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정희천,Van Giap Nguyen,문형준,박용호,박봉균 대한수의학회 2019 Journal of Veterinary Science Vol.20 No.5
Porcine endogenous retroviruses (PERVs) integrate into germline DNA as proviral genome that enables vertical transmission from parents to their offspring. The provirus usually survives as part of the host genome rather than as an infectious agent, but may become pathogenic if it crosses species barriers. Therefore, replication-competent PERV should be controlled through selective breeding or knockout technologies. Two microRNAs (miRNAs), dual LTR1 and LTR2, were selected to inhibit the expression of PERV in primary porcine kidney cells. The inhibition efficiency of the miRNAs was compared based on their inhibition of different PERV regions, specifically long terminal repeats (LTRs), gag, pol, and env. Gene expression was quantified using real-time polymerase chain reaction and the C-type reverse transcriptase (RT) activity was determined. The messenger RNA (mRNA) expression of the PERV LTR and env regions was determined in HeLa cells co-cultured with primary porcine kidney cells. The mRNA expression of the LTR, gag, pol, and env regions of PERV was dramatically inhibited by dual miRNA from 24 to 144 h after transfection, with the highest inhibition observed for the LTR and pol regions at 120 h. Additionally, the RT activity of PERV in the co-culture experiment of porcine and human cells was reduced by 84.4% at the sixth passage. The dual LTR 1+2 miRNA efficiently silences PERV in primary porcine kidney cells.
치와와에서 발생한 외상적 뇌손상 증례; 연속적인 임상적 및 전산화 단층영상 소견
이희천,원진희,문종현,정해원,정동인 한국임상수의학회 2014 한국임상수의학회지 Vol.31 No.4
A dog (Chihuahua, 2-year-old, intact female) was referred to us because of cluster seizure. She had historyof falling from height few days before presentation. Brain computed tomography (CT) results demonstrated fractureline on right temporal bone and hypodense, edematous changes of the adjacent brain parenchyma on right cerebralparenchyma. Based on history, clinical signs, and diagnostic imaging findings, this patient was diagnosed to traumaticbrain injury. After diagnosis, the patient was well controlled with anti-inflammatory drug and anti-epileptic drugs. When30, 480, and 1260 days after initial brain CT examination, we performed serial brain CT rechecks. This case reportdescribes serial clinical and brain CT findings after traumatic brain injury.
이희천,김나현,조규완,정해원,문종현,김지현,서정향,정동인 한국임상수의학회 2014 한국임상수의학회지 Vol.31 No.2
Abstract : An 11-year-old intact female Maltese was referred because of 1 week history of cluster seizure episodes. Based on brain CT scan, brain tumor was strongly suspected. The patient was euthanized according to client’s requestand we performed necropsy after euthanasia. The gross findings of the postmortem coronal sections of the brain showedthat the mass was relatively well-demarcated, reddish in colored, and was present inside the left lateral ventricle andcompressed adjacent tissues. The tumor mass had 2 distinct histopathological features: perivascular pseudorosette-likestructures and a whirl-like arrangement of fibrillary cells. The immunohistochemical profile showed strong GFAPpositivity and moderate S-100 expression, sparsely dotted staining with Ki-67. Based on the histopathological andimmunohistochemical findings, the present case diagnosed to ependymoma.
말티즈견에서 발생한 파종성혈관내응고를 동반한 거미막하 출혈 증례
정해원,이희천,문종현,정동인 한국임상수의학회 2014 한국임상수의학회지 Vol.31 No.4
An 11-year-old male Maltese dog was presented with sudden onset of convulsion and right sided circling. On neurological examination, left side proprioception and menace reflexes were delayed. Blood examinations indicatedsevere thrombocytopenia and increased hepatic enzymes. On brain magnetic resonance imaging, lesions were foundedon the left lateral subarachnoid space area. Those lesions showed hyperintense on T1-weighted images, hyperintenseon T2-weighted images and hyperintense on fluid attenuated inversion recovery images. Cerebrospinal fluid analysisrevealed xanthochromia and erythrophagocytosis. Coagulation test results demonstrated that fibrin degradation productand D-dimer concentrations were higher than normal range. The patient expired few hours after presentation. Thiscase report demonstrates intracranial hemorrhage with disseminated intravascular coagulation in a dog.
정금아,노희천,정선문,조미옥 (사)한국정부회계학회 2023 정부회계연구 Vol.21 No.1
This study investigates the effectiveness of the government subsidy performance evaluation (hereafter, evaluation). The evaluation aims to reduce fraudulent and redundant subsidy receipts, thus enhancing the subsidy program's efficiency and effectiveness. However, the subsidy system needs help with the evaluation cycle setting, deficiency of review competence, poor correlation between evaluation indicators and results, and lack of reliability and comparability of evaluation reports. This study suggests the following improvements. First, a follow-up review is essential to assess the subsidy performance over the entire operating period. Second, to ensure adequate capabilities, the review committee should consider the size and expertise in its formation and examinations by exception. Third, it is necessary to devise specialized evaluations given the subsidy characteristics, and facilitate the use of information within the existing subsidy system. Lastly, accounting experts may further improve the reliability and comparability of evaluation reports. Overall, this study contributes to the efficient resource allocation and fiscal sustainability of government funds by proposing improvements for subsidy performance evaluation. 본 연구는 보조사업 연장평가제도의 실효성을 진단하고 개선방안을 제시한다. 보조사업의 부정・중복수급을 줄이고 효율성 및 효과성 제고목적으로 ‘국고보조금 연장평가제도’가 운영중이다. 현행 제도에는 평가주기설정의 평가실효성 문제, 평가사업수 대비 평가역량 부족, 평가결과와 일부지표와의 연관성 결여 문제, 연장평가보고서의 신뢰성 및 비교가능성 결여 문제가 있다. 본 연구는 다음의 연장평가제도의 개선방안을 제시한다. 첫째, 보조사업의 전기간의 실적이 평가결과에 반영될 수 있도록 후속평가를 진행하고, 둘째, 평가단이 평가역량을 발휘할 수 있도록 평가단의 규모와 전문성을 고려하여 구성하고 집중심사제의 도입을 제안한다. 셋째, 연장평가의 세부 성과지표와 평가결과가 유의하게 연계될 수 있도록 보조사업의 특성(규모증가 추이, 사업주체, 속성 등)을 고려하여 개별 평가방식을 고안하고, 운영중인 보조사업 시스템과 연계하여 정보활용도를 높여야 한다. 마지막으로, 회계전문가의 검증을 받아 연장평가보고서가 제공하는 정보의 신뢰성과 비교가능성을 제고할 것을 제안한다. 본 연구에서 제시하는 보조사업 연장평가제도의 개선방안은 국가재정의 효율적 배분과 건전성을 제고하는 데 기여한다.
윤희천(Yun Hee Cheon),민관식(Min Kwan Sik),정인준(Jeong In Jun),유금도(Yu G?m Do) 대한공간정보학회 2010 한국지형공간정보학회 학술대회 Vol.2010 No.1
본 연구에서는 재해관리 및 대응의 일환으로 재해 현장에서 필요한 정보를 효과적으로 제공하기 위해 과거 풍수해로 인한 침수피해 이력정보를 분석하여 수치영상을 이용한 침수흔적도를 구축하였다. 기존의 지형도 및 지적도를 대체하여 생성한 수치영상 기반의 침수흔적도는 침수관련 정보를 표기함에 있어 그 가능성과 활용성에 초점을 두고 향후 재해관리 업무효율성 향상 및 재해대응 능력 강화에 기여할 것으로 판단된다.