0.8μm CMOS 표준 셀 라이브러리의 설계와 검증

이재철,이충훈,오용호 圓光大學校 基礎自然科學硏究所 1997 基礎科學硏究誌 Vol.15 No.2

0.8㎛ CMOS 공정 기술을 사용하여 셀 라이브러리를 개발하고 성능을 평가하였다. 셀 라이브러리는 150여 개의 기본 리프 셀(leaf cell)과 이들의 상호 연결만 기록한 마크로 기능(macro function) 블럭으로 구성하였다. 셀 라이브러리의 성능을 측정하고 논리 시뮬레이션 모델을 개발하기 위하여 평가 칩을 설계하여 제작하였다. 셀 배치 및 배선 프로그램으로 설계한 마크로 기능(82C37)칩을 실제 제작하여 시뮬레이션 모델의 정확성을 측정하고 라이브러리의 신뢰도를 평가하였다. We developed a standard cell library using 0.8㎛ CMOS process technology and evaluated the performance of the library. The library is consisted of 150 basic leaf cells and the macro functions which have the connection information of leaf cells. Also, we designed and produced a performance chip to evaluate the cell library and to develop a logic simulation model. Finally, we designed and macro function chip with a cell placement and routing program to measure the accuracy of the simulation model and the reliability of the library.

HIV 감염 환자에서 발생한 편평 콘딜롬 1예

이해웅,오상현,장성은,최지호,문기찬,고재경 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.4

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

시클러 캡슐(세파클러 250㎎)에 대한 경보세파클러 캡슐의 생물학적동등성

조혜영,강현아,김세미,박찬호,오인준,임동구,문재동,이용복 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1

The purpose of the present study was to evaluate the bioequivalence of two cefaclor capsules, Ceclor (Lilly Korea Co., Ltd.) and Kyongbocefaclor (Kyongbo Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of cefaclor from the two cefaclor formulations in vitro was tested using KP VIII Apparatus II method with various dissolution media (pH 1.2. 4.0. 6.8 buffer solution and water). Twenty four healthy male subjects. 22.96±1.52 years in age and 67.03±7.90 kg in body weight, were divided into two groups and a randomized 2x2 cross-over study was employed. After one capsule containing 250 mg of cefaclor was orally administered, blood was taken at pre-determined time intervals and the concentrations of cefaclor in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. In addition. the pharmacokinetic parameters such as AUC_(t), C_(max) and T _(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t). C_(max) and untransformed Tmaa. The results showed that the differences between two formulations based on the reference drug, Ceclor. were -1.90%, 2.68% and -7.60% for AUCt, C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.91-log 1.06 and log 0.92-log 1.18 for AU', and C_(max), respectively). Thus. the criteria of the KFDA bioequivalence guideline were satisfied, indicating Kyongbocefaclor capsule was bioequivalent to Ceclor capsule.

중추에서 Prostaglandin계가 Renin-angiotensin System에 미치는 영향

최영태,김종승,문성호,오형균,김재훈,전제열,염철호,윤평진 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.1

Role of prostaglandins on the renin-angiotensin system in the central nervous system was examined in normotensive and 2-kidney, 1 clip (2K1C) hypertensive rats. The experiment was done under thiopental (50 ㎎/㎏, IP) anesthesia. Captopril and indomethacin were injected into the right lateral cerebral ventricle. Arterial blood pressure and heart rate were recorded from the femoral artery. Intracerebroventricular (ICV) captopril (1 ㎎) caused a decrease in mean arterial pressure in both normotensive and 2K1C hypertensive rats. The depressor response to captopril was more sensitive in hyper-tensive rats than in normotensive rats. Indomethacin treatment (ICV, 200 ㎎) altered the depressor response to captopril neither in normotensive nor in hypertensive rats. These results suggest that the cardiovascular effect of renin-angiotensin system in the central nervous system may not be mediated via prostaglandin systems in normotensive and 2KlC hypertensive rats.

비유피-4 정(염산프로피베린 20㎎)에 대한 건일염산프로피베린 정의 생물학적동등성

조혜영,박은자,강현아,백승희,김세미,박찬호,오인준,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.5

The purpose of the present study was to evaluate the bioequivalence of two propiverine hydrochloride tablets. BUP-4 (Jeil Pharm. Co., Ltd.) and Kuhnil Propiverine Hydrochloride (Kuhnil Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The propiverine release from the two propiverine hydrochloride formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with a variety of dissolution media (pH 1.2, 4.0, 6.8 buffer solutions, water and blend of polysorbate 80 into pH 6.8). Twenty six healthy male subjects, 23.73 ± 2.79 years in age and 67.04 ± 7.93 kg in body weight, were divided into two groups and a randomized 2 x 2 cross-over study was employed. After one tablet containing 20 mg as propiverine hydrochloride was orally administered, blood was taken at predetermined time intervals and the concentrations of propiverine in serum were determined using HPLC method with UV detector. The dis-solution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC" C _(max) and T _(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC, C_(max), and untransformed T_(max). The results showed that the differences between two formulations based on the BUP-4 were 0.17%, 7.98% and 4.55% for AUC,, C_(max), and respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically trans-formed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.88)-log(l .12) and log(0.90)-log(l.15) for AUC, and _(max), respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Kuhnil Propiverine Hydrochloride tablet was bioequivalent to BUP-4 tablet.

Case Reports : A Case of Primary Adenosquamous Carcinoma of the Liver Presented with Liver Abscess

Oh Sang Kwon,Hong Sik Lee,Dong Wook Koh,Young Jig Cho,Yeon Ho Park,Dong Kyu Park,Yong Leul Oh,Jae Hong Seo,Hoon Jai Chun,Sun Ho Um,Sang Woo Lee,Jai Hyun Choi,Chang Duck Kim,Ho Sang Ryu 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.4

Primary adenosquamous carcinoma of the liver is a very rare type of cholangiocarcinoma and is defined as a cancer containing both squamous and adenomatous components in the same lesion. Recently, we experienced a primary adenosquamous carcinoma of the live

국가 기후변화 위기관리 정책 및 연구개발에 관한 연구

Jai Ho Oh 위기관리 이론과 실천 2015 Crisisonomy Vol.11 No.2

현재의 기후변화 증거와 온실가스 추세와 지표는 모두 잘못된 방향을 향하고 있어 21세기에는 지구환경이 안 전할 수 있는 한계를 넘어설 가능성이 매우 높아졌다. 하지만 국제사회의 지구온난화를 늦추려는 노력은 국가별 구체적 목표 및 이행방향에 관한 내용이 없어 실제적인 이행 여부는 여전히 불투명한 상황이다. 이러한 상황을 고려하여 국가위기관리라는 관점에서 주요 선진국의 기후변화에 관한 정책 방향과 연구개발 체계를 비교하여 우 리나라의 정책과 연구개발에서 나타난 문제점이 토의되었다. 우리나라의 경우, 기후변화대책위원회가 최고 조정 기구로 만들어졌으나 종합적인 로드맵을 제시하지도 또 부처별 연구개발에 조정 기능도 충분하지 못하였다. 그 결과, 기후변화와 관련된 기초과학 기술 분야와 기후변화적응 분야 추진은 형식적일 수밖에 없었다. 기후변화 대 응을 위한 보다 체계화된 정책과 연구개발 추진을 위해서는 부처와는 독립된 국가적인 기후변화 지휘탑과 대응 전략 조직이 필요하다. 제시된 대응 시스템은 기후변화에 관한 국가적 목표와 실행의 시간적 가치 사이의 균형을 맞출 수 있도록 설계되어야 한다. 기후변화 대응시스템의 지휘탑은 기후변화에 대응하는 국가 전략을 제시하고, 각 부처의 기후변화 정책 및 연구개발 이행에 관한 감독 및 평가를 하여야 할 것이다. 또 기후변화 위기관리 지 휘체계는 기후변화를 충격과 제한이라는 관점에서만 대응책을 강구하는 것이 아니라 식량, 물, 에너지 위기를 지 속가능한 방법으로 개발하는 기회로 전환시키는 역할도 수행해야 할 것이다. Besides current trend and indicators of the evidences in climate change records and the atmospheric greenhouse gases concentration are heading to wrong direction so that it is more likely exceed the endurable range for the sustainable earth. However, international efforts are still limited with neither concrete target nor strategic plan. Thus, it is hard to expect any practical actions by both developed and developing country. Under these circumstances our policy and R&D options have been reviewed in a point of view of climate change risk management in comparison with present policy and R&D state of the major leading countries. The countermeasure committee for climate change was established to play a roll the highest mediation organization in Korea, However, it has enough capability neither to set the road map of national goal against climate change up nor to mediate discrepancies among the departments conducting policy and R&D on climate change issues. Accordingly, it does only formally carry out basic scientific research and climate change adaptation studies. It has been suggested to have a climate change risk management system consist of a solid control tower and cascading strategic components independent from the existing government organization to carry forward the systematic policy development and R&D. The suggested risk management system for climate change should be designed to provide a balance between governmental goal and value of action timely. The main mission of this control tower might be to set the national strategic plan up, and monitor and evaluate the action of government organization along the strategic plan. Furthermore, it plays a roll not only to handle the climate change in terms of impact and restriction but also to convert these crises of food, water and energy to opportunity for sustainable development.

Operational forecasts over East Asia using Global Model GME (40 ㎞/40 Layer) of DWD

Jai Ho Oh,H. S. Chaudhari 한국기상학회 2005 한국기상학회 학술대회 논문집 Vol.2005 No.-

Overall GME forecasts show good agreement with observations. Computational performance of GME model has been demonstrated on KISTI Teracluster. New model shows remarkable improvement in prediction of sea level pressure.

Simulation of Regional Climate over East Asia using Dynamical Downscaling Method

Oh Jai-Ho,Kim Tae-Kook,Min Young-Mi 한국수자원학회 2002 한국수자원학회 학술대회 Vol.2002 No.1