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Spheroid 조합자극치료 적용이 신체구성에 미치는 영향
홍성찬,김영빈,정동혁,박병근,김유성,이성진 원광대학교 체력과학연구소 2008 體力科學硏究 Vol.30 No.1
The present study aims to explore the effects of applying spheroid-combined stimulating therapy on body composition. For this aim. 20 persons were selected as subjects and 10 of them each were assigned to the experimental group and control group, respectively. The experimental group was applied a 12-week combined stimulating therapy and changes in physical constitution of the members were measured before application and 4, 8 and 12 weeks after application. From the study, following conclusions could be drawn: First, body weights of the experimental group decreased from 59.9kgs before application of the spheroid-combined stimulating therapy to 57.2kgs 12 weeks after application, no significant but 4.51% change. Second, body fats of the experimental group changed from 18.8kgs before application to 16.4kgs 12 weeks after application, no significant but 12.77% reduction. Third, % fats of the experimental group decreased from 31.2% before application to 28.6% 12 weeks after application, no significant change but 8.33% reduction. Fourth, body mass index(BMI) of the experimental group decreased from 23.23 kg/㎡ before application of the therapy to 21.43kg/㎡ after application, no significant but 8.03% reduction. As seen above, the 12-week application of the spheroid-combined stimulating therapy produced no significant changes in physical constitution as physical exercise did, but improved physical constitution by reducing certain amount of boy weight, body fat, % fat and BMI. In order to detect more positive and significant changes in physical constitutions, continued studies and clinical experiments should be performed to more diverse subjects using technically reinforced equipment for spheroid-combined stimulating therapy.
A Mutation in <i>PMP2</i> Causes Dominant Demyelinating Charcot-Marie-Tooth Neuropathy
Hong, Young Bin,Joo, Jaesoon,Hyun, Young Se,Kwak, Geon,Choi, Yu-Ri,Yeo, Ha Kyung,Jwa, Dong Hwan,Kim, Eun Ja,Mo, Won Min,Nam, Soo Hyun,Kim, Sung Min,Yoo, Jeong Hyun,Koo, Heasoo,Park, Hwan Tae,Chung, Ki Public Library of Science 2016 PLoS genetics Vol.12 No.2
<▼1><P>Charcot-Marie-Tooth disease (CMT) is a heterogeneous group of peripheral neuropathies with diverse genetic causes. In this study, we identified p.I43N mutation in <I>PMP2</I> from a family exhibiting autosomal dominant demyelinating CMT neuropathy by whole exome sequencing and characterized the clinical features. The age at onset was the first to second decades and muscle atrophy started in the distal portion of the leg. Predominant fatty replacement in the anterior and lateral compartment was similar to that in CMT1A caused by <I>PMP22</I> duplication. Sural nerve biopsy showed onion bulbs and degenerating fibers with various myelin abnormalities. The relevance of <I>PMP2</I> mutation as a genetic cause of dominant CMT1 was assessed using transgenic mouse models. Transgenic mice expressing wild type or mutant (p.I43N) <I>PMP2</I> exhibited abnormal motor function. Electrophysiological data revealed that both mice had reduced motor nerve conduction velocities (MNCV). Electron microscopy revealed that demyelinating fibers and internodal lengths were shortened in both transgenic mice. These data imply that overexpression of wild type as well as mutant <I>PMP2</I> also causes the CMT1 phenotype, which has been documented in the <I>PMP22</I>. This report might expand the genetic and clinical features of CMT and a further mechanism study will enhance our understanding of <I>PMP2</I>-associated peripheral neuropathy.</P></▼1><▼2><P><B>Author Summary</B></P><P>Isolation of causative mutation is still challenging in genetic diseases with a variety of genetic causes. We discovered a mutation in a novel gene from a family exhibiting a peripheral neuropathy by virtue of next-generation sequencing. Although the family shows characteristic clinical features of hereditary motor and sensory neuropathy, we could not find a mutation from well-known genes. To demonstrate the clinical relevance of the novel gene, we generated transgenic mice, which carry the patients’ mutation within their chromosome. The transgenic mice exhibited the same phenotype as the patients including peripheral neuropathic symptoms and reduced locomotor function. We also observed the affected peripheral nervous system through electron microscopy. It seems that the expression of the mutant protein impairs the myelin of peripheral nervous system. These data might expand the genetic, clinical, and pathophysiological features of the peripheral neuropathy and a further investigation will enhance our understanding of disease in the peripheral nervous system.</P></▼2>
A family with axonal sensorimotor polyneuropathy with TUBB3 mutation
HONG, YOUNG BIN,LEE, JA HYUN,PARK, HYUNG JUN,CHOI, YU-RI,HYUN, YOUNG SE,PARK, JI HOON,KOO, HEASOO,CHUNG, KI WHA,CHOI, BYUNG-OK SPANDIDOS PUBLICATIONS 2015 MOLECULAR MEDICINE REPORTS Vol.11 No.4
<P>Mutations in the 관???tubulin isotype III (TUBB3) gene result in TUBB3 syndrome that includes congenital fibrosis of the extraocular muscle type 3 (CFEOM3), intellectual impairments and/or an axonal sensorimotor neuropathy. In the present study, a TUBB3 D417N mutation was identified in a family with axonal sensorimotor polyneuropathy by whole exome sequencing. The proband exhibited gait disturbance at the age of 12 years and was wheelchair bound at 40 years. However, the proband's cousin exhibited gait disabilities at 45 years of age and was still able to walk when he was 60 years old. Ophthalmoplegia and intellectual impairment were not observed in either patient. A sural nerve biopsy identified an absence of large myelinated fibers without demyelinating degeneration. Based on these clinical features, the two patients exhibited an axonal peripheral neuropathy without CFEOM3. These results therefore suggested that certain TUBB3 mutations may predominantly be associated with axonal peripheral neuropathy. Furthermore, the results also suggested that TUBB3 mutations may be implicated in modulating the inter??? and intra???familial heterogeneity of clinical phenotypes.</P>
( Yun Bin Lee ),( Joon Yeul Nam ),( Jeong-hoon Lee ),( Young Chang ),( Hyeki Cho ),( Young Youn Cho ),( Eun Ju Cho ),( Su Jong Yu ),( Hwi Young Kim ),( Dong Ho Lee ),( Jeong Min Lee ),( Seong Gyu Hwan 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Whether a sustained virologic response (SVR) improves long-term outcomes in chronic hepatitis C (CHC) patients with earlier-stage fibrosis has not been established. We investigated the differential effect of SVR on the risk of outcomes according to hepatic fibrosis grade. Methods: Fibrosis grade was categorized using FIB-4: <1.45, low-probability of significant fibrosis; 1.45-3.25, intermediate-probability; and ≥3.25, high-probability. Primary and secondary endpoints were hepatocellular carcinoma (HCC) occurrence and death, respectively. Results: Among 1,373 included CHC patients, 744 patients were treated with interferon-based or -free regimens and 622 (83.6%) achieved SVR. The 5-year cumulative incidences of HCC were 12.3%, 12.7%, and 3.4% in the untreated group, the non-SVR group, and the SVR group, respectively (P<.001 by log-rank test) (Figure A). SVR was independently associated with lower risk of HCC (vs. untreated: adjusted hazard ratio [aHR], 0.150; 95% confidence interval [CI], 0.067-0.332; P<.001) and overall death (vs. untreated; aHR, 0.162; 95% CI, 0.056-0.472; P<.001) during the median observation of 3.5 (interquartile range, 1.4-6.6) years. The SVR group had significantly lower risk of HCC than the untreated group among patients with intermediate-probability (n=492: aHR, 0.061; 95% CI, 0.008-0.479; P=.008) and high-probability (n=446: aHR, 0.217; 95% CI, 0.087-0.540; P=.001) of significant fibrosis, but not among patients with low-probability (n=258: adjusted HR, 0.884; 95% CI, 0.044-17.637; P=.94) (Figure B-D). Among 622 patients achieving SVR, 314 patients received IFN-based therapy and 308 received DAA therapy. Type of antiviral agent that induced SVR was not associated with HCC risk (vs. IFN-based therapy; adjusted HR, 2.383; 95% CI, 0.183-30.998; P=.51) and all-cause mortality (vs. IFN-based therapy; adjusted HR, 2.885; 95% CI, 0.372-22.346; P=.31). HRs were maintained after balancing with inverse probability weighting. Conclusions: SVR was associated with reduced risk of HCC development and all-cause mortality in patients with CHC.
Seo, Yu Bin,Song, Joon Young,Cheong, Hee Jin,Cho, Young Duck,Wie, Seong-Heon,Jeong, Hye Won,Kim, Woo Joo Blackwell Publishing Ltd 2014 Influenza and other respiratory viruses Vol.8 No.1
<P>The Hospital-based Influenza Morbidity and Mortality (HIMM) surveillance system is an emergency room (ER)-based influenza surveillance system in Korea that was established in 2011. The system was established under the assumption that integrated clinical and virologic surveillance could be performed rapidly and easily at seven tertiary hospitals' ER. Here, we assessed the correlation between data generated from the HIMM surveillance system and the Korean national influenza surveillance systems during the 2011–2012 influenza season using cross-correlation analysis and found strong correlations. Rapid antigen-test-based HIMM surveillance would predict the start of influenza epidemic earlier than pre-existing influenza-like-illness-based surveillance.</P>
김영빈(Young Bin Kim),강대영(Dae Young Kang),유형민(Hyung Min Yu),한승오(Seung Oh Han),김수인(Su In Kim),권지운(Ji Woon Kwon),조용근(Yong Geun Cho) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.4
본 논문은 굴착기용 전자제어 컨트롤 밸브의 신뢰성 평가를 위한 장비개발 방안을 기술하였다. 현재 개발 중인 굴착기 전자제어 컨트롤 밸브 신뢰성 평가 장비는 100 톤 급 이하 굴착기에 장착되는 컨트롤 밸브에서 발생되는 고장을 파악하기 위해 내구수명 시험과 압력 손실, 내·외부 누유, 스풀 습동, EPPR Valve 응답성, Relief Valve 특성 및 미터링 특성의 성능시험 등이 가능하다. 본 신뢰성 평가 장비 개발 연구를 통해 국산 컨트롤 밸브의 신뢰성 확보를 위한 기초 자료로 활용할 예정이다. This paper describes an equipment development plan for the reliability evaluation of electronic control valves for excavators. Excavator electronic control valve reliability evaluation equipment currently under development is a durability test and pressure loss, internal/external oil leakage, spool sliding, EPPR valve responsiveness, and relief to identify failures occurring in control valves mounted on excavators below 100ton class. It is possible to perform performance tests of valve characteristics and metering characteristics. This reliability evaluation equipment development study will be used as basic data for securing the reliability of domestic control valves.