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      • SCOPUSKCI등재
      • SCOPUSKCI등재

        간섬유화의 비침습적 진단: transient elastography (FibroScan(R))

        김승업 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.1(S)

        Transient elastography (TE, FibroScan(R)) is a novel non-invasive method that has been proposed for the assessment of liver fibrosis in patients with chronic liver diseases, by measuring liver stiffness. TE is a rapid and user-friendly technique that can be easily performed at the bedside or in the outpatient clinic with immediate results and good reproducibility. Combining TE with serum markers increases diagnostic accuracy and as a result, liver biopsy could be avoided for initial assessment in some patients with chronic liver disease. As TE has excellent patient acceptance it could be useful for monitoring fibrosis progression and regression in the individual case, but more data are awaited for this application. Guidelines are needed for the use of TE in clinical practice.

      • 간경변증과 문맥압항진증의 영상진단 : 초음파를 이용한 간탄력도 검사

        김승업 대한간학회 2013 간학회 싱글토픽 심포지움 Vol.2013 No.1

        Although liver biopsy is the best method for assessing liver fibrosis, it is an invasive procedure, with rare, but potentially life-threatening, complications. Thus, attempts to develop non-invasive methods have led to the use of transient elastography (FibroScan®; EchoSens, Paris, France) and acoustic radiation force impulse (ARFI) elastography (Acuson S2000; Siemens, Mountain View, USA) for assessment of liver fibrosis. Transient elastography is a novel non-invasive method that has been proposed for the assessment of liver fibrosis in patients with chronic liver diseases, by measuring liver stiffness. Transient elastography is a rapid and user-friendly technique that can be easily performed at the bedside or in the outpatient clinic with immediate results and good reproducibility Combining transient elastography with serum markers increases diagnostic accuracy and as a result, liver biopsy could be avoided.for initial assessment in some patients with chronic liver disease. As transient elastography has excellent patient acceptance, it could be useful for monitoring fibrosis progression and regression in the individual case, but more data are awaited for this application. Recently, ARFI elastography, which uses radiation forced impulses to measure liver stiffness while using B-mode ultrasonography, has been introduced. Transient elastography has a fixed region of interest (ROI) at a fixed insertion depth, whereas ARFI enables elastography inside a flexible ROI of lxo.6 em diameter at variable insertion depths. Therefore, liver stiffness measurement (LSM) in patients with ascites and obesity is feasible. Furthermore, ARFI elastography has the advantage that it enables LSM during a routine ultrasonographic evaluation of the abdomen. Based on the cumulated knowledge, guidelines are being awaited for the use of transient elastography and ARFI elastography in clinical practice.

      • KCI등재

        정신치료 집단 Supervision 경험

        임효덕,강석헌,김승업 大韓神經精神醫學會 1990 신경정신의학 Vol.29 No.4

        The author reviewed the 32 tape recordings of successive series of psychotherapy group supervision sessions, and studied the reaction of supervisees through a questionnaire. The group supervision sessions were conducted by a psychotherapy supervisor of Kyung-pook National University Hospital from February 1988 to July 1989. Twenty-one psychiatric residents and one co-supervisor participated. Each session ran 90 minutes once every other week. A supervisee's psychotherapy case was reported and it was followed by group discussion, supervisor's interventions and summary remarks. The tape recordings were analyzed in terms of most frequent mistakes and shortcomings of psychotherapy practice. The author distributed a questionnaire to find the reactions of the participants to the supervision sessions. The results could be summarized as follows ; The frequent mistake and the lack of therapeutic ability indicated by the supervisor were therapeutic interchange without clear understanding of the patient's nuclear emotions or central dynamics, the therapist's inability for empathic understanding and the therapist's lack of genuine interest in the patient. In terms of the technical shortcomings of the resident therapists, insufficient clarifications of the important issues, the tendency to neglect the formal history taking, frequent changes of the topic by the therapists because of their own needs and anxiety, premature interpretations and closed question methods. In the answer of the questionnaire composed of 18 items, all 21 participants responded that the supervision experience was helpful in understanding theoretical as well as practical aspects of psychotherapy, but some reported that the experience was perceived as provoking undue anxiety and even hostility. The author concludes that the group psychotherapy supervision model is suitable for the resident training in psychotherapy and the competence of the supervisor is the prerequisite condition for the group supervision.

      • KCI등재

        Diagnostic Performance of Serum Asialo-α1-acid Glycoprotein for Advanced Liver Fibrosis or Cirrhosis in Patients with Chronic Hepatitis B or Nonalcoholic Fatty Liver Disease

        김승업,전미영,임태섭 대한소화기학회 2019 대한소화기학회지 Vol.74 No.6

        Background/Aims: The utility of asialo-α1-acid glycoprotein (AsAGP) for assessing the fibrotic burden is unknown. This study examined the diagnostic performance of the AsAGP level for advanced liver fibrosis or cirrhosis in patients with chronic hepatitis B (CHB) or nonalcoholic fatty liver disease (NAFLD). Methods: From July to December 2018, 48 patients with CHB and 75 with NAFLD were recruited prospectively. Transient elastography was used as the reference standard for liver fibrosis, and the cutoff liver stiffness values were defined as 10.0 kilopascal (kPa) for ≥F3 and 12.0 kPa for F4 in CHB patients, and 9.0 kPa for ≥F3 and 11.8 kPa for F4 in NAFLD patients. Results: To predict stage ≥F3 and F4 fibrosis, the areas under the receiver operating characteristic curves of the AsAGP level in patients with CHB were 0.788 (95% CI 0.647-0.930; p=0.005) and 0.825 (95% CI 0.674-0.976; p=0.004), respectively. The cutoff AsAGP levels in patients with CHB that maximized the sum of the sensitivity and specificity values were 1.31 (sensitivity 100.0%, specificity 52.6%) and 1.55 (sensitivity 75.0%, specificity 80.0%), respectively. In contrast, the AsAGP level was similar regardless of the fibrosis stage in patients with NAFLD (all p>0.05 between the stages). Conclusions: The AsAGP level showed acceptable diagnostic accuracy in predicting advanced liver fibrosis and cirrhosis in patients with CHB but not in those with NAFLD. Further studies will be needed to validate the diagnostic performance of the AsAGP level in patients with NALFD.

      • SCIESCOPUSKCI등재
      • KCI등재

        Spontaneous Bacterial Peritonitis in Patients with Hepatitis B Virus-Related Liver Cirrhosis: Community-Acquired versus Nosocomial

        김승업,안상훈,전영은,이천균,박준용,김도영,한광협,전재윤,김신영,정규식 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.2

        Purpose: Spontaneous bacterial peritonitis (SBP) frequently develops in patients with liver cirrhosis; however, there is little data to suggest whether the acquisition site of infection influences the prognosis. This study compared the bacteriology, clinical characteristics and treatment outcomes of community-acquired SBP (CA-SBP) and nosocomial SBP (N-SBP). Materials and Methods: The medical records of 130 patients with hepatitis B virus (HBV)-related liver cirrhosis, who had experienced a first episode of SBP between January 1999 and December 2008, were reviewed. Results: The study population included 111 (85.4%) patients with CA-SBP and 19 (14.6%) patients with N-SBP. Baseline and microbiological characteristics as well as clinical course, including in-hospital mortality, did not differ between patients with CA-SBP and those with N-SBP (all p>0.05). The median survival time was 6.5 months, and 117 (90.0%) patients died during the follow-up period. Patients with CA-SBP and N-SBP survived for median periods of 6.6 and 6.2 months, respectively, without significant difference (p=0.569). Time to recurrence did not differ between patients with CA-SBP and N-SBP (4.7 vs. 3.6 months, p=0.925). Conclusion: The acquisition site of infection did not affect clinical outcomes for patients with HBV-related liver cirrhosis who had experienced their first episode of SBP. Third-generation cephalosporins may be effective in empirically treating these patients, regardless of the acquisition site of the infection.

      • KCI등재후보

        화소 라벨링에 의한 얼굴 특징 인수 추출

        김승업,이우범,김욱현,강병욱 한국융합신호처리학회 2001 융합신호처리학회 논문지 (JISPS) Vol.2 No.2

        The main purpose of this study is to propose the algorithm about the extraction of the facial feature. To achieve the above goal, first of all, this study produces binary image for input color image. It calculates area after pixel labeling by variant block-units. Secondly, by contour following, circumference have been calculated. So the proper degree of resemblance about area, circumference, the proper degree of a circle and shape have been calculated using the value of area and circumference. And Third, the algorithm about the methods of extracting parameters which are about the feature of eyes, nose, and mouse using the proper degree of resemblance, general structures and characteristics(symmetrical distance) in face have been accomplished. And then the feature parameters of the front face have been extracted. In this study, twelve facial feature parameters have been extracted by 297 test images taken from 100 people, and 92.93 % of the extracting rate has been shown. 본 논문에서는 얼굴의 특징 추출 알고리즘을 제안한다. 사람의 얼굴에 대한 특징 인수를 추출하기 위하여 우선 이진 영상을 생성한다. 하나 하나의 고립된 영역으로 분리하기 위하여 화소 라베링을 한 후 만들어진 가변 블록 단위로 면적을 구하고, 윤곽선 추적 방법에 의하여 둘레를 추한 후 면적, 둘레, 원형도 및 모양의 유사도를 구한다. 전체 유사도와 일반적인 구조 및 특징을 활용하여 눈, 코, 입의 특징 요소를 추출한 후 12개의 얼굴의 특징 인수들을 추출한다. 얼굴의 왼쪽 눈과 오른쪽 눈 사이의 거리, 왼쪽 눈과 코와의 거리, 오른쪽 눈과 코와의 거리, 왼쪽 눈과 입과의 거리, 오른쪽 눈과 입과의 거리, 코와 입과의 거리 및 각 거리간의 기울기를 이용하여 100명으로부터 획득한 297개의 원 영상을 대상으로 12개의 특징 인수를 추출한 결과 92.73%의 추출 성공률을 보였다.

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