FCT 5 : Fractional laser-assisted topical imiquimod 5% cream treatment for recalcitrant common warts in children

( Hyun Chang Ko ),( Jeong Min Kim ),( Hyun Ho Cho1 ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Conventional destructive modalities for warts like cryotherapy or laser ablation have some limitations that are excruciating pain during procedure, in especially pediatric patients. Imiquimod is a topical immune response modifier that was approved for treating genital and perianal warts. But, thick stratum corneum of common warts may act as a barrier against drug permeation via the skin. Objectives: To evaluate efficacy and safety of above treatment. Methods: Eleven pediatric patients (6 female and 5 male, mean age 12.5 years) were included in this study. The lesions were treated by fractional 2940 nm Er:YAG laser for achieving the penetration of stratum corneum with 1 or 2 weeks intervals. Then, imiquimod 5% cream was self-applied once daily for 5 days a week. Assessment of response and adverse effects was performed every 2 weeks until complete clearance or up to maximum of 48 weeks. Pain during procedure was checked by VAS (0-10). Results: 8 out of 11 (72.7%) patients experienced complete clearance of all warts lesions. Mean duration of total treatment was 29.7 (16-48) weeks. Mean number of fractional laser treatment was 17.5 (8-37) times. No significant adverse effect was observed. VAS score of the pain during fractional laser treatment was 2.4 (1-4), comparing with 6.2 (5-8) during cryotherapy. Conclusion: Fractional ErYAG laser-assisted topical 5% imiquimod cream is an effective and safe treatment option for recalcitrant common warts of the children do not tolerate pain well.

수산물채취 잠수부에서 발생한 중증감압병 37예 분석

조수헌,양대현,최헌 大韓産業醫學會 1989 대한직업환경의학회지 Vol.1 No.1

1986년 12월부터 1988년 11월까지 2년간 지방공사 강남병원 고압산소치료센타에 내원하였던 489명의 감압병환자중 신경계증상 등 중증증상을 보인예는 39명이었다. 이중 수산물채취 잠수작업중 중증감압병에 이환되어 미해군 재가압치료표에 따라 치료가 끝난 37명에 대하여 일반적 특성 및 잠수의학적 특성에 관한 자료를 조사하였다. 중증감압병환자의 67.5%가 25∼34세 연령층에 있었으나 10.8%는 45∼49세의 고연령층 이었다. 1년 미만의 잠수경력을 가진 예가 21.6%이었으며, 잠수기술은 70%가 체계적인 교육보다는 현장에서 잠수작업을 거들면서 기술을 습득하였다. 감압병 발병당일의 잠수형태에서는 31∼50m의 수심에서 2∼8회의 반복잠수 후에 흉부통증 또는 하지감각장애 등의 증상이 나타났는데, 증상발현은 수면부상후 30분이내에 83.7 %가 그리고 3시간이내에 100% 나타났다. 증상발현후 재가압치료를 받기까지의 경과시간은 평균 18시간으로, 재가압치료를 받아 완치된 경우에 있어서는 평균 12일의 입원기간중 11.3회의 고압산소요법을 실시하였다. 중증감압병의 경과 및 회복에는 발생전날의 반복잠수와 주증상발현후 재가압 치료까지의 경과시간이 지연되는 경향을 보였다. Hospital records were reviewed for 486 divers who have been diagnosed as decompression sickness(DCS) at Kangnam General Hospital between December 1986 and November 1988. Among 39 cases classified as serious DCS(type II), the patients had been fishery diving in 97.4% of the cases. The ages of the afflicted divers ranged from 22 to 47 years, with a mean of 31.5% years. The divers were experienced being less than one year in 21.6% and 70% of them learned diving skill by self-taught. In 86.5% of the cases the divers had made multiple divies ranged in depth from 31 to 50 meters. Thirty-one(83.7%) of the patients noted their symptoms within 30 minutes of surfacing. The spinal cord was most often affected, and the most common symptoms were 'numbness' or 'tingling' in one or more extremities and discomfort or pain on the chest. Recompression treatment was delayed for 18 hours in average after the onset of dysbaric symptoms and this treatment is more likely to be effective the sooner that it commences after the onset of dysbaric symptoms.

면역억제제를 사용치 않은 동소성 간이식 실험견의 조직병리소견

조원현,최순옥,김인호,임태진,김성수,박준희,김우석,김현철,최규택,김진모,권건영 大韓移植學會 1994 Korean Journal of Transplantation Vol.8 No.1

한국 재래 우 및 산양 위장관의 somatostatin cell에 대한 면역조직화학적 분포

조성환,김현수,박배근,윤원기,손화영 충남대학교 수의과대학 동물의과학연구소 1995 動物醫科學硏究誌 Vol.3 No.-

The relative frequency and distribution of somatoatatin immunoreactive cells were investigated by the immunohistochemical method in the gastrointestinal tract of the Korean native cattle and goat. The results obtained were as follows: In the Korean native cattle, somatoststin cells were a few in the pyloric and duodenal region and rarely seen in fundic region, jejunum, ileum, cecum, proximal colon, central coil, distal colon and rectum. In the Korean native goat, somatostatin cells were the most numerous in the pyloric region and the next in the fundic region. And they were a few in the duodenum, not detected in the cecum and sparse in the jejunum, ileum, proximal colon, central coil, distal colon and rectum.

슈만의 피아노작품「크라이스레리아나, op.16」과 E.T.A.호프만의 소설「카터 무어」에 나타난 구조적 연관성

조현수 명지대학교 예체능연구소 1999 藝體能論集 Vol.10 No.-

The Relationship between literature and music implied in R.Schumann's Kreisleriana provides performers with specific clues to understanding the content of the music. It is thought that E.T.A. Hoffmann's novel, Kater Murr might have influenced Schumann when he wrote Kreisleriana. They share the similar structure and character. The purpose of this paper is to compare Kreisleriana with Kater Murr in order (1) to understand how the music is structured as a unified cycle even though it is often fragmentary, and includes abrupt contrasts, and (2) to discover how Schumann associated particular compositional techniques with different kinds of emotional expression or character portrayal.

Dehydroepiandrosterone과 노화

조수현 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.1

There is an increasing evidence that dehydroepiandrosterone(DHEA) is an important mammalian steroid. Cancers. artherosclerosis, and dectease of immunloogical responses and brain function are frequently observed in aging. These changes in aging is accompanied by a progressive decline in the sectetion of the adrenal DHEA, the steroids at the highest concentration in the blood of young man. Until recently, no specific molecular or cellular target of DHEA has been described. However, the mode of action of DHEAprobably involved two series of mechanisms : 1) transformation of DHEA into active sex steroids(andregen, esterogen) that promote overall anabolic effects in several tissue, and 2) effects in the central nervous system through an inhibition of the GABAA receptor and a potentiator of NMDA and sigma receptor function. In the last few years, striking effects of DHEA has been obtained mostly in animal experiments. The preventive and/ or therapeutic activity of DHEA has been reported for the development of arte-rial lision, diabetes, cancer, infection and improvement of physical and psychological well-being. A steroid without(up to now)a proper selective receptor, and acting in part through metabolites, DHEA is not a typical hormone. At present there is only the intention of relieving, for as long as ossible, some of damage caused by aging within the framework of research based on physionlogical data and under medical surveillance. Several years will be necesary to pass from precise and limited observations to al sure, dfficacious DHEA useable by many people.

백워드 설계에 기반한 융합인재교육(STEAM) 프로그램 개발 및 적용

조수현,박창언 이화여자대학교 사범대학 교과교육연구소 2013 교과교육학연구 Vol.17 No.4

본 연구는 백워드 설계 모형에 기반한 과학 중심융합 인재 교육(STEAM) 프로그램의 개발과 적용 사례를 소개하는 것으로 초등학교에 적합한 융합인 재교육(STEAM) 방법을 논의하는 데 목적을 두고 있다. 본 연구의 연구 문제는 다음과 같다. 첫째, 백워드 설계에 기반한 초등 과학과 STEAM교육 프로그램은 어떻게 구성할 수 있는가? 둘째, 백워드 설계에 기반한 초등 과학과 STEAM교육이 학습자의 융합적 소양측면에서 어떠한 영향을 미치는가? 또한 본프로그램에 대한 교사들의 숙의는 어떠한가? 현재 국가정책적으로 융합인 재교육을 굉장히 강조하고 있는 추세이다. 이러한 현실에서 본 연구는 STEAM교육을 초등 일반 단위 학급 내에서 어떻게 효과적으로 구현될 수 있을지에 대한 고민으로부터 출발하여 STEAM 프로그램을 개발하고 실질적 운영 사례를 통해 STEAM교육 실천 가능성에 대한 경험적 논의를 시도하였다. 본 연구는 초등학교 3학년 동물 단원을 대상으로 한 초등융합 인재 교육 프로그램 개발 및 적용 연구로서 이해 중심설계 방식인 백워드의 원리와 Drake의 탈교과적 방법에 기초해 융합인 재교육 프로그램을 개발하였다. 또한 STEAM교육을 실행하고 있는 현장 교사들의 협의를 바탕으로 현장의 상황과 요구를 최대한 반영하여 프로그램을 개발하였다. 그리고 이를 직접 적용해 본 것을 학생들의 융합적 소양에 대한 검토뿐 아니라 실제 교사들의 숙의와 경험적 맥락에서 분석하고 논의하였다는데 의의가 있다. 이 연구를 통해 얻은 결과는 다음과 같다. 첫째, 본 프로그램의 효과를 알아보기 위해 실험반과 비교반의 사전․ 사후 융합적 소양검사를 해본 결과 감성적 체험, 창의적 설계, 내용 융합의 측면에서 STEAM을 적용한 실험 반 학생들의 결과가 비교반에 비해 높게 나타났다. 둘째, 본 프로그램 공개 수업후 교사협의 내용을 상황 제시, 창의적 설계, 감성적 체험의 세 가지 STEAM 요소 관점에서 분석해 본 결과 본프로그램에 대해 긍정적인 반응이 나타났다 This study introduces the development and application of S-STEAM education conducted with third-grade students in J elementary school. It suggests an ideal teaching/learning methodology for STEAM education suitable for elementary science and shares ideas about STEAM education. The focus of this study is the following. First, how could the STEAM program for science be organized based on backward design? Second, how would the students think and feel about the STEAM factors after the STEAM program? And, through deliberative procedures, how would teachers feel about a program based on STEAM? The most significant meaning about this program is that it was developed on a basis of teacher discussions and classroom situations, followed by incisive consultations about STEAM. The results are as follows. The effectiveness of this program was analyzed by students and teachers on a basis of three STEAM factors developed by the Korea Foundation for the Advancement of Science and Creativity. The program seems to be effective and meaningful for elementary science STEAM education. Two main methods were used: backward design that pursued an understanding of topics and a trans-disciplinary methodology. These provided the procedure for the organization of this program and were key to the success of the STEAM program that was developed in this study.

적절한 용량 이하의 경구용 향응고제 사용 중 발생한 뇌출혈 환자의 임상 양상

조수진,황흥곤,나찬영,이영탁,최현배,조태구 世宗醫學硏究所 2000 世宗醫學 Vol.17 No.2

선천성 관동정맥루의 경피적 경도관 Coil 색전 1례

조준식,김동수,서정기,장양수,김현승,이도연 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.9

다수 영구치의 매복 및 맹출 지연의 교정치험례

조사현,양규호,김수지 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.3

This report presents a case of adolescent patient who had multiple impacted teeth and no systemic disease, and was treated with removable and fixed orthodontic appliances. The results obtained through these cases were summarized as follows: 1. Even in the case without systemic disease, there can be the delayed eruption of multiple teeth. 2. If the root formation is not completed, root have no excessive curvature, axial inclination of the tooth is not excessive, and there is eruption space, the tooth can be induced to normal occlusion. 3. Since esthetically proper occlusion and dentition was acquired by recovery of the impacted teeth ot normal occlusion, the prosthodontic treatment after extraction of the impacted teeth was less needed. 4. This treatment brought psychological stability to pubertal patient who was interested in his facial profile.