Original Articles : Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients

( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3

Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)

전통누룩 진균류를 이용한 입국의 제조 및 입국곰팡이의 동정

김재호 ( Jae Ho Kim ),권영희 ( Young Hee Kwon ),이애란 ( Ae Ran Lee ),김혜련 ( Hye Ryun Kim ),안병학 ( Byung Hak Ahn ) 한국균학회 2012 韓國菌學會誌 Vol.40 No.4

다양한 향미를 가진 막걸리의 개발을 위해 전통누룩으로부터 분리한 곰팡이로 입국을 제조한 후 품질특성을 분석하여 입국의 규격에 적합하며 이취가 없고 관능이 우수한 9균주를 입국 제조용 우수균주로 최종 선발하였다. 선발된 균주는 Aspergillus oryzae(C1-5-2-2, C20-7-3, CN1.3.1-4, CN16.19.1-1, N152-1, N220-1), Mycocladus corymbiferus (N162-2), Rhizopus oryzae(N20), Lichtheimia corymbifera (N21)로 동정되었으며, 제조한 입국의 산도는 5.0~6.8, 당화력은 128~241sp이었다. Various koji were prepared by fungi isolated from traditional nuruk and their quality characteristics were investigated. Acidity and saccharification power of their koji were ranged in 5.0~6.8 and 128sp~241sp. Nine fungi which were showed good quality and sensory evaluation were identified by analysis of their nucleotide sequences with PCR-amplified 18S rDNA internal transcribed spacer-1(ITS-1) and ITS-4 genes. Among them, six strains were identified as Aspergillus oryzae and the other strains were identified as Mycocladus corymbiferus, Rhizopus oryzae, Lichtheimia corymbifera.

한약에 의해 유발된 급성 간질성 신염 2례

김덕윤,박동건,김응석,강영모,양창헌,이정호,이동철,이영현,김정란 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

간질성 신염은 신장의 간질을 선택적으로 침범하는 염증성 질환으로 여러가지 원인에 의해 유발되며, 이 중 약물에 의한 경우는 각종 항생제, 비스테로이드성 진통제, 항경련제, 이뇨제, 면역억제제등에 의한 증례들이 보고되고 있다. 현재 각종 질환-특히 만성질환-의 치료에서 한약이 차지하는 비중이 적지 않으나, 그 각각의 성분들이 유발할 수 있는 부작용들에 대한 연구는 거의 없는 실정이다. 저자들은 관절염 치료를 위해 중국산 한약을 복용한 후 복통, 피로감 및 육안적 혈뇨를 주소로 내원한 두 환자에서, 단백뇨와 신기능 장애를 보여 시행한 신조직 생검상 급성 간질성 신염에 합당한 병리학적 소견을 보이고, 한약 복용 중지 후 급속한 회복을 보여, 한약에 의해 유발된 것으로 사료되는 급성 간질성 신염 2예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Acute interstitial nephritis is a disease characterized by renal interstitial inflammatory cell infiltration and acute renal functional deterioration. This is caused mainly by antibiotics, NSAID and diuretics such as thiazide, but cases induced by herb medication are rare. We experienced two cases of acute interstitial nephritis after treatment with herb medication. One 71-year-old female patient and the other 60-year-old female were admitted to the hospital because of general weakness and gross hematuria. Microscopic hematuria, pyuria, and proteinuria were presented. After definitive diagnosis with a renal biopsy, we noted rapid recovery of renal function by drug withdrawal and steroid therapy. We report these cases with a review of the referenced literatures. Key Words : Herb medication, Acute Interstitial nephritis.

교합면을 포함하지 않는 2급 글래스 아이오노머 시멘트 수복물의 변연누출

이영란,허복,이희주 大韓齒科保存學會 1998 Restorative Dentistry & Endodontics Vol.23 No.1

The microleakage of direct-access Class 2 restorations was evaluated. Cavities were prepared at mesial and distal proximal enamel surfaces of 20 extracted human molars through buccal window. Prepared cavities were filled with Ketac-Fil, Ketac-Silver, and Fuji Ⅱ LC, following manufacturer's instructions. 4 specimens of each restorations were made through sectioning 1/4 of bucco-lingual length mesio-distally after thermocycling between 5℃ and 60℃ and imerging 0.5% basic-fuchsin dye solution. Leakage at both occlusal and gingival margin of each specimen was scored 0 to 3 with stereomicroscope. The results were as follows: 1. At occlusal margin, leakage in Ketac-Fil group was more than Ketac-Silver and Fuji Ⅱ LC group(ANOVA p<0.05) and there was no significant difference between Ketac-Silver and Fuji Ⅱ LC goup(p>0.05), and at gingival margin, there was no significant difference amang materials(p>0.05). 2. Occlusal margin leaked more than gingival margin in Ketac-Silver and Fuji Ⅱ LC group(t-test p<0.05). 3. Leakage was different according to bucco-lingual location in Ketac-Fil and Fuji Ⅱ LC group, and lingaul specimen exhibited more leakage(ANOVA p<0.05).

《竹取物語》성립에 관한 일고찰

이영란 효성여자대학교 한국전통문화연구소 1996 韓國傳統文化硏究 Vol.11 No.-

『竹取物語』の內容の中で, 特に翁による主人公かぐや姬の發見の部分と, 後半部の月の世界への昇天を語る部分は, 『萬葉集』『風土記』『今昔物語集』その他に, 類似する話として傳ぇられている. これはすなわちこの物語の素材が全篇にわたって古代に傳ぇられていた多くの民間說話をはじめ, いろいろの多樣な傳承屑話に基づいているのを語っている. それで本考では, この物語の中核をなす素材が具體的にどんなものであるかを考察し, それが 作品の中ではどうふうに取り扱われているのかを調べることで, この物語の主題性について考えてみることにしたい. 『竹取物語』は 素材の面から見ると大きく羽衣傳承と難題求婚譚の二つの流れをなしているが, いずれにしろ古代傳承それ自體がそのまま作品に なったのではなく, 傳えられていろいろの素材を消化し, 創作されたものと認めなければならい要素が多いにある. つまり この作品は日本古代に傳えられていた民間素材をもとにして, それが羽衣傳承が創作のヒントとなり 作品の現實性を加える效果も出す實在人物名を使つた難題求始譚を混ぜて出來あがつた假名散文作品である.

康有爲의 敎育改革

이영란 조선대학교 전통문화연구소 1999 전통문화연구 Vol.6 No.-

도로 노면의 형상과 강우의 임계 지속시간을 고려한 적정 우수 유출량 산정 및 영향분석

이종태,김영란,김갑수,윤세의,박영민 대한상하수도학회 2003 상하수도학회지 Vol.17 No.2

When calculating the storm runoff from road surface, it is recommendable to introduce the critical duration of rainfall by means of the RUNOFF (SWMM) model, or the Rational method with the travel time values of the kinematic wave' or Kerby's equation modified by multiplying the correction factor of 2.3 or 1.1, respectively. But the travel time of 5-10 minutes suggested in the Guide Manual for Sewer Design is too long to use for calculating road surface runoff. The peak runoff rate increases as the road sectional slope increases, whereas it shows the opposite results for an increase in the longitudinal slope. Also, the effects of the width and length of the road on the surface runoff rates increases greatly, as their values increase.

Aflatoxin B_1과 Dexamethasone이 白鼠 肝 Kupffer 細胞와 內皮細胞에 미치는 影響에 關한 走査電子顯微鏡的 硏究

이영호,김수일,박경란,노승무,김원식 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.1

For the study on the effects of aflatoxin B_1 and corticosteroid to the Kupffer cells and endothelial cells of the liver, aflatoxin B_1(1mg/kg) and dexamethasone(4mg/kg) were administrated to the 3 groups of rats; the aflatoxin B_1-treated group, the dexamethasone-treated group, and the aflatoxin B_1 and dexamethasone-treated group. The liver tissues were fixed by perfusion with 0.5% glutraldehyde and 0.5% paraformaldehyde solution at 1, 12, and 24 hours after the administration. The fixed liver tissues were cracked and observed Kupffer cells and endothelial cells under scanning electron microscope. The results were as follows; 1. In aflatoxin B_1-treated group, the Kupffer cells were destructed severely and the endothelial cells were destructed partially. 2. In dexamethasone-treated group, the cytoplasmic processes of the Kupffer cells were shortened, but the endothelial cells showed no morphological changes. 3. Destructive changes of Kupffer cells and endothelial cells in the aflatoxin B_1-treated group were reduced after administration of dexamethasone. 4. The large Kupffer cells were destructed and disappered after administration of aflatoxin B_1, but small Kupffer cells were found until 24 hours after administration. 5. In aflatoxin B_1 and dexamethasone treated group, Kupffer cells were destructed severely but the capacity to catch foreign particles were remained. Accordingly, it is considered that aflatoxin B_1 will destruct Kupffer cells severely and the endothelial cells partially, but dexamethasone will reduce the destructive changes of the Kupffer cells and endothelial cells induced by aflatoxin B_1 respectively.

중학생의 아토피피부염 유무에 따른 생활양식 비교 연구

이화자,조영란,박지은 韓國學校保健學會 2005 韓國學校保健學會誌 Vol.18 No.2

Purpose:This study compared lifestyles of middle school students with and without atopic dermatitis in order to obtain the baseline information for health education. Methods:This study involved 256 students from 20 middle schools in Busan who suffered from atopic dermatitis and 231 students from 2 middle schools in Busan who did not have atopic dermatitis. Results:Students with atopic dermatitis had a lower family income (塔=16.99, p<.001) and were more likely to come from a nuclear family (塔=10.28, p<.001) than control students. 98% of the students with atopic dermatitis had several skin symptoms. 78.5% of students with atopic dermatitis reported experiencing difficulties in their daily because of their condition. Students with atopic dermatitis took shorter baths and used soap less frequently than the students in the control group. The students with atopic dermatitis cleaned their houses and bedclothes more often than normal students in an attempt to remove cockroaches and house-dust mites. Students with atopic dermatitis also ate fast and instant foods more often than normal students. Conclusions:Some lifestyle differences exist between students with and without atopic dermatitis. Therefore, education and guidance may be important to promote good health and improve lifestyle quality.

高天原 神話

李永蘭 대구효성가톨릭대학교 1992 연구논문집 Vol.45 No.1