, no significant increase in the occurrence of micronucleated polychromatic erythrocytes was observed in ICR male mice intraperitoneally administered with CJ-50001 at the doses of 5, 2.5 and 1.25 mg/kg. These results indicate that CJ-50001 has no mutagenic potential in these in vitro and in vivo systems.

연속배양에서 단일항체 생산성 향상을 위한 무혈청 배지의 단계적 유입

강재구,박형환,이현용 한국미생물 · 생명공학회 1990 한국미생물·생명공학회지 Vol.18 No.1

Lectin related inducer can enhance IgG$_1$ production rate from murine hybridoma cells by employing step-feeding of serum free media with producing about 40 mg/$\ell$ of monoclonal antibodies. This step-feeding perfusion process also proves to be able to cutivate animal cells when serum free media can not support the growth of these cells in perfusion process, as well as to improve production rate. This process yields about 28 x 10$^{-10}$ mg of MAb/cells/h compared to 11.1 x 10$^{-10}$ and 4.0 x 10$^{-11}$ mg/cells/h for perfusion process and batch cultivation with 10% serum containing media, respectively. Murine hybridoma 세포배양시 lectin 계통의 생산 증진제가 무혈청 배지의 단계적 유입에 의해 약 40mg/l의 단일항체를 생산함으로서 단일항체의 생산성을 증가시킬 수 있음이 확인됐으며, 또한 이 배양공법으로 무혈청 배지에서 연속배양이 불가능한 세포의 배양이 가능했다. 이같은 무혈청 배지의 단계적 유입공법으로 약 28 x $10^{-10}$mg/cells/h의 속도로 단일항체가 생산된 것에 비해, 10 혈청이 포함된 배지로는 연속 배양시 11.1 x $10^{-10}$mg/cells/h 의 속도로 생산됐으며 회분배양의 경우는 4.0 x $10^{-11}$mg/cells/h의 속도로 생산됐다.

측정 탐침의 각도, 거리, 개구수 변화가 반사계 두께 결정에 미치는 영향

강재구,임동순 한국산업경영시스템학회 2021 한국산업경영시스템학회 학술대회 Vol.2021 No.추계

HepG2 cell에서 quercetin의 HO-1 발현을 통한 mitochondria의 생합성 유도 효과에 관한 연구

강재구,장상철,이기승,김진희,정명수,Kang, Jaekoo,Jang, Sang Chul,Lee, Ki Seung,Kim, Jin Hee,Chong, Myong Soo 대한한의정보학회 2015 大韓韓醫情報學會誌 Vol.21 No.1

Flavonoids show diverse bioactivities, such as anti-oxidant, anti-cancer, anti-allergic, anti-inflammatory, and anti-viral. Quercetin is one of the flavonoids present in a wide range of plants, especially onions and consumed all over the world. Recently, it is known that quercetin induces mitochondrial biogenesis in vivo and in vitro. However, detail mechanism of these actions remains unknown. We investigated quercetin's effects on mitochondrial biogenesis in HepG2 cells, and determined the mechanisms involved. We found that quercetin treatment induced the expression of mitochondrial biogenesis activators, $PGC-1{\alpha}$, NRF-1, TFAM, and mitochondrial proteins, cytochorome c and complex IV (COXIV). Moreover, amount of mitochondrial DNA was also increased by quercetin. Quercetin has been known to induce heme oxygenase (HO)-1 in several types of cells. Here, we found quercetin induces HO-1, and inhibition of HO-1 or CO, which is product of HO-1, decreased quercetin-induced mitochondrial biogenesis such as induction of $PGC-1{\alpha}$, NRF-1, TFAM, cytochorome c, COXIV, and mitochondrial DNA. These findings imply that quercetin can increase mitochondrial biogenesis via HO-1/CO system. High glucose results in dysfunction of mitochondria biogenesis. In the present study, 25 mM glucose decreased mitochondrial biogenesis and this damage was restored by quercetin. Conversely, inhibition of HO-1 or CO inhibited quercetin-induced mitochondrial biogenesis rescue. These results suggest that quercetin enhances mitochondrial biogenesis via HO-1/CO system and hence, can rescue mitochondria from damage by high glucose.

절차적 패턴의 자동 생성을 위한 인터랙티브 디자인 시스템

강재구,황용호,홍현기 한국정보과학회 2004 정보과학회논문지 : 시스템 및 이론 Vol.31 No.10

절차적(procedural) 텍스쳐는 다양한 해상도로 텍스쳐 공간을 표현할 수 있으며, 매우 적은 저장 공간을 사용하는 장점을 가지고 있다. 그러나 절차적 표현을 위한 암시적(implicit) 방법을 이해하기 어렵고 프로그래밍에 익숙하지 않은 일반 사용자가 다루기 힘들다. 본 논문에서는 사용자의 직관적인 디자인 작업을 통해 절차적 패턴을 자동으로 생성하는 인터랙티브 시스템이 제안된다. 전체 디자인 과정은 다중 레이어(layer)를 기반으로 하며 데이타, 연산 및 출력 노드 등으로 구성된 그래프 구조로 표현된다. 제안된 시스템은 일반 사용자에게 유연한 인터페이스를 제공하여 프로그래밍 작업 없이 절차적 텍스쳐 쉐이더를 자동으로 생성하도록 한다. 시뮬레이션 결과로부터 제안된 방법이 다양한 패턴을 효과적으로 제작할 수 있음을 확인하였다. Procedural texture has many advantages that its representation is extremely compact and unfixed in resolution. However, it can be difficult for an end-user having no programming skill to build and debug. This paper presents a new interactive design system for procedural texture generation. The user's interactive design process based on multi-layer operations is represented with a graph structure, which consists of the data node, the operation and the output. Since our system generates automatically a shading language, a user who is not acquainted with implicit concepts can make procedural texturing by using an intuitive and flexible interface. Simulation results showed that the proposed method can make a variety of texture patterns efficiently.

홈 네트워크(Home Network) 트랜드와 모델

강재구,김성완,임승린,Gang, Jae-Gu,Kim, Seong-Wan,Im, Seung-Rin 한국컴퓨터정보학회 2008 한국컴퓨터정보학회지 Vol.16 No.2