정상 청력인 노인과 젊은 성인에서 고음역 감각신경성 난청이 청각의 시간적 해상도에 미치는 영향: Gaps-In-Noise 검사 수행력

강용경,이은섭,윤상원,심현준,안용휘 대한이비인후과학회 2015 대한이비인후과학회지 두경부외과학 Vol.58 No.12

Background and Objectives Auditory temporal resolution, which refers to the time-related aspects of acoustic processing, can be evaluated by the Gaps-In-Noise (GIN) test. We investigated whether the presence of high frequency sensorineural hearing loss (HF-SNHL) affects the temporal resolution of GIN performance in older adults with normal hearing. Subjects and Method Hearing tests including the GIN test were performed in 87 subjects with normal pure tone average. The GIN threshold and percentage of correct answers were compared among 4 groups of participants; older adults with normal hearing (n=18), older adults with HF-SNHL (n=24), young adults with normal hearing (n=24) and young adults with HF-SNHL (n=21). Results There was no significant difference in the mean GIN thresholds between the HF-SNHL group (5.8±0.8 msec) and the normal hearing group (6.0±0.8 msec) in older adults, whereas the mean GIN thresholds of HF-SNHL group was higher than that of the normal group in young adults (4.6±0.3 msec vs. 4.2±0.5 msec, p<0.05). The mean percentage of correct answers of HF-SNHL group (62.5±5.5%) was not significantly different from that of the normal hearing group (60.6±3.9%) in the old, unlike in the young (71.3±4.0% with HF-SNHL vs. 76.9±4.3% with normal hearing, p<0.05). Age only showed a significant correlation with the GIN performance. Neither the GIN threshold nor the GIN perception level had any relation with the presence of HF-SNHL in older adults. Conclusion We found no evidence that supported the influence of HF-SNHL on auditory temporal resolution in older adults. These results imply that HF-SNHL may be of little importance in gap detection after age-related changes in central auditory system.

연하에 동반된 클릭음을 주증상으로 하는 이관 개방증 환자에서 이관 고실측 개구부 폐쇄로 치유된 증례

강용경,곽민영,심현준 대한이비인후과학회 부산,울산,경남 지부회 2014 임상이비인후과 Vol.25 No.2

Swallowing associated click sound with tympanic membrane movement is very rare symptom. Recently wemet a patient with same symptom, and the click sound was disappeared after plugging the tympanic orifice ofE-tube with autologous cartilage. We present an unusual case of click sound accompanied with swallowingcured by plugging the tympanic orifice of E-tube.

활성산소 소거활성에 따른 꾸지뽕잎 추출물의 신경세포 보호 효과

강용경,이은아,박해룡,Kang, Young-Kyoung,Lee, Eun-Ah,Park, Hae-Ryong 한국식품조리과학회 2012 한국식품조리과학회지 Vol.28 No.6

In an attempt to identify the neuroprotective effect of Cudrania tricuspidata (CT) leaves against ROS (reactive oxygen species)-induced oxidative stress in neuronal cells, the extracts from CT leaves were investigated using PC12 cells and N18-RE-105 cells. The methanolic and ethanolic extracts from CT were denoted as CTM (Cudrania tricuspidata Leaves methanolic extracts) and CTE (Cudrania tricuspidata Leaves ethanolic extracts), respectively. The neuroprotective effects of the extracts were measured by DCF-DA assay, MTT reduction assay, and LDH release assay. The PC12 cells exposed to $H_2O_2$-induced oxidative stress and the N18-RE-105 cells exposed to glutamate-induced oxidative stress were treated with various concentrations of CTM and CTE. The results, CTM treatments resulted in the induction of a dose-dependent protective effect in PC12 cells and N18-RE-105 cells. Interestingly, CTE also showed neuroprotective effect in PC12 cells and N18-RE-105 cells. Therefore, these results suggest that CTM and CTE could be a new potential candidate as neuroprotective agents against ROS-induced oxidative stress in neuronal cells.

췌장암 세포주에 대한 꾸지뽕잎 추출물의 세포독성 효과

강용경,최정운,이은아,장현석,이정민,박해룡 대한암예방학회 2011 Journal of cancer prevention Vol.16 No.4

Natural products have recently become the focus of increased research interest, due to their potential for pharmacological activities. In this paper, we report on the cytotoxic effects of ethanolic extracts from Cudrania tricuspidata Bureau (CTE) against human pancreatic cancer cells. The primary objective of this study was to determine the mechanisms inherent in CTE-induced cytotoxicity and apoptosis in PANC-1and AsPC-1 cells. We found that CTE induced cytotoxicity in a dose-dependent manner, as determined by the results of an MTT reduction assay, an LDH release assay and colony formation assay. As expected,CTE induced characteristic apoptosis signs in PANC-1 and AsPC-1 cells, including apoptotic body via Hoechst staining. These results indicate that CTE may contains bioactive materials and potential candidates as a chemotherapeutic agent in human pancreatic cancer cells. These results indicate that CTE may contain bioactive materials and potential candidates as the chemotherapeutic agent in human pancreatic cancer cells. (Cancer Prev Res 16, 333-339, 2011)

양측 돌발성 난청이 동반된 Klebsiella 수막염으로 사망한 증례와 문헌고찰

강용경,이은섭,심현준 대한이비인후과학회 2015 대한이비인후과학회지 두경부외과학 Vol.58 No.10

Bilateral sudden sensorineural hearing loss (SSNHL) is very uncommon. Unlike unilateral SSNHL, bilateral SSNHL is more closely associated with serious systemic diseases and shows a more severe degree of hearing loss, poorer hearing prognosis and more significant impairment in morbidity. Although meningitis is one of possible causes of bilateral SSNHL, only a few cases were reported. We present a case of fatal Klebsiella meningitis accompanied by bilateral SSNHL with a literature review.

비중격 골-연골 이식물을 이용한 미단부 비중격연장이식술

이은섭,강용경,윤상원,김지선 대한이비인후과학회 2015 대한이비인후과학회지 두경부외과학 Vol.58 No.11

The septal extension graft from the septum has become a common method of correcting a small or drooping nose in Korea. It can provide superior tip projection and definition if there is a sufficient amount of cartilage and nasal septal stability. In our case, the caudal type septal extension graft was applied unilaterally using septal osteocartilaginous graft harvested in one piece during septoplasty. It was useful in patients who needed septal extension graft in spite of the insufficient amount of available septal cartilage. For those patients, it could be used to achieve the cephalic rotation of drooping tip and the strengthening of septal support effectively. The nasal septal osteocartilaginous graft may serve as an alternative material for conchal cartilage or costal cartilage for caudal septal extension graft if the stable nasal support is maintained and the harvested graft is applied appropriately.

Neuroglial Choristoma of the Middle Ear with Massive Tympanosclerosis: A Case Report and Literature Review

심현준,강용경,안용휘,홍영옥 대한청각학회 2016 Journal of Audiology & Otology Vol.20 No.3

Neuroglialchoristoma is a rare cerebral heterotopia typically involving extracranial midline structures of the head and neck, including the nose, nasopharynx and oral cavity. It rarely involves non-midline structures, such as the middle ear, mastoid and orbit. We report the case of a 63-year-old woman with right-sided hearing loss and aural fullness who was diagnosed with neuroglialchoristoma of the middle ear and mastoid. To our knowledge, this is the first report on neuroglialchoristomawith massive tympanosclerosis. The presence of combination supported the inhalation theory of neuroglialchoristoma, given that tympanosclerosis is typically caused by Eustachian tube dysfunction.

한국인에서 오노디 세포의 유병률에 대한 영상학적 연구

이승주,강용경,이은섭,김지선 대한이비인후과학회 2015 대한이비인후과학회지 두경부외과학 Vol.58 No.12

Background and Objectives The Onodi cell is the posterior-most ethmoid air cell that lies superior to the sphenoid sinus, and has intimate relationship with the optic nerve. The aim of this study was to evaluate Onodi cell prevalence, protrusion and bony dehiscence of the optic nerve in Korean population using computed tomography (CT). Subjects and Method A retrospective analysis was performed on 129 Korean patients who consecutively underwent CT between January 2014 and December 2014. The presence of Onodi cells and protrusion and bony dehiscence of the optic nerve were analyzed using 3-dimensional CT images. Results A total of 70 males and 59 females were studied. Onodi cells were present in 61 (47.3%) patients but in 88 CT slides (34.1%); this consisted of 27 Onodi cells found bilaterally (44.3%), 18 on the right side only (29.5%), and 16 on the left only (26.2%). Of the total 61 patients with Onodi cells, the optic nerve protrusion and dehiscence were present in 34.4% and 23.8% of the studied CT slides. There was no statistically significant relationship between the presence of Onodi cells and protrusion and bony dehiscence of the optic nerve. Conclusion In our study, Onodi cells were found in almost half of the patients. This prevalence is higher than previously reported in the literature. In patients with Onodi cells, the optic nerve protrusion and dehiscence were present in about 1/3 and 1/5 of the total slides, respectively. Therefore, the identification of these cells is essential prior to endoscopic sinus and skull base surgery to prevent potential complications.

비수술적 방법에 의해 치료된 횡정맥동 혈전증 1예

곽민영,강용경,심현준,안용휘 대한이비인후과학회 부산,울산,경남 지부회 2014 임상이비인후과 Vol.25 No.2

Recent advances in antibacterial drugs have greatly reduced the incidence of intracranial complications of tem-poral bone infections. We report an unusual case of a 77-year-old male with lateral sinus thrombosis that devel-oped after subclinical mastoiditis, presenting with dyspnea, mild fever and right arm weakness. The patient washospitalized for septic pneumonia, and brain images showed left lateral sinus thrombosis with otitis media. Sur-gical intervention was not performed because general condition was stabilized by intravenous antibiotics and an-ticoagulation.

한국인에서 상악동 내측 지붕과 접형동 및 후사골동과의 관계에 대한 영상학적 연구

이승주,곽민영,강용경,김지선 대한이비인후과학회 2015 대한이비인후과학회지 두경부외과학 Vol.58 No.10

Background and Objectives The aim of this study was to perform radiologic study assessing the utility of the medial maxillary sinus roof (MMSR) as a reference point for providing a safe route of entry into the sphenoid and the posterior ethmoid sinuses in Korean patients. Subjects and Method We retrospectively reviewed 82 consecutive ostiomeatal computed tomographic scans of Korean adult patients performed from January 2014 to December 2014. Using the nasal floor as a reference point, the vertical distances to the highest MMSR, natural sphenoid ostium, anterior sphenoid roof and floor and posterior ethmoid skull base were measured. Then the vertical distances from the highest MMSR to the sphenoid ostium, anterior sphenoid roof and floor and posterior ethmoid skull base were calculated. The maxillary sinus to posterior ethmoid height ratio was calculated. Results The average height of the highest MMSR relative to the nasal floor was measured to be 33.95±3.36 mm. The vertical distance from the highest MMSR to the natural sphenoid ostium, anterior sphenoid roof and floor and posterior ethmoid skull base was 1.87±3.52 mm, 11.77±3.30 mm, 6.09±3.16 mm, and 15.46±3.07 mm respectively. The mean ratio of the maxillary sinus to the posterior ethmoid height was 2.3±0.56. Conclusion The MMSR can be used as a reliable landmark to localize the natural sphenoid ostium and to enable a safe entry into the posterior ethmoid. Moreover, it provides a reasonable margin of safety from the skull base.