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( Youngwoo Jang ),( Heekyung Ahn ),( Eunyoung Kim ),( Jungkeun Moon ),( Yangbin Jeon ),( Kyuchan Lee ),( Yeonho Park ),( Eunyoung Cho ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Primary cardiac cancer is a very rare disease, as the prevalence is 0.001 to 0.03%. Primary cardiac angiosarcoma is one of the most frequent types of primary cardiac cancers, however, is characterized by extremely poor prognosis, as the mean survival is reported to be only three to four months, and optimal treatment is unknown. Here we report a patient of primary cardiac angiosarcoma with hemorrhagic pericardial effusion who achieved a durable response with tumor excision followed by concurrent chemoradiotherapy with docetaxel. A sixty year old male with underlying history of diabetes mellitus presented with rapidly progressing shortness of breath. Cardiac tamponade was diagnosed, and 420 cc of bloody fiuid was drained with pericardiocentesis. The patient`s blood pressure was restored to within normal limit after pericardial effusion drainage. Subsequent chest computed tomography scan, echocardiography and cardiac Magnetic Resonance Image revealed a 4.5x3.5cm sized infiltrative mass in the right atrium. Tumor excision was performed, of which pathologic findings revealed cardiac angiosarcoma with tumor involvement of resection margin. The patient underwent adjuvant radiotherapy (5000cGys/30fractions) with concurrent chemotherapy with docetaxel. There was no evidence of recurrence until ten months later, when multiple liver metastases were found on CT scan. Hepatic metastasectomy with periop chemotherapy with weekly paclitaxel was followed. As of Jul 2014, the patient is receiving chemotherapy with overall survival of 16 months and counting. Currently there are only three published case reports of cardiac angiosarcoma which showed response to radiation and taxane, and this is the fourth case report of successful treatment. Further investigation on this regimen is warranted.
Jang, Albert Youngwoo,O Brien, Connor,Chung, Wook-Jin,Oh, Pyung Chun,Yu, Jongwook,Lee, Kyounghoon,Kang, Woong Chol,Moon, Jeonggeun UNKNOWN 2018 CIRCULATION JOURNAL Vol.82 No.6
<P>Conclusions: Based on this retrospective analysis, the routine use of IUC may increase length of stay and UTI complications in AHF patients without reducing the risk for major cardiovascular and cerebrovascular events or 30-day rehospitalization rate.</P>
Epidemiology of PAH in Korea: An Analysis of the National Health Insurance Data, 2002–2018
Albert Youngwoo Jang,Hyeok-Hee Lee,Hokyou Lee,Hyeon Chang Kim,Wook-Jin Chung 대한심장학회 2023 Korean Circulation Journal Vol.53 No.5
Background and Objectives: Pulmonary arterial hypertension (PAH) is a rare but fatal disease. Recent advances in PAH-specific drugs have improved its outcomes, although the healthcare burden of novel therapeutics may lead to a discrepancy in outcomes between developing and developed countries. We analyzed how the epidemiology and clinical features of PAH has changed through the rapidly advancing healthcare infrastructure in South Korea. Methods: PAH was defined according to a newly devised 3-component algorithm. Using a nationwide health insurance claims database, we delineated annual trends in the prevalence, incidence, medication prescription pattern, and 5-year survival of PAH in Korea. Cumulative survival and potential predictors of mortality were also assessed among 2,151 incident PAH cases. Results: Between 2002 or 2004 and 2018, the prevalence and incidence of PAH increased 75-fold (0.4 to 29.9 per million people) and 12-fold (0.5 to 6.3 per million person-years), respectively. The proportion of patients on combination PAH-specific drug therapy has also steadily increased up to 29.0% in 2018. Among 2,151 incident PAH cases (median [interquartile range] age, 50 [37–62] years; 67.2% female), the 5-year survival rate and median survival duration were 71.8% and 13.1 years, respectively. Independent predictors of mortality were age, sex, etiology of PAH, diabetes, dyslipidemia, and chronic kidney disease. Conclusions: This nationwide study delineated that the prevalence and incidence of PAH have grown rapidly in Korea since the early 2000s. The use of combination therapy has also increased, and the 5-year survival rate of PAH in Korea was similar to those in western countries.
텀블강화형 스로틀 밸브 및 분리판에 의한 실린더내의 유동 특성에 관한 수치해석적 연구
장영우(Youngwoo Jang),고재경(Jaekyung Go),김창완(Chang-Wan Kim) 대한기계학회 2023 대한기계학회 춘추학술대회 Vol.2023 No.11
Intensifying the tumble flow of the GDI engine is essential for improving the efficiency of the engine. In this study, we investigated in-cylinder flow characteristics by tumble intensifying throttle valve and separator. This was conducted through 3D transient flow analysis using computational fluid dynamics (CFD). The tumble intensifying throttle valve and separator generated reverse flow due to pressure difference inside the intake port and intensified the tumble flow. As a result, models with tumble intensifying throttle valve and separator improved Tumble Ratio (TR) and Turbulence Kinetic Energy (TKE) by 170% and 29.1%, respectively, compared to basic models.
Performance Analysis of Software Architectures with Real-time Kernel Patches for the Rescue Robot
Youngwoo Lee,Myeong Eon Jang,Jun Kim,Yong Woon Park 제어로봇시스템학회 2014 제어로봇시스템학회 국제학술대회 논문집 Vol.2014 No.10
This paper introduces software architectures of the Rescue Robot that lifts and moves wounded soldiers in battle fields or hospitals. Since the Rescue Robot interacts with humans, the robot needs a real-time operation for human safety. Moreover, it is necessary that a large number of calculations and various sensing data to move the soldiers without any damages. One of challenging problems of designing the robot software architecture is that a large number of calculations and data would disturb to decrease a response time taken until robot reacting from user’s commands or emergency sensing data. The Rescue Robot uses Linux with real-time kernel patches as a real-time operating system and EtherCAT as a real-time network. We test three kinds of software architectures, Linux, Xenomai, and RTAI, for the Rescue Robots about the time taken until output commands are sent to joint motors just after the sensing data or input commands are delivered. Furthermore, we suggest a method to handle urgent commands or data quickly with a slightly modified kernel and a kernel module that reduces the time dramatically. This paper also analysis the difference of the real-time kernel patches.