Replacements for Chromate Pigments in Anticorrosion Primers for Aluminum Alloys

( Zhang Zhang Yin ),( Wim Van Ooij ),( Paula Puomi ) 한국부식방식학회(구 한국부식학회) 2007 Corrosion Science and Technology Vol.6 No.4

Two New Species of Placolecis (Lichenized Ascomycota) from China

( An Cheng Yin ),( Xin Yu Wang ),( Dong Liu ),( Yan Yun Zhang ),( Mei Xia Yang ),( Li Juan Li ),( Li Song Wang ) 한국균학회 2019 Mycobiology Vol.47 No.4

Two new species of the lichen genus Placolecis are discovered in China, namely P. kunmingensis An. C. Yin & Li S. Wang and P. sublaevis An. C. Yin & Li S. Wang. The new combination P. loekoesiana (S.Y. Kondr., Farkas, J.J. Woo & Hur) An. C. Yin is proposed. Placolecis kunmingensis is characterized by having simple, spherical or ellipsoid, hyaline spores, and pear-shaped pycnidia; while P. sublaevis can be distinguished by its thallus forming larger aggregations with slightly flattened lobes at the thallus margin, and urn-shaped pycnidia. Descriptions, a phylogenetic tree and a key are provided for all the known Placolecis species in China.

Mathematical formulation and an improved moth–flame optimization algorithm for parallel two-sided disassembly line balancing based on fixed common stations

Zhang Yu,Zhang Zeqiang,Yin Tao,Liang-Wei Jiang 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.1

Nowadays, rapid product iterations result in large quantities of end-of-life products. To meet the fast-growing demand for remanufacturing engineering, companies have quickened the standardization and industrialization of waste dissembling. Two-sided disassembly lines can effectively disassemble large-sized products on both sides of the lines, and parallel disassembly lines can disassemble multiple products simultaneously with fewer workstations and higher production efficiency. Combining the two types of disassembly can effectively increase the disassembly efficiency of large-sized products. However, the parallel two-sided disassembly line has not been fully investigated because of the essential complexity of the problem. Therefore, this research introduced the parallel two-sided disassembly line balancing problem with fixed common stations. First, a multi-objective mixed-integer programming model is established to solve the problem for the first time. The model is proved to be correct through small-scale numerical examples. Second, a multi-objective improved moth–flame optimization algorithm is implemented to solve the proposed large-scale problems. The proposed algorithm employs a two-phase decoding approach to design the scheme and a discrete moth for fire operation to search and replace new individuals, and then a restart strategy is introduced to reduce the probability of the population falling into a local optimum. Finally, the algorithm solved extensive disassembly line balancing problems with different layouts, including the straight-line, two-sided, and parallel two-sided, and case studies demonstrated the reliability and validity of the proposed method.

MiRNA Synergistic Network Construction and Enrichment Analysis for Common Target Genes in Small-cell Lung Cancer

Zhang, Tie-Feng,Cheng, Ke-Wen,Shi, Wei-Yin,Zhang, Jin-Tao,Liu, Ke-Di,Xu, Shu-Guang,Chen, Ji-Quan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Background: Small-cell lung cancer (also known as SCLC) is an aggressive form and untreated patients generally die within about 3 months. To obtain further insight into mechanism underlying malignancy with this cancer, an miRNA synergistic regulatory network was constructed and analyzed in the present study. Method: A miRNA microarray dataset was downloaded from the NCBI GEO database (GSE27435). A total of 546 miRNAs were identified to be expressed in SCLC cells. Then a miRNA synergistic network was constructed, and the included miRNAs mapped to the network. Topology analysis was also performed to analyze the properties of the synergistic network. Consequently, we could identified constitutive modules. Further, common target genes of each module were identified with CFinder. Finally, enrichment analysis was performed for target genes. Results: In this study, a miRNA synergistic network with 464 miRNAs and 2981 edges was constructed. According to the topology analysis, the topological properties between the networks constructed by LC related miRNAs and LC unrelated miRNAs were significantly different. Moreover, a module cilque0 could be identified in our network using CFinder. The module included three miRNAs (hsa-let-7c, hsa-let-7b and hsa-let-7d). In addition, several genes were found which were predicted to be common targets of cilque0. The enrichment analysis demonstrated that these target genes were enriched in MAPK signaling pathways. Conclusions: Although limitations exist in the current data, the results uncovered here are important for understanding the key roles of miRNAs in SCLC. However, further validation is required since our results were based on microarray data derived from a small sample size.

S100A4 Gene is Crucial for Methionine-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

Yin-Hua Zhang,De-Ping Ding,De-Qiang Ma,Juan Li,Lin-Li Chen,Kang-Jian Ao,You-You Tian 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.9

Purpose: To explore the influence of S100 calcium binding protein A4 (S100A4) knockout (KO) on methionine-choline-deficient(MCD) diet-induced non-alcoholic fatty liver disease (NAFLD) in mice. Materials and Methods: S100A4 KO mice (n=20) and their wild-type (WT) counterparts (n=20) were randomly divided into KO/MCD, Ko/methionine-choline-sufficient (MCS), WT/MCD, and WT/MCS groups. After 8 weeks of feeding, blood lipid and liverfunction-related indexes were measured. HE, Oil Red O, and Masson stainings were used to observe the changes of liver histopathology. Additionally, expressions of S100A4 and proinflammatory and profibrogenic cytokines were detected by qRT-PCR andWestern blot, while hepatocyte apoptosis was revealed by TUNEL staining. Results: Serum levels of aminotransferase, aspartate aminotransferase, triglyceride, and total cholesterol in mice were increasedafter 8-week MCD feeding, and hepatocytes performed varying balloon-like changes with increased inflammatory cell infiltrationand collagen fibers; however, these effects were improved in mice of KO/MCD group. Meanwhile, total NAFLD activity scoresand fibrosis were lower compared to WT+MCD group. Compared to WT/MCS group, S100A4 expression in liver tissue of WT/MCD group was enhanced. The expression of proinflammatory (TNF-α, IL-1β, IL-6) and profibrogenic cytokines (TGF-β1, COL1A1,α-SMA) in MCD-induced NAFLD mice were increased, as well as apoptotic index (AI). For MCD group, the expressions ofproinflammatory and profibrogenic cytokines and AI in KO mice were lower than those of WT mice. Conclusion: S100A4 was detected to be upregulated in NAFLD, while S100A4 KO alleviated liver fibrosis and inflammation, inaddition to inhibiting hepatocyte apoptosis.

DNA Repair Capacity in Peripheral Blood Lymphocytes Predicts Efficacy of Platinum-based Chemotherapy in Patients with Gastric Cancer

Zhang, Yi-Yin,Gu, Kang-Sheng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

Objective: To investigate the correlation between ERCC1 expression levels in tumor tissue and peripheral blood lymphocytes (PBL) from patients with gastric cancer and assess the relationship between PBL DNA repair rate (DRR) and the efficacy of platinum chemotherapy. Methods: A total of 53 patients with gastric cancer receiving surgery and 20 controls were studied. ERCC1 protein expression in tumour tissue and PBL were determined by immunohistochemical staining. The PBL DRRs of 47 advanced patients and 20 controls were estimated by comet assay. Results: The positive expression rates of ERCC1 were 67. 9%, 56. 6% and 10.0% in tumour tissues, PBLs of gastric cancer patients, and PBLs of the control group. PBL ERCC1 expression correlated with that in tissue (${\chi}^2$=15. 463, p=0.000). Pearson contingency coefficient=0.475). DRRs of cancer patients by tail length (TL) (Z=4. 662, p=0.000) and tail moment (TM) (Z=3. 827, p=0.000) were significantly lower than that of control group. When TL was applied as an indicator, the correlation between DRR and chemotherapy efficacy was significant (Spearman rank correlation r=0.327, p=0.032). Patients with low levels of DRR in PBL presented better short-term efficacy of chemotherapy than those with high levels of DRR. Conclusions: The ERCC1 expression in PBLs may indirectly reflect ERCC1 expression in gastric cancer tissues. Compared with non-cancer populations, patients with gastric cancer may have lower DNA repair capacity. DRR in PBL may predict the short-term efficacy of platinum-based chemotherapy for patients with advanced gastric cancer.

Inter-domain Alliance Authentication Protocol Based on Blind Signature

Zhang Jie,Zhang Qi-kun,Gan Yong,Yin Yifeng,Tan Yu-an 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.12

In large distributed networks, many computers must be mutual coordination to complete some works under the certain conditions, these computers may come from different domains. For ensuring secure cross domains to access resources among these computers in different domains, this paper proposes a multi-domain union authentication protocol. The protocol adopts blind signature to achieve mutual authentication among entities in different domains. This scheme overcomes the complexity of certificate transmission and the network bottlenecks in the scheme of PKI-based. It can trace the entity identity and supports two-way entities anonymous authentication, which avoid the authority counterfeiting its member to access other domain’s resources. Analysis shows that its advantages on security and communication-consumption.

VEHICLE DYNAMIC CONTROL ALGORITHM AND ITS IMPLEMENTATION ON CONTROL PROTOTYPING SYSTEM

Zhang, Y.,Yin, C.,Zhang, J. The Korean Society of Automotive Engineers 2006 International journal of automotive technology Vol.7 No.2

A design of controller for vehicle dynamic control(VDC) and its implementation on the real vehicle were introduced. The controller has been designed using a three-degrees-of-freedom(3DOF) yaw plane vehicle, and the control algorithm was implemented on the vehicle by control prototyping system dSPACE. A hybrid control algorithm, which makes full use of the advantages of robust and fuzzy control, was adopted in the control system. Field test results show that the performance of the vehicle handling dynamics with hybrid controller is improved obviously compared to that without VDC and with simple robust controller on skiddy roads(friction coefficients lower than 0.3).

Digital heart for life

Yin Hua Zhang 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.5

RPTOR methylation in the peripheral blood and breast cancer in the Chinese population

Yin Yifei,Lei Shuifang,Li Lixi,Yang Xiaoqin,Yin Qiming,Xu Tian,Zhou Wenjie,Li Hong,Gu Wanjian,Ma Fei,Yang Rongxi,Zhang Zhengdong 한국유전학회 2022 Genes & Genomics Vol.44 No.4

Background: Altered regulatory-associated protein of mTOR, complex 1 (RPTOR) methylation levels in peripheral blood was originally discovered as breast cancer (BC)-associated risk factor in Caucasians. Objective: To explore the relationship between RPTOR methylation and BC in the Chinese population, we conducted two independent case-control studies. Methods: Peripheral blood samples were collected from a total of 333 sporadic BC cases and 378 healthy female controls for the DNA extraction and bisulfite-specific PCR amplification. Mass spectrometry was applied to quantitatively measure the levels of methylation. The logistic regression, Spearman's rank correlation, and Non-parametric tests were used for the statistical analyses. Results: In our study, we found an association between BC and RPTOR_CpG_4 hypomethylation in the general population (per-10% of methylation, OR 1.29, P = 0.012), and a weak association between BC and RPTOR_CpG_8 hypomethylation in the women with older age (per-10% of methylation, OR 2.34, P = 0.006). We also identified age as a confounder for the change of RPTOR methylation patterns, especially at RPTOR_CpG_4, which represented differential methylation comparing age groups especially in the BC cases (age < 50 years vs age ≥ 50 years by Mann-Whitney U test, P < 0.0001 for BC cases and P = 0.079 for controls). Conclusion: Our study validated the association between hypomethylation of RPTOR and BC risk in the Chinese population also with weak effect and mostly for postmenopausal women. In addition, our findings provided novel insight for the regulation of DNA methylation upon aging or the change of hormone levels.