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현명호,오병훈,김인석 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.3
목적 및 방법 : 본 연구에서는 신경영상기법 촬영을 이용하여 교통사고환자(48명)를 기질적 병변 유·무에 따라 집단을 구분하고 이들의 신호탐지력에 차이가 있는지를 알아보기 위하여 Vienna Test System의 신호탐지력 검사를 실시하였다. 결 과 : 변량분석 결과 기질적 병변이 발견된 환자는 발견되지 않은 환자에 비하여 신호를 정확하게 탐지하지 못하였으나 오경보반응의 차이는 없었다. 그리고 기질적 병변이 발견된 환자는 발견되지 않은 환자에 비하여 자극민감도가 낮았고, 반응기준에서 차이가 없었다. 결 론 : 본 연구에서 기질적 병변이 발견된 환자의 신호탐지력이 저하되어 있는 것은 동기나 정서적 측면보다는 초기 인지단계에서 자극을 정확하게 수용하고 처리하지 못하고 있음을 뜻한다. Objective : The purpose of this study was to investigate the differences of signal detection between the traffic accident patients with and without brain lesions in neuroimaging techniques. Methods : Subjects were 48 traffic accident patients. All subjects were asked to detect the signals in Signal Detection test of Vienna Test System. Results : The number of correct response and the stimulus sensitivity were significantly higher in group without lesion than group with lesion, but the number of false alarm and the response criterion were not. Conclusion : These results suggest that a cause of lower signal detection of the patients with brain lesions was not motivational and emotional impairment but cognitive impairment.
화영지통탕(和營止痛湯)의 혈관신생억제효과(血管新生抑制效果)에 관한 실험적(實驗的) 연구(硏究)
김인석,박준혁,강희,김성훈,유영법,심범상,최승훈,안규석,Kim, In-Seok,Park, Joon-Hyuck,Kang, Hee,Kim, Sung-Hoon,Yu, Young-Beob,Shim, Bum-Sang,Choi, Seung-Hoon,Ahn, Koo-Seok 대한암한의학회 2001 大韓癌韓醫學會誌 Vol.7 No.1
The purpose of this study is to prove the angiogenesis effects of WhaYoungJiTongTang (hereinafter referred to as the 'WYJTT'). For the study, by utilizing liver cancer cell line; SK-HEP-1, lung cancer cell line: A549, stomach cancer cell line: AGS and bovine capillary endothelial cell: BCE, the effects of the WYJTT on toxicity and proliferation ability of cells and the effects on anti-angiogenesis of bovine capillary endothelial cell and of mice's aorta were studied. 1. Cell viability assay In comparison with the control group, when $100{\mu}g/ml$ of WYJTT was injected, the viability was reduced in SK-Hep-1, $400{\mu}g/ml$ in A549 and $200{\mu}g/ml$ in AGS. 2. Cell proliferation assay In comparison with the control group, when $600{\mu}g/ml$ of WYITT was injected, DNA synthesis was reduced to 35.1% in the SK-Hep-1, 56.0% in A549, and 25.8% in BCE (bovine capillary endothelial cell); and when $400{\mu}g/ml$ was injected, DNA synthesis was reduced to 12.1 in AGS. 3. Tube formation assay In the event that BCE is injected with WYJTT in each of its content gradient, the anti-angiogenesis was effective in amounts of $400{\mu}g/ml$ with 6 hours of the treatment. 4. Aortic ring assay In comparison with the control group, the angiogenesis was restricted to the remarkable degree in amount of $200{\mu}g/ml$: 10% in $400{\mu}g/ml$; and fully inhibited in each of $800{\mu}g/ml$ and $1600{\mu}g/ml$. As a result of the experiments mentioned above, WYJTT showed its anti-angiogenesis effects against cancer cell line.