Enzyme-Linked Immunosorbent Assay를 이용한 Plasminogen Activator Inhibitor-1(PAI-1)의 측정법 개발과 심부정맥 혈전증 환자에서의 변동에 관한 연구

박선양,계경채,김병국,김노경,이문호,이규섭,박문규,박근조 해성병원 1992 海星病院論文集 Vol.1 No.-

一酸化炭素中毒

朴根祚,金明植 서울대학교 의과대학 내과동문회 1973 含春內科 Vol.4 No.2

중추신경계를 침범하지 않은 전신성 Cryptococcosis의 치유례

박근조,한용철 대한결핵 및 호흡기학회 1975 춘계학술대회 초록집 Vol.40 No.-

Enzyme - Linked Immunosorbent Assay 를 이용한 Plasminogen Activator Inhibitor - 1 ( PAI - 1 ) 의 측정법 개발과 심부정맥 혈전중 환자에서의 변동에 관한 연구

박선양(Seon Yang Park),계경채(Kyung Chae Kye),김병국(Byoung Kook Kim),김노경(Noe Kyeong Kim),이문호(Moon Ho Lee),이규섭(Kye Sup Lee),박문규(Moon Kye Park),박근조(Keun Jo Park) 대한내과학회 1989 대한내과학회지 Vol.36 No.2

N/A It has been suggested that impaired fibrinolysis plays a role in the development of deep vein thrombosis. The net fibrinolytic activity of blood is dependent on the sum of different types of plasminogen activators (PAs) and plasminogen activator inhibitors (PAIs). Therefore, assessment of each component of the fibrinolytic system is important in order to understand the underlying basis of thrombotic disorders. Certain pathological conditions may exhibit elevated plasma PAI which may inactivate endogenous PA by forming PA-PAI complexes. These enzymatically inactive complexes will not be detected by most functional assays. As PAs released into the circulation are captured within minutes by the excess of PAIs, it is reasonable to assume that PAIs may play an important role in regulating the activity of PAs, and hence the net fibrinolytic activity of the blood. Among the different forms of PAIs, PAI-1 synthesizd and secreted by the endothelial cells and found in the platelets has been suggested to play a major role in the regulation of fibrinolytic activity of the blood. For these reasons, we developed an enzyme-linked immunosorbent assay specific of human PAI-1 and measured its plasma levels in normal Korean subjects and in patients with deep vein thrmbosis. 1) Our ELISA for PAI-l measured both the free PAI-1 and u-PA-PAI-1 complexes. 2) The PAI-1 concentration of our PAI-1 standard, a conditioned medium of cultured human umbilical vein endothelial cells, was 257 ng/ml. 3) The PAI-1 concentrations of EDTA plasma in 16 normal Korean subjects ranged from 0-12,8 ng/ ml (4. 8+ 3.4 ng/ml). 4) The plasma PAI-1 levels in 13 patients with deep vein thrombosis were elevated to 2.8-38.4 ng/ml (16.6+ 9.8 ng/ml). This difference was statistically significant when compared to normal subjects (p<0.001). 5) With a cut-off value of 15.0 ng/ml (up to 3 SD from the mean) for normal plasma PAI-1 concentrations, 6 of the 13 patients (46.2%) with deep vein thrombosis were found to have elevated PAI-1 levels in their plasma, while all the normal subjects had their plasma PAI-1 levels in the normal range.

一部地域 老人들의 主權的 建康水潗에 영향을 미치는 IADL에 관한 硏究

김근조,박흥기,권혁수,배수찬 대한정형물리치료학회 2001 대한정형도수물리치료학회지 Vol.7 No.1

This research have been made to define how the IADL (Instrumental Activity of Daily Living) performance and the subjective health index of the Aged are affected by their residential circumstance, gender and age, and how deeply these two factors are related and interact. For the period of June 1 to July 31, 2000, we had conducted a questionnaire and direct interview with 693 persons over age sixty-five (65) in Daejon and in other adjacent area, grouping into three different residential types The Aged living at home, The Aged living at welfare facilities and The Aged living alone, and studied on how the IADL performance and the subjective health index of the Aged are influenced and interact as per their characteristics, daily activity and mentality. We had analyzed all the data obtained through this research by the method of : - analysis of frequency as per specific factors by SPSS 10.0/PC+, - x^2 test, - t - test, - ANOVA, - multiple regression analysis by factors. The research concludes followings : a. It appears that the three (3) factors such as gender, age and residential circumstance of the Aged deeply affect the IADL performance and subjective health index of the Aged. (p<0.01) b. With regard to IADL performance of the Aged by the gender, it was analyzed that the female-Aged gains 23.8 point on average, which shows the performance of the female-Aged is less independent. (p<0.01). In addition, it was also found that the IADL performance is becoming less and less independent following their age increasing. In analyzing IADL performance by the residential type, it appears that the Aged living at welfare facilities gains the lowest 21.5 points and is least independent. It was also found that the Aged living at welfare facilities need some assistances from others for their performing IADL. (20-24 point) (p<0.001) c. With regard to the subjective health index of the all-Aged participated in this research, the analysis indicates 8.8 point and this is considered as a point of general standard (7-10 point). In analyzing this index by the gender, the female-Aged gains only 8.6 point which explains a lot of female-Aged consider they are not really healthy. (p<0.001) In analyzing this index by the residential type, the Aged living at welfare facilities and the Aged living alone gain the comparatively lower point, - respectively 8.4 point for the Aged living at welfare facilities and 8.8 point for the Aged living alone. The Aged living at these two residential types express they are obviously in a bad situation of health. (p<0.001) d. With regard to the factors affecting the IADL performance and the subjective health index of the Aged, it was analyzed that the IADL performance can largely be affected by the factors such as depression, frequency of going-out and age rising, and that the subject health index can also deeply be affected by depression, pain and by how much they are satisfied with their current living conditions. e. It was analyzed that the interacting between the IADL performance and the subjective health index is not that strong but even weak. As a result, we were able to conclude that the IADL performances is less independent in case of the female-Aged, the Aged living at welfare facilities, and following the age rising. As for the subjective health state the Aged themselves are aware of, we concluded that the female-Aged, the Aged living at welfare facilities and the Aged living alone, are more critical about their health. From this research, we were able to realize that, when the OMT (Orthopedic Manual Therapy) needed, the physical therapists are really required to have a correct and cautious understanding of the situation in which the aged persons are, and take care of them with more concerns and more improved treatment.

환자의 일반적 특성과 의료기관에 따른 물리치료 서비스 및 물리치료사에 대한 만족도 조사 - 김천지역 중심으로 -

박흥기,정병옥,김근조,안병헌,Park, Hung-Ki,Jung, Byeong-Ok,Kim, Geun-Jo,Ahn, Byung-Heon 대한물리치료과학회 2008 대한물리치료과학회지 Vol.15 No.4

Background: The purpose of this study show the degree of physical therapy service and physical therapist according to medical institution by measuring and determining the factor affecting patient satisfaction in the Gimcheon city. Methods: For this study 100 questionnaires were distributed to medical institution, Gimcheon city from Jul 20 to Aug 5, 2008. The consisted of total 28 items. The contents item divided the general characteristics into nine heads, the satisfaction of physical therapy service into nine heads, and the physical therapy into ten heads. Survey data were collected by a written questionnaire. The collected date were analyzed by t-test, ANOVA. Results: There was difference with statistic value in physical therapy according to medical security and handicapped or non-handicapped(p<.05). There was difference with statistic value in physical therapy service and physical therapist according to medical institution. The score of patient satisfaction at welfare facilities was significantly lesser than other medical institution(p<.05). Conclusion: There was difference with statistic value in physical therapy service and physical therapist according to a number of patients of physical therapy a day.

한국인의 고관절 회전 가동 범위의 측정 및 비교 고찰

박흥기,김근조,주무열 대한정형물리치료학회 2003 대한정형도수물리치료학회지 Vol.9 No.1

The test for internal and external rotation of hip joint, was donet from September 2 to 9, 2002, with the participation of 50 male/female university students who are in a normal health condition. Results are : 1. When applying the external rotation of 45 degrees angle ; 1) In a sitting position, for male it results in an increase of 5 degrees on right and left sides each. 2) In a sittmg position, for female there is no change on both right and left sides. 3) In a supine position, for both male and female it results in an increase of 5 to 10 degrees on right and left sides each. 4) In a prone position, for male it results in an increase of 5 degrees on the left side only. 5) In a prone position, for female it results in an increase of 5 to 10 degrees on right and left sides each. 2. When applying the internal rotation of 45 degrees angle ; 1) In a sitting position, for male it results in a decrease of 5 degrees on right and left sides each. 2) In a sitting position, for female there is no change on both right and left sides. 3) In a supine and prone position, there is no change for male. 4) In a supine position, for female it results in an increase of 5 to 10 degrees on right and left sides each. 5) In a prone position, for female it results in an increase of 5 degrees on right and left sides each.

자세 변화와 도구 사용 시 최대 들숨과 날숨 시 호흡근의 근활성도 차이

김근조(Keun-Jo Kim),장영(Zang Rong),조동혁(Dong-hyeok Jo),정주은(Ju-eun Jeong),김경규(Gyeong-gyu Kim),김문규(Mun-kyu Kim),김민지(Min-zy Kim),김현승(Hyun-seung Kim),박경현(Kyeong-hyeon Park),박새롬(Sae-rom Park),이영준(Yeong-jun Lee) 대한심장호흡물리치료학회 2021 대한심장호흡물리치료학회지 Vol.9 No.1

Purpose : In this study, we aimed to measure how respiratory muscle activity changes as posture changes. We also aimed to measure the inspiratory sternocleidomastoid (SCM) and upper trapezius (UT) muscle activities as well as expiratory rectus abdominis (RA) and oblique abdominis (OA) muscle activities in healthy male and female university students in their twenties. Methods : Using the percentage of reference voluntary contraction (% RVC) with electromyography, we measured the SCM, UT, RA, and OA muscle activities in 16 healthy male and female university students in their 20s according to position change and breather tool use. Results : We found that the average value of inspiratory and expiratory muscle activities by posture was highest when using the breather tool. When using the tool with 10-mm and 2-mm straws for standard breathing at rest in the sitting position, a statistically significant increase in SCM, UT, and OA activities occurred (p < 0.05). For standard breathing at rest in the supine position, a statistically significant increase in SCM, RA, and OA activities occurred (p < 0.05). Conclusion : In clinical application, it may be better to use a respiratory muscle-strengthening tool to increase the activity of inspiratory and expiratory muscles.

대호(大湖)의 수질변화에 관한 연구

심재환,박근조,김원기 한국환경농학회 1988 한국환경농학회지 Vol.7 No.2

大湖 防潮堤 築造 後 淡水湖의 水質을 調査하여 염농도 및 일반수질변화가 관개용수원에 미치는 영향을 糾明하고자 '84年 에서 '88年 5月 까지의 調査結果를 要約하면 다음과 같다. 1. 大湖 淡水湖의 水溫分布는 암거탄구 設置地點인 -14m 상부에는 季節變化에 따른 氣溫의 영향으로 變化(6-25℃)가 많았으며, 암거탄구 이하에서는 11.9℃로 年中 變化가 없었다. 2. 防潮堤 앞 제일 깊은곳의 年度別 수질변화는 pH7.6 ECl6,800-1,472μm hos/㎝, DO 9.2-10.8ppm, BOD 1.3-2.5ppm, COD 2.4-5.3ppm, T-N 0.22-2.29pp, T-P는 0.01-0.10ppm을 나타내었다. 3. 大湖 淡水層의 평균 수질성적('88년)은 pH 7.6, EC1,745um hos/㎝, DO 10.8ppm, BOD 1.8pp, COD 2.4pp, T-N 0.52ppm, T-P 0.05ppm으로 全 地點에서 비슷한 傾向이었다. 4. 淡水層(6m)에서의 鹽度變化는 締切 前 29,000ppm에서 '84年 3月 11,000ppm '85年 3月 4,300ppm,'86年, '87年 3月에는 2,000ppm, '88년 3月에는 900ppm 까지 낮아졌다. 湖內 平均 鹽度 29,000ppm 정도에 서 '88年 3月 1,200ppm 까지 낮아졌다. 또한 암거탄구 상부의 평균염도('87年)는 1,300ppm 정도였으며, 탄구아래는 海水와 같은 30,000ppm정도였다. 5. 淡水層에서 가장 높은 염도를 나타낸 地點은 防潮堤 앞 부근이며,'84年에는 5,835ppm 이었다. 6. 調査時期別 鹽度變化는 갈수기인 '87年 5月 2,000ppm에서 홍수기 후 8月 800ppm, 풍수기인 9月에는 485ppm까지 낮아졌다. 7. 鹽分躍層 깊이는 암거탄구 地點인 -l4m까지 維持되어 淡水湖化가 進行되었다. 그러므로 大湖 淡水層의 수질은 農業用水源으로는 큰 문제가 없으며, 삽교호로부터 除鹽用水의 供給도 불필요할 것으로 사료된다. This study was designed to find out whether the water quality of Lake Daeho would be suitable for Sgricultural purposes during 1984-1988 perird. Thr results were as follows ; 1. There was an apparent seasonal temperature fluctuation(6-25℃) above the entrance of the culvert at the depth of 14m, but the temperature below remained constant at 11,9℃. 2. The yearly water qualities observed at the deepest site by the seadike were 7.4-7.5 pH, 16,800-1,472 umhos/cm EC, 9.2-10.8ppm DO, 1.3-2.5ppm DOD, 2.4-5.3ppm COD. 0.22-2.29ppm T-N, 0.01-0.l0ppm T-P. 3. The average values of water qualities at the epilimnion in 1988 were 7.6 pH, 1,745umhos/cm EC, 10.8ppm DO, 1.8ppm DOD, 2.4ppm COD, 0.52ppm T-N, 0.05ppm T-P. 4. The salinity of the epilimnion at a 6m depth was 29,000ppm before the final closure of the seadike. It was 11,000 ppm in March 1984, 4,300ppm in March 1985, 2,000ppm in March 1986 and 1987, and 900ppm in March 1988. The salinity of the whole water column decreased from 29.000ppm to 1,200 ppm in March 1988. The average salinity above and below the culvert in 1987 was about 1,300ppm, and 30,000ppm respectively reaching that of seawater. 5. The highest salinity was observed at the epilimnion by the seadike, showing about 5,835ppm in 1984. 6. The seasonal salinity fluctuation was 2,000ppm in May, 800ppm in October, and 485ppm in September 1987. 7. The halocline was observed at the depth of 14m where the entrance of the culvert was located. Therefore, the epilimnion water is suitable for agricultural purposes, and the intake of water from Lake Sapkyo seems to be unnecessary.

국산 청력 보호구 <귀마개>의 보호효과에 관한 실험보고

송동빈,황정민,박근조,한광수 국군의무사령부 1981 대한군진의학학술지 Vol.12 No.1