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Yu Jun Wong,Vy H. Nguyen,Hwai-I Yang,Jie Li,Michael Huan Le,Wan-Jung Wu,Nicole Xinrong Han,Khi Yung Fong,Elizabeth Chen,Connie Wong,Fajuan Rui,Xiaoming Xu,Qi Xue,Xin Yu Hu,Wei Qiang Leow,George Boon-B 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.3
Background/Aims: Chronic hepatitis B (CHB) and fatty liver (FL) often co-exist, but natural history data of this dual condition (CHB-FL) are sparse. Via a systematic review, conventional meta-analysis (MA) and individual patient-level data MA (IPDMA), we compared liver-related outcomes and mortality between CHB-FL and CHB-no FL patients. Methods: We searched 4 databases from inception to December 2021 and pooled study-level estimates using a random- effects model for conventional MA. For IPDMA, we evaluated outcomes after balancing the two study groups with inverse probability treatment weighting (IPTW) on age, sex, cirrhosis, diabetes, ALT, HBeAg, HBV DNA, and antiviral treatment. Results: We screened 2,157 articles and included 19 eligible studies (17,955 patients: 11,908 CHB-no FL; 6,047 CHB-FL) in conventional MA, which found severe heterogeneity (I2=88–95%) and no significant differences in HCC, cirrhosis, mortality, or HBsAg seroclearance incidence (P=0.27–0.93). IPDMA included 13,262 patients: 8,625 CHB-no FL and 4,637 CHB-FL patients who differed in several characteristics. The IPTW cohort included 6,955 CHB-no FL and 3,346 CHB-FL well-matched patients. CHB-FL patients (vs. CHB-no FL) had significantly lower HCC, cirrhosis, mortality and higher HBsAg seroclearance incidence (all P≤0.002), with consistent results in subgroups. CHB-FL diagnosed by liver biopsy had a higher 10-year cumulative HCC incidence than CHB-FL diagnosed with non-invasive methods (63.6% vs. 4.3%, P<0.0001). Conclusions: IPDMA data with well-matched CHB patient groups showed that FL (vs. no FL) was associated with significantly lower HCC, cirrhosis, and mortality risk and higher HBsAg seroclearance probability.
Yu Xue,Youting Dong,Yaochen Lou,Qiaoying Lv,Weiwei Shan,Chao Wang,Xiaojun Chen 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.4
Objective: This study aimed to investigate the impact of molecular classification and PTEN, KRAS and PIK3CA gene mutation on the outcome of fertility-preserving treatment in the patients with endometrioid endometrial cancer (EEC) and endometrial atypical hyperplasia (EAH). Methods: This is a single-center retrospective study. A total of 135 patients with EEC and EAH receiving fertility-preserving treatment and molecular classification were reviewed. The distribution of the four types of molecular classification was described. The impact of non-specific molecular profile (NSMP), mismatch repair-deficiency (MMRd), and PTEN, KRAS and PIK3CA gene mutation on the outcome of fertility-preserving treatment was analyzed. Results: Of the patients analyzed, 86.7% (117/136) were classified as having NSMP; 14 (10.4%), MMRd; 1 (0.7%), POLEmut EAH; and 3 (2.2%), p53abn EEC. The patients having NSMP and MMRd achieved similar 16-, 32-, and 48-week complete response rates. The patients harboring tier I and tier II PTEN mutations (PTENmut-Clin) achieved lower cumulative 32-week CR rates than those with PTEN-others (without PTENmut-Clin) (22/47, 46.8% vs. 50/74, 67.6%; p=0.023; odds ratio=0.422; 95% confidence interval [CI]=0.199–0.896). Insulin-resistance (hazard ratio [HR]=0.435; 95% CI=0.269–0.702; p=0.001) and PTENmut-Clin (HR=0.535; 95% CI=0.324–0.885; p=0.015) were independent negative predictors for lower 32-week CR rates. Conclusion: PTENmut-Clin is an independent risk factor for unfavorable fertility-preserving treatment outcomes in the patients with EEC and EAH. The patients with MMRd receiving fertility-preserving treatment achieved outcomes similar to those of the patients with NSMP. The molecular profiles might guide fertility-preserving treatment in the prognosis and clinical decisions.
Yu, Min,Liu, Lei,Zhang, Bing-Lan,Chen, Qi,Ma, Xue-Lei,Wu, Yu-Ke,Liang, Chun-Shui,Niu, Zhi-Min,Qin, Xin,Niu, Ting Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12
Background: This study was performed to analyze the prognostic implications of pretreatment or preoperative thrombocytosis in women with gynecologic malignancies. Material and Methods: We surveyed 2 medical databases, PubMed and EMBASE, to identified all relevant studies. A total of 14 (n=3,490) that evaluated the link between thrombocytosis and 5-year survival were included. REVMAN version 5.1 was used for our analysis and publication bias was evaluated using the Begg's funnel plot and tested by STATA 11.0. Risk ratios (RRs) with 95% confidence intervals (CIs) generated by the random effect model were used to assess the strength of any association. Results: 709(20.3%) of the 3,490 patients exhibited thrombocytosis (platelet counts > $400{\times}10^9/L$) at primary diagnosis, and their mortality was 1.62-fold higher compared with the others (RR=1.62, 95%CI=[1.28-2.05], p<0.0001). Thrombocytosis failed to have a stronger effect on the survival of advanced patients of stages III to IV in our study (n=478, RR=1.29, 95% CI=[1.13-1.48], p=0.0003), nor in women with cervical cancer in stage IB (n=1371, RR=1.73, 95% CI=[1.71-2.58], p=0.007). In addition, when adjusted for different carcinoma, it was associated with worse prognosis for all except the ones with vulvar cancer (n=201, RR=0.43, 95% CI=[0.14-1.29], p=0.13). Conclusions: This meta-analysis indicated that thrombocytosis might be associated with a worse prognosis for patients with gynecologic malignancies but without specificity or sensitivity for the ones in advanced stage. When adjusted for different gynecologic malignancies, it showed a significant effect on survival of all except vulvar cancers.
H-mode experimental integrated modeling of impurity injection to control divertor heat flux on HL-2A
Yu Peng,Huang Qianhong,Zhong Yijun,Wu Ting,Wang Jun,Wang Zhanhui,Gong Xue-yu 한국물리학회 2023 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.82 No.8
Based on the METIS integrated modeling platform, combined with the experimental data of the #34512 shot detached divertor operation on the HL-2A, this paper selects suitable physical models, and compares and analyzes the integrated modeling results with the experimental results. The modeling results are in good agreement with the experimental results. On this basis, the reason for the decrease of the peak heat fux on the divertor targets is investigated using the METIS simulator. The results show that the two factors of entering the H-mode and the radiation enhancement efect generated by impurity injection work together to reduce the heat fow on the targets. Finally, the diferent efects of N, Ar and Ne impurity gases on the heat fux reduction of the targets are simulated under the condition that the plasma line-average efective charge (Zef) is kept unchanged. The results show that N and Ar are both better than Ne in controlling the heat fow on the targets, and N has the best compatibility in the core, which can not only reduce the boundary heat fow but also maintain the core confnement performance.
Yu Xue,Yao Zhang,Jinqiang Li 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.1
This work aims to explore optimal design and control of thermal buckling for composite laminates with piezoelectric fiber reinforced composite (PFRC) actuators. Fourvariable trigonometric shear deformation theory without introduction of a shear correction factor is used in the structural modeling. The high accuracy of the present approach is examined by analyzing the critical buckling temperature and natural frequency compared with references results. A temperature feedback control approach is proposed in designing the controller. Taking fiber angle as the optimization design variable, layerwise optimization approach (LOA) is applied to maximize critical buckling temperature of piezolaminated plate and a set of stacking sequences are obtained. The resulting analysis demonstrates that the proposed control approach can clearly increase the critical buckling temperature of piezo-laminated plates. The optimization process developed is useful in devising stacking sequences for the piezo-laminated structures in thermal environments.
Xue Yu,Lingling Wang,Miaomiao Liu,Qiuli Li,Xiuying Dai 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.4
Objective This study aimed to investigate the prevalence of externalizing behavior problems (EBPs) and its influencing factors among Hui left-behind children (LBC) in rural China.Methods A cross-sectional study was conducted among school students from the southern rural areas in Ningxia, China (2012–2013). The general self-made questionnaire, Egma Minnen av Bardndosna Uppforstran, Eysenck Personality Questionnaire (for Children), Piers-Harris Children’s Self-Concept Scale, and Achenbach’s Child Behavior Checklist (for parents) were used to investigate the related information. Binary logistic regressions were conducted.Results The prevalence of EBPs in boys Hui LBC was significantly higher than that of non-LBC (12.37% vs. 6.84%, χ<sup>2</sup>=4.09, and p=0.04). Multivariate logistic regression analysis showed that low self-awareness of behavior (odds ratio [OR]=29.78), introversion (OR=21.67) and intermediate personality (OR=15.83), poor academic performance (OR=11.65) and both parent migrating (OR=2.73) were the risk factors for the EBPs of Hui LBC, while middle and high father refusal and denial (OR=0.11, OR=0.09) were their protective factors.Conclusion Our findings suggest that both parent migrating is a potential risk factor for EBPs among Hui LBC. Hui boys LBC should be paid more attention when formulating relevant policies.
Yu Peng,He Xue-jun,Ren Ai-di 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.12
The alongside replenishment scheduling problem with time constraint determining the partition of the ships, the order of replenishment and the allocation of time to the ships at the same time is analyzed. It is equivalent to a multi-stage flow shop scheduling problem with the object of maximizing the effectiveness value of ship fleet. The problem solving process is divided into three steps, and based on the analysis of the three steps, a heuristic algorithm is proposed. The algorithm firstly considers the time allocated to each ship, and then sequences the ships by heuristic rule combining greed with insertion, finally determines the ships partitioning to the port and standard side. Emulating example with different problems’ scale and time constraints shows that the proposed heuristic algorithm is superior to some other algorithms.
Fuzzy regression method for prediction and control the bead width in the robotic arc-welding process
Xue, Yu,Kim, I.S.,Son, J.S.,Park, C.E.,Kim, H.H.,Sung, B.S.,Kim, I.J.,Kim, H.J.,Kang, B.Y. Elsevier 2005 Journal of materials processing technology Vol.164-165 No.-
<P><B>Abstract</B></P><P>In the manufacturing industry, quality is of prime importance and a reduction in rejects rates is desirable to reduce costs, improve productivity as well as satisfy customer quality requirements. Many quality problems arise due to poorly set process variables, and this is often due to lack of welding skill on the part of the mechanised or robotic system suppliers. However, the automated welding system has not been achieved much because of difficulties of the mathematical model and sensor technologies. In this paper, the possibilities of the fuzzy regression method in modeling the bead width in the robotic arc-welding process are presented. Fuzzy regression is a well-known method to deal with the problems with a high degree of fuzziness so that the approach is employed to build the relationship between four process variables and the quality characteristic, such as bead width. Using the developed model, the proper prediction of the process variables for obtaining the optimal bead width can be determined.</P>