녹용대보탕(鹿茸大補湯)이 AAPH로 유발된 산화병태(酸化病態)모델 흰 쥐의 항산화(抗酸化) 작용(作用)에 미치는 영향

배나영,안택원,Bae, Na-Young,Ahn, Taek-Won 사상체질의학회 2007 사상체질의학회지 Vol.19 No.2

1. Objectives This study aimed to investigate the anti-oxidative effect of Nocyongdaebo-tang (NYD) decoction in oxidized rats induced by AAPH. 2. Methods AAPH (2.2-azobis-2 aminodinopropane-hydrochloride) was injected intraperitoneally to induce oxidization and NYD was orally administered to the rats. To observe the anti-oxidative effect of NYD, we performed blood chemistry analysis, histological analysis, and evaluated the levels of SOD, catalase, glutathione, NO and MDA in liver. 3. Results & Conclusions 1) Serum Albumin level was increased significantly in the NYD group as compared with the control group and the saline group. 2) Serum LDL-cholesterol level was reduced significantly in the NYD group as compared with the control group. 3) GPT level in liver was reduced significantly in the NYD group as compared with the control group. 4) SOD, catalase activity and glutathione levels were increased significantly in the NYD group as compared with the control group and the saline group. 5) The levels of NO and MDA were reduced significantly in the NYD group as compared with the control group. 6) The degenerative change of liver tissue of NYD group was decreased in comparison with the control group. In conclusion, NYD decoction is considered to have an anti-oxidative effect in rats.

사상체질병증 임상진료지침: 예방 및 위험인자

배나영,이의주,Bae, Na-Young,Lee, Eui-Ju 사상체질의학회 2015 사상체질의학회지 Vol.27 No.1

Objectives This research was proposed to present Clinical Practice Guideline (CPG) for Prevention of Sasangin disease pattern of Sasang Constitutional Medicine (SCM) and diseases closely related with Sasang constitution. Each CPG was developed by the national-wide experts committee consisting of SCM professors. Methods At first, we searched the literatures related to SCM such as "Dongeuisusebowon", Textbook of SCM and Clinical Guidebook of SCM. Also we searched the articles related to the studies about risk factors for Sasangin disease pattern of both at home and abroad. Finally, we selected leading risk factors of Sasangin disease pattern and developed CPG for prevention of Sasangin disease pattern of SCM. And then, we searched the literatures related SCM such as "Dongeuisusebowon" and the articles on the correlation between disease and Sasang constitution using case-control studies, observational studies or cross sectional studies of both at home and abroad. Next, we selected diseases closely related with Sasang constitution on the basis of articles including prevalence rate and odds ratio between disease and Sasang constitution and finally developed CPG for these diseases. Results and Conclusions We categorized risk factors of Sasang disease pattern into 2 types: non-modifiable and potentially modifiable. 3 items (age, sex and genetic factors) were classified as non-modifiable risk factors of Sasang disease pattern. 6 items (original symptom, stress, diet and nutrition, physical activity, alcohol and drug misuse) were classified as less well-documented or potentially modifiable risk factors of Sasangin disease pattern. We found out Sasang constitution is more likely to develop some diseases. It was proven that Sasang constitution increase the risk of hypertension, diabetes mellitus, metabolic syndrome, stroke, nonalcoholic fatty liver and obstructive sleep apnea. And there is high probability of Sasang constitution being potential risk factor for obesity, hyperlipidemia, allergy and cancer. Also, we found out Taeeumin is independent risk factor for hypertension, diabetes mellitus, metabolic syndrome, stroke, nonalcoholic fatty liver and obstructive sleep apnea. Therefore we recommend that Taeeumin need to prevent these disease by regular checkups and aggressive management.

심혈관계 질환의 위험인자와 사상체질 사이의 연관성 및 활성산소가 이에 미치는 영향에 대한 임상적 연구

한경수,배나영,이한얼,안택원,Han, Kyung-Su,Bae, Na-Young,Lee, Han-Eol,Ahn, Taek-Won 사상체질의학회 2007 사상체질의학회지 Vol.19 No.2

1. Objectives The purpose of this study was to prove the correlation between risk factor of cardiovascular disease and Sasang Constitution and to investigate the effect of oxygen free radical on this correlation. 2. Methods We analyzed 129 patients who visited Cheonan oriental medical hospital from Apr 1, 2007 until May 31, 2007, for medical examination, which Includes Sasang Constitution examination, blood chemistry test and physical examination. And we classified their results into 4 groups based on with blood lipoprotein level and body mass index. 3. Results and Conclusions Mean of lipoprotein in blood was not significantly different among constitutions but with body mass index, was significantly higher in Taeumin than others. And count of dyslipoproteinemia was significantly higher in Taeumin group than soeumin. Therefore, according to our results, risk of cardiovascular disease was higher in Taeumin than other constitutions. Oxygen free radical did not have much effect on correlation between risk factor of cardiovascular disease and Sasang Constitution. However, there was some evidence in soeumin group, that oxygen free radical may have effect on origination of hyperlipidemia.

소양인(少陽人) 부종(浮腫) 환자(患者) 치험례(治驗例)

안택원,배나영,Ahn, Taek-Won,Bae, Na-Young 사상체질의학회 2005 사상체질의학회지 Vol.17 No.3

1. Objectives The purpose of this study is to evaluate the effectivity of the Korean herbal medicine therapy which is based on the Sasang constitutional medicine for the Soyangin Edema Patient 2. Methods Patient who diagnosed as Soyangin by physical characteristic, posture and symptoms is evaluated with length of patient' Lt. calf, ankle, foot circumference after medication 3. Results After medicine, 1) Length of patient' Lt. calf was on the decrease from 37.2cm to 34.4cm 2) Length of patient' Lt. ankle was on the decrease from 27.8cm to 25.4cm 3) Length of patient' Lt. foot was on the decrease from 28.0cm to 25.7cm Edema of a Soyangin patient responded well to the treatment with Dojeokgangki-tang 4. Conclusions The case study shows an efficient results by using Dojeokgangki-tang in treatment of Soyangin edema patient.

태음인 조열병증(燥熱病證)으로 진단한 원인불명의 팔다리 저림 및 위약감 환자 치험 1례

이미숙,배나영,Lee, Mi-Suk,Bae, Na-Young 사상체질의학회 2015 사상체질의학회지 Vol.27 No.3

Objectives The aim of this study was to report significant improvement of paresthesia and weakness in the limbs of unknown cause after treatment with Mangeummoonmu-tang and Cheongeummoonmu-tang in a Taeeumin patient. Methods The patient was diagnosed as Taeeumin Dry-Heat (Joyeol) pattern and treated with Mangeummoonmu-tang, Cheongeummoonmu-tang and acupuncture. The patient's subjective symptoms of paresthesia and weakness were observed using Global Assessment Scale (GAS) during the treatment period. Results and Conclusion The symptoms of paresthesia and weakness decreased from GAS 100 to GAS 0 for two weeks. Furthermore, the patient's symptoms of fatigue and xeroderma were reported to be improved after treatment. In conclusion, this study shows that Sasang constitutional medicine can be effective treatment for Taeeumin patient with paresthesia and weakness in the limbs of unknown cause.

열다한소탕(熱多寒少湯) 가감방(加減方)의 자가탐식(自家貪食) 유도 활성과 관련 단백질 탐색

김희주,배나영,장문희,양현옥,안택원,Kim, Hee-Ju,Bae, Na-Young,Jang, Moon-Hee,Yang, Hyun-Ok,Ahn, Taek-Won 사상체질의학회 2013 사상체질의학회지 Vol.25 No.3

Objectives Modified Yeolda-Hanso tang (MYH) is a traditional herbal formula in Korea for various diseases. MYH is containing the 10 herbs : Pueraria lobata (Willd.) Ohwi, Angelica tenuissima Nakai, Scutellaria baicalensis Georgi, Platycodon grandiflorum (Jacq), Angelicae Dahurica, Cimicifuga heracleifolia Kom, Raphanus sativa L., Polygala tenuifolia (Willd), Acorus gramineus Soland and Dimocarpus longan Lour. The 10 herbs is constituted as a ratio of the 6:4:2:1:2:2:2:4:6:6. We investigated neuroprotective effects of MYH on human neuroblastoma SH-SY5Y cells and evaluated the ability of MYH to prevent and treat for neurodegenerative diseases such as Parkinson's disease via basal autophagy enhancement. Methods Pharmacological induction of Autophagy by MYH in SH-SY5Y cells: Induction of autophagy by MYH in human neuroblastoma SH-SY5Y cells was carreid out by immunoblot analysis with several autophagy markers. SH-SY5Y cells were treated with MYH at the concentration of 400 and $800{\mu}g/ml$ for 24 hr. Specifically, the autophagosome proteins LC3 II and Atg5 levels were increased and autophagy pathway related proteins such as beclin-1, PI3 Kinase class III protein, ULK1, mTOR and AMPK were activated. Conclusions MYH can enhance the induction of autophagy through key regulator AMPK, mTOR, and Beclin-1 and it should be considered as a possible candidate of neuroprotective agents for such as Parkinson's disease.

태음병 황달증으로 진단한 소음인 황달 환자 치험 1례

이미숙,배나영,Lee, Mi-Suk,Bae, Na-Young 사상체질의학회 2016 사상체질의학회지 Vol.28 No.3

Objectives This case study is about a Soeumin patient with jaundice identified as Greater-Yin accompanied Jaundice pattern. In this study, we report significant improvements of anorexia, dyspepsia, fatigue and weight loss after treatment with Hyangsayangyi-tang, Insambaekhaogwanjung-tang and acupuncture.Methods The patient was identified as Greater-Yin accompanied Jaundice pattern and treated with Hyangsayangyi-tang, Insambaekhaogwanjung-tang and acupuncture. The Global Assessment Scale (GAS) was used to assess the improvements of anorexia, dyspepsia, fatigue and pelvic pain after the treatment. And the liver function test was performed to measure the overall function of the liver.Result and Conclusion The symptoms of anorexia, dyspepsia, fatigue and pelvic pain were improved from GAS 100 to GAS 0-10 for four months. And The liver function test showed improved the response to treatment. The levels of AST (aspartate aminotransferase)/ALT (alanine aminotransferase) decreased from 43/42 to 29/14 IU/L. The level of total bilirubin was decreased from 2.7 to 1.9 mg/dL. Furthermore total weight gain was 8 kg from starting weight of 36.5 kg for four months. In conclusion, this study shows that Sasang constitutional medicine can be effective and safe treatment for the Soeumin patient with jaundice.

수화기제탕(水火旣濟湯) 증류액이 노화 흰쥐의 비장세포 면역활성에 미치는 영향

최재송,배나영,안택원,Choi, Jae-Song,Bae, Na-Young,Ahn, Teak-Won 사상체질의학회 2011 사상체질의학회지 Vol.23 No.3

1. Objectives: The purpose of this study is to investigate the effect of Suhwagije-tang(SGT) distillate on the immune activity of spleen cells of aged SD rats. 2. Methods: We used 10, 50, 72 weeks old SD rats in this study. Spleen cells from SD rats were stimulated with ConA and treated with 1% Vitamin C(Vit.C) or Suhwagijetang distillate(SGT). After 24 hours, the concentrations of IL-2, IL-4, IL-10, IFN-${\gamma}$ in the cell culture supernatant were measured by ELISA. 3. Results and Conclusions 1) At all concentration of SGT distillate, survival rates of liver cells were higher than the control group. In addition, 50% SGT distillate group's cell survival rates were significantly higher than other groups. 2) In 10 weeks SD rats(SGT group), the concentration of IL-2 significantly decreased in comparison with ConA group, Vit.C group. In 52 weeks SD rats(SGT group), the concentration of IL-2 significantly decreased in comparison with ConA group. 3) In 10, 52 weeks SD rats(SGT group), the concentration of IL-4 significantly decreased in comparison with ConA group. 4) In 10 weeks SD rats(SGT group), the concentration of IL-10 significantly decreased in comparison with ConA group. And in 72 weeks SD rats(SGT group), the concentration of IL-10 significantly increased in comparison with Vit.C group. 5) In 52, 72 weeks SD rats(SGT group), the concentration of IFN-${\gamma}$ significantly decreased in comparison with 10 weeks SD rats(SGT group). These results suggest that Suhwagije-tang(SGT) distillate has the effect of increasing the immune activity of spleen cells of aged SD rats.

조위승청탕(調胃升淸湯)으로 호전된 올리브교소뇌위축증 환자 1례

이미숙,배나영,Lee, Mi-Suk,Bae, Na-Young 사상체질의학회 2013 사상체질의학회지 Vol.25 No.3

Objectives The aim of this study was to examine significant improvement of dizziness, gait disturbance, insomnia and xerostomia after treatment with Jowisengcheong-tang in a Taeeumin patient with olivopontocerebellar atrophy (OPCA). Methods The patient's subjective and objective symptoms were observed daily throughout the hospitalization period using global assessment (G/A), and the Unified Multiple System Atrophy Rating Scale (UMSARS) was used to assess the overall function of patient. Results The symptoms of dizziness and xerostomia decreased from G/A 100 to G/A 10~30 for five days, and the UMSARS score decreased in Part I,II. Conclusions This case showed that Sasang constitutional medicine treatment can be effective treatment method for OPCA. We consider that consistent treatment can contribute to improve the patient's quality of life.

태음인(太陰人) 조열증(燥熱證)으로 진단한 진행된 파킨슨병 환자 치험례

이미숙,박유경,배나영,Lee, Mi-Suk,Park, Yu-Gyeong,Bae, Na-Young 사상체질의학회 2013 사상체질의학회지 Vol.25 No.4

Objectives This case study was about a Taeeumin patient with advanced Parkinson's disease diagnosed as Dry-heat symptomatic pattern. In this study, we reported significant improvement of motor and non-motor symptoms of this patient after Sasang constitutional medicine treatment. Methods The patient was diagnosed with Taeeumin Dry-heat symptomatic pattern and treated with Taeeumin's constitutional medications and acupuncture. The primary outcome measure for this study is Unified Parkinson Disease Rating Scale(UPDRS) to assess the overall function of patient. Secondary outcome assessments include Global Assessment Scale(GAS), change of patient's sleep, stool and urine. Results and Conclusions The patient treated with Taeeumin's constitutional medications and acupuncture had reduction in UPDRS (specifically Part II, Part III and Part IV) and GAS of motor symptoms. Furthermore, patient's sleep, stool and urine were reported to be normal after treatment. In conclusion, this study shows that Sasang constitutional medicine can be effective treatment for Taeeumin patient with Advanced Parkinson's disease diagnosed as Dry-heat symptomatic pattern.