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당뇨병에서 고혈당이 아니라 인슐린과 인슐린 유사 성장 인자 1 신호의 감소가 위 카할 간질 세포 감소의 기전이다
홍성표 ( Sung Pyo Hong ) 대한소화기기능성질환·운동학회 2005 Journal of Neurogastroenterology and Motility (JNM Vol.11 No.1
환자나 동물 모델에서 당뇨병성 위장질환의 병태생리로 카할 간질 세포(ICC: interstitial cell of Cajal)의 손상이 소개된다. 당뇨병에서 카할 간질 세포(ICC)의 고갈은 만성적인 고혈당이나 인슐린 신호의 소실 혹은 비효율에서 비롯될 수 있다. 장기적인 생체 실험에서 혈당과 인슐린의 독립적인 조절이 어렵기 때문에 장기간의 기관 배양을 이용하였다. 쥐의 위 근육을 정상 혈당과 고혈당의 기본 배지에 1-3개월간 배양하였는데 인슐린이나 인
14세기 초 영국에서의 범죄 실태와 그 처벌 : 폭행사건을 중심으로
洪成杓(Hong Seong-Pyo) 역사교육연구회 2003 역사교육 Vol.88 No.-
The objective of this article is to search the answers of the following questions. First, who did commit assault, men or women? Did men commit mainly outrage or women did? And why? Second, what did make use of instrument to commit violence? Third, how did put on trial to a criminal suspect for assault? Fourth, what is social viewpoint about assault. How can village or town community prevent assault? Did they enforce system to prevent assault? In order to explain the answers of all these questions, I study Calendar of Patent Rolls and Wakefield Court Rolls(1279~1347), which is court record of Wakefield manor in Yorkshire. I analyze 369 cases and I can finally reach to the following conclusions. According to Professor Barbara A. Hanawalt, crime increased during the Great Famine(1315~1317). Her contention is right, but the crime, which is related to assault, did not only increase because of the Great Famine. During that period, King Edward invaded Scotland for several years. From every point of view, we must trace the origins of increase of crime in the early fourteenth century England. Many persons, several men or women, used violence to one or a few persons on the whole. And assault related to plunder a person of his/her goods, especially com and livestock. Contrary to expectations of professor Barbara A. Hanawalt, I can find that women participated in assault is more small in number than men, but it is not different the method of assault between men and women. Assault did not occur between collateral relation but chiefly appeared between non-blood relation. Because of the king"s peace and the common welfare, an offender of assault was chiefly punished by a fine from 6 pence to 12 pence. By the way it is not different to be fined for doing assault between men and women. The main function of the frankpledge system was to provide mutual surety as well as crime prevention. Each frankpledge unit was divided into a number of tithings which were intended to contain ten men. With respect to one who has taken to flight, careful inquiry must be made as to whether he is to enter a tithing or not. If every tithings are not inspected by sheriff twice a year, the tithings will be amerced before the justices for not producing the said malefactor for trial. By this system, we can understand how medieval English tithings make efforts for the prevention of criminal offences and social disorder.
Discovery of a Highly Specific and Potent Pan-RAF Inhibitor
홍성표,이윤호,최남송,남기엽,안순길 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.10
We describe the structure-based design and synthesis of N-(2,6-difluorophenyl)-3-(9H-purin-6-yl)pyridine-2-amine derivatives as a selective pan-RAF kinase inhibitor. The synthesized compounds showed highly potent and specific inhibition of the BRAFV600E mutant cell line. Among them, N-(3-((3-(9H-purin-6-yl)pyridine-2-yl)amino)-2,4-difluorophenyl)furan-3-sulfonamide (4b) exhibited the most potent inhibitory activities against protein kinase enzymes BRAFV600E, BRAFWT, and CRAF (IC50 of 2, 2, and 1 nM, respectively) and a mutant cell line bearing a BRAFV600E mutation, A375P (GI50 of 7 nM).
계획 기반의 재난대응 및 상황관리를 위한 eSOP 시스템 활용 방안 연구
홍성표(Hong Sung Pyo),정종수(Cheung Chong Soo) 한국방재학회 2017 한국방재학회논문집 Vol.17 No.6
지자체 등 재난관리책임기관에서는 신속하고 체계적인 재난대응을 위해 위기관리 매뉴얼의 개선과 함께 “재난대응수칙작성지침”을 새로 마련하여 재난대응계획을 수립하고 있다. 그밖에도 여러 공공 및 민간분야에서는 비상대처계획, 업무연속성계획 등 여러 유형의 재난대응계획을 수립하고 있다. 그런데 이들 재난대응계획을 보다 효과적으로 수립·관리하고 재난 발생시 활용성을 높이기 위해서는 표준행동절차(SOP) 형식으로 대응계획을 수립하고 이를 시스템화 해서 대응 및 상황관리 등에 활용할 수 있어야 한다. 이에 본 연구에서는 eSOP(전자표준행동절차) 형태로 재난대응계획을 수립하고 재난대응 및 상황관리에 활용하기 위한 방안을 제시한다. Disaster management agencies such as local governments are preparing disaster response plans through improvement of crisis management manuals and preparation of “guideline of disaster response instruction” for rapid and systematic disaster response. In addition, various types of disaster response plans, such as emergency response plan and business continuity plan are also devised in various public and private sectors. In order to better establish and manage these disaster response plans and enhance utilization in the event of a disaster, the response plan should be established in the form of a standard operation procedure (SOP) and utilized for disaster response & situation management. In this study, many ways for disaster response planning in the form of eSOP (electronic SOP) and utilization of disaster response & situation management are suggested.