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Song, Ilchan,Lee, Young Koung,Kim, Jin Wook,Lee, Seung-Won,Park, Se Ra,Lee, Hae Kyung,Oh, Soyeon,Ko, Kinarm,Kim, Mi Kyung,Park, Soon Ju,Kim, Dae Heon,Kim, Moon-Soo,Kim, Do Sun,Ko, Kisung Korean Society for Molecular and Cellular Biology 2021 Molecules and cells Vol.44 No.10
Transgenic Arabidopsis thaliana expressing an anti-rabies monoclonal antibody (mAb), SO57, was obtained using Agrobacterium-mediated floral dip transformation. The endoplasmic reticulum (ER) retention signal Lys-Asp-Glu-Leu (KDEL) was tagged to the C-terminus of the anti-rabies mAb heavy chain to localize the mAb to the ER and enhance its accumulation. When the inaccurately folded proteins accumulated in the ER exceed its storage capacity, it results in stress that can affect plant development and growth. We generated T<sub>1</sub> transformants and obtained homozygous T<sub>3</sub> seeds from transgenic Arabidopsis to investigate the effect of KDEL on plant growth. The germination rate did not significantly differ between plants expressing mAb SO57 without KDEL (SO plant) and mAb SO57 with KDEL (SOK plant). The primary roots of SOK agar media grown plants were slightly shorter than those of SO plants. Transcriptomic analysis showed that expression of all 11 ER stress-related genes were not significantly changed in SOK plants relative to SO plants. SOK plants showed approximately three-fold higher mAb expression levels than those of SO plants. Consequently, the purified mAb amount per unit of SOK plant biomass was approximately three times higher than that of SO plants. A neutralization assay revealed that both plants exhibited efficient rapid fluorescent focus inhibition test values against the rabies virus relative to commercially available human rabies immunoglobulins. KDEL did not upregulate ER stress-related genes; therefore, the enhanced production of the mAb did not affect plant growth. Thus, KDEL fusion is recommended for enhancing mAb production in plant systems.
국가 암검진 사업의 대장암 선별검사로 시행한 면역화학 분변잠혈검사의 의의
임준욱 ( Jun Uk Lim ),배나영 ( Na Young Bae ),송원경 ( Won Koung Song ),차재명 ( Jae Myung Cha ),이정일 ( Joung Il Lee ) 대한장연구학회 2010 Intestinal Research Vol.8 No.2
Background/Aims: Colorectal cancer (CRC) is one of the major causes of death and poses a major public health concern. The National CRC Screening Programme (NCSP) provides annual CRC screening using a fecal occult blood test for individuals >50 years of age since 2004. The purpose of the current study was to determine the outcomes and efficacy of a fecal immunochemical test (FIT) based on the NCSP in a quality-controlled university hospital setting. Methods: We retrospectively reviewed the medical records and a standardized questionnaire from the NCSP of 3,852 individuals who underwent a FIT between March and December 2009. All of the subjects submitted a stool specimen for a FIT, while a double-contrast barium enema or colonoscopy was performed as a confirmatory examination for FIT-positive individuals. The CRC screening rate and rate of detection colorectal adenomas, advanced adenomas, and colorectal cancers by FIT were evaluated. Results: The CRC screening rate with FIT was very high (72.3%), but the positive rate of detection by FIT was only 1.3%. The rate of detection for colorectal cancers, adenomas, and advanced adenomas by FIT was 0.08%, 0.39%, and 0.13%, respectively. The quantitative values of FIT in individuals with colorectal adenomas and cancers were significantly higher than other colorectal diseases. Men (P=0.001) and elderly individuals (P=0.039) were significantly more common in the FIT-positive group than the FIT-negative group. Approximately 28% of the subjects with FIT-positive tests did not receive a confirmatory examination. Conclusions: Although the FIT had a low rate of detection, the FIT was a useful screening tool for detection of CRC in the NCSP. It will be important to increase CRC screening rates and confirmatory examination rates. (Intest Res 2010;8:126-134)
Keun-hong Kim,Xiangqi Meng,Eun-whee Kang,Koung-won Seo,Song-hee Lee,Soon-deok Lee 한국사회적질학회 2021 사회적질연구 Vol.5 No.3
중국은 1979년 이후로 한자녀정책을 주요 정책으로 추진해왔고, 이로 인해 저출산 사회로 전환되었 다. 또한 발전된 보건과 의료기술로 노인들의 수명이 급격히 늘어나면서 중국의 고령화율 역시 급증하 였다. 이렇듯 수발이 필요한 고령인구는 급증하였으나, 현재 중국에는 이들을 돌볼 돌봄인력이나 인프 라가 턱없이 부족한 상태이다. 본 연구는 이러한 노인수발 문제를 해결하기 위한 제도적 해법으로 노인 장기요양보험에 주목한다. 본 연구는 중국 노인장기요양보험제도의 도입과정과 시범사업 등을 살펴본 후, 노인장기요양보험제도 도입의 선도국가인 한국으로부터 어떤 정책교훈을 얻을 수 있는지 살펴보았 다. 본 연구는 연구를 수행함에 있어 주로 문헌연구 분석을 사용하였다. 본 연구는 두 가지 의의를 갖는다. 첫째, 중국 노인장기요양보험제도의 시범사업을 개관함으로써 그 흐름은 물론 그에 관한 기초 자료를 제공하고 있다. 둘째, 중국의 노인수발 문제를 연구함에 있어 기존 연구들에서 찾아볼 수 없는 비교사회정책학적 접근법, 특히 동아시아 사회복지에 대한 비교연구를 수행하였다. China implemented the one-child policy in 1979 and has experienced its various negative effects since then. In particular, the social phenomenon during the transition of its society to an aging one is a representative example of the negative effects. During its transition to an aging society, China has been in a situation where it has had to deal with problems related to the elderly and family support that some East Asian countries such as Japan and South Korea has also experienced. With this as background, this study tried to focus on long-term care insurance for the elderly as an institutional solution for solving various problems that arose during its transition to an aging society. Specifically, the introduction process of long-term care insurance system for the elderly in China was examined, and some implications were obtained from the policies in South Korea, which is known as an advanced country regarding this system. Through various related literature and prior research, the study summarized the background to the introduction of the long-term care insurance system for the elderly in China, the progress of the trial program of the long-term care insurance system for the elderly in China, the expansion of the trial program, and implications of the long-term care insurance system for the elderly in South Korea. The implications of this study are as follows: First, this research is significant in that it will show how the pilot operation of China's long-term care insurance system flowed along with basic related data. Second, it is meaningful as South Korea’s long-term care insurance system was explored as an institutional way to address problems related to providing support for the elderly in China.