황체의 생성과 생리작용의 기전에 관여하는 에스트로겐의 역할(총설)

민태희,이승형 강원대학교 동물생명과학연구소 2024 동물자원연구 Vol.35 No.1

난소에서는 내분비계 호르몬의 작용에 의해 생리학적 현상이 일어나며 황체가 생성하게 된다. 이 과정에서 생식호르몬인 에스트로겐은 난포와 황체에서 분비되어 황체의 생성과 퇴화의 작용에 관여하게 된다. 에스트로겐은 에스트로겐 수용체–α와 –β의 결합에 의해서 생식호르몬의 합성을 조절한다. 난소에서는 에스트라디올–17β 가 주로 합성되며 황체의 생리작용과 혈관신생과정의 신호전달경로 기전에 관여하게 된다. 또한, 에스트로겐은 프로게스테론의 합성을 조절하는데, 이 작용은 StAR에 의해 이동된 콜레스테롤이 미토콘드리아 안에서 P450scc가 프레그네놀론으로 전환시키고, 활면소포체로 이동하여 3β–HSD에 의해 프로게스테론으로 전환된다. 그리고, 에스트로겐 수용체–α는 프로게스테론 수용체의 프로모터 부위에 결합되어 활성을 촉진하기도 한다. 또한, 에스트로겐은 뉴런에서 분비되는 키스펩틴에 의해서 분비가 자극되기도 한다. 이는 고나도트로핀 방출 호르몬의 분비를 자극하여 난포자극호르몬과 황체형성호르몬의 활성을 촉진한다. 그리고, 에스트로겐과 키스펩틴의 상호작용은 난포의 발달과 배란, 황체의 생리현상에 직접적으로 관여할 가능성이 있다. 게다가, 황체의 생성되기 위한 환경조건에는 혈관신생과정과 밀접한 관계가 있다. 혈관신생과정에서 중요한 역할을 하는 주요인자는 VEGF이며 혈관세포의 생존, 증식, 이동에 관여하는 신호경로기전의 대표적인 물질이다. 특히, VEGF–A는 혈관세포의 생리작용에 관여하는 핵심적인 인자이다. VEGF는 수용체 VEGFR–2와 결합하여 PI3K, Akt, MAPK, ERK 등의 신호전달경로에 관여한다. 또한, VEGF는 저산소 유도 인자인 HIF–1α와 결합하여 VEGF의 분비를 자극한다. 그리고, 에스트로겐은 HIF–1α의 활성을 촉진시키며, Akt의 활성과 mTOR의 작용이 VEGF를 자극하게 된다. 따라서, 황체에서의 에스트로겐의 역할은 난소와 황체의 생리현상에 깊이 관여하며 내분비계 호르몬의 합성과 분비를 조절하는 중요한 생식호르몬이다 할 수 있다. The physiological functions of the ovary and development of the corpus luteum occur through the activation of endocrine hormones. In this process, estrogen, a reproductive hormone, is secreted in the ovarian follicle and corpus luteum and affects corpus luteum formation and regression. Estrogen controls the synthesis of reproductive hormones by binding to estrogen receptor–α and –β. Estradiol–17β, synthesized in the ovary, regulates the physiological function of the corpus luteum and the angiogenesis signaling pathway. Estrogen controls progesterone synthesis, which is regulated by StAR-transported cholesterol, P450scc-converted pregnenolone in mitochondria, and 3β-HSD-synthesized progesterone in the smooth endoplasmic reticulum. Estrogen secretion is also stimulated by kisspeptin and regulated by gonadotropin-releasing hormone, follicle-stimulating hormone, and luteinizing hormone. Moreover, the formation of the corpus luteum is closely regulated by angiogenesis. VEGF is an important factor in angiogenesis and plays a role in the survival, proliferation, and migration of endothelial cells. Especially, VEGF–A is a key factor in the physiological functions of endothelial cells. VEGF binds VEGFR–2 and affects the signaling pathways of PI3K, Akt, MAPK, and ERK. Also, VEGF binds to HIF–1α, inducing VEGF secretion. Estrogen promotes the activation of HIF–1α, while the activation of mTOR and Akt stimulates VEGF secretion. Therefore, estrogen is a major reproductive hormone in physiological function and the synthesis and secretion of endocrine hormones in the ovary and corpus luteum.

활성탄 담지 귀금속 촉매를 이용한 CVOC 제거특성 연구

민태희,박훈,송민우,강민,김경림,김병환 한국공업화학회 2002 한국공업화학회 연구논문 초록집 Vol.2002 No.1

활성탄 담지 금속 산화물 촉매상에서 CVOC의 산화반응 특성연구

민태희,박훈,김형식,송민우,강민,김경림 한국공업화학회 2002 한국공업화학회 연구논문 초록집 Vol.2002 No.0

산업현장에서의 광범위한 사용과 소각로 배가스에 함유된 물질로서 강한 유독성으로 인해 Chlorinated VOC는 대기오염에 큰 영향을 미치고 있다. 처리방법 중 촉매연소법은 일반적으로 사용되어지고 있는 열 분해 방법(incineration) 에 비해 300 ~ 600°C 정도의 낮은 온도에서 적용할 수 있기 때문에 높은 에너지 효율공정이라 할 수 있으며, 반응생성물로는 carbon dioxide, hydrochloric add등을 생성한다. 촉매의 형태로는 귀금속 담지촉매와 전이금속 산화물 등이 있는데, 이는 acid site과 redox properties와 관련이 있어 acidic 성질을 가진 산화물이 연구되어지고 있다. 하지만 탄소 담지 촉매에 대한 연구는 거의 이루어지지 않고 있는 상태이다. 본 연구에서는 담체로 사용되는 상업용 활성탄(Norit Co.)에 cobalt와 chromium 을 담지한 촉매로 실험을 수행하였다. CVOC로는 methylene chloride를 사용하였으며, BET, XRD, XPS, TPD, SEM등을 통해 반응활성과 비표면적, 표면의 산세기, 금속의 산화상태, morphology등을 알아보았다

AT-2266(??)의 호흡기 감염증에 대한 임상효과

신길자,이은령,경난호,민태희 대한감염학회 1986 감염 Vol.18 No.1

The clinical effects of AT-2266(??) was observed in 30 cases of respiratory tract infection between Dec '85 and March '86. The following results were obtained: 1) Overall efficacy of therapy revealed excellent control in 12 cases(40%), good control in 16 cases(53.3%) and no effect in 2 cases(6.7%). 2) In 3 cases(10.0%), side effect was observed such as nausea and anorexia, but no serious side reaction was observed. 3) There were no significant change in CBC, Urinalysis, liver function test, BUN and creatinine during the treatment. 4) Mean duration of treatment was 11.1±5.4 days.

An investigation of catalytic oxidation of methylene chloride over carbon supported metal oxide catalysts

강민,민태희,박훈,송민우,김경림,김병환 한국공업화학회 2002 한국공업화학회 연구논문 초록집 Vol.2002 No.1

첨착활성탄을 이용한 염소계 화합물 (dichloromethan)의 흡착특성 연구

박훈,민태희,강민,송민우,김경림 한국공업화학회 2002 한국공업화학회 연구논문 초록집 Vol.2002 No.1

인슐린 비의존형 당뇨병(NIDDM)환자에 있어서 혈청지질 농도 및 인슐린 치료후 변화에 대한 연구

경난호,김윤자,민태희,김진수 梨花女子大學校 醫科大學 醫科學硏究所 1988 EMJ (Ewha medical journal) Vol.11 No.4

It is well kown that an increased incidence of atherosclerosis in diabetic patients, and hyperlipemia might contribute to its development. Although diabetic populations are increasing in Korea, there are few reports showing abnonmalities of serum lipid metabolism in these patients. Various lipid values in serum were measured in 22 NIDDM and impaired with those of 20 normal control group to assess abnormalities of lipid metabolism. Follwoing results are obtained ; 1) Total lipid concentration was significantly higher in diabetics than in normal control(P<0.01). After control of hyperglycemia, total lipid concentration was significantly decreased(P<0.05). 2) Triglyceride concentration was significantly higher diabetics than in normal control(p<0.01). After control of hyperglycemia, its concentraion was significantly decreased(P<0.05). 3) Total cholesterol concentration was higher in diabetics than normal control, but there were no statistical significances. After control of hyperglycemia, there were on difference among each group.

호흡기질환에 있어서 Ambroxol의 임상효과에 대한 연구

신길자,경난호,민태희 梨花女子大學校 醫科大學 醫科學硏究所 1985 EMJ (Ewha medical journal) Vol.8 No.4

The expectorant effect of Ambroxol was observed in 13 cases of respiratory diseases(5 cases with bronchial asthma, 2 cases with acute bronchitis, 2 cases with lung ca, 2 cases with pneumonia, 1 case with chronic bronchitis and 1 cases with pulmonary tuberculosis) between Nov. '83 and Mar. '84. The folliwing results were obtained; 1) Clinical improvement of % of cases after treatment with Ambroxol was 78% of cough, 62% of frequency of sputum expectoration, 59% of amount of sputum vloume, 80% of expectoration and 75% of color of sputum. 2) Clinical improvement of pulmonary function test was as follows;(1) Improvement of less than 10% of FVC was 9 cases(69.2%) improvement between 10% and 20% of FVC was 3 cases(23.1%), and improvement of more than 20% of FVC was 1 case(7.7%). (2) Improvement of less than 10% of FEV_1/FVC was 11 cases(84.6%), improvement between 10% and 20% of FEV_1/FVC was 2 cases(15.4%)3) No remarkable side effects was observed.

만성 신부전환자에서 당불인내성 예견 지표로서의 Serum Reverse T₃에 관한 연구

손현주,김진수,민태희,경란호 대한내분비학회 1987 Endocrinology and metabolism Vol.2 No.2

To investigate the thyroid hormonal change and the usefulness of serum reverse T_3(rT_3) assay in predicting glucose intolerance in patients with chronic renal failure(CRF), we measured the serum thyroid hormone using radioimmunoassay and HbA_1C. Also we performed oral glucose tolerance test(OGTT) in 17 patients with CRF on hemodialysis therapy and 20 normal control subjects(NS). The following results were obtained: 1) The serum T_3 and T_4 concentrations were significantly lower in patients with CRF(89.11±14.11 ng/dl and 4.93±0.92 ug/dl, respectively) than in NS(156.80±21.38 ng/nl and 9.11±1.65 ug/dl, respectively). 2) The serum rT_3 concentration in patients with CRF was within and below the normal range, but the mean (183.92±52.40 pg/ml) was significantly lower than in NS(250.54±25.75 pg/ml). 3) The serum TSH concentration was within the normal range in patients with CRF. And the mean serum TSH(2.68±1.18 uu/ml) did not differ significantly from that of NS(2.08±1.00 uu/ml). 4) The serum TBG concentration was within the normal range in patients with CRF. But the mean serum TBG(18.32±4.39 ug/ml) was significantly lower than that of NS(28.50±8.97 ug/ml). 5) The serum rT_3 concentration of eight patients with CRF who showed impaired OGTT(226.10±45.97 pg/dl) was significantly higher than that of nine patients with CRF who showed normal OGTT(146.42±16.78 pg/dl). And in the whole patients with CRF, there was significant relationship between blood glucose levels and serum rT_3 concentrations. 6) In patients with CRF, the serum rT_3 assay showed a speccifictity of 100% and a sensitivity of 88% in predicting glucose intolerance. 7) HbA_1C was not good indicator for assessing carbohydrate metabolic state in patients with CRF. It was concluded that the serum rT_3 could be useful indicator for prediction glucose intolerance in patients with CRF. Future study for rT_3 in patients with CRF on hemodialysis and peritoneal dialysis will be needed for practical use.

아메바性 心囊炎의 一例

朴鍾亮,朴利甲,閔泰喜 醫藥係社 1954 綜合 醫學 Vol.11 No.3