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EPIC 센서를 이용한 Hand Tracking 및 Calibration 알고리즘
조정재,김영철,Jo, Jung Jae,Kim, Young Chul 한국스마트미디어학회 2013 스마트미디어저널 Vol.2 No.1
논문에서는 EPIC(Electronic Potential Integrated Circuit) 센서를 이용한 Hand tracking 및 Calibration 알고리즘을 연구하였다. 주변의 전위차를 감지하는 EPIC 센서의 특성을 분석하고, 이러한 특성을 고려한 EPIC 센서들 간의 감지된 진폭의 차를 이용하여 이차원 좌표 변환을 구현하였다. 이에 추가적으로 주변 환경에 민감한 EPIC 센서의 특성을 고려한 Calibration 알고리즘을 구현하였으며, 효과적으로 목표물을 추적하도록 칼만 필터 알고리즘을 적용하였다. 구현된 알고리즘은 검증 및 분석을 위해 윈도우 어플리케이션 환경으로 구현하였으며 EPIC 센서의 아날로그 데이터를 추출하기 위해 DAQ(Data Acquisition) API 함수를 사용하였다, DAQ 하드웨어는 전기적 신호를 측정 및 생성할 수 있는 기능을 가지고 있으며, DAQ API를 통해 아날로그 또는 디지털 신호를 측정 및 생생할 수 있다. 측정된 아날로그 신호를 구현된 알고리즘을 통해 사용자의 손의 움직임에 따라 EPIC 센서에서 전위차를 감지함으로써 PC의 mouse cursor 움직임을 확인한다. In this paper, we research the hand tracking and calibration algorithm using the EPIC sensor. We analyze the characteristics of EPIC sensor to be more sensitive in the around E-filed, and then we implement the 2-dimensional axis-transformation using the difference of detected amplitude between EPIC sensors. In addition, we implement the calibration algorithm considering the characteristics of EPIC sensor, and then we apply the Kalman filter to efficiently track a target. Thus, we implement the environment of window applications for verification and analysis the implemented algorithm. In turn, we use the DAQ API to extract the analog data. The DAQ hardware has the function of measuring and generating an electrical signal. Moreover, we confirm the movement of mouse cursor by detecting the potential difference depending on the movement of the user's hands.
Development of a simultaneous LC–MS/MS method to predict in vivo drug–drug interaction in mice
조정재,조준현,김선주,이재목,이상규 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.4
Cocktail substrates are useful in investigatingdrug–drug interactions (DDI) that can rapidly identify thecytochrome P450 (CYP) isoforms that interact with testdrugs. In this study, we developed and validated five probedrugs for CYP1A, CYP2B, CYP2C, CYP2D, and CYP3Ausing LC–MS/MS to determine CYP activities in mice. The five probe substrates were caffeine (2 mg/kg), bupropion(30 mg/kg), omeprazole (4 mg/kg), dextromethorphan(40 mg/kg), and midazolam (2 mg/kg) for CYP1A,CYP2B, CYP2C, CYP2D, and CYP3A, respectively. Thecocktail substrates were orally administered to male5-week-old ICR mice over 0–240 min. The analyticalmethod was validated; it showed high selectivity, linearity,and acceptable accuracy. We confirmed the lack of interactionof this cocktail in the control state (no effect of CYPinducer or inhibitor) and suggested AUCratio (metabolite/substrate) as a unit to evaluate DDI in vivo. In addition,the cocktail assay was applied for the determination ofpharmacokinetic parameters against phenobarbital as aselective CYP2B inducer and ketoconazole as a strongCYP3A inhibitor. The concentration of cocktail substratesand the LC–MS/MS method were optimized. In conclusion,we developed a simultaneous and comprehensiveanalysis system for predicting potential DDI in mice.
조정재,조필중,이상규 사단법인 한국질량분석학회 2018 Mass spectrometry letters Vol.9 No.2
Ginseng (Panax ginseng Meyer) has been used as traditional herbal drug in Asian countries. Ginsenosides are major components having pharmacological and biological efficacy like anti-inflammatory, anti-diabetic and anti-tumor effects. To con- trol the quality of the components in diverse ginseng products, we developed a new quantitative method using LC-MS/MS for 13 ginsenosides; Rb1, Rb2, Rc, Rd, Re, Rf, 20(S)-Rh1, 20(S)-Rh2, Rg1, 20(S)-Rg3, F1, F2, and compound K. This method was successfully validated for linearity, precision, and accuracy. This quantification method applied in four representative ginseng products; fresh ginseng powder, white ginseng powder, red ginseng extract powder, and red ginseng extract. Here the amounts of the 13 ginsenosides in the various type of ginseng samples could be analyzed simultaneously and expected to be suitable for quality control of ginseng products.
조정재,이상규 사단법인 한국질량분석학회 2017 Mass spectrometry letters Vol.8 No.4
Ginseng (Panax ginseng Meyer) is a well-known health functional food used as a traditional herbal drug in Asian countries owing to its diverse pharmacological effects. Herb-drug interactions may cause unexpected side effects of co-administered drugs by the alteration of pharmacokinetics through effects on cytochrome P450 activity. In this study, we investigated the herb-drug interactions between Korean red ginseng extract (KRG) and five CYP-specific probes in mice. The pharmacokinetics of KRG extract induced-drug interactions were studied by cassette dosing of five CYP substrates for CYP1A, 2B, 2C, 2D, and 3A and the LC-MS/MS analysis of the blood concentration of metabolites of each of the five probes. The linearity, precision, and accuracy of the quantification method of the five metabolites were successfully confirmed. The plasma concentrations of five metabolites after co-administration of different doses of the KRG extract (0, 0.5, 1, and 2 g/kg) were quantified by LC-MS/MS and dose-dependent pharmacokinetic parameters were determined. The pharmacokinetic parameters of the five metabolites were not significantly altered by the dose of the KRG extract. In conclusion, the single co-administration of KRG extract up to 2 g/kg in vivo did not cause any significant herb-drug interactions linked to the modulation of CYP activity.