"Do You Really Know Your Students?" -Investigating Elementary Mathematics Teachers` Awareness

( Yu Liang Chang ),( Su Chiao Wu ),( Der Ching Yang ) 한국수학교육학회 2010 수학교육 프로시딩 Vol.45 No.-

The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes

Yu-Chu Wang,Kung-Chao Chang,Bo-Wen Lin,Jenq-Chang Lee,Chien-Hsien Lai,Li-Jyuan Lin,Yun Yen,Chang-Shen Lin,Shiang-Jie Yang,Peng-Chan Lin,Chung-Ta Lee,Liang-Yi Hung 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Heterogeneous nuclear ribonucleoprotein (hnRNP) Q1, an RNA-binding protein, has been implicated in many posttranscriptional processes, including RNA metabolism and mRNA splicing and translation. However, the role of hnRNP Q1 in tumorigenesis remains unclear. We previously performed RNA immunoprecipitation (RIP)-seq analysis to identify hnRNP Q1-interacting mRNAs and found that hnRNP Q1 targets a group of genes that are involved in mitotic regulation, including Aurora-A. Here, we demonstrate that altering the hnRNP Q1 level influences the expression of the Aurora-A protein, but not its mRNA. Stimulation with epidermal growth factor (EGF) enhances both binding between hnRNP Q1 and Aurora-A mRNA as well as the efficacy of the hnRNP Q1-induced translation of Aurora-A mRNA. The EGF/hnRNP Q1-induced translation of Aurora-A mRNA is mediated by the mTOR and ERK pathways. In addition, we show that hnRNP Q1 up-regulates the translation of a group of spindle assembly checkpoint (SAC) genes. hnRNP Q1 overexpression is positively correlated with the levels of Aurora-A and the SAC genes in human colorectal cancer tissues. In summary, our data suggest that hnRNP Q1 plays an important role in regulating the expression of a group of cell cycle-related genes. Therefore, it may contribute to tumorigenesis by up-regulating the translation of these genes in colorectal cancer.

Applying spray pyrolysis to synthesize MnOx for decomposing isopropyl alcohol in ozone- and thermal-catalytic oxidation

Chung-Liang Chang,Hsunling Bai,Yu-Huei Liu,Yu-Chih Lin 한국화학공학회 2009 Korean Journal of Chemical Engineering Vol.26 No.4

Manganese oxides (MnOx) were prepared by spray pyrolysis methods (MnS) and calcination at 600 and 1,000℃ (Mn600 and Mn1000) in this study. Further, the efficiencies of oxidizing isopropanol (IPA) by these MnOx utilizing ozone (OZCO) and thermal catalytic oxidation (TCO) were compared. The results indicated that MnS, which are characterized by larger surface areas, processed gas hourly space velocity of 42,000 h−1 and inlet IPA concentration of 400 ppm performing IPA decomposition efficiencies approaching 100%, and the reaction temperature was operated at only 85℃ for OZCO. The reaction temperature of TCO operated above 270℃ decomposed IPA at the same efficiency.

Study on Adsorption Desulfurization of Biogas Using Iron Oxide Particles

( Cheng-chang Lien ),( Min-wei Wang ),( Liang-yu Jian ),( Jeng-liang Lin ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

The contained hydrogen sulfide in biogas leads to corrosion of metal equipment. In addition, the high concentration of hydrogen sulfide can also hurt the health of humans and animals. As to be a renewable energy with both environmental protection and safety, biogas must be removed and purified before being used. In this study, a solid-state desulfurization device was designed. The biogas flow through the bottom of the transparent desulfurization column which is made of acrylic glass, the iron oxide particles were placed in the desulfurization column as desulfurizer, change the biogas flow and the height of iron oxide particles in the desulfurization column to experiment on desulfurization, measure the concentration of hydrogen sulfide adsorbed by the iron oxide particles at the above of the desulfurization column, then discuss the change of the hydrogen sulfide removed rate in biogas with the experimental period. The experimental result shows that the removed rate of hydrogen sulfide decreases with the increase of biogas flow, and it also increases with the iron oxide particle height in the desulfurization column, the longer stagnation inside the desulphurization column, will cause the better removed efficiency of hydrogen sulfide. In addition, the removed efficiency of hydrogen sulfide gradually decreases with the increase of the desulfurization period. The average desulfurization efficiency was 95.16% at biogas flow of 25 ℓ / min, iron oxide particle height of 15.3 cm and desulfurization period is 70 minutes.

Increase in Plasma Glucose Lowering Action of Rosiglitazone by Electroacupuncture at Bilateral Zusanli Acupoints (ST.36) in Rats

Hui-Ching Pai,Chung-Yuh Tzeng,Yu-Chen Lee,Chin-Hsien Chang,Jaung-Geng Lin,Juei-Tang Cheng,Shih-Liang Chang 사단법인약침학회 2009 Journal of Acupuncture & Meridian Studies Vol.2 No.2

Objectives: Hypoglycemia induced by electroacupuncture (EA) is due to an increase of insulin secretion and/or mediation of β-endorphin. We applied EA at the Zusanli (ST.36) acupuncture point (acupoint) in combination with rosiglitazone (TZD) administration to evaluate their effect on plasma glucose and to explore possible mechanisms of action. Methods: Thirty six normal adult Wistar rats were randomly divided into four groups: the 0.1 mg/kg TZD group (0.1TZD), 0.1 mg/kg TZD and EA group (0.1TZD + EA), EA group, and control group. In other experiments, streptozotocin was used to induce type 2 diabetes mellitus in neonatal rats; these were then randomly divided into a 0.1TZD group, 0.1TZD + EA group, and EA group and changes in plasma glucose and insulin concentrations evaluated. Results: A marked hypoglycemic response was observed in the normal rat 0.1TZD, 0.1TZD + EA and EA groups, with the response more significant in the 0.1TZD + EA group than in the 0.1TZD group. Among the diabetic animals, the hypoglycemic responses in the 0.1TZD + EA and EA groups were greater than in the 0.1TZD group. In both the normal and diabetic rats, insulin secretion was increased by EA or 0.1TZD + EA treatment, but not by 0.1TZD. Conclusions: The plasma glucose lowering action of rosiglitazone was increased by EA in both normal and diabetic rats, indicating that the application of EA may enhance the hypoglycemic action of this insulin sensitizer. Objectives: Hypoglycemia induced by electroacupuncture (EA) is due to an increase of insulin secretion and/or mediation of β-endorphin. We applied EA at the Zusanli (ST.36) acupuncture point (acupoint) in combination with rosiglitazone (TZD) administration to evaluate their effect on plasma glucose and to explore possible mechanisms of action. Methods: Thirty six normal adult Wistar rats were randomly divided into four groups: the 0.1 mg/kg TZD group (0.1TZD), 0.1 mg/kg TZD and EA group (0.1TZD + EA), EA group, and control group. In other experiments, streptozotocin was used to induce type 2 diabetes mellitus in neonatal rats; these were then randomly divided into a 0.1TZD group, 0.1TZD + EA group, and EA group and changes in plasma glucose and insulin concentrations evaluated. Results: A marked hypoglycemic response was observed in the normal rat 0.1TZD, 0.1TZD + EA and EA groups, with the response more significant in the 0.1TZD + EA group than in the 0.1TZD group. Among the diabetic animals, the hypoglycemic responses in the 0.1TZD + EA and EA groups were greater than in the 0.1TZD group. In both the normal and diabetic rats, insulin secretion was increased by EA or 0.1TZD + EA treatment, but not by 0.1TZD. Conclusions: The plasma glucose lowering action of rosiglitazone was increased by EA in both normal and diabetic rats, indicating that the application of EA may enhance the hypoglycemic action of this insulin sensitizer.

Nonlinear bending analysis of magnetoelectroelastic rectangular plates using higher order shear deformation theory

Yu-fang Zheng,Liang-liang Xu,Chang-ping Chen 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.3

Nonlinear bending analysis was performed of magnetoelectroelastic (MEE) composite plates under a mechanical and magnetoelectric (ME) load by using von Karman’s nonlinear geometric equation and the higher order shear deformation theory (HSDT). Nonlinear higher order partial differential equations for MEE plates were derived by using Hamiltonian equilibrium equation. The MEE plate is considered to have clamped boundary condition. The nonlinear high-order equations can turn into algebraic equations through Galerkin method. Then the effects of scale effect of MEE plate (for instance, the aspect ratio) and external load (for instance, mechanical) on the displacement of the considered MEE plate were investigated.

Changes in prostate-specific antigen kinetics during androgen-deprivation therapy as a predictor of response to abiraterone in chemonaïve patients with metastatic castration-resistant prostate cancer

Chung-Lin Lee,Ying-Hsu Chang,Chung-Yi Liu,Ming-Li Hsieh,Liang-Kang Huang,Yuan-Cheng Chu,Hung-Cheng Kan,Po-Hung Lin,Kai-Jie Yu,Cheng-Keng Chuang,Chun-Te Wu,See-Tong Pang,I-Hung Shao 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.5

Purpose: Metastatic castration-resistant prostate cancer (mCRPC) has a poor prognosis. Abiraterone acetate (AA), enzalutamide, and chemotherapy are first-line treatments for patients with mCRPC. This study examined prognostic factors for AA response in the form of prostate-specific antigen (PSA) kinetics throughout androgen-deprivation therapy (ADT) in chemonaïve patients with mCRPC. Materials and Methods: We retrospectively included data from 34 chemonaïve patients with mCRPC who had received AA at some point between January 2017 and December 2018. We separated patients into two study arms according to the decrease in PSA percentages after use of AA for 3 months. We correlated PSA kinetics parameters with response and compared the two study groups with respect to PSA kinetics. Results: The patients’ median age was 77 years. In the total group of patients, 64% had a response to AA, whereas 35% did not. The ratio of the PSA level at nadir to the level during ADT was significantly higher in the AA-sensitive group (19.78 vs. 1.03, p=0.019). Conclusions: Patients who experienced a dramatic change in PSA level during ADT were more likely to be resistant to AA after progression to mCRPC. Chemotherapy rather than AA might be more suitable as a first-line treatment for these patients.

Application of physical vapor deposition process to modify activated carbon fibers for ozone reduction

Yu-Chih Lin,Chung-Liang Chang,Tser-Sheng Lin,Hsunling Bai,Ming-Gu Yan,Fu-Hsiang Ko,Chia-Tien Wu,Cheng-Hsiung Huang 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.3

This study utilized the activated carbon fiber (ACF) modified with metal catalyst via physical vapor deposition (PVD) process (ACF/PVD) to diminish ozone. Furthermore, the ozone removal efficiency of ACF/PVD was compared with that of original ACF and ACF modified with metal catalyst via impregnation process (ACF/impregnation). In addition to the kinds of coated metal and the inlet ozone concentrations, the effects of the coating thickness and the reaction temperature on ACF/PVD for ozone removal were also examined. The results indicate that the ozone removal efficiency of ACF/PVD is better than that of original ACF and ACF/impregnation. The ozone removal efficiency of different metal-coated ACF/PVD in the superior order is gold (Au), and manganese (Mn). The increase of Au-coated thickness (3 nm to 80 nm) on ACF/PVD will enhance the ozone removal. However, when the Mn-coated thickness on ACF/PVD is larger than 15 nm, the ozone removal efficiency displays a declining trend. Furthermore, a higher reaction temperature will result in a better ozone removal of ACF/PVD and the original ACF.

Spectroscopic and Chemical Speciation of Chromium in Contaminated Paddy Soils

Liang-Ching Hsu,Yu-Min Tzou,Yu-Ting Liu,Chiung-Fen Chang 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

A PSTN Terminal for FSK Decoding and DTMF Dialing Applications

Liang Xin-Tao,Fan Qing-Yu,Lin Wen-Chang 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.5

To realize Frequency Shift Keying (FSK) decoding and Dual-Tone Multi-Frequency (DTMF) dialing, a novel hardware and software solution is presented. These two signals are used to receive or send messages respectively in this solution which can meet different requirements of many Public Switched Telephone Network (PSTN) applications. The hardware used CPC5622 as the phone line interface Data access arrangement (DAA), HT9032D as the FSK decoder, and C8051f120 as the DTMF generator and system controller. The software, mainly composed of DTMF dialing and FSK decoding subprograms, was written and debugged with the hardware and finally succeeded to realize the terminal. The results performed under Huawei C&C08 switch show that the terminal can realize dialing by encoding standard DTMF signals and extracting the caller's information from the standard FSK signals in the PSTN. The CPC5622 as well as C8051f120 has some free Inputs, outputs, and other hardware resources, which make the PSTN terminal scalable and available to a variety of PSTN devices and applications.