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- 저자 : ( Yuan Xing Zhang ) (검색결과 39 건)
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ZHANG Xing-yuan,CHEN Minye,XU Hai-rong,LI Pei-qi 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.8
Binary-tree support vector machine (SVM) has such advantages as small repeated operation workload, fast classification speed and dead zone inexistence, but the structural design can influence the classification accuracy thereof. In order to rationally design the structure of the binary-tress SVM, a multi-classification algorithm (AHP-BSVM) combining analytic hierarchy process (AHP) and binary-tree SVM is proposed in this paper. Firstly, the analytic hierarchy process is adopted to establish the evaluation system model so as to comprehensively evaluate multiple influencing factors for determining the weight values of various faults; then, the faults are ordered by the weight values and the structure of the binary-tree SVM is determined according to the fault sequence; finally, the proposed algorithm is adopted for fault diagnosis and analysis. The simulation experiment shows: compared with other algorithms, the proposed algorithm has higher recognition accuracy and higher classification accuracy, and is applicable to multi-classification, thus having good promotion prospect.
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The miR-145-5p/CD36 pathway mediates PCB2-induced apoptosis in MCF-7 cells
Yuan Yuan,Caihua Xue,Qiang Wu,Mengjie Wang,Jiahua Liu,Longfei Zhang,Qianwen Xing,Jingyan Liang,Hua Wu,Zhi Chen 한국유전학회 2021 Genes & Genomics Vol.43 No.2
Background Procyanidin B2 (PCB2) can increase the levels of anti-infammatory and immune mediators. Objectives However, its molecular mechanism in human breast cancer remains unclear. This study aimed to investigate the antitumor efect of PCB2 on MCF-7 cells and to examine the underlying mechanism. Methods The fow cytometry and EdU incorporation assays were measured the PCB2-induced BMECs. The expression levels of infammatory factors and immune response genes were upregulated in MCF-7 cells, high-throughput sequencing was used to detect diferentially expressed genes in blank and PCB2-treated MCF-7 cells. Results The results showed that PCB2 induced the apoptosis of MCF-7 cells. CD36 profles were afected in MCF-7 cells. Additionally, prediction software identifed a miR-145-5p binding site in the CD36 sequence. Luciferase reporter assays and Western blot analysis were used to verify the regulatory relationships between the diferentially expressed miRNA miR145-5p and CD36. MiR-145-5p and its key target (CD36) constitute a potential miRNA-mRNA regulatory pair. Functional studies in MCF-7 cells revealed that CD36 promotes but miR-145-5p inhibits apoptosis. Conclusion Overall, these data suggest that miR-145-5p inhibits the enhancing efect of PCB2 on CD36 expression by binding CD36 and subsequently regulating apoptosis, the immune response and anti-infammatory pathways. These results provide theoretical and experimental support for the treatment of breast cancer.
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Wen, Yuan-Yuan,Yang, Shu-Juan,Zhang, Jian-Xing,Chen, Xin-Yue Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Background: Genetic factors and environmental factors play a role in pathogenesis of esophageal squamous cell carcinoma (ESCC). Previous studies regarding the association of folate intake and Methylenetetrahydrofolate reductase C677T polymorphism with ESCC was conflicting. We conducted a meta-analysis to investigate the association of MTHFR C677T and folate intake with esophageal cancer risk. Methods: MEDLINE, EMBASE and the Chinese Biomedical Database were searched in our study. The quality of studies were evaluated by predefined scale, and The association of polymorphisms of MTHFR C677T and folate intake and ESCC risk was estimated by Odds ratio (ORs) with 95% confidence intervals (CIs). Results: 19 studies (4239 cases and 5575 controls) were included for meta-analysis. A significant association was seen between individuals with MTHFR 677 CT [OR(95%)=1.47(1.32-1.63)] and TT [OR(95%)=1.69(1.49-1.91)] genotypes and ESCC risk (p<0.05). Low intake of folate had significantly higher risk of esophageal cancer among individuals with CT/TT genotype [OR(95%)=1.65(1.1-2.49)], while high intake of folate did not find significant high risk of esophageal cancer among individuals with CT/TT genotype [OR(95%)=1.64 (0.82-3.26)]. Conclusions: Our meta-analysis indicated the folate intake and MTHFR 677CT/TT are associated with the risk of ESCC, and folate showed a significant interaction with polymorphism of MTHFR C677T.
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Zhang, Chuan-Peng,Liu, Tie,Yuan, Jinghua,Sanhueza, Patricio,Traficante, Alessio,Li, Guang-Xing,Li, Di,Tatematsu, Ken’ichi,Wang, Ke,Lee, Chang Won,Samal, Manash R.,Eden, David,Marston, Anthony,Liu, Xia American Astronomical Society 2018 The Astrophysical journal Supplement series Vol.236 No.2
<P>In order to understand the initial conditions and early evolution of star formation in a wide range of Galactic environments, we carried out an investigation of 64 Planck Galactic cold clumps (PGCCs) in the second quadrant of the Milky Way. Using the (CO)-C-13 and (CO)-O-18 J = 1-0 lines and 850 mu m continuum observations, we investigated cloud fragmentation and evolution associated with star formation. We extracted 468 clumps and 117 cores from the (CO)-C-13 line and 850 mu m continuum maps, respectively. We made use of the Bayesian distance calculator and derived the distances of all 64 PGCCs. We found that in general, the mass-size plane follows a relation of m similar to r(1.67). At a given scale, the masses of our objects are around 1/10 of that of typical Galactic massive star-forming regions. Analysis of the clump and core masses, virial parameters, densities, and mass-size relation suggests that the PGCCs in our sample have a low core formation efficiency (similar to 3.0%), and most PGCCs are likely low-mass star-forming candidates. Statistical study indicates that the 850 mu m cores are more turbulent, more optically thick, and denser than the (CO)-C-13 clumps for star formation candidates, suggesting that the 850 mu m cores are likely more appropriate future star formation candidates than the (CO)-C-13 clumps.</P>
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Xing Zong-yi,Zhang Yuan,Qin Yong,Jia Li-min,Wu Ying-ying 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
The paper presents an approach to model the electrohydraulic system of a certain mine-sweeping weapon using the Radial Basis Function (RBF) neural networks. In order to obtain accurate and simple RBF neural networks efficiently, a hierarchical genetic algorithm (HGA) is used to train the neural networks, in which the number of hidden units and the parameters of centers are optimized by the HGA simultaneously. The spread factors and the weights of the neural networks are calculated by the linear algebra methods for relieving computational burden. The proposed algorithm is applied to the modelling of the electrohydraulic system, and the results clearly indicate that the obtained RBF neural network can model the hydraulic system satisfactorily. The comparison results also show that the proposed algorithm performs better than the traditional methods.
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Effects of Insect Hormones on the Replication of Nucleopolyhedrovirus
Zhang, Zhi-Fang,Yi, Yong-Zhu,Xiao, Qing-Li,He, Jia-Lu,Zhou, Ya-Jing,Zhang, Yuan-Xing Korean Society of Sericultural Science 2002 International Journal of Industrial Entomology Vol.4 No.2
An experimental study was undertaken to quantify the effects of insect hormones on the replication of nucleopolyhedrovirus (NPV). The results demonstrated that TCID/ sub 50/ at 72 h post-infection (hpi) rose systematically from 0.55$\times$10$^{8}$ /m1, for untreated cells, up to 1.67$\times$10$^{8}$ / ml at 3$\mu$g/ml, then dropped down to 1.45$\times$10$^{8}$ /m1 at 4 $\mu$g/ml, by adding ecdysone to the culture medium for Bm-N cells infected with a wild-type Bambyx mori. nucleopolyhedrovirus (BmNPV). The optimum enhancement of about 3 times on budded virus (BV) titer at 72 hpi was given at 3 $\mu$g/ml of ecdysone. While the polyhedra number had no obvious variation within the range of concentrations from 0 to 4 $\mu$g/ml. By addition of juvenile hormone analogue (JHA) into the media with this concentration range, the BmNPV TCID/ sub 50/ and polyhedra number at 72 hpi did not show significant changes. Also, the addition of either 3 $\mu$g/ml of ecdysone or 3 $\mu$g/ml of JHA to the culture media did not appear to affect the TCID/ sub 50/ and polyhedra number significantly in infected Sf-21 cells with the autographa californica nucleopolyhedrovirus (AcMNPV).
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Yuan Peng,Yongsheng Zhang,Jiaopeng Sun,Enyuan Xing,Huatai Yu 한국지질과학협의회 2018 Geosciences Journal Vol.22 No.2
This paper documents the geochemistry of clastic sedimentary rocks from the Upper Carboniferous Zongwulong Group in the Zongwulong structural belt of the Qaidam Basin, NW China, in order to trace the sources of the sediments and to understand their tectonic settings at the time of deposition of the Zongwulong Group. Although the major elements differ among different samples, their low mean chemical index of alteration mean CIA = 51.04–64.79), plagioclase index of alteration (mean PIA = 51.41–69.54), and relatively high mean index of compositional variability (mean ICV = 1.18–1.56) indicate relatively low maturity and weak to moderate chemical weathering of their source. The Zr/Sc-Th/Sc diagram and relatively high mean ICV suggest that all sediments of Zongwulong Group have undergone no significant sediment recycling. All samples yield relatively high Al2O3/TiO2 ratios (16–27), strong LREE/HREE differentiation (mean LaN/YbN = 10.83–12.66), and obvious negative Eu anomalies (mean Eu/Eu* = 0.61–0.79). Combined with characteristic ratios (La/Sc, Th/Sc, Cr/Th, and Th/Co) and the provenance discriminant diagrams (Al2O3-(CaO* + Na2O)-K2O and Ni-TiO2), these results indicate felsic source rocks. Combined with the findings of previous studies, the representative values (La, Ce, ΣREE, V, Rb/Sr, Eu/Eu*, La/Sc, Th/Sc, and Zr/Th) and tectonic setting discriminants (SiO2-K2O/Na2O, Fe2O3 + MgO-Al2O3/SiO2, La/Sc-Ti/Zr, and Th-Sc-Zr/10) indicate that the Zongwulong Group sediments were deposited in a back-arc extensional basin behind the active continental margin-continental island arc tectonic setting.
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Zhang Li,Cao Ya,Zhang Li-Jun,Wang Meng-Yao,Wang Xiao-Tong,Yang Xing-Zhuo,Duan Ting-Yu,Yuan Ming-Long 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.3
Bacterial symbionts in aphids are known to benefit the insect host and associated with aphid’s ecological adaptation. The pea aphid (Acyrthosiphon pisum), an important legume pest worldwide, carries at least eight endosymbionts, providing a model system to study insect–bacteria interactions. However, species diversity and geographic variations of endosymbionts are unknown in Chinese populations; therefore, we characterized symbiont communities and diversity of 27 pea aphid samples from 13 geographic populations of China. Via amplicon high-throughput sequencing and diagnostic PCR, we found that bacterial communities of Chinese populations were dominated by Proteobacteria and Firmicutes. Among eight known endosymbionts, five (Buchnera, Serratia, Hamiltonella, Regiella, and Rickettsia) were detected by both methods, with a specific geographical distribution. The obligate symbiont, Buchnera, was present in all aphid samples, while the four facultative symbionts showed a significant geographic variation. Each population was randomly infected with distinct endosymbionts, ranging from three to five species. Serratia and Rickettsia showed relatively higher abundance in central regions of China, Regiella was predominant in eastern and western China, whereas Ham iltonella showed an extremely low abundance and was absent in four populations. Samples grouped by altitudes showed a significant diversity difference, whereas there was no significant difference between red and green body colors. Bacterial community structures of the Chinese pea aphid populations were mainly influenced by environmental factors, other than body colors. These data can guide the development of potential biocontrol techniques against this aphid.
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Zong-Xing Zhang,Shan-Hua Xu,Lin Mu,Sheng-Yuan Peng 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.7
To investigate the flexural behavior of corroded steel beams strengthened by carbon fiber reinforced polymer (CFRP) plate, flexural test of five steel beams were carried out. The effects of corrosion and prestressing force levels on the flexural capacity, failure modes and interfacial stress were investigated. Meanwhile, considering the corrosion surface the calculation method of flexural capacity of corroded beams strengthened by CFRP plate was also established. The results showed that failure modes of corroded beams were the fracture of the CFRP plate after the shear failure of interface on the mid-span and fracture location of CFRP plate was mostly at the loading point. The rough surface of the corroded steel can enhance the efficiency of stress transfer at the interface, thereby improving the effective bond length of the interface. The shear stress was mainly concentrated on the CFRP plate end, and peak value appeared at the loading point. Compared the reference beam, the ultimate flexural capacity of the corroded beam strengthened by CFRP plate with 15% prestress level increased at a ratio of 21%, and utilization ratio of the CFRP plates was up to 71.59%.
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